Main Points Loss of rnaset2 results in inflammation and lysosomal‐deficient microglia failing to digest dying neurons. Targeting microglia restores embryonic microglial defects to clear neurodevelopmental apoptosis. Mutants have reduced survival and locomotor defects. Abstract The contribution of microglia in neurological disorders is emerging as a leading disease driver rather than a consequence of pathology. RNAseT2‐deficient leukoencephalopathy is a severe childhood white matter...
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Background Investigating scientific publication trends in the field of oncology may highlight opportunities for improved representation, mentorship, collaboration, and advancement for women. Methods We conducted a bibliometric analysis of Annals of Surgical Oncology; Cancer; International Journal of Radiation Oncology, Biology, Physics (IJROBP); JAMA Oncology; and Journal of Clinical Oncology in 1990, 2000, 2010, and 2017. Full name and degree credentials per author role (ie, first or...
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After reports from the Women's Health Initiative randomized trial evaluating estrogen plus progestin, there was a sudden, substantial, and sustained decrease in all categories of menopausal hormone therapy, and the first reduction in age‐adjusted breast cancer incidence in more than 20 years was seen in 2003‐2004 among US women 50 years of age or older. Subsequent trends in breast cancer incidence have been described, but most reports have not focused on the postmenopausal age group or fully engaged...
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Background Infigratinib (BGJ398) is a potent and selective fibroblast grown factor receptor 1 to 3 (FGFR1‐3) inhibitor with significant activity in patients with advanced or metastatic urothelial carcinoma bearing FGFR3 alterations. Given the distinct biologic characteristics of upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB), the authors examined whether infigratinib had varying activity in these settings. Methods Eligible patients had metastatic...
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Background The incidence of primary liver cancer (PLC) continues to increase worldwide. The incidence trends and patterns of PLC associated with different age at diagnosis remain unknown. Methods We collected detailed information on PLC between 1990 and 2017 from Global Burden of Disease Study 2017. Estimated annual percentage changes in the PLC age‐standardized incidence rate (ASR) diagnosed by age, sex, region, and etiology were calculated to quantify the temporal trends in PLC ASR....
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Related ArticlesWnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea In Vitro. Biomed Res Int. 2019;2019:7878906 Authors: Wang X, Han Y, Wang M, Bo C, Zhang Z, Xu L, Liu W, Wang H Abstract It has been reported that paclitaxel administration could cause sensorineural hearing loss, and Wnt activation is important for the development and cell protection of mouse cochlea. However, the effect of Wnt signaling...
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Related ArticlesLINC01018 confers a novel tumor suppressor role in hepatocellular carcinoma through sponging microRNA-182-5p. Am J Physiol Gastrointest Liver Physiol. 2019 08 01;317(2):G116-G126 Authors: Wang S, Xu M, Sun Z, Yu X, Deng Y, Chang H Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Emerging evidence has demonstrated that some long noncoding RNAs (lncRNAs) are involved in the development and...
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Related ArticlesMechanical, Cellular, and Proteomic Properties of Laryngotracheal Cartilage. Cartilage. 2019 07;10(3):321-328 Authors: Pauken CM, Heyes R, Lott DG Abstract The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical...
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Related ArticlesKL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020 Mar 20;126:110068 Authors: Lee HS, Kim YR, Lee IK, Kim UK, Baek JI, Lee KY Abstract Cisplatin (CP) is a chemotherapeutic drug used to treat cancerous solid tumors, but it causes serious side effects, including ototoxicity. The major cause of CP-induced ototoxicity is increased levels of mitochondrial...
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Related ArticlesIncidental findings on CT angiography of the head and neck in stroke patients. Evaluation of frequency and detection rate. Clin Neurol Neurosurg. 2020 Mar 20;193:105783 Authors: Rositzka M, Hoffmann KT, Meyer HJ, Surov A Abstract OBJECTIVE: A comprehensive CT algorithm in suspected ischemic stroke consists of a native CT scan, CT perfusion imaging of the brain and a CT angiography from the aortic arch to the vertex. Besides core findings...
