Brain Sciences, Vol. 10, Pages 195: The BDNF Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review Brain Sciences doi: 10.3390/brainsci10040195 Authors: Brown Vickers Stuart Cechova Ward Brain-derived neurotropic factor (BDNF) is an abundant and multi-function neurotrophin in the brain. It is released following neuronal activity and is believed to be particularly important in strengthening neural networks....
Wed Mar 25, 2020 02:00
Brain Sciences, Vol. 10, Pages 191: The Effect of Mental Fatigue on Neuromuscular Function is Similar in Young and Older Women Brain Sciences doi: 10.3390/brainsci10040191 Authors: Morris Christie The purpose of this study was to examine the effect of a mentally fatiguing task on neuromuscular function in young and older women. Neuromuscular measures were obtained prior to and following 20 minutes of a mentally fatiguing task. Maximal force output significantly decreased after the...
Wed Mar 25, 2020 02:00
Brain Sciences, Vol. 10, Pages 192: Underlying Neurobiological and Neurocognitive Mechanisms of Impulsivity in Risk-Taking Behaviors Brain Sciences doi: 10.3390/brainsci10040192 Authors: Cyders Impulsivity has been widely implicated in many maladaptive risk-taking and clinical disorders associated with such behaviors [1,2], and may be the most frequently noted criteria in the Diagnostic Statistical Manual for Mental Disorders [3] across a wide variety of disorder classes [4] [...]
Wed Mar 25, 2020 02:00
Brain Sciences, Vol. 10, Pages 190: A Simple Pattern of Movement is not Able to Inhibit Experimental Pain in FM Patients and Controls: an sLORETA Study Brain Sciences doi: 10.3390/brainsci10030190 Authors: Gentile Ricci Vecchio Libro Delussi Casas-Barragàn Tommaso Motor cortex activation seems to induce an analgesic effect on pain that would be different between patients with fibromyalgia (FM) and control subjects. This study was conducted to analyze the changes...
Tue Mar 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 189: Olfactory Memory in Depression: State and Trait Differences between Bipolar and Unipolar Disorders Brain Sciences doi: 10.3390/brainsci10030189 Authors: Kazour Richa Char Atanasova El-Hage : Background: Changes in olfactory recognition memory may constitute sensory markers in depression. Significant differences may exist between unipolar and bipolar depression. Our study compares olfactory memory between control, unipolar, and bipolar...
Tue Mar 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 188: The Reaction Switching Produces A Greater Bias to Prepotent Response than Reaction Inhibition Brain Sciences doi: 10.3390/brainsci10030188 Authors: Kirill Fadeev Tatyana Alikovskaia Alexey Tumyalis Alexey Smirnov Kirill Golokhvast There is a discussion about common or various mechanisms of response inhibition and response switching. To understand these mechanisms, we used a modified Go/NoGo task with three stimulus categories. The subjects...
Tue Mar 24, 2020 02:00
Brain Sciences, Vol. 10, Pages 187: Valproic Acid-Induced Hyperammonemic Encephalopathy in a Patient with Bipolar Disorder: A Case Report Brain Sciences doi: 10.3390/brainsci10030187 Authors: Meng-Yu Wu Fang-Yu Chang Jian-Yu Ke Chien-Sheng Chen Po-Chen Lin Tzong-Shi Wang Valproic acid (VPA) is widely used to control various seizure disorders and psychiatric disorders. Valproic acid-induced hyperammonemic encephalopathy (VHE) is a rare but dangerous complication of VPA-induced...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 783: A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score Cancers doi: 10.3390/cancers12040783 Authors: Charlotte Maulat Cindy Canivet Célia Touraine Sophie Gourgou Bertrand Napoleon Laurent Palazzo Nicolas Flori Guillaume Piessen Pierre Guibert Stéphanie Truant Eric Assenat Louis Buscail Barbara Bournet Fabrice Muscari the BACAP Consortium Surgery remains the only curative treatment...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 784: Role of BET Inhibitors in Triple Negative Breast Cancers Cancers doi: 10.3390/cancers12040784 Authors: Durga Khandekar Venkataswarup Tiriveedhi Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional super-regulators that control gene expression. These proteins have been shown to upregulate transcriptional machinery leading to over expression of genes involved in cell proliferation and carcinogenesis. Based on favorable...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 775: Recent Advances in Immunotherapy for Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12040775 Authors: Shigeharu Nakano Yuji Eso Hirokazu Okada Atsushi Takai Ken Takahashi Hiroshi Seno Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since most patients are diagnosed at advanced stage and the current systemic treatment options using molecular-targeted drugs remain unsatisfactory. However, the recent success...