Kenneth A. Forde, MD, 1934–2019

EAES/SAGES consensus conference on acute diverticulitis: a paradigm shift in the management of acute diverticulitis

Clinical prediction model for tumor progression in Barrett’s esophagus Abstract Background Individuals with Barrett’s esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study aimed to identify a risk prediction model for tumor progression in individuals with BE based on age, sex, and risk factors found at upper endoscopy, enabling tailored surveillance. Methods This nested case–control study originated from a cohort of 8171 adults diagnosed with BE in 2006–2013 in the Swedish Patient Registry. Cases had EAC/HGD (n = 279) as identified from the Swedish Cancer Registry, whereas controls had no EAC/HGD (n = 1089). Findings from endoscopy and histopathology reports were extracted from medical records at 71 Swedish hospitals and from the Swedish Patient Registry. Multivariable logistic regression provided odds ratios (OR) with 95% confidence intervals (CIs). Results Older age (OR 1.02 [95% CI 1.01–1.03] per year), male sex (OR 2.8 [95% CI 1.9–4.1]), and increasing maximum BE length (OR 2.3 [95% CI 1.4–3.9] for segments 3–8 cm and OR 4.3 [95% CI 2.5–7.2] for segments ≥ 8 cm) increased the risk of EAC/HGD, while the circumferential extent of the BE, hiatal hernia or reflux esophagitis did not. A model based on age, sex, and maximum BE length predicted 71% of all EAC/HGD cases. Conclusions A simple combination of the variables age, sex and maximum BE length showed fairly good accuracy for predicting tumor progression in BE. This clinical risk prediction model may help to tailor future surveillance programs.

SAGES Advanced GI/MIS fellowship redesign: pilot results and adoption of new standards Abstract Introduction SAGES is responsible for defining educational content for Advanced GI/MIS fellowships administered through the fellowship council (FC). In Fall 2016, to better define core content contained in these fellowships, SAGES proposed new case log criteria including minimum volumes within six defined categories. To test feasibility of these criteria, SAGES conducted a pilot study during the 2017–2018 academic year. Methods Advanced GI/MIS fellowship programs directors (PD’s) who also held leadership roles in SAGES were invited to participate in the pilot. Fourteen programs including 17 fellows volunteered. To assess generalizability, 2016–2017 case log data for the volunteered pilot programs were compared to all other advanced GI/MIS programs (n = 92). To assess feasibility of the new criteria, pilot programs’ 2017–2018 case logs were compared to 3 years of historical fellows’ case logs (n = 326). Fisher’s exact test was used for comparisons with p < 0.05 considered significant. Results Complete data were available for 16 pilot fellows (median 251.5 advanced MIS cases and 62.5 endoscopies per fellow). According to 2016–2017 data, pilot programs were not statistically different from non-pilot programs regarding achievement of any defined category minimum. Compared to historical controls, the 2017–2018 pilot fellows were significantly more likely to meet the defined category minimum for foregut cases and demonstrated a non-significant trend toward higher achievement of minimums for bariatrics, inguinal hernia, ventral hernia, and endoscopy. Pilot fellows were significantly less likely to meet the minimum for HPB/solid organ/colorectal/thoracic cases. Based on these data, SAGES eliminated the HPB/solid organ/colon/thoracic category and, in partnership with the FC, approved staged implementation of the remaining criteria over 3 years. Conclusions The pilot study provided feasibility and generalizability evidence that allowed inclusion of appropriate defined categories for establishment of the new Advance GI/MIS fellowship criteria. We anticipate that the revised criteria will enhance the educational benefit of these fellowships.

The PINCH-Phone: a new screenings method for recurrent incisional hernias Abstract Background Debate persists on the optimal management of incisional hernias due to paucity of accurate recurrence rates. Reoperation rates implicate a severe underestimation of the risk of a recurrence. Therefore, long-term postoperative clinic visits allowing physical examination of the abdomen are deemed necessary. However, these are time and costs consuming. Aim of this study was to develop and evaluate a new screenings method for recurrent hernias, the ‘PINCH-Phone’ (Post-INCisional-Hernia repair-Phone). Methods The PINCH-Phone is a telephone questionnaire. In this multicenter prospective study, the PINCH-Phone was answered by patients after incisional hernia repair. Afterwards the patients were seen at the clinic and physical examination was done to detect any recurrences. Results The PINCH-Phone questions were answered by 210 patients with a median postoperative follow-up of 36 months. Fifty-six patients were seen after multiple incisional hernia repairs. In 137 patients who had replied positively to one or more questions, 28 recurrent incisional hernias were detected at physical examination. Six recurrences were noted in 73 patients who had replied negatively to all questions. The overall sensitivity and specificity of the PINCH-Phone were 82% and 38%, respectively. Conclusion The PINCH-Phone appears a simple and valuable screenings method for recurrences after incisional hernia repair and, hence, is recommended for implementation.

EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice Abstract Background Acute diverticulitis (AD) presents a unique diagnostic and therapeutic challenge for general surgeons. This collaborative project between EAES and SAGES aimed to summarize recent evidence and draw statements of recommendation to guide our members on comprehensive AD management. Methods Systematic reviews of the literature were conducted across six AD topics by an international steering group including experts from both societies. Topics encompassed the epidemiology, diagnosis, management of non-complicated and complicated AD as well as emergency and elective operative AD management. Consensus statements and recommendations were generated, and the quality of the evidence and recommendation strength rated with the GRADE system. Modified Delphi methodology was used to reach consensus among experts prior to surveying the EAES and SAGES membership on the recommendations and likelihood to impact their practice. Results were presented at both EAES and SAGES annual meetings with live re-voting carried out for recommendations with < 70% agreement. Results A total of 51 consensus statements and 41 recommendations across all six topics were agreed upon by the experts and submitted for members’ online voting. Based on 1004 complete surveys and over 300 live votes at the SAGES and EAES Diverticulitis Consensus Conference (DCC), consensus was achieved for 97.6% (40/41) of recommendations with 92% (38/41) agreement on the likelihood that these recommendations would change practice if not already applied. Areas of persistent disagreement included the selective use of imaging to guide AD diagnosis, recommendations against antibiotics in non-complicated AD, and routine colonic evaluation after resolution of non-complicated diverticulitis. Conclusion This joint EAES and SAGES consensus conference updates clinicians on the current evidence and provides a set of recommendations that can guide clinical AD management practice.

Laparoscopic versus open mesohepatectomy for patients with centrally located hepatocellular carcinoma: a propensity score matched analysis Abstract Background Although laparoscopic mesohepatectomy (LM) has been performed for patients with centrally located hepatocellular carcinoma (CL-HCC), its short- and long-term benefits compared with traditional open surgery remain unclear. The aim of the present study was to explore the independent role of LM in the prognosis of patients with CL-HCC. Methods A retrospective analysis was undertaken of 348 patients who underwent mesohepatectomy for CL-HCC between January 2012 and October 2017 in our hospital. The impact of the surgical methods on long-term prognosis was evaluated by multivariable regression analysis. In addition, patients in the LM group were matched in a 1:3 ratio with open mesohepatectomy (OM) group. Results Some 307 patients underwent OM and 41 had LM. In both adjusted and non-adjusted models, patients in LM group had similar overall survival (OS, both P > 0.05) and disease-free survival (DFS, both P > 0.05) compared to OM patients. The mean (s.d.) OS in LM and OM groups was 41.6 (7.2) and 46.4 (1.4) months, respectively. The mean (s.d.) DFS in LM and OM groups was 37.7 (5.9) and 33.4 (1.5) months, respectively. After propensity score-matched (PSM) analysis, 96 patients remained in OM group and 32 patients in LM group. In the PSM subset, patients in LM group still had comparable OS (P = 0.120) and DFS (P = 0.757) compared to patients in the OM group. After PSM, patients receiving LM had longer vascular exclusion time (P = 0.006) and shorter hospital stay (P = 0.004). In addition, LM was associated with reduced postoperative morbidity after PSM adjustment (P = 0.026). Conclusions LM is associated with fewer complications and does not compromise survival compared with OM. LM can be recommended as a safe and reasonable surgical option in selected patients with CL-HCC.

