Abstract The therapeutic effect of electroacupuncture (EA) on inflammatory pain has been well recognized clinically, but the mechanism is unclear. Interleukin-10 (IL-10), which is produced by regulatory T (Treg) cell, is a key anti-inflammatory cytokine for relieving inflammatory pain. Therefore, the aim of this study is to investigate whether EA could inhibit CFA-induced pain and attenuate inflammation progression by regulating the...
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Related ArticlesAntitumorigenic Effects of Inhibiting Ephrin Receptor Kinase Signaling by GLPG1790 against Colorectal Cancer Cell Lines In Vitro and In Vivo. J Oncol. 2020;2020:9342732 Authors: Colapietro A, Gravina GL, Petragnano F, Fasciani I, Scicchitano BM, Beirinckx F, Pujuguet P, Saniere L, Van der Aar E, Musio D, De Felice F, Mattei V, Martellucci S, Maggio R, Tombolini V, Festuccia C, Marampon F Abstract Erythropoietin-producing hepatocellular...
Thu Mar 19, 2020 12:32
Related ArticlesLncRNA MIR503HG Inhibits Non-Small Cell Lung Cancer Cell Proliferation by Inducing Cell Cycle Arrest Through the Downregulation of Cyclin D1. Cancer Manag Res. 2020;12:1641-1647 Authors: Xu S, Zhai S, Du T, Li Z Abstract Introduction: LncRNA MIR503HG has been reported to participate in liver cancer and ALK-negative anaplastic large-cell lymphoma, while its role in non-small cell lung cancer (NSCLC) is unknown. We therefore investigated...
Thu Mar 19, 2020 12:32
Related ArticlesAnticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells. Int J Nanomedicine. 2020;15:1457-1468 Authors: Zhang T, Du E, Liu Y, Cheng J, Zhang Z, Xu Y, Qi S, Chen Y Abstract Purpose: Zinc oxide nanoparticles (nZnO) have been widely used in the medicine field. Numerous mechanistic studies for nZnO's anticancer effects are merely performed under high concentration exposure....
Thu Mar 19, 2020 12:32
Related ArticlesFolate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine. Int J Nanomedicine. 2020;15:1397-1408 Authors: Hou L, Song Z, Xu Z, Wu Y, Shi W Abstract Background: siRNA-mediated polo-like kinase 1 (PLK1) silencing has been proposed as a promising therapeutic method for multiple cancers. However, the clinic application of this method is still hindered by the low specific delivery of siPLK1 to desired tumor lesions....
Thu Mar 19, 2020 12:32
Related ArticlesAntiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways. J Enzyme Inhib Med Chem. 2020 Dec;35(1):759-772 Authors: Jiao R, Xu F, Huang X, Li H, Liu W, Cao H, Zang L, Li Z, Hua H, Li D Abstract A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human...
Thu Mar 19, 2020 12:32
Related ArticlesPolyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest. Biomolecules. 2020 Mar 14;10(3): Authors: Dyshlovoy SA, Tarbeeva D, Fedoreyev S, Busenbender T, Kaune M, Veselova M, Kalinovskiy A, Hauschild J, Grigorchuk V, Kim N, Bokemeyer C, Graefen M, Gorovoy P, von Amsberg G Abstract From a root bark of Lespedeza bicolor Turch we isolated...
Thu Mar 19, 2020 12:32
Related ArticlesCytotoxic Evaluation and Anti-Angiogenic Effects of Two Furano-Sesquiterpenoids from Commiphora myrrh Resin. Molecules. 2020 Mar 13;25(6): Authors: S Alqahtani A, Nasr FA, Noman OM, Farooq M, Alhawassi T, Qamar W, El-Gamal A Abstract Commiphora myrrh resin (Myrrh) has been used in traditional Arabic medicine to treat various inflammatory diseases. Two furano-sesquiterpenoids, 2-methoxyfuranodiene (CM1) and 2-acetoxyfuranodiene (CM2),...
Thu Mar 19, 2020 12:32
Related ArticlesChitosan Oligosaccharides Attenuate Amyloid Formation of hIAPP and Protect Pancreatic β-Cells from Cytotoxicity. Molecules. 2020 Mar 13;25(6): Authors: Meng QY, Wang H, Cui ZB, Yu WG, Lu XZ Abstract The deposition of aggregated human islet amyloid polypeptide (hIAPP) in the pancreas, that has been associated with β-cell dysfunction, is one of the common pathological features of patients with type 2 diabetes (T2D). Therefore, hIAPP...
