Abstract Purpose The different mechanisms that trigger the autoimmune attack to the thyroid between Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are still unclear. The aim of this study was to recognize thyroid antigens specific CD8+ T-cell epitopes and explore the relationship between these epitopes and thyroid autoantibodies, duration and classification in these two diseases. ...
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Related ArticlesPeritumoral edema as a biomarker of the aggressiveness of breast cancer: results of a retrospective study on a 3 T scanner. Breast Cancer Res Treat. 2020 Mar 17;: Authors: Panzironi G, Moffa G, Galati F, Marzocca F, Rizzo V, Pediconi F Abstract PURPOSE: To determine whether there is a correlation between the presence of peritumoral edema detected on T2-weighted sequences and pathological prognostic factors and specific biological subtypes...
Thu Mar 19, 2020 13:09
Related ArticlesNeoadjuvant treatment strategies for HER2-positive breast cancer: cost-effectiveness and quality of life outcomes. Breast Cancer Res Treat. 2020 Mar 17;: Authors: Hassett MJ, Li H, Burstein HJ, Punglia RS Abstract PURPOSE: Achieving a pathologic complete response (pCR) with neoadjuvant therapy for HER2-positive breast cancer is associated with less recurrence and improved clinical outcomes compared to having residual cancer at surgery....
Thu Mar 19, 2020 13:09
Related ArticlesmiR-125a Induces HER2 Expression and Sensitivity to Trastuzumab in Triple-Negative Breast Cancer Lines. Front Oncol. 2020;10:191 Authors: Ninio-Many L, Hikri E, Burg-Golani T, Stemmer SM, Shalgi R, Ben-Aharon I Abstract The EGFR/HER2 signaling network is an effective therapeutic target for HER2-positive cancers, which are known for their aggressive biological course. Evidence indicates that the EGFR/HER2 network plays a role in the aggressive...
Thu Mar 19, 2020 13:09
Related Articles[Gender differences in clinical features and performance of sleep questionnaires in adults with obstructive sleep apnea syndrome]. Rev Med Chil. 2019 Oct;147(10):1291-1302 Authors: Saldías Peñafiel F, Salinas Rossel G, Cortés Meza J, Farías Nesvadba D, Peñaloza Tapia A, Aguirre Mardones C, Díaz Patiño O Abstract BACKGROUND: Women with obstructive sleep apnea-hypopnea syndrome (OSAS) are less likely to be assessed or to receive an appropriate...
Thu Mar 19, 2020 15:05
Related Articles[Performance of sleep questionnaires for the diagnosis of obstructive sleep apnea syndrome]. Rev Med Chil. 2019 Dec;147(12):1543-1552 Authors: Saldías Peñafiel F, Brockmann Veloso P, Santín Martínez J, Fuentes-López E, Valdivia Cabrera G Abstract Background The diagnosis of obstructive sleep apnea syndrome (OSAS) is based on nocturnal records: polysomnography or respiratory polygraphy. However, their high costs limit their use. Aim To...
Thu Mar 19, 2020 15:05
Related ArticlesOccupational balance and sleep among women. Scand J Occup Ther. 2020 Mar 18;:1-9 Authors: Magnusson L, Håkansson C, Brandt S, Öberg M, Orban K Abstract Background: In occupational therapy, while several studies have focussed on occupational balance, few have investigated it in the context of sleep.Aims: The aim of this study was to investigate the associations between sleep and occupational balance among women.Material and methods: In...
Thu Mar 19, 2020 15:05
Related Articles[Social Security Code XIV: the new "Act Regulating Social Compensation Law" of 12 December 2019-what the ENT expert should know]. HNO. 2020 Mar 17;: Authors: Michel O PMID: 32185426 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:07
Related Articles[91st Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery in Berlin : What quality makes the difference?] HNO. 2020 Mar 17;: Authors: Dietz A PMID: 32185425 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:07
Related ArticlesInner Workings: Understanding the evolution of cell types to explain the roots of animal diversity. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5547-5549 Authors: Callier V PMID: 32184373 [PubMed - in process]
Thu Mar 19, 2020 13:04
Related ArticlesMRTFB regulates the expression of NOMO1 in colon. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Zhao T, Hu Y, Zang T, Cheng L PMID: 32184333 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:04
Related ArticlesReply to Zhao et al.: NOMO1 is a potential target gene of MRTFB. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Marian TA, Wei Z PMID: 32184332 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:04
Related ArticlesDecoding across sensory modalities reveals common supramodal signatures of conscious perception. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Sanchez G, Hartmann T, Fuscà M, Demarchi G, Weisz N Abstract An increasing number of studies highlight common brain regions and processes in mediating conscious sensory experience. While most studies have been performed in the visual modality, it is implicitly assumed that similar processes...