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Related ArticlesSinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in "carcinoma ex papilloma". Ann Diagn Pathol. 2020 Mar 13;46:151504 Authors: Maisch S, Mueller SK, Traxdorf M, Weyerer V, Stoehr R, Iro H, Hartmann A, Agaimy A Abstract Among the three major histological subtypes of sinonasal papillomas, inverted (ISP) and oncocytic (OSP) sinonasal papillomas tend to undergo...
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Related Articlesβ-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma. Mol Omics. 2020 Mar 23;: Authors: Chandler KB, Alamoud KA, Stahl VL, Nguyen BC, Kartha VK, Bais MV, Nomoto K, Owa T, Monti S, Kukuruzinska MA, Costello CE Abstract Epidermal growth factor receptor (EGFR) is a major driver of head and neck cancer, a devastating malignancy with a major sub-site in the oral cavity manifesting...
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Related ArticlesSignificant Mendelian genetic contribution to pediatric mild-to-moderate hearing loss and its comprehensive diagnostic approach. Genet Med. 2020 Mar 17;: Authors: Kim BJ, Oh DY, Han JH, Oh J, Kim MY, Park HR, Seok J, Cho SD, Lee SY, Kim Y, Carandang M, Kwon IS, Lee S, Jang JH, Choung YH, Lee S, Lee H, Hwang SM, Choi BY Abstract PURPOSE: Timely diagnosis and identification of etiology of pediatric mild-to-moderate sensorineural hearing...
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Related ArticlesARIA 2019, Allerjik Rinite Tedavi Yaklaşımı-Türkiye. Turk Thorac J. 2020 Mar 01;21(2):122-133 Authors: Yorgancıoğlu AA, Gemicioğlu B, Cingi C, Kalaycı Ö, Kalyoncu AF, Bachert C, Hellings P, Pfaar O, Schünemann HJ, Wallace D, Bedbrook A, Czarlewski W, Bousquet J Abstract Gerçek yaşamda, çevresel maruziyetlerin de etkilediği rinit ve astım mültimorbidite durumlarında, dijitalleşmiş ve kişiye odaklanan tedaviler için bütünleştirilmiş...
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Related ArticlesApplication of integrated positron emission tomography/magnetic resonance imaging in evaluating the prognostic factors of head and neck squamous cell carcinoma with positron emission tomography, diffusion-weighted imaging, dynamic contrast enhancement and combined model. Dentomaxillofac Radiol. 2020 Mar 23;:20190488 Authors: Dang H, Chen Y, Zhang Z, Shi X, Chen X, Zhu X, Hou B, Xing H, Xue H, Jin Z Abstract OBJECTIVES: This study...
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Related ArticlesLoss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Head Neck. 2020 Mar 23;: Authors: Pandey S, Osman TA, Sharma S, Vallenari EM, Shahdadfar A, Pun CB, Gautam DK, Uhlin-Hansen L, Rikardsen O, Johannessen AC, Costea DE, Sapkota D Abstract BACKGROUND: We previously showed a tumor-suppressive function of S100A14 in oral squamous cell carcinoma...
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Related ArticlesOptimizing number of cycles of induction chemotherapy for patients with nasopharyngeal carcinoma: Retrospective survival analysis. Head Neck. 2020 Mar 23;: Authors: He Y, Zhao Z, Wang Y, Chai J, He J, Wang J, He L, Guan H, Wei Z, Liu Z, Mu X, Peng X Abstract BACKGROUND: Induction chemotherapy followed by concurrent chemoradiotherapy is one of the standards of care for patients with nasopharyngeal carcinoma, but the optimal number...
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Related ArticlesIdentification of cancer hallmark-associated gene and lncRNA cooperative regulation pairs and dictate lncRNA roles in oral squamous cell carcinoma. J Cell Mol Med. 2020 Mar 23;: Authors: Lin K, Song LJ, Ma J, Zhang TS, You DY, He YW Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in the oral and maxillofacial region. Numerous cancers share ten common traits ("hallmarks") that govern the transformation...
