Publication date: Available online 18 March 2020Source: Cancer/RadiothérapieAuthor(s): J. Bouter, J. Lacroix, J. Baud, J. Thariat
Thu Mar 19, 2020 13:58
Publication date: Available online 18 March 2020Source: Cancer/RadiothérapieAuthor(s): C. Lahmamssi, J.-B. Guy, N. Benchekroun, Z. Bouchbika, N. Taoufik, H. Jouhadi, S. Sahraoui, A. Benider, M. Ben Mrad, O. Jmour, A. Bousarsar, M.L. Lan, Q. Lei, M. Benna, D. Moslemi, A. Vallard, N. Magné
Thu Mar 19, 2020 13:58
Publication date: Available online 19 March 2020Source: Pathology - Research and PracticeAuthor(s): Ming-Jen Sheu, Chia-Lin Chou, Ching-Chieh Yang, Sung-Wei Lee, Yu-Feng Tian, Chen-Yi Lin, Sheng-Yen Hsiao, Shang-Hung Chen, Wen-Tsung Huang
Thu Mar 19, 2020 13:58
Background The doublesex and mab-3 related transcription factor 1 (Dmrt1) is a highly conserved gene across numerous vertebrates and invertebrates in sequence and function. Small aminoacid changes in Dmrt1 are associated with turnovers in sex determination in reptiles. Dmrt1 is upregulated in males during gonadal development in many species, including the painted turtle, Chrysemys picta, a reptile with temperature-dependent sex determination (TSD). Dmrt1 is reported to play different...
Thu Mar 19, 2020 02:00
Burkholderia pseudomallei is a Gram-negative bacillus that causes melioidosis and is recognized as an important public health problem in southeast Asia and northeast Australia. The treatment of B. pseudomallei infection is hampered by resistance to a wide range of antimicrobial agents and no vaccine is currently available. At present, the underlying mechanisms of B. pseudomallei pathogenesis are poorly understood. In our previous study, we reported that a B. pseudomallei short-chain dehydrogenase...
Thu Mar 19, 2020 02:00
Fish skin and gut microbiomes contribute to host health and growth and are often significantly different in aquaculture-reared fish compared to wild fish. Determining how factors associated with aquaculture, including altered diet and abiotic conditions, affect the microbiome will assist with optimizing farming practices and non-invasively assessing fish health. Here, juvenile yellowtail kingfish (Seriola lalandi) housed at optimal (22 °C) and non-optimal (26 °C) water temperature were fed a fishmeal...
Thu Mar 19, 2020 02:00
Background A subgroup of adolescent and young adult (AYA) survivors of cancer during adolescence report high levels of psychological distress. To date, evidence-based psychological interventions tailored to the cancer-related concerns experienced by this population are lacking. The present study aimed to (1) examine the feasibility and preliminary efficacy of an individualized cognitive behavioral therapy (CBT) intervention for AYA survivors of cancer during adolescence; and (2)...
Thu Mar 19, 2020 02:00
Background Pacific walruses (Odobenus rosmarus divergens) are a conspicuous and important component of the Bristol Bay ecosystem and human social systems, but very little is known about walrus ecology in this region, principally their feeding ecology. The present work provides contemporary data on the diets of walruses at four haulout locations throughout Bristol Bay between 2014 and 2018. Methods We analyzed scat and...
Thu Mar 19, 2020 02:00
Studies on personality have revealed that some personality traits are strongly correlated; thus, researchers may be able to acquire data for variables related to different personality traits from one measurement. Therefore, the aim of the present study was to test whether spontaneous movement traits used in fish personality measurements are correlated or vary among different contexts in a common Chinese cyprinid fish, the pale chub (Zacco platypus, Cyprinidae). The median swimming speed, percent...
Thu Mar 19, 2020 02:00
We describe Miconia lucenae R.Goldenb. & Michelang., a new species from the montane Atlantic Forest in Santa Teresa in the state of Espírito Santo. Our analysis, based on three plastid spacers (atpF-atpH, psbK-psbl and trnS-trnG), one plastid gene (ndhF, not available for M. lucenae), and two nuclear ribosomal loci (nrITS and nrETS), showed that it belongs to a small clade with Miconia paradoxa (Mart. ex DC.) Triana (Minas Gerais) and M. michelangeliana R.Goldenb. & L.Kollmann (Espírito Santo)....
