Related ArticlesA review of IGF1 signaling and IGF1-related long noncoding RNAs in chemoresistance of cancer. Curr Cancer Drug Targets. 2020 Feb 28;: Authors: Liu L, Li X Abstract Cancer is still a serious public issue that humans face. Chemoresistance is one of the most important reasons for relapse and poor prognosis. The accumulated data support that the polymorphisms in IGF1 are correlated with both circulating IGF1 levels and cancer risk，and activation...
Thu Mar 19, 2020 13:38
Abstract Purpose of Review: The high mortality rate for hepatocellular carcinoma (HCC) relative to its prevalence underscores the need for curative-intent therapies. Image-guided therapies such as ablation and embolization have an established role as primary or neoadjuvants preparing patients for curative treatment. Recent Findings: For...
Thu Mar 19, 2020 02:00
Opinion statement The treatment of advanced melanoma has undergone a dramatic transformation over the last decade with the advent of targeted and immunomodulatory therapies. This transition from cytotoxic chemotherapy has yielded improvements in both survival and quality of life; yet despite their therapeutic advantages, these treatments have been associated with a diverse range of cutaneous adverse events (AEs). These range from relatively benign eczematous conditions to more...
Thu Mar 19, 2020 02:00
Opinion statement Lymphomas are highly heterogeneous tumors and different histologies are characterized by significant differences in biology. Despite the structural and molecular differences between lymphoma types, it is well recognized that the tumor microenvironment plays a critical role in the lymphoma survival and growth. Over the past few years, understanding of this notion has brought immunotherapy to the forefront of lymphoma treatment by targeting the tumor microenvironment...
Thu Mar 19, 2020 02:00
Opinion statement The opioid epidemic is one of the most important public health crises as opioid-related deaths have become a leading cause of accidental death in the USA. Various efforts have been made to understand how to safely and appropriately prescribe opioids for patients with chronic pain, including those with cancer-related pain. We find the guidelines proposed by the Expert Consensus White Paper on the use of methadone to be current, comprehensive, and practical....
Thu Mar 19, 2020 02:00
Related ArticlesNeoadjuvant chemotherapy as a comprehensive treatment in patients with laryngeal and hypopharyngeal carcinoma. Acta Otolaryngol. 2020 Mar 18;:1-7 Authors: Wei XF, Srivastava A, Lin P, Li L, Zhang S, Peng X, Liu C, Liu L, Wu LR, Li GJ, Li YC Abstract Background: Neoadjuvant chemotherapy is important for advanced laryngeal and hypopharyngeal carcinoma (LHC).Aims/objectives: To determine the efficacy and toxicity of the combination of docetaxel,...
Thu Mar 19, 2020 13:29
Related ArticlesADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020 Mar 16;37(3):324-339.e8 Authors: Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X Abstract Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell...
Thu Mar 19, 2020 13:29
Related ArticlesComparison of two methods of locating proximal femoral nail anti-rotation in the treatment of femoral intertrochanteric fractures. J Orthop Surg Res. 2020 Mar 17;15(1):108 Authors: Tian RH, Zhang QM, Chu FL, Li XY, Jiang Z, Han L, Sun P, Wang HB, Chi YL, Wu B Abstract BACKGROUND: To compare the efficacy of three-point locating versus routine locating techniques for implanting helical blades for proximal femoral nail anti-rotation-II in...
Thu Mar 19, 2020 13:29
Related ArticlesThe Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy. Int J Mol Sci. 2020 Mar 08;21(5): Authors: Lee K, Lee SH, Kim TH Abstract Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation...
Thu Mar 19, 2020 13:29
Related ArticlesOutcomes of Simultaneous Resections and Classical Strategy for Synchronous Colorectal Liver Metastases in Sweden: A Nationwide Study with Special Reference to Major Liver Resections. World J Surg. 2020 Mar 17;: Authors: Valdimarsson VT, Syk I, Lindell G, Sandström P, Isaksson B, Rizell M, Norén A, Ardnor B, Sturesson C Abstract BACKGROUND: About 20% of patients with colorectal cancer have liver metastases at the time of diagnosis, and...
Thu Mar 19, 2020 13:27
Related ArticlesProton beam therapy utilization in adults with primary brain tumors in the United States. J Clin Neurosci. 2020 Mar 14;: Authors: Stross WC, Malouff TD, Waddle MR, Miller RC, Peterson J, Trifiletti DM Abstract The utilization of proton beam therapy (PBT) as the primary treatment of adults with primary brain tumors (APBT) was evaluated through query of the National Cancer Database (NCDB) between the years 2004 and 2015. International Classification...