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 781: Radiopharmaceuticals for Breast Cancer and Neuroendocrine Tumors: Two Examples of How Tissue Characterization May Influence the Choice of Therapy Cancers doi: 10.3390/cancers12040781 Authors: Alberto Signore Chiara Lauri Sveva Auletta Michela Varani Livia Onofrio Andor W.J.M. Glaudemans Francesco Panzuto Paolo Marchetti Molecular medicine has gained clinical relevance for the detection and staging of oncological diseases, to guide therapy...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 777: Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research Cancers doi: 10.3390/cancers12040777 Authors: Mohamed Elbadawy Amira Abugomaa Hideyuki Yamawaki Tatsuya Usui Kazuaki Sasaki Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical disease...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 780: Aptamer-Equipped Protamine Nanomedicine for Precision Lymphoma Therapy Cancers doi: 10.3390/cancers12040780 Authors: Zihua Zeng Ching-Hsuan Tung Youli Zu Anaplastic large cell lymphoma (ALCL) is the most common T-cell lymphoma in children. ALCL cells characteristically express surface CD30 molecules and carry the pathogenic ALK oncogene, both of which are diagnostic biomarkers and are also potential therapeutic targets. For precision therapy, we report...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 779: Early Predictors of Objective Response in Patients with Hepatocellular Carcinoma Undergoing Lenvatinib Treatment Cancers doi: 10.3390/cancers12040779 Authors: Issei Saeki Takahiro Yamasaki Satoyoshi Yamashita Tadasuke Hanazono Yohei Urata Takakazu Furutani Yuichiro Yokoyama Toshiyuki Oishi Masaki Maeda Teruaki Kimura Yurika Kotoh Ryo Sasaki Takashi Miyaji Takashi Oono Yuki Aibe Takuro Hisanaga Takuya Iwamoto Toshihiko...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 776: Biobanking in Molecular Biomarker Research for the Early Detection of Cancer Cancers doi: 10.3390/cancers12040776 Authors: Kim Lommen Selena Odeh Chiel C. de Theije Kim M. Smits Although population-wide screening programs for several cancer types have been implemented in multiple countries, screening procedures are invasive, time-consuming and often perceived as a burden for patients. Molecular biomarkers measurable in non-invasively collected samples...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 778: Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer Cancers doi: 10.3390/cancers12040778 Authors: Patricia García Lorena Rosa Sergio Vargas Helga Weber Jaime A. Espinoza Felipe Suárez Isabel Romero-Calvo Nicole Elgueta Vanessa Rivera Bruno Nervi Javiera Obreque Pamela Leal Eduardo Viñuela Gloria Aguayo Sabrina Muñiz Alfredo Sagredo Juan C. Roa Carolina Bizama Gallbladder...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 782: Expression Pattern and Biological Significance of the lncRNA ST3GAL6-AS1 in Multiple Myeloma Cancers doi: 10.3390/cancers12040782 Authors: Domenica Ronchetti Katia Todoerti Cristina Vinci Vanessa Favasuli Luca Agnelli Martina Manzoni Francesca Pelizzoni Raffaella Chiaramonte Natalia Platonova Nicola Giuliani Pierfrancesco Tassone Nicola Amodio Antonino Neri Elisa Taiana The biological impact of long non-coding RNAs (lncRNAs)...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 772: PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer Cancers doi: 10.3390/cancers12040772 Authors: Agarwal Chakravarthi Behring Kim Chandrashekar Gupta Bajpai Elkholy Balasubramanya Hardy Diffalha Varambally Manne The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient survival. We...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 773: Outcome of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia Before Second-Generation FLT3 Tyrosine Kinase Inhibitors: A Toulouse–Bordeaux DATAML Registry Study Cancers doi: 10.3390/cancers12040773 Authors: Sarah Bertoli Pierre-Yves Dumas Emilie Bérard Laetitia Largeaud Audrey Bidet Eric Delabesse Suzanne Tavitian Noémie Gadaud Thibaut Leguay Harmony Leroy Jean-Baptiste Rieu Jean-Philippe Vial François Vergez Nicolas...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 771: VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer Cancers doi: 10.3390/cancers12040771 Authors: Daniela Barros-Silva João Lobo Catarina Guimarães-Teixeira Isa Carneiro Jorge Oliveira Elena S. Martens-Uzunova Rui Henrique Carmen Jerónimo RNA methylation at position N6 in adenosine (m6A) and its associated methyltransferase complex (MTC) are involved in tumorigenesis....