Thu Mar 19, 2020 02:00
Background Iron overload is one of common complications of β-thalassemia. Systemic iron homeostasis is regulated by iron-regulatory hormone, hepcidin, which inhibits intestinal iron absorption and iron recycling by reticuloendothelial system. In addition, body iron status and requirement can be altered with age. In adolescence, iron requirement is increased due to blood volume expansion and growth spurt. Heterozygous β-globin knockout mice (Hbbth3/+; BKO) is a mouse model of thalassemia widely...
Thu Mar 19, 2020 02:00
Background The Puck commune is one of the largest agricultural regions in the Pomeranian Voivodship that due to the pollution of the coastal zone negatively affects the functioning of the Puck Bay, including health of its inhabitants, and causes decrease in tourism as well as in overall economic value of the region. The objective of the undertaken study was to assess the extent of risk to the environment posed by the pesticides used in agricultural production in the coastal area...
Thu Mar 19, 2020 02:00
Sex reversal is a complex biological phenomenon exhibited by Cynoglossus semilaevis. Some genetic females may irreversibly convert to pseudomales, thus increasing aquaculture costs because males grow much more slowly than females. In this study, an integrative analysis of transcriptome and proteome was performed to compare differences in gene and protein expression in females and pseudomales after gonad differentiation in C. semilaevis. Based on RNA-Seq results, 1893 genes showed differences in expression...
Thu Mar 19, 2020 02:00
RNA-fluorescence in situ hybridization (FISH) is a powerful tool to visualize target messenger RNA transcripts in cultured cells, tissue sections or whole-mount preparations. As the technique has been developed over time, an ever-increasing number of divergent protocols have been published. There is now a broad selection of options available to facilitate proper tissue preparation, hybridization, and post-hybridization background removal to achieve optimal results. Here we review the technical aspects...
Thu Mar 19, 2020 02:00
Background The western Mediterranean archipelagos have a rich endemic fauna, which includes five species of reptiles. Most of these archipelagos were colonized since early historic times by anthropochoric fauna, such as ship rats (Rattus rattus). Here, I evaluated the influence of ship rats on the occurrence of island reptiles, including non-endemic species. Methodology I analysed a presence-absence database encompassing...
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15263-3Granular materials are abundant in nature, but we haven’t fully understood their rheological properties as complex interactions between particles are involved. Here, Vo et al. show that granular flows can be described by a generalized dimensionless number based on stress additivity.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-14970-1Excitation energy transfer within light-harvesting complex II underlies plant photosynthesis but its detailed mechanism is not yet understood. Here the authors explore, by 2D electronic-vibrational spectroscopy, the role of mixing of vibrational and electronic degrees of freedom.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15234-8Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarbose titer in Actinoplanes species.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15265-1Magnons - collective excitations of electron spins - promise compact and fast electronics. However, the generation of short wave magnons is still quite challenging. Here, the authors demonstrate that by introducing a ferromagnetic layer, conventional coplanar waveguides can be used to efficiently generate such magnons.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15277-xVIP-expressing neurons play a central role in circadian timekeeping within the mammalian central clock. Here the authors use opto- and chemogenetic approaches to show that VIP neuronal activity regulates rhythmic activity in downstream hypothalamic target neurons and their physiological functions.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15324-7Kucha is a rare variety of tea tree that produces the non-stimulatory theacrine instead of caffeine. Here the authors show that theacrine synthase from Kucha has N9-methyltransferase activity resulting from amino acid substitutions that explain substrate specificity and could potentially guide production of caffeine-free tea.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15232-wThe ultrafast optical dynamics of plasmon-quantum emitter systems have rarely been explored. Here, the authors study those dynamics by interferometrically probing nonlinear optical emission from porous gold nanosponges with zinc oxide emitters, allowing sum-frequency generation enhancement from individual hot spots.
