IJMS, Vol. 21, Pages 2253: Cancer Diagnosis through SERS and Other Related Techniques International Journal of Molecular Sciences doi: 10.3390/ijms21062253 Authors: Maria Blanco-Formoso Ramon A. Alvarez-Puebla Cancer heterogeneity increasingly requires ultrasensitive techniques that allow early diagnosis for personalized treatment. In addition, they should preferably be non-invasive tools that do not damage surrounding tissues or contribute to body toxicity. In this context, liquid...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2254: Lead (Pb) as a Factor Initiating and Potentiating Inflammation in Human THP-1 Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21062254 Authors: Emilia Metryka Patrycja Kupnicka Patrycja Kapczuk Donata Simińska Maciej Tarnowski Marta Goschorska Izabela Gutowska Dariusz Chlubek Irena Baranowska-Bosiacka The aim of this study was to assess the influence of lead (Pb) at low concentrations (imitating Pb levels in...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2252: Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes International Journal of Molecular Sciences doi: 10.3390/ijms21062252 Authors: Camino Tamara Lago-Baameiro Nerea Bravo Susana Belén Sueiro Aurelio Couto Iván Santos Fernando Baltar Javier Casanueva F. Felipe Pardo María Extracellular vesicles (EVs) have recently emerged as a relevant way...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2251: Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration International Journal of Molecular Sciences doi: 10.3390/ijms21062251 Authors: Hamid-Reza Ahmadi-Ashtiani Parisa Bishe Anna Baldisserotto Piergiacomo Buso Stefano Manfredini Silvia Vertuani Cutaneous stem cells, gained great attention in the field of regenerative medicine as a potential therapeutic target for the treatment of skin and hair disorders...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2250: Norepinephrine-Induced DNA Damage in Ovarian Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062250 Authors: Rocio Lamboy-Caraballo Carmen Ortiz-Sanchez Arelis Acevedo-Santiago Jaime Matta Alvaro N.A. Monteiro Guillermo N. Armaiz-Pena Multiple studies have shown that psychological distress in epithelial ovarian cancer (EOC) patients is associated with worse quality of life and poor treatment adherence. This may influence...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2248: Association of a Disrupted Dipping Pattern of Blood Pressure with Progression of Renal Injury during the Development of Salt-Dependent Hypertension in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21062248 Authors: Abu Sufiun Asadur Rahman Kazi Rafiq Yoshihide Fujisawa Daisuke Nakano Hideki Kobara Tsutomu Masaki Akira Nishiyama The aim of the present study is to investigate whether a disruption of the dipping pattern...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2247: Lineage Decision-Making within Normal Haematopoietic and Leukemic Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062247 Authors: Geoffrey Brown Lucía Sánchez Isidro Sánchez-García To produce the wide range of blood and immune cell types, haematopoietic stem cells can “choose” directly from the entire spectrum of blood cell fate-options. Affiliation to a single cell lineage can occur at the level of the haematopoietic...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2246: Characterization, Expression Pattern and Antiviral Activities of Mx Gene in Chinese Giant Salamander, Andrias davidianus International Journal of Molecular Sciences doi: 10.3390/ijms21062246 Authors: Yanan Liu Yiqun Li Yongze Zhou Nan Jiang Yuding Fan Lingbing Zeng Mx, Myxovirus resistance is an important interferon-stimulated protein that mediates antiviral responses. In this study, the expression and activities of Chinese giant salamander,...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2249: AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062249 Authors: Katja Merches Alfonso Schiavi Heike Weighardt Swantje Steinwachs Nadine Teichweyde Irmgard Förster Katrin Hochrath Beatrix Schumak Natascia Ventura Patrick Petzsch Karl Köhrer Charlotte Esser Background Aryl hydrocarbon receptor (AHR)-deficient mice do not support the expansion...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2245: Transcriptome Analysis in Renal Transplant Biopsies Not Fulfilling Rejection Criteria International Journal of Molecular Sciences doi: 10.3390/ijms21062245 Authors: Francesc Moreso Joana Sellarès María José Soler Daniel Serón The clinical significance of renal transplant biopsies displaying borderline changes suspicious for T-cell mediated rejection (TCMR) or interstitial fibrosis and tubular atrophy (IFTA) with interstitial inflammation has not been...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2243: Accurate Representation of Protein-Ligand Structural Diversity in the Protein Data Bank (PDB) International Journal of Molecular Sciences doi: 10.3390/ijms21062243 Authors: Nicolas K. Shinada Peter Schmidtke Alexandre G. de Brevern The number of available protein structures in the Protein Data Bank (PDB) has considerably increased in recent years. Thanks to the growth of structures and complexes, numerous large-scale studies have been done in various...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2244: Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes International Journal of Molecular Sciences doi: 10.3390/ijms21062244 Authors: Marco Hoffmann Nils Hersch Sven Gerlach Georg Dreissen Ronald Springer Rudolf Merkel Agnes Csiszár Bernd Hoffmann Highly efficient, biocompatible, and fast nucleic acid delivery methods are essential for biomedical applications and research. At present, two main strategies...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2242: Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model International Journal of Molecular Sciences doi: 10.3390/ijms21062242 Authors: Chae-Eun Yang Sewoon Choi Ju Hee Lee Eun Hye Kang Hyo Min Ahn Tai Suk Roh Chae-Ok Yun Won Jai Lee An adenoviral vector (Ad) expressing a Wnt decoy receptor (sLRP6E1E2) is known to induce an anti-fibrotic effect by inhibiting Wnt signaling....
