Environmental Justice, Volume 12, Issue 4, Page 194-203, August 2019.
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Abstract Considering the interplay between regional diversification and local community processes is a relatively nascent field of study. Here, I examined the phylogenetic and functional structure of African muroid assemblages at both regional (eight bioregions) and local (72 communities) levels to assess the relative roles of historical processes, environmental filtering and ecological interactions in community assembly. In addition, I used patterns of phylogenetic and functional...
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Related ArticlesCausative Factors for Complications in Transpalatal Advancement. Ann Otol Rhinol Laryngol. 2019 Aug 13;:3489419867969 Authors: Chan L, Kitpornchai L, Mackay S Abstract INTRODUCTION: Transpalatal advancement (TPA) is a procedure that is used when modern variants of uvulopharyn-gopalatoplasty are unable to provide enough anterior traction. Although successful in reduction of obstructive sleep apnea (OSA) parameters, it also comes with...
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Abstract This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t0)-, immediately post (t1)-, and 1-h post (t2) propofol administration....
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Investigating Macrophages Plasticity Following Tumour–Immune Interactions During Oncolytic Therapies
Abstract Over the last few years, oncolytic virus therapy has been recognised as a promising approach in cancer treatment, due to the potential of these viruses to induce systemic anti-tumour immunity and selectively killing tumour cells. However, the effectiveness of these viruses depends significantly on their interactions with the host immune responses, both innate (e.g., macrophages, which accumulate in high numbers inside solid tumours) and adaptive (e.g., ...
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Abstract Most studies of motifs of biological regulatory networks focus on the analysis of asymptotical behaviours (attractors, and even often only stable states), but transient properties are rarely addressed. In the line of our previous study devoted to isolated circuits (Remy et al. in Bioinformatics (Oxford, England) 19(Suppl. 2):172–178, 2003), we consider chorded circuits, that are motifs made of an elementary positive or negative circuit with a chord, possibly a self-loop....
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Related ArticlesCurrent advances in BCG-unresponsive non-muscle invasive bladder cancer. Expert Opin Investig Drugs. 2019 Aug 15;:1-14 Authors: Tse J, Singla N, Ghandour R, Lotan Y, Margulis V Abstract Introduction: The current first line therapy for high grade (HG) non-muscle invasive bladder cancer (NMIBC) is intravesical Bacillus Calmette-Guerin (BCG). Patients who recur or progress despite BCG are recommended to undergo radical cystectomy or participate...
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Abstract Objectives The relationship between the degree of a postoperative effective orifice area and temporal regression of a left ventricular mass after aortic valve replacement for aortic stenosis is unclear in patients without patient–prosthesis mismatch. We therefore investigated the relationship and independent predictors of left ventricular mass regression. Methods ...
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Abstract Objective Although surgical ventricular restoration for ischemic cardiomyopathy is expected as an alternative or bridge to heart transplantation, post-operative remodeling of left ventricle (LV) needs to be addressed. This study aimed to examine the effect of basic fibroblast growth factor (bFGF), which induces angiogenesis and tissue regeneration in ischemic myocardium, to prevent remodeling after surgical ventricular restoration...
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Zusammenfassung Die Therapieoptionen der peripheren arteriellen Verschlusskrankheit (pAVK) bestehen, abhängig vom Fontaine-Stadium, aus konservativen und revaskularisierenden Verfahren. Ziele der konservativen Therapie sind stadienabhängig die Verhinderung des Krankheitsprogresses, die Steigerung der Gehleistung, die Schmerzreduktion, die Ulkusabheilung und der Beinerhalt. Eine ausreichende Evidenz und Leitlinienempfehlungen existieren in allen Stadien für den Nikotinverzicht,...
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Zusammenfassung Prophylaktische Operationen sind ein wesentlicher Bestandteil der gefäßchirurgischen Tätigkeit. Die Indikation dazu ist mit zunehmendem Alter der Patienten kritischer zu stellen, da die Lebenserwartung naturgemäß sinkt, die Komplikationsrate aber mit dem Alter regelhaft steigt. Das Dilemma, das sich für das älter werdende Patientenklientel und deren Behandler in der Abwägung von Risiko und Nutzen vorbeugender Therapien ergibt, wird im folgenden Übersichtsartikel...
