Hypertrophic cardiomyopathy (HCM) is characterized by an abnormal increase in myocardial mass that affects cardiac structure and function. HCM is the most common inherited cardiovascular disease in humans (0.2%) and the most common cardiovascular disease in cats (14.7%). Feline HCM phenotype is very similar to the phenotype found in humans, but the time frame for the development of the disease is significantly shorter. Similar therapeutic agents are used in its treatment and it has the...
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Abstract Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), and transfer RNA fragments (tRFs), are differently expressed in breast cancer (BC) and can be detected in blood circulation. Circulating small RNAs and small RNAs in extracellular vesicles (EVs) have emerged as ideal markers in small RNA‐based applications for cancer detection. In this study, we first performed small RNA sequencing to assess the expression of circulating small RNAs in...
09:35
Summary Gene rearrangements of MLL/KMT2A or RUNX1 are the major cause of therapy‐related leukemia. Moreover, MLL rearrangements are the major cause of infant leukemia, and RUNX1 rearrangements are frequently detected in cord blood. These genes are sensitive to topoisomerase II inhibitors, and various genes have been identified as potential fusion partners. However, fetal exposure to these inhibitors is rare. Therefore, we postulated that even a proliferation signal itself might induce gene rearrangements...
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Laryngo-Rhino-OtolDOI: 10.1055/a-1130-6375 Hintergrund Die Schnittführung für den Zugangsweg bei der Versorgung mit Cochlea-Implantaten und aktiven Mittelohrimplantaten wie Vibrant Soundbridge und Bonebridge hat sich in den letzten Jahren in Richtung minimalinvasiver Zugangswege entwickelt.Für das aktive Mittelohrimplantat CARINA wird eine im Vergleich deutlich größere Schnittführung empfohlen, die der der CI-Versorgung vor ca. 2 Jahrzehnten entspricht.Hierdurch sind erhöhte Komplikationsraten...
Wed Mar 25, 2020 01:00
Ribosomal subunits are assembled on a precursor rRNA that includes four spacers in addition to the mature rRNA sequences. The 5’ external transcribed spacer (5' ETS) is the most prominent one that recruits U3 snoRNA and a plethora of proteins during the early assembly of 90S small subunit pre-ribosomes. Here, we have conducted a comprehensive mutational analysis of 5' ETS by monitoring the processing and assembly of a plasmid-expressed pre-18S RNA. Remarkably, nearly half of the 5' ETS sequences,...
Wed Mar 25, 2020 19:24
ABSTRACT Bacterial ribosomal proteins (r-proteins) encoded by non-essential genes often carry out very important tasks in translation. In particular, this is the case of a small basic bacteria-specific r-protein L31 (bL31). Recent studies revealed a crucial role of bL31 in formation of the protein-protein intersubunit bridge B1b and hence its contribution to ribosome dynamics. In addition, bL31 counteracts ribosome destabilization by certain nascent peptides, and it may facilitate translation initiation...
Tue Mar 24, 2020 21:05
British Journal of Cancer, Published online: 26 March 2020; doi:10.1038/s41416-020-0805-yProgression-free survival as a surrogate for overall survival in oncology trials: a methodological systematic review
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British Journal of Cancer, Published online: 25 March 2020; doi:10.1038/s41416-020-0806-xAdherence to the WCRF/AICR 2018 recommendations for cancer prevention and risk of cancer: prospective cohort studies of men and women
Wed Mar 25, 2020 02:00
British Journal of Cancer, Published online: 25 March 2020; doi:10.1038/s41416-020-0804-zImpairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells
Wed Mar 25, 2020 02:00
British Journal of Cancer, Published online: 25 March 2020; doi:10.1038/s41416-020-0809-7Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells
Wed Mar 25, 2020 02:00
British Journal of Cancer, Published online: 25 March 2020; doi:10.1038/s41416-020-0785-yClinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial
Wed Mar 25, 2020 02:00
British Journal of Cancer, Published online: 25 March 2020; doi:10.1038/s41416-020-0811-0Prognostic and clinical impact of PD-L2 and PD-L1 expression in a cohort of 437 oesophageal cancers