Thu Mar 19, 2020 12:32
Related ArticlesOn-Chip Synthesis of Hyaluronic Acid-Based Nanoparticles for Selective Inhibition of CD44+ Human Mesenchymal Stem Cell Proliferation. Pharmaceutics. 2020 Mar 13;12(3): Authors: Chiesa E, Riva F, Dorati R, Greco A, Ricci S, Pisani S, Patrini M, Modena T, Conti B, Genta I Abstract In this study, an innovative microfluidics-based method was developed for one-step synthesis of hyaluronic acid (HA)-based nanoparticles (NPs), by exploiting...
Thu Mar 19, 2020 12:32
Related ArticlesThe Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer. Int J Mol Sci. 2020 Mar 13;21(6): Authors: Ding L, Cao J, Lin W, Chen H, Xiong X, Ao H, Yu M, Lin J, Cui Q Abstract Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory enzymes involved in cell...
Thu Mar 19, 2020 12:32
Related ArticlesInduction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells. Molecules. 2020 Mar 09;25(5): Authors: Arumugam A, Ibrahim MD, Kntayya SB, Mohd Ain N, Iori R, Galletti S, Ioannides C, Abdull Razis AF Abstract Gluconasturtiin, a glucosinolate present in watercress, is hydrolysed by myrosinase to form gluconasturtiin-isothiocyanate (GNST-ITC), which...
Thu Mar 19, 2020 12:32
Related ArticlesPrunellae Spica Extract Suppresses Teratoma Formation of Pluripotent Stem Cells through p53-Mediated Apoptosis. Nutrients. 2020 Mar 09;12(3): Authors: Kim A, Lee SY, Seo CS, Chung SK Abstract Induced pluripotent stem cells (iPSCs) have similar properties to embryonic stem cells in terms of indefinite self-renewal and differentiation capacity. After in vitro differentiation of iPSCs, undifferentiated iPSCs (USCs) may exist in cell...
Thu Mar 19, 2020 12:32
Related ArticlesCross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival. Cells. 2020 Mar 09;9(3): Authors: Cristofaro I, Alessandrini F, Spinello Z, Guerriero C, Fiore M, Caffarelli E, Laneve P, Dini L, Conti L, Tata AM Abstract Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key feature of malignant gliomas...
Thu Mar 19, 2020 12:32
Related ArticlesRole of p53 in the Regulation of Cellular Senescence. Biomolecules. 2020 Mar 08;10(3): Authors: Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A Abstract The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence...
Thu Mar 19, 2020 12:32
Related ArticlesMicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle. J Cell Physiol. 2019 04;234(4):4910-4923 Authors: Zhao F, Zhou LH, Ge YZ, Ping WW, Wu X, Xu ZL, Wang M, Sha ZL, Jia RP Abstract MicroRNAs (miRNAs), a group of small noncoding RNAs, are widely involved in the regulation of gene expression via binding to complementary sequences at 3'-untranslated regions (3'-UTRs) of target messenger RNAs. Recently,...
Thu Mar 19, 2020 12:32
Related ArticlesVestibular drop attacks in Ménière's disease and its association with migraine. Eur Arch Otorhinolaryngol. 2020 Mar 17;: Authors: Pyykkö I, Pyykkö N, Manchaiah V Abstract PURPOSE: We explored the association of vestibular drop attacks (VDA) with or without migraine in patients with Ménière's disease (MD) and compared with patients classified as vestibular migraine (VM). METHOD: The study involved a cross-sectional survey design....
Thu Mar 19, 2020 12:28
Related ArticlesSurgical complications of cochlear implantation: a 25-year retrospective analysis of cases in a tertiary academic center. Eur Arch Otorhinolaryngol. 2020 Mar 17;: Authors: Binnetoglu A, Demir B, Batman C Abstract PURPOSE: Despite the advances made in cochlear implantation techniques, the associated complication rates are still high. Here, we aimed to analyze cases, with extensive follow-up data, associated with a large sample of patients...
Thu Mar 19, 2020 12:28
Related ArticlesMgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit. Mol Biol Cell. 2020 Mar 18;:mbcE19120677 Authors: Matta SK, Kumar A, D' Silva P Abstract Mgr2, a newly identified subunit of the TIM23 complex function as a gatekeeper of presequence translocase, thereby maintains quality control of inner membrane preproteins sorting. However, precise recruitment of the Mgr2 subunit to the core channel and...
Thu Mar 19, 2020 14:25
Related ArticlesMechanistic insights into actin-driven polarity site movement in yeast. Mol Biol Cell. 2020 Mar 18;:mbcE20010040 Authors: Ghose D, Lew D Abstract Directed cell growth or migration are critical for the development and function of many eukaryotic cells. These cells develop a dynamic "front" (also called "polarity site") that can change direction. Polarity establishment involves autocatalytic accumulation of polarity regulators, including...
