Abstract The human stratum corneum (SC) contains an abundant amount of carotenoid antioxidants, quenching free radicals and thereby protecting the skin. For the precise measurements of the depth‐dependent carotenoid concentration, confocal Raman microscopy is a suitable method. The quantitative concentration can be determined by the carotenoid related peak intensity of a Gaussian function approached at ≈1524 cm−1 using non‐linear regression. Results show that the carotenoid concentration is higher...
Abstract Apolipoprotein B mRNA editing enzyme, catalytic polypeptide‐like (APOBEC) family consists of deaminases. Some isozymes of APOBEC3 are induced upon human papillomavirus infection or development of psoriasis skin lesions. However, the involvement of APOBEC3 in keratinocyte differentiation has not been addressed. We herein sought to evaluate the roles of APOBECs in mouse primary keratinocyte differentiation. We found that expression levels of APOBEC1 and APOBEC3 were increased during calcium‐induced...
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Thyroid, Ahead of Print.
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Facial nerve baroparesis is a rare complication of middle ear barotrauma reported almost exclusively in overpressure events related to diving and flying. Until the development of Eustachian tube balloon dilation, no diving compatible options existed to effectively and safely prevent recurrence. We present a case of a U.S. Navy diver with a history of repeated ipsilateral facial nerve paresis that occurred during diving. The patient underwent Eustachian tube balloon dilation of the affected side....
Objectives/Hypothesis To report the efficacy and safety of transtympanic plugging of the eustachian tube (ET) using a silicone plug (Kobayashi plug) for chronic patulous ET (PET). Study Design Prospective and multicenter trial conducted in which 30 PET patients were resistant to at least 6 months of conservative treatment. Methods The efficacy and safety of 28 and 27 patients, respectively, were analyzed. All patients fulfilled inclusion and exclusion criteria. The primary end point...
Objectives/Hypothesis This study aimed to provide evidence of whether unfractionated heparin used as adjuvant therapy in conjunction with systemic corticosteroid therapy improves hearing recovery in patients with profound idiopathic sudden sensorineural hearing loss (ISSNHL), and to compare the effect of this treatment with those of additional intratympanic corticosteroid therapy. Study Design Retrospective chart review. Methods Eighty‐seven patients with profound ISSNHL (≥90 dB) and...
Objectives The purpose of this study is to determine the effects of various prognostic factors for early glottic cancer patients who underwent radiotherapy. Methods We retrospectively reviewed the all patients who were treated at our hospital for early glottic squamous cell carcinoma from 2004 to 2016. Data included patient's age, sex, T classification, tumor size, pathological grade, anterior commissure involvement, subglottic extension, laryngeal ventricle involvement, and restriction of...
Objectives/Hypothesis To investigate the natural progression of hearing loss in patients with high‐frequency hearing loss whose audiograms met the criteria for a hybrid cochlear implant (CI). Study Design Retrospective database review. Methods We retrospectively identified patients who met the criteria for a hybrid CI from our audiometric database. We also recorded the etiology of hearing loss in each patient and excluded patients with retrocochlear etiologies, those age <6 years,...
Introduction Thyroid lobectomy is recommended with total laryngectomy in the National Comprehensive Cancer Network guidelines. However, it is associated with a 32% to 89% risk of hypothyroidism, which is a problem for patients without access to thyroid hormone monitoring and replacement. A number of studies have reported a low incidence of thyroid gland involvement and recommended preserving the thyroid gland in favorable cases. Yet there are no studies that report whether thyroid preserving laryngectomy...
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Related ArticlesComparison of prognostic implications between the 7th and 8th edition of AJCC TNM staging system for head and neck soft-tissue sarcoma in adult patients. Eur Arch Otorhinolaryngol. 2019 Aug 09;: Authors: Kim H, Choi N, Baek CH, Son YI, Jeong HS, Chung MK Abstract PURPOSE: This study aimed to investigate the prognostic factors for head and neck soft-tissue sarcoma (HNSTS) in adults, with the comparisons between the 7th and 8th edition...