Thu Mar 19, 2020 13:25
Publication date: Available online 18 March 2020Source: Revue des Maladies RespiratoiresAuthor(s): S. Valentin, M. Zysman, A. Guillaumot, E. Gomez, F. Chabot, A. Chaouat
Thu Mar 19, 2020 13:22
Publication date: Available online 19 March 2020Source: Journal of Surgical EducationAuthor(s): Erika R. Francis, Stephanie Bernard, Morgan L. Nowak, Sarah Daniel, Johnathan A. Bernard
Thu Mar 19, 2020 13:21
Related ArticlesLongitudinal effects of a novel advanced pneumatic compression device on patient-reported outcomes in the management of cancer-related head and neck lymphedema: A preliminary report. Head Neck. 2020 Mar 18;: Authors: Gutiérrez C, Mayrovitz HN, Naqvi SHS, Karni RJ Abstract BACKGROUND: Head and neck cancer (HNC) survivors experience head and neck lymphedema (HNL), which requires treatment to prevent morbidity. We explore the self-reported...
Thu Mar 19, 2020 15:18
Related ArticlesClinical reasoning and hypothesis generation in expert clinical swallowing examinations. Int J Lang Commun Disord. 2020 Mar 17;: Authors: McAllister S, Tedesco H, Kruger S, Ward EC, Marsh C, Doeltgen SH Abstract BACKGROUND: A clinical swallow examination (CSE) provides integral information that informs the diagnostic decision-making process within dysphagia management. However, multiple studies have highlighted a high degree of reported...
Thu Mar 19, 2020 13:20
Related ArticlesThe Recline and Head Lift Exercises: A Randomized Clinical Trial Comparing Biomechanical Swallowing Outcomes and Perceived Effort in Healthy Older Adults. J Speech Lang Hear Res. 2019 03 25;62(3):631-643 Authors: Fujiki RB, Oliver AJ, Malandraki JB, Wetzel D, Craig BA, Malandraki GA Abstract Purpose The aim of this study was to compare biomechanical swallowing outcomes and perceived effort as well as detraining effects of the established...
Thu Mar 19, 2020 13:20
Related ArticlesSarcopenia is associated with worse recovery of physical function and dysphagia and a lower rate of home discharge in Japanese hospitalized adults undergoing convalescent rehabilitation. Nutrition. 2019 05;61:111-118 Authors: Yoshimura Y, Wakabayashi H, Bise T, Nagano F, Shimazu S, Shiraishi A, Yamaga M, Koga H Abstract OBJECTIVE: The aim of this study was to evaluate the effect of sarcopenia on functional outcomes, including activities...
Thu Mar 19, 2020 13:20
Related Articlesβ-elemene suppresses the malignant behavior of esophageal cancer cells by regulating the phosphorylation of AKT. Acta Histochem. 2020 Mar 14;:151538 Authors: Liang Y, Li S, Zheng G, Zhang L Abstract BACKGROUND: Esophageal cancer is a digestive tract malignancy, ranking sixth among the world's deadliest tumor incidence. However, the pathogenesis of esophageal cancer is complex and the prognosis remains poor. Therefore, in-depth study...
Thu Mar 19, 2020 13:19
Related ArticlesHow can preclinical cognitive research further neuropsychiatric drug discovery? Chances and challenges. Expert Opin Drug Discov. 2020 Mar 18;:1-12 Authors: Gyertyán I Abstract Introduction: Disorders of the brain pose the biggest health challenge of this century with new and highly efficacious medications urgently needed. This article discusses the challenges of meeting this increasing demand by neuropsychiatric drug discovery.Areas covered:...
Thu Mar 19, 2020 13:19
Related ArticlesImpact of enteral arginine supplementation on lysine metabolism in humans: A proof-of-concept for lysine-related inborn errors of metabolism. J Inherit Metab Dis. 2020 Mar 18;: Authors: Schmidt Z, Murthy G, Ennis M, Stockler-Ipsiroglu S, Elango R Abstract BACKGROUND: Patients with lysine-related inborn errors of metabolism (pyridoxine dependent epilepsy [PDE] and glutaric aciduria type 1 [GA1]), follow a lysine-restricted diet with arginine-fortified...