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2240: SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062240 Authors: Jeaho Lim Juyoung Son Jaewook Ryu Ja-Eun Kim SIRT2, a member of the Class III HDAC family, participates in diverse cellular processes and regulates several pathological conditions. Although a few reports show that SIRT2 regulates the cell cycle, the causes and outcomes...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2239: Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21062239 Authors: Maria Csobonyeiova Stefan Polak Lubos Danisovic Huntington’s disease (HD) is an inherited, autosomal dominant, degenerative disease characterized by involuntary movements, cognitive decline, and behavioral impairment ending in death. HD is caused by an expansion in the number of CAG repeats...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2241: Insights into Interactions of Flavanones with Target Human Respiratory Syncytial Virus M2-1 Protein from STD-NMR, Fluorescence Spectroscopy, and Computational Simulations International Journal of Molecular Sciences doi: 10.3390/ijms21062241 Authors: Hêmily M. R. Piva Jéssica M. Sá Artemiza S. Miranda Ljubica Tasic Marcelo A. Fossey Fátima P. Souza Ícaro P. Caruso The human Respiratory Syncytial Virus (hRSV) is the most frequent agent of respiratory...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2238: AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans International Journal of Molecular Sciences doi: 10.3390/ijms21062238 Authors: Christopher Wong Richard Roy Caenorhabditis elegans larvae can undergo developmental arrest upon entry into the dauer stage in response to suboptimal growth conditions. Dauer larvae can exit this stage in replete conditions with no reproductive consequence. During this diapause...
Tue Mar 24, 2020 02:00
IJMS, Vol. 21, Pages 2237: Analysis of the Activity and Expression of Cyclooxygenases COX1 and COX2 in THP-1 Monocytes and Macrophages Cultured with BiodentineTM Silicate Cement International Journal of Molecular Sciences doi: 10.3390/ijms21062237 Authors: Katarzyna Barczak Mirona Palczewska-Komsa Alicja Nowicka Dariusz Chlubek Jadwiga Buczkowska-Radlińska BiodentineTM is a material based on hydrated calcium silicate with odontotropic properties. However, from the clinician’s...
Tue Mar 24, 2020 02:00
IJNS, Vol. 6, Pages 25: Processing Newborn Bloodspot Screening Results for CF International Journal of Neonatal Screening doi: 10.3390/ijns6020025 Authors: Barben Chudleigh Every newborn bloodspot screening (NBS) result for cystic fibrosis (CF) consists of two parts: a screening part in the laboratory and a clinical part in a CF centre. When introducing an NBS programme, more attention is usually paid to the laboratory part, especially which algorithm is most suitable for the region...