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Related ArticlesCross-cultural adaption and validation of the Chronic Otitis Media Questionnaire 12 (COMQ-12) in the Italian language. Eur Arch Otorhinolaryngol. 2019 Aug 08;: Authors: Quaranta N, De Robertis V, Milella C, Pontrelli M, Greco A, Fiorella ML, Pontillo V, de Vincentiis M, Phillips JS, Ralli M Abstract PURPOSE: The evaluation of Health-Related Quality of Life (HRQoL) in patients with chronic otitis media COM has gained attention over the...
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Related ArticlesEndoscopic stapedotomy: a comparison between 4 mm and 3 mm nasal endoscope. Eur Arch Otorhinolaryngol. 2019 Aug 07;: Authors: Pradhan P, Preetam C Abstract BACKGROUND: Although, both the microscopic and endoscopic stapes surgery have claimed a parallel audiological outcome, the comparison between two standard endoscopes (4 mm and 3 mm) in endoscopic stapedotomy is not well documented. We have compared the clinical utility and audiological...
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Post-orthodontic white-spot lesions (WSL) in esthetically relevant incisor and canine areas impair dentofacial esthetics, and preventive dentistry treatment is definitely required in case of enamel cavitations...
The required pretreatment of CAD/CAM ceramic materials before resin composite cement application varies among studies. The aim of the present study was to evaluate the effect of hydrofluoric acid concentration...
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Abstract Objectives Two major classifications of frontoethmoidal cells, Lee and Kuhn’s and the IFAC (International Frontal Sinus Anatomy Classification), distinguish anterior, posterior and medial cells. The European anatomical position paper includes also lateral cells. According to the IFAC, anterior cells push the frontal sinus drainage pathway (FSDP) medially, posteriorly or posteromedially. Posterior cells push the FSDP anteriorly. The only medial cell, pushing the FSDP laterally is the...
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AbstractRecent studies suggest that frugivorous primates might display a preference for the ethanol produced by microbia in overripe, fermenting fruit as an additional source of calories. We therefore assessed the taste responsiveness of eight spider monkeys (Ateles geoffroyi) to the range of ethanol concentrations found in overripe, fermenting fruit (0.05-3.0%) and determined taste preference thresholds as well as relative taste preferences for ethanol presented in sucrose solutions and in fruit...
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Eur Thyroid J 2019;8:I–IV
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Patients with SCD syndrome (SCDS) may present with a myriad of auditory and/or vestibular complaints. Treatment of SCDS depends on severity of symptoms and impact on quality of life. Surgery is recommended for patients with debilitating auditory and/or vestibular symptoms. The goal of surgery is to create a durable and watertight seal of the bony SCC defect, thereby eliminating the “third window”. Repair involves either resurfacing and/or plugging of the dehiscent superior canal to eliminate the...
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Publication date: Available online 10 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Kristen L. Yancey, Loyce J. Cheromei, Jackie Muhando, Jim Reppart, James L. Netterville, Asitha DL. JayawardenaABSTRACTObjectiveTo develop a sustainable, comprehensive, intervention-based approach to pediatric hearing care in low- and middle income countries (LMICs) where global hearing loss is most heavily concentrated.MethodsCommunity health workers (CHWs) in Kilifi county,...
Publication date: Available online 10 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mohammad Soleimani, Sepehr Eslami, Reza Amani-Bei, Sadra Ansaripour
Publication date: Available online 10 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Aaqilah Bhamjee, Talita le Roux, Kurt Schlemmer, Jenny Perold, Nicolize Cass, Kelly Schroeder, Dani Schlesinger, Deon Ceronio, Bart VinckAbstractObjectiveTo determine and describe parent-perceived challenges related to the pediatric cochlear implantation process and support services received.MethodA multicenter survey study across six cochlear implant (CI) programs in South Africa...
