When a large asteroid hit the Earth 66 million years ago, it sent huge curtains of dust flying tens of kilometres up into the air that quickly covered the planet
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Disease‐Specific Strains of α‐Synuclein in Multiple System Atrophy and Parkinson's Disease: But Why?
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Rictal bristle morphology and follicle anatomy are diverse across certain Caprimulgiform species. Species with short, thin, branching bristles that lack mechanoreceptors tend to forage pre‐dusk in open habitats, whereas species with longer rictal bristles and mechanoreceptors around their bristle follicle tend to forage at night and in more closed habitats. Abstract Avian rictal bristles are present in many species of birds, especially in nocturnal species. Rictal bristles occur along the upper...
This study is the first to image human arachnoid trabeculae in situ and quantify the spatial distribution across the cerebrum. Incorporation of this spatial heterogeneity may improve the accuracy of computational models of human TBI, and enhance understanding of brain injury dynamics. Abstract Traumatic brain injury (TBI) is a common injury modality affecting a diverse patient population. Axonal injury occurs when the brain experiences excessive deformation as a result of head impact. Previous...
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Background: Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage. The current monitoring approach involves measuring plasma glucose intermittently, but this does not provide a comprehensive assessment of glycemic control and may fail to detect episodes of hypoglycemia. Objective: To determine whether Dexcom G5®, a continuous glucose monitoring system (CGMS), is an accurate and effective method for monitoring...
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Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related mortality worldwide. Although multidisciplinary therapeutic strategies have improved treatment outcomes, the overall prognosis for patients with GC remains poor. Recently, immunotherapeutic agents targeting immunosuppressive proteins such as anti-programmed death-1 receptor and anti-programmed death ligand-1 (PD-L1) have emerged as effective treatment options for various cancers, including GC. In addition...
Purpose: Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B (APOBEC3B) is a recently discovered protein that is considered important in causing mutations in tumor cell genome bases. Whether APOBEC3B is expressed in nasopharyngeal carcinoma (NPC) still remains unknown. Studies have shown that programmed-cell-death receptor-1 ligand (PD-L1) is highly expressed in NPC, but its clinical significance has not been fully elucidated. We aimed to evaluate APOBEC3B and PD-L1 protein expression...
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