Publication date: Available online 24 March 2020Source: GeneAuthor(s): Selçuk Özdemir
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Cancers, Vol. 12, Pages 783: A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score Cancers doi: 10.3390/cancers12040783 Authors: Charlotte Maulat Cindy Canivet Célia Touraine Sophie Gourgou Bertrand Napoleon Laurent Palazzo Nicolas Flori Guillaume Piessen Pierre Guibert Stéphanie Truant Eric Assenat Louis Buscail Barbara Bournet Fabrice Muscari the BACAP Consortium Surgery remains the only...
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Cancers, Vol. 12, Pages 784: Role of BET Inhibitors in Triple Negative Breast Cancers Cancers doi: 10.3390/cancers12040784 Authors: Durga Khandekar Venkataswarup Tiriveedhi Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional super-regulators that control gene expression. These proteins have been shown to upregulate transcriptional machinery leading to over expression of genes involved in cell proliferation and carcinogenesis. Based on favorable...
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Cancers, Vol. 12, Pages 775: Recent Advances in Immunotherapy for Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12040775 Authors: Shigeharu Nakano Yuji Eso Hirokazu Okada Atsushi Takai Ken Takahashi Hiroshi Seno Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death since most patients are diagnosed at advanced stage and the current systemic treatment options using molecular-targeted drugs remain unsatisfactory. However, the...
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Cancers, Vol. 12, Pages 781: Radiopharmaceuticals for Breast Cancer and Neuroendocrine Tumors: Two Examples of How Tissue Characterization May Influence the Choice of Therapy Cancers doi: 10.3390/cancers12040781 Authors: Alberto Signore Chiara Lauri Sveva Auletta Michela Varani Livia Onofrio Andor W.J.M. Glaudemans Francesco Panzuto Paolo Marchetti Molecular medicine has gained clinical relevance for the detection and staging of oncological diseases,...
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Cancers, Vol. 12, Pages 777: Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research Cancers doi: 10.3390/cancers12040777 Authors: Mohamed Elbadawy Amira Abugomaa Hideyuki Yamawaki Tatsuya Usui Kazuaki Sasaki Prostate cancer (PC) is the most prevalent cancer in men and the second main cause of cancer-related death in Western society. The lack of proper PC models that recapitulate the molecular and genomic landscape of clinical...
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Cancers, Vol. 12, Pages 780: Aptamer-Equipped Protamine Nanomedicine for Precision Lymphoma Therapy Cancers doi: 10.3390/cancers12040780 Authors: Zihua Zeng Ching-Hsuan Tung Youli Zu Anaplastic large cell lymphoma (ALCL) is the most common T-cell lymphoma in children. ALCL cells characteristically express surface CD30 molecules and carry the pathogenic ALK oncogene, both of which are diagnostic biomarkers and are also potential therapeutic targets. For precision therapy,...
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Cancers, Vol. 12, Pages 779: Early Predictors of Objective Response in Patients with Hepatocellular Carcinoma Undergoing Lenvatinib Treatment Cancers doi: 10.3390/cancers12040779 Authors: Issei Saeki Takahiro Yamasaki Satoyoshi Yamashita Tadasuke Hanazono Yohei Urata Takakazu Furutani Yuichiro Yokoyama Toshiyuki Oishi Masaki Maeda Teruaki Kimura Yurika Kotoh Ryo Sasaki Takashi Miyaji Takashi Oono Yuki Aibe Takuro Hisanaga Takuya...
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Cancers, Vol. 12, Pages 776: Biobanking in Molecular Biomarker Research for the Early Detection of Cancer Cancers doi: 10.3390/cancers12040776 Authors: Kim Lommen Selena Odeh Chiel C. de Theije Kim M. Smits Although population-wide screening programs for several cancer types have been implemented in multiple countries, screening procedures are invasive, time-consuming and often perceived as a burden for patients. Molecular biomarkers measurable in non-invasively collected...
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Cancers, Vol. 12, Pages 778: Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer Cancers doi: 10.3390/cancers12040778 Authors: Patricia García Lorena Rosa Sergio Vargas Helga Weber Jaime A. Espinoza Felipe Suárez Isabel Romero-Calvo Nicole Elgueta Vanessa Rivera Bruno Nervi Javiera Obreque Pamela Leal Eduardo Viñuela Gloria Aguayo Sabrina Muñiz Alfredo Sagredo Juan C. Roa Carolina...
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Cancers, Vol. 12, Pages 782: Expression Pattern and Biological Significance of the lncRNA ST3GAL6-AS1 in Multiple Myeloma Cancers doi: 10.3390/cancers12040782 Authors: Domenica Ronchetti Katia Todoerti Cristina Vinci Vanessa Favasuli Luca Agnelli Martina Manzoni Francesca Pelizzoni Raffaella Chiaramonte Natalia Platonova Nicola Giuliani Pierfrancesco Tassone Nicola Amodio Antonino Neri Elisa Taiana The biological impact of long...