Wed Mar 25, 2020 02:00
IJNS, Vol. 6, Pages 24: Universal Implementation of Newborn Screening in India International Journal of Neonatal Screening doi: 10.3390/ijns6020024 Authors: Mookken Newborn screening is a successful program in many developed countries. In India, the benefits of dried blood spot screening have been recognized and that screening is slowly gaining traction. There are significant issues standing in the way of universal implementation of a newborn screening program in India: awareness, cost,...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 906: Sacubitril/Valsartan Induces Global Cardiac Reverse Remodeling in Long-Lasting Heart Failure with Reduced Ejection Fraction: Standard and Advanced Echocardiographic Evidences Journal of Clinical Medicine doi: 10.3390/jcm9040906 Authors: Castrichini Manca Nuzzi Barbati De Luca Korcova Stolfo Lenarda Merlo Sinagra Sacubitril/valsartan reduces mortality in heart failure with reduced ejection fraction (HFrEF) patients, partially...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 905: Bedside Renal Doppler Ultrasonography and Acute Kidney Injury after TAVR Journal of Clinical Medicine doi: 10.3390/jcm9040905 Authors: Peillex Marchandot Bayer Prinz Matsushita Carmona Heger Trimaille Petit-Eisenmann Jesel Ohlmann Morel Acute kidney injury (AKI) following transcatheter aortic valve replacement (TAVR) is associated with a dismal prognosis. Elevated renal resistive index (RRI), through renal Doppler ultrasound...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 904: Upstroke Time Per Cardiac Cycle as A Novel Parameter for Mortality Prediction in Patients with Acute Myocardial Infarction Journal of Clinical Medicine doi: 10.3390/jcm9040904 Authors: Hsu Lee Tsai Chen Chi Chang Chu Lin Lee Lai Sheu Su Background: Acute myocardial infarction (AMI) is one of the leading causes of death in the world. How to simply predict mortality for AMI patients is important because the appropriate...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 903: Long-Term Follow-Up of Patients with Catecholaminergic Polymorphic Ventricular Arrhythmia Journal of Clinical Medicine doi: 10.3390/jcm9040903 Authors: Veith El-Battrawy Roterberg Raschwitz Lang Wolpert Schimpf Zhou Akin Borggrefe Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited disorder causing life-threatening arrhythmias. Long-term outcome studies of the channelopathy are limited....
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 902: Surgical Nuances to Reduce and Manage Cerebrospinal Fluid Leaks after Microvascular Decompression Journal of Clinical Medicine doi: 10.3390/jcm9040902 Authors: Go Hwang Han Background: No dural substitute has proven to be complication-free in a large clinical trial, even suggesting some benefit during watertight closure. However, primary dural closure is not always possible due to dural shrinkage from electrocautery for dural bleeding. Objective: This...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 907: Importance of Footwear Outsole Rigidity in Improving Spatiotemporal Parameters in Patients with Diabetes and Previous Forefoot Ulcerations Journal of Clinical Medicine doi: 10.3390/jcm9040907 Authors: López-Moral Molines-Barroso Álvaro-Afonso Uccioli Senneville Lázaro-Martínez We aimed to identify if any differences existed in spatiotemporal parameters during gait among different densities of rocker soles in patients with a history of neuropathic...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 900: Strengthened Default Mode Network Activation During Delay Discounting in Adolescents with Anorexia Nervosa After Partial Weight Restoration: A Longitudinal fMRI Study Journal of Clinical Medicine doi: 10.3390/jcm9040900 Authors: Doose King Bernardoni Geisler Hellerhoff Weinert Roessner Smolka Ehrlich The capacity of patients with anorexia nervosa (AN) to resist food-based rewards is often assumed to reflect excessive self-control....