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00442A, PaperJiaying Zhang, Xiangyu Feng, Jing Wang, Guozhen Fang, Jifeng Liu, Shuo WangA new core-shell structured nanomaterial based on Fe3O4 nanoparticle and 2, 3-dialdehyde nanocrystalline cellulose (DAC) coating and its high efficiency in preconcentration of glycoproteins were described in this work. DAC...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00397B, PaperYuanyuan Guo, Chao Zhao, Yushen Liu, Heran Nie, Xiaoxiao Guo, Xiu-Ling Song, Kun Xu, Juan Li, Juan WangFluorescent-based assays have been regarded as promising tools for specific, sensitive, rapid and effective detection of Listeria monocytogenes (L. monocytogenes). Nevertheless, the aggregation-caused quenching (ACQ) of emissions is always a...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Mar 25, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00451K, PaperJunshu Lin, Quan Wang, Xiaoyu Wang, Yunyao Zhu, Xi Zhou, Hui WeiBiothiols play an important role in living cells and are associated with many diseases. Thus, it is necessary to develop a facile, cost-effective, and convenient analytical method for detection of...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Mar 25, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00348D, PaperZhanjun Yang, Juan Li, Huifang Shen, Suhua Yu, Geshan Zhang, Chuanli Ren, Xiaoya HuIn this research, a novel manganese dioxide nanorods-anckored graphene oxide (MnO2 NRs/GO) composite was synthesized by a simple hydrothermal method for the electrochemical sening application. A highly sensitive electrochemical sensor...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Mar 25, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02518A, PaperMirjana Miletić, Sonja Aškrabić, Jan Rüger, Borislav Vasic, Lela Korićanac, Abdullah Saif Mondol, Jan Dellith, Jürgen Popp, Iwan Schie, Zorana D Dohčević-MitrovićDesign of nanoparticles for application in medical diagnostics and therapy requires a thorough understanding of various aspects of nanoparticle-cell interactions. In this work, two unconventional methods for the study of...The content of this RSS Feed (c) The Royal Society...
Tue Mar 24, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00450B, PaperGege Ding, Junsheng Wang, Lanlan Wang, Jiang Zou, Peitao Tian, Yichi Zhang, Xinxiang Pan, Dongqing LiA novel method for quantitative detection of the viability of a single microalgae cell by two-level photoexcitation is proposed in this paper. This method overcomes the difficulty of traditional methods...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Mar 24, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00066C, PaperHui Zhang, Bin Qiao, Qunqun Guo, Juqian Jiang, Chenxin Cai, Jian ShenFacile detection of tumour-derived extracellular vesicles (EVs) is crucial to cancer diagnosis. Herein, a facile and label-free electrochemical aptasensor was fabricated to detect tumour-derived EVs based on a target-induced proximity...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Mar 24, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02500F, PaperSerkan Erdemir, Serdar Karakurt, Sait MalkonduMonitoring of excess Al3+ in biological and environmental samples is major goal for scientists due to its harmful effects. Thus, the development of selective and convenient techniques for Al3+ recognition...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Mar 24, 2020 02:00
Neighboring sequences of a gene can influence its expression. In the phenomenon known as transcriptional interference, transcription at one region in the genome can repress transcription at a nearby region in cis. Transcriptional interference occurs at a number of eukaryotic loci, including the alcohol dehydrogenase (Adh) gene in Drosophila melanogaster. Adh is regulated by two promoters, which are distinct in their developmental timing of activation. It has been shown using transgene insertion that...
Wed Mar 25, 2020 22:31
The molecular interactions between tomato and Cladosporium fulvum have been an important model for molecular plant pathology. Complex genetic loci on tomato chromosomes 1 and 6 harbor genes for resistance to Cladosporium fulvum, encoding receptor like-proteins that perceive distinct Cladosporium fulvum effectors and trigger plant defenses. Here, we report classical mapping strategies for loci in tomato accessions that respond to Cladosporium fulvum effector Ecp5, which is very sequence-monomorphic....
Tue Mar 24, 2020 23:33
In light of the COVID-19 pandemic and its impact on audiology practices, the Academy of Doctors of Audiology (ADA) organized a town hall meeting on March 23rd to discuss pressing operational and compliance issues and to share helpful resources. Central to the discussion was telehealth, which is in the spotlight as audiologists and hearing care providers find ways to provide remote, contact-less care. While the HHS Office for Civil Rights has the eased restrictions on the use of non-HIPAA-compliant...