Thu Mar 19, 2020 14:25
Related ArticlesCellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1. Mol Biol Cell. 2020 Mar 18;:mbcE20020161 Authors: Griffiths NW, Del Bel LM, Wilk R, Brill JA Abstract The complex functions of cellular membranes, and thus overall cell physiology, depend on the distribution of crucial lipid species. Sac1 is an essential, conserved, ER-localized phosphatase whose substrate, phosphatidylinositol 4-phosphate (PI4P), coordinates...
Thu Mar 19, 2020 14:25
Related ArticlesDifferential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets. Mol Biol Cell. 2020 Mar 18;:mbcE20010014 Authors: Yue L, McPhee MJ, Gonzalez K, Charman M, Lee J, Thompson J, Winkler D, Cornell RB, Pelech S, Ridgway ND Abstract CTP:phosphocholine cytidylyltransferase (CCT) α and CCTβ catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. CCTα is activated...
Thu Mar 19, 2020 14:25
Wed Mar 18, 2020 05:07
Related ArticlesInfluence of short-term dexamethasone on the efficacy of 177 Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer. Prostate. 2020 Mar 18;: Authors: Derlin T, Sommerlath Sohns JM, Schmuck S, Henkenberens C, von Klot CAJ, Ross TL, Bengel FM Abstract BACKGROUND AND AIM: Corticosteroids alone or in combination therapy are associated with favorable biochemical responses in metastatic castration-resistant prostate cancer...
Thu Mar 19, 2020 14:18
Related ArticlesTowards customizable thin-panel low-Z detector arrays: Electrode design for increased spatial resolution ion chamber arrays. Phys Med Biol. 2020 Mar 18;: Authors: Albert S, Brivio D, Aldelaijan SI, Sajo E, Hesser JW, Zygmanski P Abstract Purpose:The purpose of the present development is to employ 3D printing to prototype an ion chamber array with a scalable design potentially allowing increased spatial resolution and a larger active area....
Thu Mar 19, 2020 14:18
Related ArticlesNursing diagnoses and NIC interventions in adult males undergoing radical prostatectomy. Rev Esc Enferm USP. 2020;54:e03541 Authors: Kocaçal E, Karadağ E Abstract OBJECTIVE: To determine NANDA-I nursing diagnoses and NIC nursing interventions in patients who underwent radical prostatectomy. METHOD: A cross-sectional and descriptive study was conducted in a research and teaching hospital in western Turkey between June 2016 and...
Thu Mar 19, 2020 14:18
Related ArticlesTargeted alpha therapy for chronic lymphocytic leukaemia and non-Hodgkin's lymphoma with the anti-CD37 radioimmunoconjugate 212Pb-NNV003. PLoS One. 2020;15(3):e0230526 Authors: Maaland AF, Saidi A, Torgue J, Heyerdahl H, Stallons TAR, Kolstad A, Dahle J Abstract Relapse of chronic lymphocytic leukaemia and non-Hodgkin's lymphoma after standard of care treatment is common and new therapies are needed. The targeted alpha therapy with 212Pb-NNV003...
Thu Mar 19, 2020 14:18
Related ArticlesLorlatinib for the treatment of ALK-positive metastatic non-small cell lung cancer. Expert Rev Anticancer Ther. 2020 Mar 18;: Authors: Choo JR, Soo RA Abstract INTRODUCTION: The treatment of lung cancer has changed dramatically with the development of tyrosine kinase inhibitors (TKIs) that target sensitizing somatic (gene) activations including anaplastic lymphoma kinase (ALK)-rearrangements. Despite remarkable initial responses, patients...
Thu Mar 19, 2020 14:18
Related ArticlesKidney retransplantation after anti-programmed cell death-1 (PD-1)-related allograft rejection. Am J Transplant. 2020 Mar 17;: Authors: Lipson EJ, Naqvi FF, Loss MJ, Schollenberger MD, Pardoll DM, Moore J, Brennan DC Abstract In this report, we describe the first kidney retransplantation performed after anti-programmed cell death-1 (PD-1)-related allograft rejection. In 2014, we administered pembrolizumab (anti-PD-1) for ~9 months to...
Thu Mar 19, 2020 12:24
Related ArticlesSmall Molecular Immune Modulators as Anticancer Agents. Adv Exp Med Biol. 2020;1248:547-618 Authors: Han Y, Zhu L, Wu W, Zhang H, Hu W, Dai L, Yang Y Abstract After decades of intense effort, immune checkpoint inhibitors have been conclusively demonstrated to be effective in cancer treatments and thus are revolutionizing the concepts in the treatment of cancers. Immuno-oncology has arrived and will play a key role in cancer treatment...
