Publication date: Available online 9 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Daiji Sakata, Takehito Uruno, Keisuke Matsubara, Tsugunobu Andoh, Kazuhiko Yamamura, Yuki Magoshi, Kazufumi Kunimura, Yasuhisa Kamikaseda, Masutaka Furue, Yoshinori Fukui
Publication date: Available online 9 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Yukai Jing, Danqing Kang, Luyao Liu, Huang Huang, Anwei Chen, Lu Yang, Panpan Jiang, Na Li, Heather Miller, Zheng Liu, Xiaofei Zhu, Jun Yang, Xiaochuan Wang, Jinqiao Sun, Zhiping Liu, Wanli Liu, Xinyuan Zhou, Chaohong LiuBackgroundB-cell receptor (BCR) signaling, combined with CD19 and CD21 signals, imparts specific control of B-cell responses. Dedicator of cytokinesis protein 2 (DOCK2) is...
Publication date: Available online 8 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Victoria X. Soriano, Rachel L. Peters, Anne-Louise Ponsonby, Shyamali C. Dharmage, Kirsten P. Perrett, Michael J. Field, Andrew Knox, Dean Tey, Sasha Odoi, Grace Gell, Beatriz Camesella Perez, Katrina J. Allen, Lyle C. Gurrin, Jennifer J. KoplinAbstractBackgroundRandomized controlled trials demonstrate that timely introduction of peanut to infants reduces the risk of peanut allergy. However,...
Publication date: Available online 8 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Cara L. Hrusch, Michelle M. Stein, Justyna Gozdz, Mark Holbreich, Erika Von Mutius, Donata Vercelli, Carole Ober, Anne I. SperlingAbstractObjectivesAmish children raised on traditional farms have lower atopy and asthma risk than Hutterite children raised on modern farms. In our previous study, we established that the Amish environment affects the innate immune response to lower asthma and...
Publication date: Available online 8 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Xiaolei Ding, Sebastian Willenborg, Wilhelm Bloch, Sara A. Wickström, Prerana Wagle, Susanne Brodesser, Axel Roers, Alexander Jais, Jens C. Brüning, Michael N. Hall, Markus A. Rüegg, Sabine A. EmingAbstractBackgroundPerturbation of epidermal barrier formation will profoundly compromise overall skin function, leading to a dry and scaly, ichthyosis-like skin phenotype, which is the hallmark...
Publication date: Available online 8 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Christopher M. Warren, Ozge N. Aktas, Ruchi S. Gupta, Carla M. Davis
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Publication date: Available online 10 August 2019Source: Autoimmunity ReviewsAuthor(s): Borja Hernández-Breijo, Alvaro Gomez, Sofia Soukka, Petter Johansson, Ioannis Parodis
Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Paola Di Benedetto, Piero Ruscitti, Zahava Vadasz, Elias Toubi, Roberto GiacomelliAbstractMacrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases. In fact, during these diseases, activated macrophages may play a critical role, promoting the inflammation as well as mediating the damage resolution. This dichotomy is referred to two end-stage phenotypes of macrophages, conventionally...
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Emanuele D'Amico, Aurora Zanghì, Clara Grazia Chisari, Francesco Patti, Mario Zappia
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Guglielmo LuccheseAbstractAggregation of immuno-proteomic data reveal that i) herpesviruses and synaptic proteins –in particular Synapsin-1 and Bassoon - share a large number of hexapeptides that also recur in hundreds of epitopes experimentally validated as immunopositive in the human host, and ii) the shared peptides are also spread among human epilepsy-related proteins. The data suggest that cross-reactive processes...
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Adrian W. Zuercher, Rolf Spirig, Adriana Baz Morelli, Tony Rowe, Fabian KäsermannAbstractIn recent years, there has been a surge in the research and development of novel molecules as potential therapeutic alternatives to traditional treatments (such as intravenous immunoglobulins) for autoimmune disorders. The aim of this review is to describe different drug development strategies and evaluate how various molecules...
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Gaël Galli, Amanda Poissonnier, Jean Philippe Guégan, Manon Charrier, Vanja Sisirak, Estibaliz Lazaro, Marie-Elise Truchetet, Christophe Richez, Patrick Legembre, Patrick Blanco
Publication date: Available online 9 August 2019Source: Autoimmunity ReviewsAuthor(s): Rong-hua Song, Qiu-ming Yao, Bin Wang, Qian Li, Xi Jia, Jin-an ZhangAbstractBackgroundOur purpose was to determine the prevalence of thyroid disorders in myasthenia gravis (MG) or whether MG was associated with an increased risk of thyroid disorders.MethodsPubmed, Embase, Web of Science, Cochrane database, Google Scholar and the Chinese Biomedical Databases were searched about the relationship between thyroid disorders...
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Ai-Lan Nguyen, Alana Eastaugh, Anneke van der Walt, Vilija G. JokubaitisAbstractMultiple sclerosis (MS) is commonly diagnosed in women of childbearing age. Having a greater understanding of the effects of pregnancy on the course of MS will lead to improved family-planning counselling for women. We found well-established evidence for a protective effect of pregnancy on relapse occurrence in historical cohorts. More...
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Ommar Omarjee, Cécile Picard, Cécile Frachette, Marion Moreews, Frederic Rieux Laucat, Pauline Sprauel, Sebastien Viel, Jean-Christophe Lega, Brigitte Bader-Meunier, Thierry Walzer, Anne-Laure Mathieu, Rolando Cimaz, Alexandre BelotAbstractSystemic lupus erythematosus (SLE) is a severe lifelong multisystem autoimmune disease characterized by the presence of autoantibodies targeting nuclear autoantigens, increased...