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 901: Sleep Disordered Breathing in Hypertrophic Cardiomyopathy—Current State and Future Directions Journal of Clinical Medicine doi: 10.3390/jcm9040901 Authors: Venkataraman Karim Rajendran Chahal Somers Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and sleep disordered breathing (SDB) is a treatable risk factor that has been seen to occur concurrently, and is known to propagate mortality and morbidity in a number of...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 897: Low Plasma Sphingomyelin Levels Show a Weak Association with Poor Neurological Outcome in Cardiac Arrest Patients: Results from the Prospective, Observational COMMUNICATE Trial Journal of Clinical Medicine doi: 10.3390/jcm9040897 Authors: Boerlin Luescher Becker Perrig Thommen Widmer Beck Vincent Tisljar Bernasconi Neyer Schuetz Sutter Marsch Hunziker There is interest in novel blood markers to improve risk...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 895: Unmet Medical Needs of Patients with Benign Prostate Enlargement Journal of Clinical Medicine doi: 10.3390/jcm9040895 Authors: Lee Park Choi Lee This study aimed to analyze the factors affecting the unmet medical needs of patients with benign prostate enlargement (BPE) based on Andersen’s behavioral model. The data were taken from the 2009–2016 Korea Health Panel Study and 3003 participants were used for analysis. “Unmet...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 898: Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth Journal of Clinical Medicine doi: 10.3390/jcm9040898 Authors: Gama Maman Vargas-Franco Omar Royer Yagita Babajko Berdal Acevedo Heymann Lézot Castaneda The primary retention of molars observed in clinic corresponds to a still-unexplained absence of molar eruption despite the presence of an eruption pathway, resembling the experimental...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 896: Strategies to Prevent Cardiovascular Toxicity in Breast Cancer: Is It Ready for Primetime? Journal of Clinical Medicine doi: 10.3390/jcm9040896 Authors: Kikuchi Shah Dent Cardio-oncology is an emerging field tasked with identifying and treating cancer therapy related cardiac dysfunction (e.g., cytotoxic agents, immunotherapies, radiation, and hormone therapies) and optimizing the cardiovascular health of cancer patients exposed to these agents. Novel...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 894: Nebulized Heparin in Burn Patients with Inhalation Trauma—Safety and Feasibility Journal of Clinical Medicine doi: 10.3390/jcm9040894 Authors: Glas Horn Binnekade Hollmann Muller Cleffken Colpaert Dixon Juffermans Knape Levi Loef Mackie Malbrain Preckel Reidinga van der Sluijs Schultz Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 899: Acute Abdominal Pain: Missed Diagnoses, Extra-Abdominal Conditions, and Outcomes Journal of Clinical Medicine doi: 10.3390/jcm9040899 Authors: Osterwalder Özkan Malinovska Nickel Bingisser Abdominal pain (AP) is a common reason for presentation to an emergency department (ED). With this prospective, observational all-comer study, we aimed to answer three questions: Which diagnoses are most often missed? What is the incidence of extra-abdominal...
Wed Mar 25, 2020 02:00
JCM, Vol. 9, Pages 892: Mitophagy in Cardiovascular Diseases Journal of Clinical Medicine doi: 10.3390/jcm9030892 Authors: Morciano Patergnani Bonora Pedriali Tarocco Bouhamida Marchi Ancora Anania Wieckowski Giorgi Pinton Cardiovascular diseases are one of the leading causes of death. Increasing evidence has shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage of these pathologies, which are strongly associated...
Tue Mar 24, 2020 02:00
JCM, Vol. 9, Pages 893: The Wearable Cardioverter-Defibrillator: Experience in 153 Patients and a Long-Term Follow-Up Journal of Clinical Medicine doi: 10.3390/jcm9030893 Authors: Rosenkaimer El-Battrawy Dreher Gerhards Röger Kuschyk Borggrefe Akin Background: The wearable cardioverter-defibrillator (WCD) is available for patients at high risk for sudden cardiac death (SCD) when immediate implantable cardioverter-defibrillator (ICD) implantation is not possible...
Tue Mar 24, 2020 02:00
JCM, Vol. 9, Pages 890: In Which Patients with Sarcoidosis Is FDG PET/CT Indicated? Journal of Clinical Medicine doi: 10.3390/jcm9030890 Authors: Keijsers Grutters Sarcoidosis is a granulomatous disease of which the etiology remains unknown. The diverse clinical manifestations may challenge clinicians, particularly when conventional markers are inconclusive. From various studies, it has become clear that fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT aids in sarcoidosis...
Tue Mar 24, 2020 02:00
JCM, Vol. 9, Pages 891: Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1 Journal of Clinical Medicine doi: 10.3390/jcm9030891 Authors: Gaku Tsuji Akiko Hashimoto-Hachiya Vu Hai Yen Sho Miake Masaki Takemura Yasutaka Mitamura Takamichi Ito Maho Murata Masutaka Furue Takeshi Nakahara Background: IL-33, one of the IL-1 superfamily cytokines, has been shown to be associated with pruritus and inflammation in atopic...
Tue Mar 24, 2020 02:00
JCM, Vol. 9, Pages 888: Treatment of Obstructive Sleep Apnea in Children: Handling the Unknown with Precision Journal of Clinical Medicine doi: 10.3390/jcm9030888 Authors: David Gozal Hui-Leng Tan Leila Kheirandish-Gozal Treatment approaches to pediatric obstructive sleep apnea (OSA) have remarkably evolved over the last two decades. From an a priori assumption that surgical removal of enlarged upper airway lymphadenoid tissues (T&A) was curative in the vast majority of...
Tue Mar 24, 2020 02:00
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