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Cancers, Vol. 12, Pages 772: PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer Cancers doi: 10.3390/cancers12040772 Authors: Agarwal Chakravarthi Behring Kim Chandrashekar Gupta Bajpai Elkholy Balasubramanya Hardy Diffalha Varambally Manne The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient...
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Cancers, Vol. 12, Pages 773: Outcome of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia Before Second-Generation FLT3 Tyrosine Kinase Inhibitors: A Toulouse–Bordeaux DATAML Registry Study Cancers doi: 10.3390/cancers12040773 Authors: Sarah Bertoli Pierre-Yves Dumas Emilie Bérard Laetitia Largeaud Audrey Bidet Eric Delabesse Suzanne Tavitian Noémie Gadaud Thibaut Leguay Harmony Leroy Jean-Baptiste Rieu Jean-Philippe Vial François...
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Cancers, Vol. 12, Pages 774: Targeted Therapies: Friends or Foes for Patient's NK Cell-Mediated Tumor Immune-Surveillance? Cancers doi: 10.3390/cancers12040774 Authors: Laura Damele Selene Ottonello Maria Cristina Mingari Gabriella Pietra Chiara Vitale In the last 20 years there has been a huge increase in the number of novel drugs for cancer treatment. Most of them exploit their ability to target specific oncogenic mutations in the tumors (targeted therapies–TT),...
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Cancers, Vol. 12, Pages 771: VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer Cancers doi: 10.3390/cancers12040771 Authors: Daniela Barros-Silva João Lobo Catarina Guimarães-Teixeira Isa Carneiro Jorge Oliveira Elena S. Martens-Uzunova Rui Henrique Carmen Jerónimo RNA methylation at position N6 in adenosine (m6A) and its associated methyltransferase complex (MTC) are involved...
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Cancers, Vol. 12, Pages 769: Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts Cancers doi: 10.3390/cancers12030769 Authors: Annette Lasham Peter Tsai Sandra J. Fitzgerald Sunali Y. Mehta Nicholas S. Knowlton Antony W. Braithwaite Cristin G. Print TP53, the most commonly-mutated gene in cancer, undergoes complex alternative splicing. Different TP53 transcripts play...
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Cancers, Vol. 12, Pages 770: The Regulatory Functions of Circular RNAs in Digestive System Cancers Cancers doi: 10.3390/cancers12030770 Authors: Xiao Yuan Ya Yuan Zhi He Diyan Li Bo Zeng Qingyong Ni Mingyao Yang Deying Yang Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of...
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Cancers, Vol. 12, Pages 768: 30 Years of Experience in the Management of Stage III and IV Epithelial Ovarian Cancer: Impact of Surgical Strategies on Survival Cancers doi: 10.3390/cancers12030768 Authors: Berenice Delga Jean-Marc Classe Gilles Houvenaeghel Guillaume Blache Laura Sabiani Houssein El Hajj Nicole Andrieux Eric Lambaudie Objective: to analyze the evolution of surgical techniques and strategies, and to determine their influence on the survival...
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Cancers, Vol. 12, Pages 766: Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment Cancers doi: 10.3390/cancers12030766 Authors: Whitney N. Goldsberry Selene Meza-Perez Angelina I. Londoño Ashwini A. Katre Bryan T. Mott Brandon M. Roane Nidhi Goel Jaclyn A. Wall Sara J. Cooper Lyse A. Norian Troy D. Randall Michael J. Birrer Rebecca C. Arend In ovarian cancer, upregulation of the Wnt/β–catenin...
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Cancers, Vol. 12, Pages 764: Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability Cancers doi: 10.3390/cancers12030764 Authors: Wa Zhang David Klinkebiel Carter J. Barger Sanjit Pandey Chittibabu Guda Austin Miller Stacey N. Akers Kunle Odunsi Adam R. Karpf A hallmark of human cancer is global DNA hypomethylation (GDHO), but the mechanisms accounting for this defect and its pathological...
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Cancers, Vol. 12, Pages 762: Proposed Modification of Staging for Distal Cholangiocarcinoma Based on the Lymph Node Ratio Using Korean Multicenter Database Cancers doi: 10.3390/cancers12030762 Authors: Yunghun You Yong Chan Shin Dong Wook Choi Jin Seok Heo Sang Hyun Shin Naru Kim Kee-Taek Jang Hongbeom Kim Chang-Sup Lim Sun Hee Chang Kang Min Han In Woong Han The 8th American Joint Committee on Cancer (AJCC) staging system for distal cholangiocarcinoma...
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Cancers, Vol. 12, Pages 765: Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics Cancers doi: 10.3390/cancers12030765 Authors: Kamila Pawlicka Umesh Kalathiya Javier Alfaro Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. NMD plays an important role in cell cycle regulation, cell viability, DNA damage response, while also serving as...
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Cancers, Vol. 12, Pages 763: Pure Large Nested Variant of Urothelial Carcinoma (LNUC) Is the Prototype of an FGFR3 Mutated Aggressive Urothelial Carcinoma with Luminal-Papillary Phenotype Cancers doi: 10.3390/cancers12030763 Authors: Veronika Weyerer Markus Eckstein Eva Compérat Hendrik Juette Nadine T. Gaisa Yves Allory Robert Stöhr Bernd Wullich Morgan Rouprêt Arndt Hartmann Simone Bertz Since 2016, large nested urothelial carcinoma (LNUC)...
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Cancers, Vol. 12, Pages 767: Protein Expression in Metastatic Melanoma and the Link to Disease Presentation in a Range of Tumor Phenotypes Cancers doi: 10.3390/cancers12030767 Authors: Yonghyo Kim Jeovanis Gil Indira Pla Aniel Sanchez Lazaro Hiram Betancourt Boram Lee Roger Appelqvist Christian Ingvar Lotta Lundgren Håkan Olsson Bo Baldetorp Ho Jeong Kwon Henriett Oskolás Melinda Rezeli Viktoria Doma Sarolta Kárpáti A. Marcell...
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Cancers, Vol. 12, Pages 761: Extended Texture Analysis of Non-Enhanced Whole-Body MRI Image Data for Response Assessment in Multiple Myeloma Patients Undergoing Systemic Therapy Cancers doi: 10.3390/cancers12030761 Authors: Kaspar Ekert Clemens Hinterleitner Karolin Baumgartner Jan Fritz Marius Horger Identifying MRI-based radiomics features capable to assess response to systemic treatment in multiple myeloma (MM) patients. Retrospective analysis of whole-body MR-image...
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Abstract Background and Objective The use of fibrinogen concentrate to treat or prevent major bleeding with regard to potential adverse reactions has not been free of controversy. Our objective was to perform a post-authorization safety study to describe the use of Clottafact® (LFB Biomedicaments) fibrinogen concentrate in real-life medical practice in Mexico. Methods ...
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This Viewpoint discusses ways the coronavirus pandemic is threatening clinical trial conduct and enrollment, and suggests ways to adapt, including changes to how outcomes data are collected and how interventions are delivered and monitored, to minimize trial disruption, maximize trial benefit, and ensure patient health and safety during the pandemic.
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This Viewpoint discusses the second surge of COVID-19 patients on postacute care facilities and offers suggestions on how the medical community and policy makers should prepare by ensuring adequate infrastructure, staff training, and protective equipment.
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This Medical News article discusses programs that enable more American Indian/Alaska Native students to enter medical school.
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Matters of the Mind offers an occasional look at recent research into the relationship between the mind and the body.
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This Viewpoint reviews the pathophysiological and observational basis for speculating that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) might worsen clinical outcomes for patients with COVID-19, and summarizes guidance from specialty societies to continue the drugs in patients who need them pending more definitive evidence of harm.
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This Viewpoint uses the absence of known effective treatment for Ebola virus disease to emphasize the costs of off-label and compassionate drug use during an infectious disease outbreak and the importance of establishing the efficacy and safety of promising drug leads in randomized trials to inform their clinical use.
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Infection is a major cause of admissions and prolonged stays in intensive care units (ICUs). Epidemiological information on the underlying source of infections, associated microorganisms, treatment, and eventual outcomes is essential for identifying gaps and opportunities to optimize patient management. Systematic and harmonized data collection across institutions allows for geographical comparisons and tracking of temporal trends and also enhances the generalizability of findings. However, such...
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This study characterizes the point prevalence and outcomes of infection among adult patients treated at international intensive care units during a 24-hour period.
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This Viewpoint from physicians with the Italian National Institute of Health confirms a higher case-fatality rate from coronavirus disease 2019 (COVID-19) in Italy compared with China and explains possible reasons, including age, cause of death definitions, and testing strategy.
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In the original publication of the article the author has found few incorrect values in the Table 1.
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Abstract Coronavirus disease (COVID-19) was declared a pandemic by the World Health Organization on 11 March 2020 because of its rapid worldwide spread. In the operating room, as part of hospital outbreak response measures, anesthesiologists are required to have heightened precautions and tailor anesthetic practices to individual patients. In particular, by minimizing the many aerosol-generating procedures performed during general anesthesia, anesthesiologists can reduce exposure...
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Publication date: 1 July 2020Source: International Journal of Biological Macromolecules, Volume 154Author(s): Jingkun Zhao, Ce Sun, Haiyan Li, Xu Dong, Xiaodong Zhang
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