Thu Mar 19, 2020 12:24
Related ArticlesmiRNAs in the Diagnosis and Prognosis of Skin Cancer. Front Cell Dev Biol. 2020;8:71 Authors: Neagu M, Constantin C, Cretoiu SM, Zurac S Abstract Skin cancer is, at present, the most common type of malignancy in the Caucasian population. Its incidence has increased rapidly in the last decade for both melanoma and non-melanoma skin cancer. Differential expression profiles of microRNAs (miRNAs) have been reported for a variety of different...
Thu Mar 19, 2020 12:24
Related ArticlesSeed, soil, and spine stereotactic radiosurgery: A unique case of metastatic dissemination. J Radiosurg SBRT. 2020;6(4):325-328 Authors: Grant SR, Brown PD, Tatsui CE, Ghia AJ Abstract A 52 year-old gentleman with metastatic pheochromocytoma received single fraction spine stereotactic radiosurgery (SSRS) to an isolated L3 metastasis. Two years later, he developed widespread osseous metastatic disease involving nearly every vertebral body...
Thu Mar 19, 2020 12:24
Related ArticlesThe Role of Adjuvant Chemoradiotherapy Over Radiotherapy After R0 Resection for Stage II-III Esophageal Squamous Cell Carcinoma. Cancer Manag Res. 2020;12:1631-1639 Authors: Song T, Chen P, Fang M, Zhang X, Du D, Wu S Abstract Purpose: This study compared the effectiveness and safety of postoperative concurrent chemoradiotherapy (POCRT) containing paclitaxel (PTX) and cisplatin (DDP) with postoperative radiotherapy (PORT) after R0 resection...
Thu Mar 19, 2020 12:24
Related ArticlesTranscatheter Intra-Arterial Infusion Combined with Interventional Photothermal Therapy for the Treatment of Hepatocellular Carcinoma. Int J Nanomedicine. 2020;15:1373-1385 Authors: Zhou J, Ling G, Cao J, Ding X, Liao X, Wu M, Zhou X, Xu H, Long Q Abstract Background: Photothermal therapy (PTT) has great potential application in the treatment of tumors. However, due to the low penetration of near-infrared light (NIR) and the low concentration...
Thu Mar 19, 2020 12:24
Related ArticlesInvolvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochem Biophys Res Commun. 2020 Mar 14;: Authors: Inoue C, Sobue S, Kawamoto Y, Nishizawa Y, Ichihara M, Abe A, Hayakawa F, Suzuki M, Nozawa Y, Murate T Abstract T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase...
Thu Mar 19, 2020 12:24
Related ArticlesNutrition and cancer: evidence gaps and opportunities for improving knowledge. Proc Nutr Soc. 2020 Mar 18;:1-6 Authors: Thorne JL, Moore JB, Corfe BM Abstract The Nutrition Society's 1st Annual Nutrition and Cancer Networking Conference brought together scientists from the fields of Nutrition, Epidemiology, Public Health, Medical Oncology and Surgery with representatives of the public, cancer survivors and cancer charities. Speakers representing...
Thu Mar 19, 2020 12:24
Related ArticlesTumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series. J Ovarian Res. 2020 Mar 17;13(1):29 Authors: Ni J, Zhou R, Cheng X, Xu X, Guo W, Chen X Abstract BACKGROUND: Olaparib, a poly ADP-ribose polymerase (PARP) inhibitor, has proven to be effective and safe as maintenance therapy and multiline therapy in ovarian cancer, especially in patients with BRCA mutations. This study...
Thu Mar 19, 2020 12:24
Related ArticlesIncreasing preparedness for caregiving and death in family caregivers of patients with severe illness who are cared for at home - study protocol for a web-based intervention. BMC Palliat Care. 2020 Mar 17;19(1):33 Authors: Alvariza A, Häger-Tibell L, Holm M, Steineck G, Kreicbergs U Abstract BACKGROUND: Family caregivers of patients with severe illness and in need for a palliative care approach, face numerous challenges and report having...
Thu Mar 19, 2020 12:24
Related ArticlesEmerging Role of Circulating Tumor Cells in Gastric Cancer. Cancers (Basel). 2020 Mar 15;12(3): Authors: Thanh Huong P, Gurshaney S, Thanh Binh N, Gia Pham A, Hoang Nguyen H, Thanh Nguyen X, Pham-The H, Tran PT, Truong Vu K, Xuan Duong N, Pelucchi C, La Vecchia C, Boffetta P, Nguyen HD, Luu HN Abstract With over 1 million incidence cases and more than 780,000 deaths in 2018, gastric cancer (GC) was ranked as the 5th most common cancer...
Thu Mar 19, 2020 12:24
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