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 774: Targeted Therapies: Friends or Foes for Patient's NK Cell-Mediated Tumor Immune-Surveillance? Cancers doi: 10.3390/cancers12040774 Authors: Laura Damele Selene Ottonello Maria Cristina Mingari Gabriella Pietra Chiara Vitale In the last 20 years there has been a huge increase in the number of novel drugs for cancer treatment. Most of them exploit their ability to target specific oncogenic mutations in the tumors (targeted therapies–TT),...
Wed Mar 25, 2020 02:00
Cancers, Vol. 12, Pages 770: The Regulatory Functions of Circular RNAs in Digestive System Cancers Cancers doi: 10.3390/cancers12030770 Authors: Xiao Yuan Ya Yuan Zhi He Diyan Li Bo Zeng Qingyong Ni Mingyao Yang Deying Yang Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 766: Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment Cancers doi: 10.3390/cancers12030766 Authors: Whitney N. Goldsberry Selene Meza-Perez Angelina I. Londoño Ashwini A. Katre Bryan T. Mott Brandon M. Roane Nidhi Goel Jaclyn A. Wall Sara J. Cooper Lyse A. Norian Troy D. Randall Michael J. Birrer Rebecca C. Arend In ovarian cancer, upregulation of the Wnt/β–catenin...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 768: 30 Years of Experience in the Management of Stage III and IV Epithelial Ovarian Cancer: Impact of Surgical Strategies on Survival Cancers doi: 10.3390/cancers12030768 Authors: Berenice Delga Jean-Marc Classe Gilles Houvenaeghel Guillaume Blache Laura Sabiani Houssein El Hajj Nicole Andrieux Eric Lambaudie Objective: to analyze the evolution of surgical techniques and strategies, and to determine their influence on the survival of patients...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 769: Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts Cancers doi: 10.3390/cancers12030769 Authors: Annette Lasham Peter Tsai Sandra J. Fitzgerald Sunali Y. Mehta Nicholas S. Knowlton Antony W. Braithwaite Cristin G. Print TP53, the most commonly-mutated gene in cancer, undergoes complex alternative splicing. Different TP53 transcripts play different...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 764: Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability Cancers doi: 10.3390/cancers12030764 Authors: Wa Zhang David Klinkebiel Carter J. Barger Sanjit Pandey Chittibabu Guda Austin Miller Stacey N. Akers Kunle Odunsi Adam R. Karpf A hallmark of human cancer is global DNA hypomethylation (GDHO), but the mechanisms accounting for this defect and its pathological consequences...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 762: Proposed Modification of Staging for Distal Cholangiocarcinoma Based on the Lymph Node Ratio Using Korean Multicenter Database Cancers doi: 10.3390/cancers12030762 Authors: Yunghun You Yong Chan Shin Dong Wook Choi Jin Seok Heo Sang Hyun Shin Naru Kim Kee-Taek Jang Hongbeom Kim Chang-Sup Lim Sun Hee Chang Kang Min Han In Woong Han The 8th American Joint Committee on Cancer (AJCC) staging system for distal cholangiocarcinoma...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 765: Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics Cancers doi: 10.3390/cancers12030765 Authors: Kamila Pawlicka Umesh Kalathiya Javier Alfaro Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. NMD plays an important role in cell cycle regulation, cell viability, DNA damage response, while also serving as a barrier...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 763: Pure Large Nested Variant of Urothelial Carcinoma (LNUC) Is the Prototype of an FGFR3 Mutated Aggressive Urothelial Carcinoma with Luminal-Papillary Phenotype Cancers doi: 10.3390/cancers12030763 Authors: Veronika Weyerer Markus Eckstein Eva Compérat Hendrik Juette Nadine T. Gaisa Yves Allory Robert Stöhr Bernd Wullich Morgan Rouprêt Arndt Hartmann Simone Bertz Since 2016, large nested urothelial carcinoma (LNUC) has been included...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 767: Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes Cancers doi: 10.3390/cancers12030767 Authors: Yonghyo Kim Jeovanis Gil Indira Pla Aniel Sanchez Lazaro Hiram Betancourt Boram Lee Roger Appelqvist Christian Ingvar Lotta Lundgren Håkan Olsson Bo Baldetorp Ho Jeong Kwon Henriett Oskolás Melinda Rezeli Viktoria Doma Sarolta Kárpáti A. Marcell Szasz István...