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Anna Bazsó, Ágnes Szappanos, Annamária Kövesdi, Rita Rásonyi, Eszter Nagy, Attila Patócs, Gyula Poór, Emese Kiss
Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Alberto Romano, Donato Rigante, Clelia CipollaAbstractThe contribution of autoimmune phenomena to dysfunction of hypophysis or hypothalamus is far to be unraveled and also the specific pathways of hypophysitis are poorly understood until now, mostly for the pediatric population. Primary hypophysitis is rare in children and often regarded as an autoimmune disorder, following the evidence of lymphoplasmacytic infiltration...
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Abstract Rationale The temporal in vivo response of epithelial cells to a viral challenge and its association with viral clearance and clinical outcomes has been largely unexplored in asthma. Objective: To determine gene expression profiles over time in nasal epithelial cells (NECs) challenged in vivo with rhinovirus‐16 (RV16) and compare to nasal symptoms and viral clearance. Methods Patients with stable mild to moderate asthma (n=20) were challenged intranasally with RV16. Nasal brush...
Abstract Background Understanding consumer perceptions is crucial if effective food safety policy and risk communication are to be developed and implemented. We sought to understand how those living with food allergy assess risk with precautionary allergen labelling (PAL) and their preference in how risks are communicated within a Quantitative Risk Assessment (QRA) framework. Methods The Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM) labelling online survey was...
Abstract Background Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by defective skin barrier and Th2 immune responses. Chitinase 3‐like 1 (CHI3L1), also known as breast regression protein 39 (BRP‐39) in mice and human homologue YKL‐40, plays important roles in Th2 inflammation and allergen sensitization. CHI3L1 has been implicated in a variety of diseases including asthma characterized by inflammation, apoptosis, and tissue remodeling, but its role in AD remains...
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Publication date: Available online 10 August 2019Source: Allergology InternationalAuthor(s): Koji Yokoyama, Takahiko Horiuchi, Chinami Hashimura, Akira Yoshida
Publication date: Available online 9 August 2019Source: Allergology InternationalAuthor(s): Shigeharu Fujieda, Yoshimasa Imoto, Yukinori Kato, Takahiro Ninomiya, Takahiro Tokunaga, Toshiki Tsutsumiuchi, Kanano Yoshida, Masanori Kidoguchi, Tetsuji TakabayashiAbstractEosinophilic chronic rhinosinusitis (ECRS) is a subgroup of chronic rhinosinusitis with nasal polyps (CRSwNP), which is associated with severe eosinophilic infiltration and intractable. Its symptoms include dysosmia, nasal obstruction,...
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Publication date: Available online 8 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Maria Angela Tosca, Marzia Duse, Gianluigi Marseglia, Giorgio Ciprandi, Elisa Anastasio, Ilaria Brambilla, Carlo Caffarelli, Loredana Chini, Riccardo Ciprandi, Paolo Del Barba, Valentina De Vittori, Maria Elisa Di Cicco, Luciana Indinnimeo, Ahmad Kantar, Maddalena Leone, Amelia Licari, Viviana Moschese, Roberta Olcese, Diego Peroni, Angela Pistorio
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Administration of interleukin (IL)-2 has led to a durable response in patients with advanced renal cancer and melanoma but is restricted for clinical application because of adverse effects, including the vascular leak syndrome (VLS). VLS is associated with increased circulating levels of the Tie2 antagonist ligand, angiopoietin 2, and decreased Tie2 receptor phosphorylation and downstream signaling in endothelial cells (ECs). Given that vascular endothelial protein tyrosine phosphatase (VE-PTP) is...
De novo metastatic castration-sensitive prostate cancer (mCSPC) is small subgroup of prostate cancer associated with poor prognosis. The aim of our study was to assess the expression of programmed death-ligand 1 (PD-L1) in tumor cells of de novo mCSPC patients. Patients referred to our institution from January 2007 to October 2017 with de novo mCSPC and available diagnostic tissue were included. We tested the PD-L1 pharmaDx qualitative immunohistochemical assay, a monoclonal rabbit anti-PD-L1, clone...
We previously found that heat-shock protein 70 (HSP70) is expressed on hepatocellular carcinoma cells and developed an HSP70 mRNA-transfected dendritic cell therapy for treating unresectable or recurrent hepatocellular carcinoma. The phase I trial was completed successfully. The purpose of this study is to identify a promiscuous epitope peptide derived from HSP70 for the purpose of developing a novel cancer peptide vaccine. Using a computational algorithm to analyze the specificity of previously...
Upregulation of T-regulatory lymphocytes (Tregs) is one of numerous immune escape mechanisms of malignancies. In the present pilot study we aimed to study the effect of adjuvant nivolumab during the initiation of treatment on circulating Tregs subpopulations in patients with stage III melanoma. We subsequently recruited patients with stage III melanoma who had the indication for adjuvant anti-programmed death 1 (PD-1) treatment with nivolumab. Blood collections were performed before the initiation...
Local and systemic inflammation significantly effects tumor progression and its response to therapy. We aim to evaluate the prognostic significance of inflammatory cells, their ratios, and a change in these indices while patients are receiving immune checkpoint inhibitors (ICIs). We retrospectively reviewed 120 malignant melanoma patients who had received any ICIs from 2011 until December 2017 and evaluated the effect of hematological indices on survival and radiographic responses. We followed the...
Mixed adenoneuroendocrine carcinoma (MANEC) is a rare, aggressive tumor arising from different localizations along the gastrointestinal tract with generally poor prognosis. We present the case of a 51-year-old female patient with histopathologically confirmed diagnosis of a MANEC of the descending colon. At presentation, the tumor had already spread to the liver causing extensive hepatic metastases. Immunohistochemical examination showed 5%–10% of tumor cells to express the programmed cell death...
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