Key points Fetal growth restriction (FGR) is a major risk factor for stillbirth and has significant impact upon lifelong health. A small, poorly functioning placenta, as evidenced by reduced transport of nutrients to the baby, underpins FGR. It remains unclear how a small but normal placenta differs from the small FGR placenta in terms of ability to transfer nutrients to the fetus. Placental transport of glutamine and glutamate, key amino acids for fetal growth, was assessed in normal mice and...
Abstract The contribution of prostaglandins (PGs) to exercise hyperaemia is controversial. In this review, we argue this is partly explained by differences between studies in exercise intensity. The effects of cyclooxygenase (COX) inhibition and PG assays, PGs contribute more at moderate to heavy, than light workloads and are mainly released by low tissue O2. But, the release and actions of PGs also depend on other O2‐dependent dilators including ATP, adenosine and NO. K+ may inhibit the action...
Key points Impairments in both central sympathetic and peripheral microvascular function contribute to blunted reflex cutaneous vasodilation during heat stress in healthy older adults. Hypercholesterolemia is associated with decrements in neuro‐vascular function; however, little is known about the impact of hypercholesterolemia on the integrated responses to heat stress. Further, whether chronic statin therapy alters skin sympathetic outflow or its relation to cutaneous vascular conductance during...
Key points We demonstrated optical activation of primary somatosensory afferents with high selectivity to fast‐conducting fibres by means of adeno‐associated virus (AAV)9‐mediated gene transduction in dorsal root ganglion (DRG) neurons. AVV9 expressing green fluorescent protein (GFP) showed high selectivity and transduction efficiency for fast‐conducting, large‐sized DRG neurons. Compared with conventional electrical stimulation, optically elicited volleys in primary afferents had higher sensitivity...
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Abstract Isomaltulose is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration. We investigated the effects of ingesting beverage containing isomaltulose and electrolytes on postexercise hydration state and physiological heat loss responses. In a randomized, single‐blind cross‐over design, ten young healthy men were hypohydrated by performing up to three 30‐min successive moderate‐intensity (50% heart rate reserve) bouts of cycling, each separated by 10 min,...
Abstract It has yet to be quantified how passive leg movement (PLM)‐induced hyperemia, an index of vascular function, is distributed beyond the common femoral artery (CFA), into the deep femoral (DFA) and the superficial femoral (SFA) arteries, which supply blood to the thigh and lower leg, respectively. Furthermore, the impact of cuffing the lower leg, a common practice, especially with drug infusions during PLM, on the hyperemic response is, also, unknown. Therefore, PLM was performed with and...
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Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Nuno Pinto, Iris Oliveira, Joana Ferreira, Jorge Gama, Maria Vaz PatoAbstractObjectiveThis TBS sham-controlled study aimed to evaluate the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) upon ipsilateral hearing thresholds after stimulation on the left auditory cortex.MethodsSixty healthy adults, aged between 19 and 32 years (median of 23 years), were randomly distributed into three groups...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Mihai Popescu, Elena-Anda Popescu, Thomas J. DeGraba, David J. Fernandez-Fidalgo, Gerard Riedy, John D. HughesAbstractObjectiveTo investigate the relationship between the severity of PTSD symptoms, modulation of alpha band oscillations, and behavioral performance in a working memory task.MethodsMagnetoencephalography data were recorded in 35 participants with combat exposure and various degrees of PTSD...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Christian Sandøe Musaeus, Knut Engedal, Peter Høgh, Vesna Jelic, Morten Mørup, Mala Naik, Anne-Rita Oeksengaard, Jon Snaedal, Lars-Olof Wahlund, Gunhild Waldemar, Birgitte Bo AndersenAbstractObjectiveQuantitative EEG power has not been as effective in discriminating between healthy aging and Alzheimer’s disease as conventional biomarkers. But EEG coherence has shown promising results in small samples. The...