Thu Mar 19, 2020 13:04
Related ArticlesSeasonal hysteresis of surface urban heat islands. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Manoli G, Fatichi S, Bou-Zeid E, Katul GG Abstract Temporal dynamics of urban warming have been extensively studied at the diurnal scale, but the impact of background climate on the observed seasonality of surface urban heat islands (SUHIs) remains largely unexplored. On seasonal time scales, the intensity of urban-rural surface temperature...
Thu Mar 19, 2020 13:04
Related ArticlesIs ionic choline and geranate (CAGE) liquid caging diet-derived fat, limiting its absorption? Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Peiretti F, Valéro R, Govers R PMID: 32184329 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:04
Related ArticlesReply to Peiretti et al.: Effect of CAGE on fat uptake and food intake. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Nurunnabi M, Ibsen KN, Tanner EEL, Mitragotri S PMID: 32184328 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:04
Related ArticlesA pheromone antagonist liberates female sea lamprey from a sensory trap to enable reliable communication. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Buchinger TJ, Scott AM, Fissette SD, Brant CO, Huertas M, Li K, Johnson NS, Li W Abstract The evolution of male signals and female preferences remains a central question in the study of animal communication. The sensory trap model suggests males evolve signals that mimic cues used in...
Thu Mar 19, 2020 13:04
Related ArticlesSpecialized cytonemes induce self-organization of stem cells. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Junyent S, Garcin CL, Szczerkowski JLA, Trieu TJ, Reeves J, Habib SJ Abstract Spatial cellular organization is fundamental for embryogenesis. Remarkably, coculturing embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) recapitulates this process, forming embryo-like structures. However, mechanisms driving ESC-TSC interaction...
Thu Mar 19, 2020 13:04
Related ArticlesEvidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M,...
Thu Mar 19, 2020 13:04
Related ArticlesAbsolute yeast mitochondrial proteome quantification reveals trade-off between biosynthesis and energy generation during diauxic shift. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: Di Bartolomeo F, Malina C, Campbell K, Mormino M, Fuchs J, Vorontsov E, Gustafsson CM, Nielsen J Abstract Saccharomyces cerevisiae constitutes a popular eukaryal model for research on mitochondrial physiology. Being Crabtree-positive, this yeast has evolved...
Thu Mar 19, 2020 13:04
Related ArticlesGq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: White AD, Jean-Alphonse FG, Fang F, Peña KA, Liu S, König GM, Inoue A, Aslanoglou D, Gellman SH, Kostenis E, Xiao K, Vilardaga JP Abstract cAMP production upon activation of Gs by G protein-coupled receptors has classically been considered to be plasma membrane-delimited, but a shift in this paradigm...
Thu Mar 19, 2020 13:04
Related ArticlesInterleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. Proc Natl Acad Sci U S A. 2020 Mar 17;: Authors: De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG Abstract Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc). IL-2 has been...
Thu Mar 19, 2020 13:04
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Thu Mar 19, 2020 13:04
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Thu Mar 19, 2020 13:04
Related ArticlesA Prospective Randomized Clinical Trial of Combination Therapy with Proton Pump Inhibitors and Mucolytics in Patients with Laryngopharyngeal Reflux. Ann Otol Rhinol Laryngol. 2020 Mar 18;:3489420913592 Authors: Chae M, Jang DH, Kim HC, Kwon M Abstract OBJECTIVES: To identify whether combination therapy with mucolytics and proton pump inhibitors (PPIs) leads to faster and more effective symptomatic relief in patients with laryngopharyngeal...
Thu Mar 19, 2020 15:05
Related ArticlesRelationships between academic self-efficacy, learning-related emotions, and metacognitive learning strategies with academic performance in medical students: a structural equation model. BMC Med Educ. 2020 Mar 17;20(1):76 Authors: Hayat AA, Shateri K, Amini M, Shokrpour N Abstract Recognition of the factors affecting the medical students' academic success is one of the most important challenges and concerns in medical schools. Hence,...