Thu Mar 19, 2020 14:46
Related ArticlesTelehealth monitoring of a hypertensive elderly patient with the new VITASENIOR-MT system: a case study. Blood Press Monit. 2020 Mar 16;: Authors: Pereira T, Pires G, Jorge D, Santos D Abstract Telehealth technologies providing remote monitoring of health parameters are a promising approach for the management of arterial hypertension in the elderly. The VITASENIOR-MT platform was developed as a telehealth solution designed to contribute...
Thu Mar 19, 2020 14:46
Related ArticlesSerum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury. Clin EEG Neurosci. 2020 Mar 18;:1550059420909676 Authors: Kinzel P, Marx CE, Sollmann N, Hartl E, Guenette JP, Kaufmann D, Bouix S, Pasternak O, Rathi Y, Coleman MJ, van der Kouwe A, Helmer K, Kilts JD, Naylor JC, Morey RA, Shutter L, Andaluz N, Coimbra R, Lang AJ, George MS, McAllister...
Thu Mar 19, 2020 14:46
Related ArticlesRongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae. J Tradit Chin Med. 2019 Dec;39(6):875-884 Authors: Zhang S, Xu J, Wang C, Feng D, Dai L, Kuang X, Zhu S, Fang Y, Chen D, He X, Feng X Abstract OBJECTIVE: To evaluate the effects of Rongchang capsule and Xifeng capsule on pentylenetetrazole- induced epilepsy in zebrafish larvae and to explore the possible mechanisms...
Thu Mar 19, 2020 13:18
Related ArticlesExtinguishing Febrile Infection-Related Epilepsy Syndrome: Pipe Dream or Reality? Semin Neurol. 2020 Mar 17;: Authors: Payne ET, Koh S, Wirrell EC Abstract Febrile infection-related epilepsy syndrome (FIRES) is a rare and devastating epileptic encephalopathy with historically abysmal neurocognitive outcomes, including a high incidence of mortality. It tends to affect children and young adults and is characterized by superrefractory status...
Thu Mar 19, 2020 13:18
Related ArticlesAdvances in the Treatment of Drug-Resistant Pediatric Epilepsy. Semin Neurol. 2020 Mar 17;: Authors: Gonzalez-Giraldo E, Sullivan JE Abstract Epilepsy is a common disorder in children and adults that causes significant morbidity and affects many aspects of a patient's lives. Two-thirds of patients with epilepsy are controlled with established antiseizure medications, leaving a significant number of patients searching for other options....
Thu Mar 19, 2020 13:18
Related ArticlesMetabolic Disorders Presenting with Seizures in the Neonatal Period. Semin Neurol. 2020 Mar 17;: Authors: Brimble E, Ruzhnikov MRZ Abstract Metabolic disorders represent rare but often treatable causes of seizures and epilepsy of neonatal onset. As seizures are relatively common in the neonatal period, systemic clues to a specific diagnosis may be lacking or shrouded by acute illness. An important role of the consulting pediatric neurologist...
Thu Mar 19, 2020 13:18
Related ArticlesAssociation of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy. Biomed Res Int. 2020;2020:8096235 Authors: Lu Y, Su Q, Li M, Dayimu A, Dai X, Wang Z, Che F, Xue F Abstract Purpose: The efficacy of valproic acid (VPA) varies widely in clinical treatment of epileptic patients. Our study is aimed at exploring a potential association between polymorphisms of SCN1A, SCN2A, and UGT2B7...
Thu Mar 19, 2020 13:18
Related ArticlesThe Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome. Front Pharmacol. 2020;11:136 Authors: Liu S, Jin Z, Zhang Y, Rong S, He W, Sun K, Wan D, Huo J, Xiao L, Li X, Ding N, Wang F, Sun T Abstract Dravet syndrome (DS) is a refractory epilepsy typically caused by heterozygous mutations of the Scn1a gene, which encodes the voltage-gated...
Thu Mar 19, 2020 13:18
Related ArticlesInvestigatory pathway and principles of patient selection for epilepsy surgery candidates: a systematic review. BMC Neurol. 2020 Mar 17;20(1):100 Authors: Ghaffari-Rafi A, Leon-Rojas J Abstract BACKGROUND: The predominant treatment for epilepsy is pharmacotherapy, yet 20-40% do not respond to anti-epileptic drugs. After becoming pharmacoresistant, some patients are worked-up to determine candidacy for epilepsy surgery. Despite the 2009...
Thu Mar 19, 2020 13:18
Related ArticlesCannabinoids, Blood-Brain Barrier, and Brain Disposition. Pharmaceutics. 2020 Mar 15;12(3): Authors: Calapai F, Cardia L, Sorbara EE, Navarra M, Gangemi S, Calapai G, Mannucci C Abstract Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds. THC and CBD lipophilicity and their neurological...