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Related ArticlesA systematic review of predictive models for recurrence and mortality in patients with tongue cancer. Eur J Cancer Care (Engl). 2020 Mar;29(2):e13211 Authors: Almangush A, Coletta RD, Nieminen P, Kowalski LP, Leivo I, Salo T PMID: 32202013 [PubMed - in process]
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Related ArticlesComprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases. Intractable Rare Dis Res. 2020 Feb;9(1):14-22 Authors: Peng C, Lu Y, Ren X, Wang Y, Zhang S, Chen M, Liu J, Fang F, Li T, Han J Abstract Wnt1 is the first member of the Wnt family that was identified. It is phylogenetically conserved and essential for oncogenesis and multiple developmental processes. This study has summarized diseases and mutations related...
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Related ArticlesInverted Papilloma of the Lacrimal Sac and Nasolacrimal Duct: A Case Report and Review of the Literature. Cureus. 2020 Feb 14;12(2):e6989 Authors: Cheang YFA, Loke D Abstract Inverted papillomas of the lacrimal sac and nasolacrimal duct are exceedingly rare. Though histologically benign, these tumors are locally aggressive, have propensity for recurrence and are associated with a chance of malignant transformation. These tumors can...
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Related ArticlesThe Modified Extended Fleur-De-Lis Latissimus Dorsi Flap for Various Complex Multi-directional Large Soft and Bone Tissue Reconstruction. Cureus. 2020 Feb 12;12(2):e6974 Authors: Ciudad P, Manrique OJ, Bustos SS, Pafitanis G, Forte AJ, Huayllani MT, Boczar D, Vargas M, Escalante S, Parra Pont L, Bustamante A, Chen HC Abstract Introduction Latissimus Dorsi (LD) myocutaneous flap is a workhorse flap for various large reconstructions. Variants...
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Related ArticlesPer-oral interstitial brachytherapy catheter insertion for boost in case of recurrent tonsillar carcinoma: dosimetry and clinical outcome. BJR Case Rep. 2020 Mar;6(1):20190059 Authors: Murakami N, Yoshimoto S, Nakamura S, Uematsu M, Kashihara T, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J Abstract High-dose-rate interstitial brachytherapy (HDR-ISBT) is relatively rarely applied for the head and neck cancer. However,...
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Related ArticlesRadiation therapy for oligometastatic oropharyngeal cancer. BJR Case Rep. 2020 Mar;6(1):20190021 Authors: Martini S, Arcadipane F, Franco P, Iorio GC, Bartoncini S, Gallio E, Guarneri AS, Ricardi U Abstract At presentation, isolated metastasis from oropharyngeal squamous cell carcinoma is rare. Liver is a relatively uncommon first site of failure, especially in the absence of other distant metastases, particularly without diagnosis...
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Related ArticlesPatulous eustachian tubes and an unusual case of fused retropharangeal internal carotid arteries with an aberrant course through the clivus and dorsum sellae. BJR Case Rep. 2020 Mar;6(1):20190017 Authors: Menyatsoe ITI, Khan NN Abstract Aberrant course of internal carotid arteries (ICA) is rarely seen. In patients who are asymptomatic, anomalies may be detected incidentally during head and neck examination. Symptomatic patients may...
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Related ArticlesALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway. J Cancer. 2020;11(9):2621-2631 Authors: Qu Y, He Y, Yang Y, Li S, An W, Li Z, Wang X, Han Z, Qin L Abstract Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our...
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Related ArticlesmiR-23a-3p/SIX1 regulates glucose uptake and proliferation through GLUT3 in head and neck squamous cell carcinomas. J Cancer. 2020;11(9):2529-2539 Authors: Wang H, Xue W, Ouyang W, Jiang X, Jiang X Abstract SIX1 overexpression has been reported in several cancers. However, its involvement in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this study we investigated the clinical significance and biological roles of...