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Zusammenfassung Hintergrund Kompetenzbasierte Aus- und Weiterbildung bilden ein Kontinuum zwischen dem Lernen während des Studiums und der Fortsetzung im Rahmen der ärztlichen Weiterbildung. Die sich rapide verändernden Rahmenbedingungen im Gesundheitswesen haben zu erheblich gestiegenen Anforderungen an Lehrende im Bereich der ärztlichen Aus- und Weiterbildung geführt. Hieraus resultierte ein Paradigmenwechsel von einem zeit- und prozessbasierten...
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Zusammenfassung Hintergrund In den letzten 25 Jahren hat das Fach Gefäßchirurgie eine rasante Entwicklung im endovaskulären Behandeln arterieller und venöser Erkrankungen durchlebt. Dazu gehört bereits in vielen Häusern die Durchführung eines perkutanen Zugangs (PZ) zum Gefäßsystem. Fragestellung Die Sinnhaftigkeit des perkutanen Behandelns wird dem chirurgischen...
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Zusammenfassung Menschen mit chronischen Wunden sehen sich vielfältigen wund- und therapiebedingten Einschränkungen im Alltagsleben ausgesetzt. Verbunden sind damit neben körperlichen Beeinträchtigungen (z. B. Schmerzen, Geruch und Exsudatmengen) auch Einschränkungen der Selbstständigkeit, des sozialen Lebens und Einschränkungen in Bezug auf ihr Selbstbild. In Deutschland existieren keine Empfehlungen zur Vereinheitlichung einer rechtzeitigen Diagnostik und Therapie, mit dem Ziel...
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Abstract This study presents a design process for the ergonomic design of a hockey stick ultrasound probe, based on clinical applications needs, competitors benchmarking and analysis of feedback about a commercially available probe. The design is performed in two phases: (1) design of the product and initial evaluation of subjective satisfaction of expert users; (2) the subsequent review of the project and the selection of the preferred probe grip design. This approach involves...
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Abstract Background Patient preferences (PP), which are investigated in PP studies using qualitative or quantitative methods, are a growing area of interest to the following stakeholders involved in the medical product lifecycle: academics, health technology assessment bodies, payers, industry, patients, physicians, and regulators. However, the use of PP in decisions along the medical product lifecycle remains limited. As the adoption...
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Abstract Introduction In 2016, SB4 (Benepali®) became the first etanercept (ETN) biosimilar to obtain marketing authorisation in Europe. Despite robust analytical and clinical comparisons, outstanding questions remain on SB4 use in routine practice. Methods A systematic search for publications on real-world evidence of SB4 effectiveness, safety...
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Abstract Introduction To assess the efficacy and safety of the subcutaneous (s.c.) secukinumab 150 mg with loading (150 mg) or without loading (150 mg no-load) regimen through 104 weeks in patients with active psoriatic arthritis (PsA) in the FUTURE 4 (NCT02294227) study. Methods Patients with PsA (N = 341) were randomized to s.c. secukinumab...
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Abstract Introduction This open-label study evaluated the immunogenicity, safety, and efficacy of sarilumab monotherapy in patients with active, moderate-to-severe rheumatoid arthritis (RA) and inadequate response or intolerance to prior conventional synthetic disease-modifying antirheumatic drugs. Methods Adults with RA (n = 132) were randomized...
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Abstract Introduction The Work Productivity and Activity Impairment Specific Health Problem Questionnaire (WPAI:SHP) is used to assess the impact of an intervention on work productivity in patients with psoriatic arthritis (PsA). Unfortunately, studies reporting changes or improvements in domains of WPAI:SHP by patients with PsA have a limited threshold of meaning due to the absence of published minimal clinically important differences...
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Abstract Purpose Given the associations between poverty and poorer outcomes among older adults with cancer, we sought to understand the effects of dual enrollment in Medicare and Medicaid—as a marker of poverty—on self-reported care experiences among seniors diagnosed with cancer. Methods Retrospective, observational study using cancer registry, Medicare...
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Related ArticlesOssifying fibroma in the mandibular angle mimicking metastatic clear cell renal cell carcinoma: A case report. Medicine (Baltimore). 2019 Aug;98(33):e16595 Authors: Matsuda S, Yoshimura H, Yoshida H, Taga M, Imamura Y, Kiyoshima T, Sano K Abstract RATIONALE: Ossifying fibroma is benign fibro-osseous neoplasm. The authors report a case of ossifying fibroma in the mandibular angle suspected as metastasis of clear cell renal cell carcinoma....