Thu Mar 19, 2020 12:59
Related ArticlesA blended learning training programme for health information providers to enhance implementation of the Guideline Evidence-based Health Information: development and qualitative pilot study. BMC Med Educ. 2020 Mar 18;20(1):77 Authors: Hinneburg J, Lühnen J, Steckelberg A, Berger-Höger B Abstract BACKGROUND: The Guideline Evidence-based Health Information was published in 2017 and addresses health information providers. The long-term goal...
Thu Mar 19, 2020 12:59
Related ArticlesExisting contradictions and suggestions: flipped classroom in radiology courses of musculoskeletal disease under Chinese medical educational mode from medical imaging student perspective. BMC Med Educ. 2020 Mar 17;20(1):75 Authors: Wu S, Pan S, Ren Y, Yu H, Chen Q, Liu Z, Guo Q Abstract BACKGROUND: Flipped classrooms have already begun to be used in many universities aboard, and they now make up for some of the short comings of the traditional...
Thu Mar 19, 2020 12:59
Related ArticlesStress, stressors and related factors in clinical learning of midwifery students in Iran: a cross sectional study. BMC Med Educ. 2020 Mar 18;20(1):78 Authors: Rezaei B, Falahati J, Beheshtizadeh R Abstract BACKGROUND: Midwifery is an emotionally challenging profession, and academic education of midwifery especially clinical learning has its own specific challenges. Midwifery students face with stressful experiences, especially related...
Thu Mar 19, 2020 12:59
Related ArticlesDo USMLE steps, and ITE score predict the American Board of Internal Medicine Certifying Exam results? BMC Med Educ. 2020 Mar 18;20(1):79 Authors: Rayamajhi S, Dhakal P, Wang L, Rai MP, Shrotriya S Abstract BACKGROUND: To evaluate if United States Medical Licensing Examination (USMLE) Step 1, USMLE Step 2 CK, USMLE Step 3, and residency third-year in-service training exam (ITE) scores predict the results of American Board of Internal...
Thu Mar 19, 2020 12:59
Abstract Background Though meningioma is the most common primary brain tumor, there is a paucity of epidemiologic studies investigating disparities in treatment and patient outcomes. Therefore, we sought to explore how sociodemographic factors are associated with rates of gross total resection (GTR) and radiotherapy as well as survival. Methods The...
Thu Mar 19, 2020 02:00
Abstract Introduction To improve the standard treatment paradigm for glioblastoma (GBM), efforts have been made to explore the efficacy of epigenetic agents as chemosensitizers. Recent data suggest possible synergy between decitabine (DAC), a DNA hypomethylating agent, and temozolomide (TMZ) in GBM, but the mechanism remains unclear. The objective of this study was to determine the effects of DAC on TMZ sensitization in a consecutively...
Thu Mar 19, 2020 02:00
Related ArticlesManaging Stable Subsolid Lung Nodules: A Possible Approach. Radiology. 2020 Mar 17;:200047 Authors: Naidich DP, Azour L PMID: 32186460 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 14:55
Related ArticlesMedical Radiation Exposure to the U.S. Population: The Turning Tide. Radiology. 2020 Mar 17;:200200 Authors: Einstein AJ PMID: 32186459 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 14:55
Related ArticlesDetection of Brain Metastases with Deep Learning Single-Shot Detector Algorithms. Radiology. 2020 Mar 17;:200261 Authors: Kikinis R, Wells WM PMID: 32186458 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 14:55
Related ArticlesPreoperative MRI Improves Surgical Planning and Outcomes for Ductal Carcinoma in Situ. Radiology. 2020 Mar 17;:200076 Authors: Pinker K PMID: 32186457 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 14:55
Related ArticlesRespiratory safety of lemborexant in healthy adult and elderly subjects with mild obstructive sleep apnea: A randomized, double-blind, placebo-controlled, crossover study. J Sleep Res. 2020 Mar 18;:e13021 Authors: Cheng JY, Filippov G, Moline M, Zammit GK, Bsharat M, Hall N Abstract Lemborexant is a dual orexin receptor antagonist indicated for the treatment of adult and elderly individuals with insomnia. Some current pharmacologic treatments...
Thu Mar 19, 2020 14:09
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