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Related ArticlesFOXA1 Suppresses the Growth, Migration, and Invasion of Nasopharyngeal Carcinoma Cells through Repressing miR-100-5p and miR-125b-5p. J Cancer. 2020;11(9):2485-2495 Authors: Peng Q, Zhang L, Li J, Wang W, Cai J, Ban Y, Zhou Y, Hu M, Mei Y, Zeng Z, Li X, Xiong W, Li G, Tan Y, Xiang B, Yi M Abstract Background: Nasopharyngeal carcinoma (NPC) is a unique subtype of head and neck cancer, within highest incidence in South China and southeastern...
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Related ArticlesChoriocapillaris flow impairment could predict the enlargement of geographic atrophy lesion. Br J Ophthalmol. 2020 Mar 22;: Authors: Sacconi R, Corbelli E, Borrelli E, Capone L, Carnevali A, Gelormini F, Querques L, Bandello F, Querques G Abstract AIM: To analyse the choriocapillaris (CC) flow status in the area that subsequently showed geographic atrophy (GA) expansion secondary to age-related macular degeneration (AMD) during 1-year...
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Related ArticlesClinical and pathological analysis of dermatofibrosarcoma protuberans with long-term follow-up. J Plast Reconstr Aesthet Surg. 2020 Feb 18;: Authors: Shi X, Tan Q Abstract BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare dermal sarcoma characterised by low-grade malignancy, slow infiltrative growth, local recurrence and rare distant metastases. OBJECTIVE: Many international studies exist on DFSP, but limited...
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Related ArticlesRNA-seq profiling and co-expression network analysis of long noncoding RNAs and mRNAs reveal novel pathogenesis of noise-induced hidden hearing loss. Neuroscience. 2020 Mar 19;: Authors: Wei W, Shi X, Xiong W, He L, Du ZD, Qu T, Qi Y, Gong SS, Liu K, Ma X Abstract Noise-induced hidden hearing loss (NIHHL), one of the family of conditions described as noise-induced hearing loss (NIHL), is characterized by synaptopathy following moderate...
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Related ArticlesContribution of Weight and Volume of the Extirpated Thyroid Gland on Voice Alterations After Total Thyroidectomy in Patients With Papillary Carcinoma of the Thyroid. J Voice. 2020 Mar 19;: Authors: Jain PV, Roy D, Manikantan K, Sharan R, Tshering P, Arun P Abstract PURPOSE: Voice change after thyroid surgery is common despite preservation of laryngeal nerves. In this study, we sought to find if the change in voice after total thyroidectomy...
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Related ArticlesScapular free flap as a good choice for mandibular reconstruction: 119 out of 280 cases after resection of oral squamous cell carcinoma in a single institution. Br J Oral Maxillofac Surg. 2020 Mar 19;: Authors: Wolfer S, Wohlrath R, Kunzler A, Foos T, Ernst C, Schultze-Mosgau S Abstract Microsurgical procedures for reconstruction after resection of head and neck tumours have become standardised and reliable. Among them, the scapular...
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Related ArticlesThe semicircular canal function tests contribute to identifying unilateral idiopathic sudden sensorineural hearing loss with vertigo. Am J Otolaryngol. 2020 Mar 13;:102461 Authors: Guan R, Zhao Z, Guo X, Sun J Abstract BACKGROUND: Few studies focused on the prognosis of unilateral idiopathic sudden sensorineural hearing loss (UISSNHL) with vertigo. OBJECTIVES: To describe how the semicircular canal (SCC) function tests may...
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Related ArticlesNecrotizing fasciitis of the entire head and neck: Literature review and case report. Biomed J. 2020 Feb;43(1):94-98 Authors: Chou PY, Hsieh YH, Lin CH Abstract Necrotizing fasciitis (NF) is uncommon but potentially lethal when it is associated with systemic disorders. We report a case of odontogenic NF in a patient with uncontrolled diabetes mellitus. The patient was referred on day 10 since the onset of odontogenic NF. Protective...
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Related ArticlesProtocol for a prospective multicenter cross-sectional observational study to investigate the role of air pollution on allergic rhinitis prevalence. Medicine (Baltimore). 2020 Mar;99(11):e19497 Authors: Liu J, Wang Y, Liu S, Cao S, Xu C, Zhang M, Liu S Abstract INTRODUCTION: Allergic rhinitis (AR) is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence...
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