Publication date: Available online 9 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Michael A. Belsky, Noel Jabbour
Publication date: Available online 9 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Malene Nøhr Demant, Ramon Gordon Jensen, Mahmood F. Bhutta, Gunnar Hellmund Laier, Jørgen Lous, Preben HomøeAbstractIntroductionGreenland has one of the highest prevalences of otitis media in the world. However, access to ear specialists throughout Greenland is limited and currently there are no national guidelines for treatment or prevention. Tele-otoscopy may be beneficial in...
Publication date: Available online 9 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Angela Wenzel, Roland Hülse, Claudio Thunsdorff, Nicole Rotter, Ian CurthoysAbstractOBJECTIVESThe video-Head-Impulse-Test (vHIT) is widely used to evaluate vestibular function. Nevertheless, there is no consensus on the necessary or ideal number of impulses performed for robust VOR gains. Therefore, the aim of our study is to analyze how many impulses are needed to receive reliable...
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Background: Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS) are effective in treating allergic rhinitis, but their effect on IL-25 release has not been studied. We aimed to study the link between IL-25 and the pathophysiology of allergic rhinitis...
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Conditions: Benign Tumor of Thyroid; HyperparathyroidismInterventions: Procedure: Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml); Drug: Dexmedetomidine plus propofol infusion; Procedure: Local infiltraion analgesia; Procedure: General anesthesia with endotracheal tubeSponsor: Mahidol UniversityRecruiting
Condition: Head and Neck CancerIntervention: Behavioral: SEA CHANGE interventionSponsors: Dublin City University; National University of Ireland, Maynooth; Newcastle University; St. James's Hospital, Ireland; St. Luke's Hospital; Royal Victoria Eye and Ear HospitalRecruiting
Conditions: Squamous Cell Carcinoma of the Head and Neck (SCCHN); Metastatic Castration Resistant Prostate Cancer (mCRPC)Interventions: Drug: avelumab; Drug: Bempegaldesleukin; Drug: talazoparib; Drug: enzalutamideSponsors: Pfizer; EMD Serono; Nektar Therapeutics; Astellas Pharma IncNot yet recruiting
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Abstract Maxillofacial trauma, a common injury in urban population following road traffic accident or act of interpersonal violence of which orbital floor fractures is common. It impairs the integrity of the extraocular muscles and may be accompanied by enophthalmos, orbital deformity and diplopia. Orbital reconstruction is essential to improve anatomical and visual deformity. Repair of orbital floor is done by autologous bone graft or synthetic implants. Compare outcome of orbital...
Abstract Otitis media with effusion (OME) has a detrimental effect on balance, which may not present as a clear symptom in children. This effect can be improved by the insertion of ventilation tubes. This study assesses balance in children suffering from OME pre and post operatively using computerized static posturography. 50 children of 3–6 years, suffering from OME were included in this observational descriptive study. These patients underwent myringotomy and grommet insertion....
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Abstract Background Though usefulness of robot assisted surgery has been largely reported and accepted, robot assisted gastrointestinal stromal tumors (GIST) treatment is rare. Hence, the aim of this study is to report a single center evaluation on gastric GIST's robotic resection. Methods Six patients were analyzed focusing on safe (conversion/complications rate; hospital stay), oncological (margin resection, recurrence rate) and feasible (operative time, technical tip and tricks) profile...
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Abstract Background Approximately 30% of nonsurgically treated patients with laryngeal squamous cell carcinoma will suffer recurrence, and many will be clinically N0; the indication for elective neck dissection (END) remains uncertain. We aimed to determine whether END is indicated during salvage laryngectomy. Methods Systematic review and meta‐analysis. Results A total of 1141 patients were identified from 17 studies. Occult nodal positivity was 13.7% (106/775) confidence interval...
Abstract Background Salvage total laryngectomy (TL) and laryngopharyngectomy (LP) after chemoradiotherapy may produce disfiguring defects with severe complications that require complex reconstructions. Methods Between January 2012 and December 2018, we enrolled 25 patients who underwent internal mammary artery perforator (IMAP) flap reconstruction after salvage TL or LP. We performed retrospective review of clinical charts to collect information such as history, timing of reconstruction,...
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