Sacral nerve stimulation improves gastric and small intestinal pace‐making activity and transit impaired by glucagon and rectal distention. The effect of sacral nerve stimulation was abolished by atropine and 4‐DAMP, suggesting a possible sacral afferent and vagal efferent neural pathway. Abstract Background/Aims In a recent study of sacral nerve stimulation (SNS) for colonic inflammation, a possible spinal‐vagal pathway was implicated. The aim of this study was to provide evidence for such...
Thu Mar 19, 2020 11:40
The patient was moaning and swearing, his emergency visible from across the department: the flattened shoulder, the dent where the humeral head used to be, the yurt-shaped bulge below the clavicle where it was now. The paramedics had made a sling from a triangular muslin cravat, but he wasn’t using…
Thu Mar 19, 2020 02:00
Hereditary angioedema is a rare, potentially life-threatening disorder characterized by attacks of cutaneous and submucosal swelling. Quincke first described its clinical presentation, and Osler’s recognition of the autosomal dominant inheritance pattern followed in 1888. The initial name of the…
Thu Mar 19, 2020 02:00
The once-simple act of writing an opioid prescription has become fraught. Physicians must check prescription monitoring databases to review patients’ histories, make sure their prescription complies with state limits on dose or number of days’ supply, and consider any practice-quality measures that…
Thu Mar 19, 2020 02:00
Last year, after a month of dry cough and shortness of breath while walking up the steep steps of Fillmore Street in San Francisco, Mary, my mother-in-law and housemate, noticed that she was becoming more and more easily winded. When her symptoms didn’t improve over the next several weeks, her…
Wed Mar 18, 2020 02:00
Publication date: Available online 19 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): T. Al-Izzi, J. Breeze, R. Elledge
Thu Mar 19, 2020 11:36
Key points The neural strategies behind the control of force during muscle pain are not well understood as previous research has been limited in assessing pain responses during low‐force contractions only. Here we compared, for the first time, the behaviour of motor units recruited at low and high forces in response to pain. The results showed that motor units activated at low forces were inhibited while those recruited at higher forces increased their activity in response to pain. When...
Thu Mar 19, 2020 11:18
Thu Mar 19, 2020 11:18
In a 2019 op-ed in the Wall Street Journal entitled "Take Two Aspirin and Call Me by My Pronouns," former University of Pennsylvania Dean of Medical Education Stanley Goldfarb echoed a dismissal that some physicians have been voicing for decades. Why should medical training focus on social factors,…
Thu Mar 19, 2020 02:00
Thirty years ago, chronic conditions such as diabetes, heart disease, and obesity accounted for less than 45% of the global disease burden. Today, they are the leading causes of death and disability worldwide, having surpassed infectious diseases such as HIV/AIDS and malaria. Although we are now…
Thu Mar 19, 2020 02:00
Chronic hepatitis C virus (HCV) infection is a major global health problem affecting 1% of the world population. The Sustainable Development Goals that were adopted by the United Nations General Assembly in 2015 included combating viral hepatitis. In May 2016, the World Health Assembly set targets…
Thu Mar 19, 2020 02:00
A few weeks ago, Dr. D. a middle-aged chief of cardiology at one of the biggest hospitals in northern Italy, developed a fever. Fearing he might have Covid-19, he sought confirmatory testing but was told there weren’t enough tests available for those who hadn’t had demonstrated exposure to an…
Wed Mar 18, 2020 02:00
Abstract Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information on half‐life, pharmacokinetics defining the neonatal Fc receptors (FcRn) and most important safety of biologicals in pregnancy...
Thu Mar 19, 2020 11:06
Thu Mar 19, 2020 11:06
Abstract The Brazelton Neonatal Behavioral Assessment Scale (NBAS) evaluates a newborn infant's autonomic, motor, state, temperament, and social‐attentional systems, which can help to identify infants at risk of developmental problems. Given the prevalence of rhesus monkeys being used as an animal model for human development, here we aimed to validate a standardized test battery modeled after the NBAS for use with nonhuman primates called the Infant Behavioral Assessment Scale (IBAS), employing...
Thu Mar 19, 2020 11:04
Spatial and altitudinal variation in Nyungwe chimpanzee ranging (100% MCP) in months when diet was dominated by onespecies: (a) Ficus lutea, (b) Symphonia globulifera, (c) Podocarpus latifolius, and (d) Syzygium guineense. MCP, minimum convex polygon. Abstract Most primates experience seasonal fluctuations in the availability of food resources and face the challenge of balancing energy expenditure with energy gain during periods of resource scarcity. This is likely to be particularly challenging...
Thu Mar 19, 2020 11:04
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:18
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:08
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:06
New England Journal of Medicine, Volume 382, Issue 12, Page 1150-1159, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1086-1088, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1136-1148, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1185-1186, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1161-1162, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1166-1174, March 2020.
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New England Journal of Medicine, Ahead of Print.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1093-1102, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1149-1149, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1184-1185, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1083-1086, March 2020.
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New England Journal of Medicine, Volume 382, Issue 12, Page 1089-1091, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Volume 382, Issue 12, March 2020.
Wed Mar 18, 2020 11:00
New England Journal of Medicine, Ahead of Print.
Wed Mar 18, 2020 11:00
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