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Related ArticlesApplication of hydroxyapatite nanoparticles in tumor-associated bone segmental defect. Sci Adv. 2019 Aug;5(8):eaax6946 Authors: Zhang K, Zhou Y, Xiao C, Zhao W, Wu H, Tang J, Li Z, Yu S, Li X, Min L, Yu Z, Wang G, Wang L, Zhang K, Yang X, Zhu X, Tu C, Zhang X Abstract Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA)...
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Related ArticlesAneurysmal Bone Cyst of the Distal Femoral Metaphysis in a Four-year-old Female Patient Presenting with a Pathologic Fracture: A Case Report. Cureus. 2019 Jun 06;11(6):e4846 Authors: Dorosh J, Vyas P Abstract Aneurysmal bone cysts (ABCs) are benign osteolytic vascular lesions that are capable of aggressive local expansion and bone destruction. These tumors are most common in adolescent patients and constitute approximately 9% of benign...
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Abstract Background Sleep disturbances are likely to be associated with emotional and behavioural problems in children. Aim The goal was to evaluate co-occurrences between sleep disturbances and behavioural and emotional problems in elementary school children by means of network analysis. Patients...
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Zusammenfassung Mit einer geschätzten Prävalenz von 0,005 % ist die idiopathische Hypersomnie eine extrem seltene Erkrankung. Sie gehört zu der Gruppe der Hypersomnolenzerkrankungen zentralen Ursprungs mit dem krankheitsdefinierenden Symptom der exzessiven Tagesschläfrigkeit. Trotz verschiedener neuroendokriner, immunologischer und genetischer Erklärungsansätze, die auch Untersuchungen der Schlafhomöostase und der zirkadianen Regulation des Schlafes einschlossen, konnten in den...
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Summary Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system (CNS). Effective treatments remain limited. Therefore, novel chemotherapy drugs with high efficiency and few adverse effects are urgently needed. Histone deacetylase (HDAC) and serum and glucocorticoid-regulated protein kinase 1 (SGK1) are targets for the prevention and treatment of GBM. Rhein has antitumor and SGK1 suppression effects, although its biological activity is limited...
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Summary Background Gastric malignancy is the third most frequently encountered cancer globally and have been documented to confer extremely poor prognosis, given their limited treatment options. The up-regulation of hepatocyte growth factor (HGF) has been found in various tumor tissues, including GC tissue, and has been linked with tumor development. Nevertheless, the pathways leading to HGF upregulation have yet to be fully explored. Methods Immunohistochemistry (IHC) assay was...
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Summary Background Checkpoint inhibitors bring marked benefits but only in a minority of patients and may also be associated with severe adverse events. Treatment outcome still cannot be faithfully predicted. The following study hypothesized that host genetics could be applied as predictive biomarkers for checkpoint inhibitor response and immune-related adverse events. We conducted a study based on germinal polymorphisms from genes coding for proteins involved in immune regulation....
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The incidence of lower extremity venous insufficiency is common in patients with pelvic venous insufficiency.
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We read with interest the article by Hwang et al1 entitled “Regression of varicose veins after cyanoacrylate closure of incompetent great saphenous veins without a localized concomitant procedure” in the Journal of Vascular Surgery: Venous and Lymphatic Disorders.
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For vascular anomalies, when clinical findings are not sufficient, auxiliary examination is essential. In this study, we characterize and differentiate the ultrasound (US) findings of deep infantile hemangioma (DIH) and venous malformation (VM).
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Communications regarding original articles and editorial management should be addressed to Peter Gloviczki, MD, and Peter F. Lawrence, MD, Editors, Journal of Vascular Surgery, 9400 W. Higgins Road, Suite 315, Rosemont IL 60018; telephone: 312-334-2355; fax: 312-334-2320; e-mail: JVASCSURG@vascularsociety.org. Information for authors appears in the July issue, at www.jvsvenous.org, and at jvs.editorialmanager.com. Authors should consult this document before submitting manuscripts to this Journal.
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In critically ill patients who were already receiving pharmacologic thromboprophylaxis, the use of intermittent pneumatic compression (IPC) did not significantly lower the incidence of deep venous thrombosis (DVT).
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News items of interest to the vascular surgeon must be received at least 8 weeks before the desired month of publication. Announcements published at no charge include those received from a sponsoring society of this Journal, those courses and conferences sponsored by state, regional, national, or international vascular surgical organizations, and university-sponsored continuing medical education courses. Send applicable events to Andrew O’Brien, Journal Manager, at a.obrien@elsevier.com. All other...
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