Thu Mar 19, 2020 13:18
Related ArticlesLesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020 Jan;37(1):79-86 Authors: Peters JM, Hyde DE, Chu CJ, Boom M, Scherrer B, Madsen JR, Stone SS, Ouaalam H, Prabhu SP, Sahin M, Warfield SK Abstract PURPOSE: Electrical source imaging may yield ambiguous results in multilesional epilepsy. The aim of this study was to test the clinical utility of lesion-constrained...
Thu Mar 19, 2020 13:18
Gray Areas in the Gray Matter: IDH1/2 Mutations in Glioma. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-8 Authors: van den Bent MJ, Mellinghoff IK, Binja R Abstract Since the first discovery of isocitrate dehydrogenase (IDH) mutations in cancer, considerable progress has been made in our understanding of their contribution to cancer development. For glioma, this has helped to identify two diagnostic groups of tumors (oligodendroglioma and astrocytoma IDHmt)...
Thu Mar 19, 2020 13:15
Related ArticlesSphenoid Sinus Giant Cell Tumor: A Case Report and Literature Review. ORL J Otorhinolaryngol Relat Spec. 2020 Mar 18;:1-6 Authors: Pousti BT, Andera L, Haugen TW Abstract We describe a 27-year-old female with a giant cell tumor of her sphenoid sinus, presenting with nasal obstruction and cranial neuropathies. Both the surgical and subsequent medical management are reviewed. Additionally, we review the overall presentation, pathophysiology,...
Thu Mar 19, 2020 15:16
Related ArticlesTracking down the White Plague: The skeletal evidence of tuberculous meningitis in the Robert J. Terry Anatomical Skeletal Collection. PLoS One. 2020;15(3):e0230418 Authors: Spekker O, Hunt DR, Paja L, Molnár E, Pálfi G, Schultz M Abstract Paleopathological diagnosis of tuberculosis (TB) essentially relies on the identification of macroscopic lesions in the skeleton that can be related to different manifestations of TB. Among these alterations,...
Thu Mar 19, 2020 15:16
Related ArticlesQuantitative Analysis of the Far-Lateral, Supra-Articular Transcondylar Transtubercular Approach Using Cadaveric Computed Tomography and Magnetic Resonance Imaging. Oper Neurosurg (Hagerstown). 2020 Mar 18;: Authors: Kodera T, Akazawa A, Yamada S, Arai H, Yamauchi T, Higashino Y, Arishima H, Iino S, Noriki S, Kikuta KI Abstract BACKGROUND: Removing the jugular tubercle (JT) is regarded as an important step in the far-lateral approach;...
Thu Mar 19, 2020 15:16
Related ArticlesPerivascular epithelioid cell tumor (PEComa) of the pterygopalatine fossa. Clin Case Rep. 2020 Mar;8(3):553-558 Authors: Dougherty MI, Payne SC, Gupta A, Mattos JL Abstract Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal tumors associated with tuberous sclerosis. These tumors are typically treated with resection and rarely recur or exhibit malignant behavior. A 78-year-old woman presented with an incidentally...
Thu Mar 19, 2020 13:14
Related ArticlesThree-Dimensional CT Morphometric Image Analysis of the Clivus and Sphenoid Sinus in Chiari Malformation Type I. Ann Biomed Eng. 2019 Nov;47(11):2284-2295 Authors: Nwotchouang BST, Eppelheimer MS, Bishop P, Biswas D, Andronowski JM, Bapuraj JR, Frim D, Labuda R, Amini R, Loth F Abstract This study evaluated three-dimensional (3D) volumetric image reconstructions to identify morphological differences of the clivus and sphenoid sinus on...
Thu Mar 19, 2020 13:14
Publication date: Available online 19 March 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Reza Tabrizi, Hossein Behnia, Parsa Behnia, Birkan Taha Ozkan
Thu Mar 19, 2020 13:10
Related ArticlesNanostructured polymer assemblies stabilize photoactivatable anticancer ruthenium complexes under physiological conditions. J Inorg Biochem. 2020 Mar 09;207:111052 Authors: Chen M, Sun W, Kretzschmann A, Butt HJ, Wu S Abstract Photoactivatable ruthenium (Ru) complexes are promising compounds for anticancer phototherapy. They must be stable under physiological conditions before they are transported to cancer cells. In this paper, we systematically...
Thu Mar 19, 2020 15:13
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου