New England Journal of Medicine, Volume 382, Issue 12, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Volume 382, Issue 12, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Volume 382, Issue 12, Page 1081-1083, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Volume 382, Issue 12, Page 1180-1183, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 10:59
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 10:59
TY-011, a novel Aurora A/B kinases inhibitor, was found in our previous study to exhibit prominent inhibitory effects on growth of gastric cancer, both in vitro and in vivo. To clarify the mechanisms of TY-011 in inhibiting proliferation of gastric cancer cells, the effects of TY-011 on mitosis, cell cycle, apoptosis and cellular DNA were checked in the present study. Our results showed that TY-011 treatment induced aberrant mitosis, G2/M phase arrest and apoptosis. Importantly, TY-011 induced evident...
Mon Mar 16, 2020 02:00
Recent findings implied the significance of reactive oxygen species (ROS) as a part of tyrosine kinase inhibitors (TKIs) pharmacological activity. Evidences also suggested that toxic effects of TKIs were related to ROS production. The results regarding benefits of vitamin E usage alongside with prescribed TKIs therapy are ambiguous. We aimed to examine oxidative stress and antioxidative defense in human serum treated with four different TKIs and their possible interactions with hydrosoluble vitamin...
Mon Mar 16, 2020 02:00
Abstract A compartmental model of the cardiorespiratory system featuring pulsatile blood flow and gas transport, as well as closed loop mechanisms of cardiorespiratory regulation is presented. Short timescale regulatory action includes baroreflex, peripheral and central chemoreflex feedback. The cardiorespiratory model is composed by compartments to describe blood flow and gas exchange in the major systemic and pulmonic regions. The control systems include formulations to afferent activity of arterial...
Thu Mar 19, 2020 10:31
Thu Mar 19, 2020 09:57
Abstract The first draft human mitochondrial DNA (mtDNA) sequence was published in 1981, paving the way for two decades of discovery linking mtDNA variation with human disease. Severe pathogenic mutations cause sporadic and inherited rare disorders that often involve the nervous system. However, some mutations cause mild organ‐specific phenotypes that have a reduced clinical penetrance, and polymorphic variation of mtDNA is associated with an altered risk of developing several late‐onset...
Thu Mar 19, 2020 09:56
We experienced a case of subretinal hemorrhage (SRH) from choroidal neovascularization (CNV) complicating Vogt-Koyanagi-Harada disease (VKH) that underwent pneumatic displacement of hematoma by intravitreal gas injection. A 76-year-old male revealed VKH relapses and optical coherence tomography showed irregular retinal pigment epithelium in his right eye and serous retinal detachment and retinal pigment epithelial detachment in his left eye. Fluorescein angiography of the left eye showed hyperfluorescence...
Thu Mar 19, 2020 09:53
Diamond dust particles were identified within patients’ eyes both during vitrectomy procedures using diamond-dusted membrane scrapers and in postoperative clinical examinations. The particles had no impact on the patients’ vision and caused no apparent sequelae. Scanning electron microscopy analysis showed the average particle size to be 23.4 μm and an unequal surface area for particle adhesion onto the soft tip. It was determined that diamond dust particles can dislodge from the silicone tip of...
Thu Mar 19, 2020 09:53
We evaluated the visual outcome of combined penetrating keratoplasty (PKP) and 25G pars plana vitrectomy (PPV) performed without a temporary keratoprosthesis or endoscopy in a patient with vitreoretinal disease complicated by severe corneal opacity. The patient was a 68-year-old woman who had severe corneal opacity and silicone oil in her left eye after several previous intraocular surgeries for rhegmatogenous retinal detachment and proliferative vitreoretinopathy. We successfully performed a combined...
Thu Mar 19, 2020 09:52
Nonbacterial thrombotic endocarditis (NBTE) is a rare entity most commonly diagnosed postmortem with rates in autopsy series ranging from 0.9 to 1.6%. A 63-year-old female with past medical history of hypertension and mitral valve prolapse presented to the hospital with shortness of breath, headache, and necrotic skin lesions on her hands and feet. Computed tomography (CT) scan of her chest demonstrated a pulmonary embolus in the right lower lung segmental artery and right upper lobe lobar to segmental...
Thu Mar 19, 2020 09:41
Postoperative management of patients with brain metastases is controversial. Besides local control, cognitive function and quality of life are the most important outcomes of postoperative radiotherapy. In this case report, we introduce a patient with aggressive recurred solid metastasis treated with repeated surgery and an individual radiotherapy approach in order to highlight that close mutual collaboration leads to a clear benefit for our patients. The local targeted radiotherapy with 35 Gy in...
Thu Mar 19, 2020 09:32
We report the case of a 65-year-old male who developed heterochronous local recurrences of gastric cancer in the jejunal pouch (J-pouch) four times after total gastrectomy. He underwent total gastrectomy, J-pouch, and Roux-en-Y reconstruction for stage II gastric cancer in 2005. Four local recurrences appeared on the esophago-jejunal anastomosis, the suture line within the pouch, the esophago-jejunal anastomosis, and the anastomosis between the jejunum and Y-loop, which were resected by partial excision...
Thu Mar 19, 2020 08:41
Neurofibromatosis type 1, an autosomal dominant genetic disorder characterized by multiple progressive tumor and nontumor manifestations, has limited treatment options. In patients with the disorder, dysfunction of the guanosine triphosphatase–activating protein neurofibromin leads to…
Wed Mar 18, 2020 02:00
The binding of proprotein convertase subtilisin–kexin type 9 (PCSK9) in the circulation by monoclonal antibodies reduces both low-density lipoprotein (LDL) cholesterol levels and the incidence of cardiovascular events. Inclisiran, a small interfering RNA (siRNA) therapeutic agent, reduces hepatic…
Wed Mar 18, 2020 02:00
Heterozygous familial hypercholesterolemia, a genetic disorder that affects 1 in 250 persons or 30 million people worldwide, is characterized by elevated levels of low-density lipoprotein (LDL) cholesterol from birth. Without treatment, the condition is associated with premature complications and…
Wed Mar 18, 2020 02:00
Beginning in December 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed Covid-19. The full spectrum of Covid-19 ranges from mild, self-limiting respiratory tract illness to severe progressive pneumonia, multiorgan failure, and…
Wed Mar 18, 2020 02:00
New Findings What is the central question of this study? When performing skillful hand movement, motor command descends especially toward distal arm muscles. Does central command evoke a vascular response selectively in the distal arm muscles during skillful hand movement? What is the main finding and its importance? We found using near‐infrared spectroscopy that unilateral skillful hand movement evoked a greater increase in oxygenation of the contralateral forearm muscle as compared...
Thu Mar 19, 2020 09:34
How to perform a rectal prolapse reduction using intraluminal packing.
Thu Mar 19, 2020 09:28
Purpose: Previous SEER (Surveillance, Epidemiology, and End Results)-Medicare analyses have shown no definitive survival benefit for adjuvant chemotherapy (AC) with fluoropyrimidines. Impact of oxaliplatin-containing regimens for elderly stage II patients in real-world setting is unknown. We explored the utilization and outcome of AC after the Food and Drug Administration (FDA) approval of oxaliplatin. Patients and Methods: Patients with stage II colon cancer (2004-2011) who underwent...
Mon Mar 16, 2020 02:00
Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma
Background Endometrial hyperplasia is a precursor to endometrioid adenocarcinoma (EMC), the most common uterine cancer. The likelihood of progression to carcinoma may be evaluated by histologic subclassification of endometrial hyperplasia, although these subclasses are subjective and only modestly reproducible among pathologists. Patient care would be improved by a more objective test to predict the risk of cancer progression. Methods Next‐generation sequencing was performed on archived...
Thu Mar 19, 2020 09:21
Background Cost‐related medication underuse (CRMU), a measure of access to care and financial burden, is prevalent among cancer survivors. The authors quantified the impact of the Patient Protection and Affordable Care Act (ACA) on CRMU in nonelderly cancer survivors. Methods Using National Health Interview Survey data (2011‐2017) for cancer survivors aged 18 to 74 years, the authors estimated changes in CRMU (defined as taking medication less than prescribed due to costs) before (2011‐2013)...
Thu Mar 19, 2020 09:21
Abstract Targeting DNA repair with small‐molecule inhibitors is an attractive strategy for cancer therapy. Majority of DNA double‐strand breaks in mammalian cells are repaired through nonhomologous end‐joining (NHEJ). It has been shown that small‐molecule inhibitors of NHEJ can block efficient repair inside cancer cells, leading to cell death. Previously, we have reported that SCR7, an inhibitor of NHEJ can induce tumor regression in mice. Later studies have shown that different forms of SCR7 can...
Thu Mar 19, 2020 09:20
Abstract Isothiocyanates (ITCs) are natural compounds abundant in cruciferous vegetables. Numerous studies have shown that ITCs exhibit anticancer activity by affecting multiple pathways including apoptosis and oxidative stress, and are expected to be developed into novel anticancer drugs. In our previous studies, we demonstrated that ITCs effectively inhibit the proliferation of non–small cell lung cancer (NSCLC) cells, also induce apoptosis and autophagy. In the present study, we found that phenethyl...
Thu Mar 19, 2020 09:20
Last year, after a month of dry cough and shortness of breath while walking up the steep steps of Fillmore Street in San Francisco, Mary, my mother-in-law and housemate, noticed that she was becoming more and more easily winded. When her symptoms didn’t improve over the next several weeks, her…
Wed Mar 18, 2020 02:00
A few weeks ago, Dr. D. a middle-aged chief of cardiology at one of the biggest hospitals in northern Italy, developed a fever. Fearing he might have Covid-19, he sought confirmatory testing but was told there weren’t enough tests available for those who hadn’t had demonstrated exposure to an…
Wed Mar 18, 2020 02:00
As Covid-19 spreads around the globe, governments have imposed quarantines and travel bans on an unprecedented scale. China locked down whole cities, and Italy has imposed draconian restrictions throughout the country. In the United States, thousands of people have been subjected to legally…
Wed Mar 18, 2020 02:00
To the Editor: As of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and clinical features of infected children are limited. A recent review of 72,314 cases…
Wed Mar 18, 2020 02:00
Covid-19 is spreading rapidly through Europe and North America, but we have few specific tools to control the growing epidemic and treat those who are sick. We rely on quarantine, isolation, and infection-control measures to prevent disease spread and on supportive care for those who become ill.…
Wed Mar 18, 2020 02:00
ABSTRACT Tumor microenvironment (TME) are vital components of tumor tissue. Increasing evidence suggest their significance in predicting outcomes and guiding therapies. However, no studies have reported a systematic analysis of clinicopathological significance of TME in lung adenocarcinoma (LUAD). Here, we inferred tumor stromal cells in 1,184 LUAD patients using computational algorithms based on bulk tumor expression data, and evaluated clinicopathological significance of stromal cells. We found...
Thu Mar 19, 2020 09:10
AbstractPleasantness is a major dimension of odor percepts. While naturally encountered odors rely on mixtures of odorants, few studies have investigated the rules underlying the perceived pleasantness of odor mixtures. To address this issue, a set of 222 binary mixtures based on a set of 72 odorants were rated by a panel of 30 participants for odor intensity and pleasantness. In most cases, the pleasantness of the binary mixtures was driven by the pleasantness and intensity of its components. Nevertheless,...
Thu Mar 19, 2020 02:00
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