Wed Mar 25, 2020 11:02
In light of the COVID-19 pandemic and its impact on audiology practices, the Academy of Doctors of Audiology (ADA) organized a town hall meeting on March 23rd to discuss pressing operational and compliance issues and to share helpful resources. Central to the discussion was telehealth, which is in the spotlight as audiologists and hearing care providers find ways to provide remote, contact-less care. While the HHS Office for Civil Rights has the eased restrictions on the use of non-HIPAA-compliant...
Wed Mar 25, 2020 11:02
By Alexis Guerra The COVID-19 pandemic has forced audiologists in private practice to face unprecedented business challenges. “You are really talking about a marketing phenomenon,” said Kenneth Smith, PhD, vice president and the director of operations for the Hearing Center of Castro Valley in California and a past president of the Academy of Doctors of Audiology (AAA). “You can give people tremendous deals on different types of things within the practice that you would normally sell at a profit...
Tue Mar 24, 2020 13:16
By Alexis Guerra The COVID-19 pandemic has forced audiologists in private practice to face unprecedented business challenges. “You are really talking about a marketing phenomenon,” said Kenneth Smith, PhD, vice president and the director of operations for the Hearing Center of Castro Valley in California and a past president of the Academy of Doctors of Audiology (AAA). “You can give people tremendous deals on different types of things within the practice that you would normally sell at a profit...
Tue Mar 24, 2020 13:16
LISTEN to these special COVID-19 podcast episodes hosted by D'Anne Rudden, AuD.🔊 Special Episode: Interview with AU Bankaitis-Smith, PhD, and Deb Abel, AuDAU Bankaitis-Smith, PhD, with her extensive work in infection control, discusses hygiene protocols and alternatives in keeping audiology clinics safe. Deb Abel, AuD, with her expertise in Coding and Reimbursement, explores the short- and long-term ramifications of business slowdown and audiology clinic closures on obtaining insurance reimbursements...
Tue Mar 24, 2020 11:23
By Shari EbertsEDITOR'S NOTE: The Hearing Journal is proud to partner with the Hearing Loss Association of America (HLAA) in providing patient handouts. For information on HLAA activities and events, visit https://www.hearingloss.org/. For a printable pdf version of this handout, click here. The world has changed a lot in the past few weeks. Physical distancing due to COVID-19 has closed restaurants, theaters, and many other "non-essential" businesses, prioritizing health care and access to food...
Tue Mar 24, 2020 10:17
LISTEN to these special COVID-19 podcast episodes hosted by D'Anne Rudden, AuD.CLICK TO LISTEN: 🔊 Special Episode: Interview with Deb Abel, AuD, and AU Bankaitis-Smith, PhDAU Bankaitis-Smith, PhD, with her extensive work in infection control, discusses hygiene protocols and alternatives in keeping audiology clinics safe. Deb Abel, AuD, with her expertise in Coding and Reimbursement, explores the short- and long-term ramifications of business slowdown and audiology clinic closures on obtaining insurance reimbursements...
Tue Mar 24, 2020 11:23
By Shari EbertsEDITOR'S NOTE: The Hearing Journal is proud to partner with the Hearing Loss Association of America (HLAA) in providing patient handouts. For information on HLAA activities and events, visit https://www.hearingloss.org. For a printable pdf version of this handout, click here. The world has changed a lot in the past few weeks. Physical distancing due to COVID-19 has closed restaurants, theaters, and many other "non-essential" businesses, prioritizing health care and access to food and...
Tue Mar 24, 2020 10:17
By Alexis GuerraDue to the COVID-19 pandemic, businesses and establishments across the United States are closing their doors until further notice, as recommended by the CDC. As of March 22, the American Academy of Audiology (AAA) Executive Committee has recommended for audiology clinics to close and find alternative virtual ways to care for their patients. But where does that leave private audiology practices and their patients?"Last week we started slowing things down and just going day by day as...
Mon Mar 23, 2020 12:35
By Alexis GuerraDue to the COVID-19 pandemic, businesses and establishments across the United States are closing their doors until further notice, as recommended by the CDC. As of March 22, the American Academy of Audiology (AAA) Executive Committee has recommended for audiology clinics to close and find alternative virtual ways to care for their patients. But where does that leave private audiology practices and their patients?"Last week we started slowing things down and just going day by day as...
Mon Mar 23, 2020 12:35
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