A novel gallbladder umbrella stent (the Shai™ Stent) for prevention of stone migration and impaction: results on feasibility and short-term safety in a porcine model Abstract Background and aims Cholelithiasis is the most common biliary tract disorder. Surgery is the treatment of choice for symptomatic gallstones. Aims of this study were to investigate the feasibility and short-term safety of a new endoscopic procedure with a specially designed Nitinol gallbladder stent for blockage of gallstone migration, the Shai™ Stent. The Shai stent is designed to enable free bile flow, which will be supposed to prevent recurrent attacks. Methods The Shai™ Stent was inserted into the gallbladder during a standard ERCP procedure using a conventional metal stent delivery system. The aim of the present study was to investigate the feasibility and safety of insertion and deployment and removal of the stent into the gallbladder of pigs. In addition, the short-term safety of the stent was evaluated. Results Fifteen stents were placed in the gallbladder of 15 pigs. Mean procedure time was 25 min (15–37). The maximum follow-up before sacrifice was 42 days. The stent in 1 pig had migrated at the 42 days follow-up but there were no macroscopic changes in its gallbladder or other organs. The stent remained in place in the remaining 12 pigs at autopsy, and the gallbladder and bile ducts were macroscopically normal. Stent removal was easily done in two pigs immediately after placement. Conclusions Correct placement and removal of the Shai™ Stent in the gallbladder is safe and feasible in pigs. Further clinical trials are warranted to confirm these results and to effectively evaluate the capability of this stent as an innovative biotechnology to block gallstones from migration and impaction.

Barriers and facilitators to deliberate practice using take-home laparoscopic simulators Abstract Background Several regions in the UK and Ireland have delivered home-based laparoscopic simulation programmes in an attempt to progress surgical trainees’ skills through deliberate practice. However, engagement with these programmes has been poor. This study aims to uncover the barriers to engagement with home-based simulation, with a view to developing an improved programme. Methods This was a qualitative study using focus groups with key stakeholders including junior surgical trainees, consultants/attendings and simulation faculty. Data were collected across four regions in three countries. Data were audio-recorded, transcribed and a thematic analysis was performed using NVivo software. Results Sixty-three individuals were interviewed in 12 focus groups (43 trainees, 20 trainers). Trainees cited competing commitments as a barrier to engaging with home-based simulation. They tended to focus on scoring ‘points’ towards career progression rather than viewing tasks as interesting, or associated with personal development. Their view was that this approach is perpetuated by the training system, which rewards trainees for publications and exams, but not for operative skill. Trainees were unsatisfied with metric feedback and wanted individual feedback from consultants (attendings). Trainees perceived consultants as lacking interest in the programmes and training in general. However, some consultants were unaware of the programmes being delivered and others felt lacking in confidence to deliver the necessary training. Conclusions Scheduled simulation sessions which provide trainees with the opportunity for consultant feedback may improve engagement. Tackling the ‘point-scoring’ culture is more challenging. This could be addressed by modified assessment structures, greater recognition and accountability for trainers, and recognition and funding of simulation strategies including in-house skills sessions.

Computerized model for objectively evaluating cutting performance using a laparoscopic box trainer simulator Abstract Background Laparoscopic box trainer simulator has recently become a tool for assessment of physicians’ surgical and laparoscopic skills, and training using such a simulator has been incorporated into the curricula of surgery syllabus. With the increased use of box trainer simulators, there is a great need for obtaining reliable and objective evaluations of the trainees’ performances. Here, we introduce an automated tool for assessing laparoscopic cutting performance by using image-processing algorithms. Methods Twenty-seven interns specializing in the fields of gynecology, urology and general surgery participated in 4–6 training sessions, in which each trainee cut a circular patch positioned inside a low-cost laparoscopic box trainer simulator. The trainees’ performances were analyzed using software that we developed. The analysis of the trainees’ performances was based upon quantitative measurements of the following four parameters obtained in each training session: standard deviation, circle-cutout area, skewness, and number of peaks. We believe that high performance in terms of a combination of the four parameters provides a reliable measure of good laparoscopic skills, and therefore we developed the software so as to generate, for each session, a score of a trainee’s laparoscopic circle-cutout performance that results from achievements related to the four parameters in combination. Results On average, the total score of experienced interns was higher than the total score of inexperienced interns. Also, some improvement from session-to-session in the scores of novice trainees was detected. Conclusions Our proposed scoring system, which is based on various image-processing algorithms, can evaluate cutting performances of trainees and classify residents by their experience. This allows each trainee to improve his/her performance by analyzing errors indicated by our software.