Thu Mar 19, 2020 02:00
Nature Communications, Published online: 19 March 2020; doi:10.1038/s41467-020-15291-zGenetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.
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Related ArticlesFactor X Deficiency Management for Elective Cesarean Delivery in a Pregnant Patient. Am J Case Rep. 2020 Mar 18;21:e920685 Authors: Krkovic M, Koosova Gajic A, Tarčuković J, Sotosek V, Stimac T, Balen S, Dangubic B, Grubjesic I Abstract BACKGROUND Congenital factor X deficiency is a rare inherited coagulopathy. Pregnancies in women with this disorder are often associated with adverse outcomes, including miscarriage, premature labor, and...
Thu Mar 19, 2020 13:51
Related ArticlesRecovery of reproductive and cardiac function in past androgen users. J Clin Endocrinol Metab. 2020 Mar 18;: Authors: Wang C PMID: 32186325 [PubMed - as supplied by publisher]
Thu Mar 19, 2020 13:49
Related ArticlesPatients with APECED have increased early mortality due to endocrine causes, malignancies and infections. J Clin Endocrinol Metab. 2020 Mar 18;: Authors: Borchers J, Pukkala E, Mäkitie O, Laakso S Abstract CONTEXT: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an autoimmune endocrinopathy with severe and unpredictable course. The impact of APECED on mortality has not been determined. OBJECTIVE: To...
Thu Mar 19, 2020 13:49
Related ArticlesPESM: predicting the essentiality of miRNAs based on gradient boosting machines and sequences. BMC Bioinformatics. 2020 Mar 18;21(1):111 Authors: Yan C, Wu FX, Wang J, Duan G Abstract BACKGROUND: MicroRNAs (miRNAs) are a kind of small noncoding RNA molecules that are direct posttranscriptional regulations of mRNA targets. Studies have indicated that miRNAs play key roles in complex diseases by taking part in many biological processes,...
Thu Mar 19, 2020 13:49
Related ArticlesSEQing: web-based visualization of iCLIP and RNA-seq data in an interactive python framework. BMC Bioinformatics. 2020 Mar 18;21(1):113 Authors: Lewinski M, Bramkamp Y, Köster T, Staiger D Abstract BACKGROUND: RNA-binding proteins interact with their target RNAs at specific sites. These binding sites can be determined genome-wide through individual nucleotide resolution crosslinking immunoprecipitation (iCLIP). Subsequently, the binding...
Thu Mar 19, 2020 13:49
Related ArticlesRASflow: an RNA-Seq analysis workflow with Snakemake. BMC Bioinformatics. 2020 Mar 18;21(1):110 Authors: Zhang X, Jonassen I Abstract BACKGROUND: With the cost of DNA sequencing decreasing, increasing amounts of RNA-Seq data are being generated giving novel insight into gene expression and regulation. Prior to analysis of gene expression, the RNA-Seq data has to be processed through a number of steps resulting in a quantification of expression...
Thu Mar 19, 2020 13:49
Related ArticlesMethylNet: an automated and modular deep learning approach for DNA methylation analysis. BMC Bioinformatics. 2020 Mar 17;21(1):108 Authors: Levy JJ, Titus AJ, Petersen CL, Chen Y, Salas LA, Christensen BC Abstract BACKGROUND: DNA methylation (DNAm) is an epigenetic regulator of gene expression programs that can be altered by environmental exposures, aging, and in pathogenesis. Traditional analyses that associate DNAm alterations with...
Thu Mar 19, 2020 13:49
AllEnricher: a comprehensive gene set function enrichment tool for both model and non-model species.
Related ArticlesAllEnricher: a comprehensive gene set function enrichment tool for both model and non-model species. BMC Bioinformatics. 2020 Mar 17;21(1):106 Authors: Zhang D, Hu Q, Liu X, Zou K, Sarkodie EK, Liu X, Gao F Abstract BACKGROUND: Function genomic studies will generally result in lists of genes that may provide clues for exploring biological questions and discovering unanticipated functions, based on differential gene expression analysis,...
Thu Mar 19, 2020 13:49
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