Immunogenic cell death in colon cancer prevention and therapy

Abstract Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune regulation. The immune system plays important roles in cancer development and treatment, and immune activation caused by chronic infection or inflammation is well‐known to increase cancer risk. During tumor development, neoplastic cells continuously interact with and shape the tumor microenvironment (TME), which becomes progressively...

Molecular Carcinogenesis

09:58

Genomic profiling reveals the pivotal role of hrHPV driving copy number and gene expression alterations, including mRNA downregulation of TP53 and RB1 in penile cancer

Abstract The incidence of penile cancer (PeCa) is increasing worldwide, however, the highest rates are reported in underdeveloped countries. The molecular mechanisms that underly the onset and progression of these tumors are still unclear. Therefore, our goal was to determine the genome‐wide copy number alterations and the involvement of human papiloma virus (HPV) (TP53 and RB1), inflammatory (COX2 and EGFR), and PI3K/AKT pathway (AKT1, AKT2, EGFR, ERBB3, ERBB4, PIK3CA, and PTEN) associated genes...

Molecular Carcinogenesis

Wed Mar 25, 2020 09:33

The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses

Abstract The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well as impacting epithelial cell motility, CXCL14 contributes to the establishment of immune surveillance within normal epithelial layers. Furthermore, CXCL14 is critical to upregulating major histocompatibility complex class I expression on tumor cells. Given these important roles, CXCL14 is often dysregulated...

Molecular Carcinogenesis

Wed Mar 25, 2020 09:33

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 Genes, Chromosomes and Cancer

Immuno‐oncology gene expression profiling of FFPE clear cell renal cell carcinoma: Performance comparison of the NanoString nCounter technology with targeted RNA sequencing

Abstract Inflammatory gene signatures are currently being explored as predictive biomarkers for immune checkpoint blockade (ICB), and particularly for the treatment of renal cell cancers. From a diagnostic point of view, the nCounter analysis platform and targeted RNA sequencing are emerging alternatives to microarrays and comprehensive transcriptome sequencing in examining formalin‐fixed and paraffin‐embedded (FFPE) cancer samples. So far, no systematic study has analyzed and compared the technical...

Genes, Chromosomes and Cancer

09:57

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