High-density ECoG improves the detection of high frequency oscillations that predict seizure outcome
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Ece Boran, Georgia Ramantani, Niklaus Krayenbühl, Maxine Schreiber, Kristina König, Tommaso Fedele, Johannes SarntheinAbstractObjectivesResidual fast ripples (FR) in the intraoperative ECoG are highly specific predictors of postsurgical seizure recurrence. However, a FR is generated by a small patch of cortical tissue. Spatial sampling with standard electrodes may thus miss clinically relevant information.MethodsWe...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Carmen Erra, Ilaria Mileti, Marco Germanotta, Martina Petracca, Isabella Imbimbo, Alessandro De Biase, Stefano Rossi, Diego Ricciardi, Alessandra Pacilli, Enrica Di Sipio, Eduardo Palermo, Anna Rita Bentivoglio, Luca PaduaAbstractObjectiveGait impairment is a highly disabling symptom for Parkinson’s disease (PD) patients. Rhythmic auditory stimulation (RAS), has shown to improve spatio-temporal gait parameters...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Carole Fortin, Jean-Philippe Pialasse, Inga Sophia Knoth, Sarah Lippé, Cyril Duclos, Martin SimoneauAbstractObjectiveThis study aims at examining the cortical dynamics of sensorimotor information processing related to balance control in participants with adolescent idiopathic scoliosis (AIS) and in age-matched controls (CTL).MethodsCortical dynamics during standing balance control were assessed in 13 girls...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Femke Dijkstra, Mineke Viaene, David Crosiers, Ilse De Volder, Patrick CrasAbstractObjectivesIsolated REM sleep without atonia (iRSWA) is regarded as prodromal phase of REM sleep behavior disorder (RBD) and synucleinopathies. Other factors, however, have also been described to cause RSWA, including sleep apnea, antidepressants use and narcolepsy. We investigated the frequency of RSWA and its different etiologies.MethodsWe...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Ezgi Fide, Derya Durusu Emek-Savaş, Tuba Aktürk, Bahar Güntekin, Lütfü Hanoğlu, Görsev G. YenerAbstractObjectivesThe present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using a passive viewing task of emotional facial expressions.MethodsTwenty-four individuals...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Ioulietta Lazarou, Spiros Nikolopoulos, Stavros I. Dimitriadis, Ioannis (Yiannis) Kompatsiaris, Martha Spilioti, Magda TsolakiAbstractObjectiveWe performed a systematic literature review on Subjective Cognitive Decline (SCD) in order to examine whether the resemblance of brain connectome and functional connectivity (FC) alterations in SCD with respect to MCI, AD and HC can help us draw conclusions on the...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Caroline Guyer, Helene Werner, Flavia Wehrle, Bigna Katrin Bölsterli, Cornelia Hagmann, Oskar G. Jenni, Reto HuberAbstractObjectivePreterm infants are at risk for altered brain maturation resulting in neurodevelopmental impairments. Topographical analysis of high-density electroencephalogram during sleep matches underlying brain maturation. Using such an EEG mapping approach could identify preterm infants...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Kazuki Oi, Shuichiro Neshige, Takefumi Hitomi, Katsuya Kobayashi, Maya Tojima, Masao Matsuhashi, Akihiro Shimotake, Daiki Fujii, Riki Matsumoto, Shuhei Kasama, Masutaro Kanda, Yoshiaki Wada, Hirofumi Maruyama, Ryosuke Takahashi, Akio IkedaAbstractObjectiveTo elucidate the effects of perampanel (PER) on refractory cortical myoclonus for dose, etiology and somatosensory-evoked potential (SEP) findings.MethodsWe...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Victoria L. Meah, Stephen A. Busch, Kelvin E. Jones, Margie H. Davenport, Craig D. SteinbackAbstractMicroneurography, a technique used to detect postganglionic sympathetic nerve traffic in humans, is increasingly used to further the understanding of autonomic regulation in health and disease. The technique involves the transcutaneous insertion of a microelectrode into a peripheral nerve, following which,...
Publication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Elmar G.M. Pels, Erik J. Aarnoutse, Sacha Leinders, Zac V. Freudenburg, Mariana P. Branco, Benny H. van der Vijgh, Tom J. Snijders, Timothy Denison, Mariska J. Vansteensel, Nick F. RamseyAbstractObjectiveWe investigated the long-term functional stability and home use of a fully implanted electrocorticography (ECoG)-based brain-computer interface (BCI) for communication by an individual with late-stage Amyotrophic...
Publication date: Available online 8 August 2019Source: Clinical NeurophysiologyAuthor(s): Jesús Pastor, Lorena Vega-ZelayaAbstractObjectiveDuring deep brain stimulation (DBS) surgery, we analysed somatosensory evoked potentials (SSEPs) using microelectrode recordings (MERs) in patients under general anaesthesia.MethodsWe obtained MERs from 5 patients with refractory epilepsy. Off-line analysis isolated local field potentials (LFPs, 2-200 Hz) and high frequency components (HFCs, 0.5-5 kHz). Trajectories...
Publication date: Available online 8 August 2019Source: Clinical NeurophysiologyAuthor(s): Francesca Ginatempo, Nicoletta Manzo, John C Rothwell, Franca DeriuAbstractObjectiveTo investigate interhemispheric inhibition (IHI) between the facial primary motor cortices (fM1s).MethodsIHI was investigated in 10 healthy subjects using paired-pulse TMS in the depressor anguli oris (DAO), upper trapezius (UT) and first dorsal interosseous (FDI) muscles. Conditioning stimuli (CS) of 90-130% resting motor threshold...
Publication date: Available online 6 August 2019Source: Clinical NeurophysiologyAuthor(s): Ryo Morishima, Toshio Shimizu, Hiroya Nishida, Hideaki Mashimo, Atsuko Arisaka, Satoko Kumada, Eiji Isozaki
Publication date: Available online 6 August 2019Source: Clinical NeurophysiologyAuthor(s): Hiroyuki Nodera
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