Tue Mar 24, 2020 02:00
Cancers, Vol. 12, Pages 761: Extended Texture Analysis of Non-Enhanced Whole-Body MRI Image Data for Response Assessment in Multiple Myeloma Patients Undergoing Systemic Therapy Cancers doi: 10.3390/cancers12030761 Authors: Kaspar Ekert Clemens Hinterleitner Karolin Baumgartner Jan Fritz Marius Horger Identifying MRI-based radiomics features capable to assess response to systemic treatment in multiple myeloma (MM) patients. Retrospective analysis of whole-body MR-image data...
Tue Mar 24, 2020 02:00
Cells, Vol. 9, Pages 793: The Diagnostic Value of Mir-133a in ST Elevation and Non-ST Elevation Myocardial Infarction: A Meta-Analysis Cells doi: 10.3390/cells9040793 Authors: Wexler Nussinovitch Numerous studies have reported correlations between plasma microRNA signatures and cardiovascular disease. MicroRNA-133a (Mir-133a) has been researched extensively for its diagnostic value in acute myocardial infarction (AMI). While initial results seemed promising, more recent studies...
Wed Mar 25, 2020 02:00
Cells, Vol. 9, Pages 791: Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers Cells doi: 10.3390/cells9040791 Authors: Golam M. Uddin Neil A. Youngson Sabiha S. Chowdhury Christopher Hagan David A. Sinclair Margaret J. Morris Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide...
Wed Mar 25, 2020 02:00
Cells, Vol. 9, Pages 792: Spatial Expression Pattern of the Major Ca2+-Buffer Proteins in Mouse Retinal Ganglion Cells Cells doi: 10.3390/cells9040792 Authors: Tamás Kovács-Öller Gergely Szarka Ádám J. Tengölics Alma Ganczer Boglárka Balogh Edina Szabó-Meleg Miklós Nyitrai Béla Völgyi The most prevalent Ca2+-buffer proteins (CaBPs: parvalbumin—PV; calbindin—CaB; calretinin—CaR) are widely expressed by various neurons throughout the brain,...
Wed Mar 25, 2020 02:00
Cells, Vol. 9, Pages 790: The Blood Circulating Rare Cell Population. What is it and What is it Good For? Cells doi: 10.3390/cells9040790 Authors: Stefan Schreier Wannapong Triampo Blood contains a diverse cell population of low concentration hematopoietic as well as non-hematopoietic cells. The majority of such rare cells may be bone marrow-derived progenitor and stem cells. This paucity of circulating rare cells, in particular in the peripheral circulation, has led many to believe...
Wed Mar 25, 2020 02:00
Cells, Vol. 9, Pages 789: The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation Cells doi: 10.3390/cells9030789 Authors: Debora Libetti Andrea Bernardini Sarah Sertic Graziella Messina Diletta Dolfini Roberto Mantovani NF-YA, the regulatory subunit of the trimeric transcription factor (TF) NF-Y, is regulated by alternative splicing (AS) generating two major isoforms, “long” (NF-YAl) and “short” (NF-YAs). Muscle cells...
Tue Mar 24, 2020 02:00
Cells, Vol. 9, Pages 787: The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution Cells doi: 10.3390/cells9030787 Authors: Michel Schmitt-Ney The nematode Caenorhabditis elegans possesses a unique (with various isoforms) FOXO transcription factor DAF-16, which is notorious for its role in aging and its regulation by the insulin-PI3K-AKT pathway. In humans, five genes (including a protein-coding pseudogene) encode for FOXO transcription factors that are targeted...
Tue Mar 24, 2020 02:00
Cells, Vol. 9, Pages 788: Phenol-Soluble Modulin-Mediated Aggregation of Community-Associated Methicillin-Resistant Staphylococcus Aureus in Human Cerebrospinal Fluid Cells doi: 10.3390/cells9030788 Authors: Deok-ryeong Kim Yeonhee Lee Hyeon-kyeong Kim Wooseong Kim Yun-Gon Kim Yung-Hun Yang Jae-Seok Kim Hwang-Soo Joo Phenol-soluble modulins (PSMs) are major determinants of Staphylococcus aureus virulence and their increased production in community-associated methicillin-resistant...
Tue Mar 24, 2020 02:00
Cells, Vol. 9, Pages 786: Systematic Identification of Housekeeping Genes Possibly Used as References in Caenorhabditis elegans by Large-Scale Data Integration Cells doi: 10.3390/cells9030786 Authors: Jingxin Tao Youjin Hao Xudong Li Huachun Yin Xiner Nie Jie Zhang Boying Xu Qiao Chen Bo Li For accurate gene expression quantification, normalization of gene expression data against reliable reference genes is required. It is known that the expression levels of commonly...
Tue Mar 24, 2020 02:00
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