Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity

Publication date: Available online 25 March 2020Source: Free Radical Biology and MedicineAuthor(s): Shashank Shrishrimal, Arpita Chatterjee, Elizabeth A. Kosmacek, Paul J. Davis, J. Tyson McDonald, Rebecca E. Oberley-Deegan

Free Radical Biology and Medicine

16h

The antioxidant activity and neuroprotective mechanism of isoliquiritigenin

Publication date: Available online 24 March 2020Source: Free Radical Biology and MedicineAuthor(s): Dingding Shi, Jiali Yang, Yueming Jiang, Lingrong Wen, Zhubin Wang, Bao Yang

Free Radical Biology and Medicine

16h

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

Publication date: Available online 23 March 2020Source: Free Radical Biology and MedicineAuthor(s): Pei Zhang, Ling Chen, Qiqi Zhao, Xixun Du, Mingxia Bi, Yong Li, Qian Jiao, Hong Jiang

Free Radical Biology and Medicine

1d

Urinary 8-oxo-7,8-dihydroguanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease

Publication date: Available online 23 March 2020Source: Free Radical Biology and MedicineAuthor(s): Yao-Dan Liang, Qian Liu, Ming-Hui Du, Zhen Liu, Si-Min Yao, Pei-Pei Zheng, Yu-Hao Wan, Ning Sun, Ying-Ying Li, Jun-Peng Liu, Yao Luo, Jian-Ping Cai, Jie-Fu Yang, Hua Wang

Free Radical Biology and Medicine

1d

A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner

Publication date: Available online 23 March 2020Source: Free Radical Biology and MedicineAuthor(s): Yuichi Saito, Tomohiro Yako, Wataru Otsu, Shinsuke Nakamura, Yuki Inoue, Aomi Muramatsu, Yasuhiro Nakagami, Masamitsu Shimazawa, Hideaki Hara

Free Radical Biology and Medicine

1d

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 Anti-Cancer Drugs - Published Ahead-of-Print

Evaluation of anti-cancer potency of silibinin on murine renal carcinoma RenCa cells in an animal model with an intact immune system

Silibinin is a flavonoid extract isolated from milk thistle and has been proved to be a promising chemotherapeutic drug for cancer. However, most of those studies were performed on the human cancer cells, where the effects of silibinin could only be observed on an animal model with a deficient immune system. RenCa cells were isolated from a murine spontaneous renal cell carcinoma, which resembles many features of human renal cell carcinoma, and have been used to establish animal models with a sound...

Anti-Cancer Drugs - Published Ahead-of-Print

17h

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 Antibodies

Antibodies, Vol. 9, Pages 7: Molecular Interaction Characterization Strategies for the Development of New Biotherapeutic Antibody Modalities

Antibodies, Vol. 9, Pages 7: Molecular Interaction Characterization Strategies for the Development of New Biotherapeutic Antibody Modalities Antibodies doi: 10.3390/antib9020007 Authors: Wang Phan Li Gill Williams Gupta Quarmby Yang The characterization of target binding interactions is critical at each stage of antibody therapeutic development. During early development, it is important to design fit-for-purpose in vitro molecular interaction...

Antibodies

17h

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