Related ArticlesNeutrophils as a Protagonist and Target in Chronic Rhinosinusitis. Clin Exp Otorhinolaryngol. 2019 Aug 10;: Authors: Wang H, Pan L, Liu Z Abstract Neutrophils have traditionally been acknowledged as the first immune cells that are recruited to inflamed tissues during acute inflammation. By contrast, their importance in the context of chronic inflammation has been studied in less depth. Neutrophils can be recruited and are largely present...
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Abstract Homozygous loss of function of the melanocortin 1 receptor (MC1R) is associated with a pheomelanotic pigment phenotype and increased melanoma risk. MC1R heterozygosity is less well studied, although individuals inheriting one loss‐of‐function MC1R allele are also melanoma‐prone. Using the K14‐Scf C57BL/6J animal model whose skin is characterized by life‐long retention of interfollicular epidermal melanocytes like that of the human, we studied pigmentary, UV responses and DNA repair capacity...
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Abstract Purpose The tongue is a specific organ for the sense of taste. It consists of the striated muscle and mucous membrane. Furthermore, it helps the functions of speech, chewing, and swallowing. In this study, we aimed to reveal some morphometric properties of the tongue in fetal cadavers. Methods The study was conducted on a total of 45 fetal tongues...
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ABSTRACT Purpose This study is to investigate the effect of milling custom fit anatomical post and cores from Fiber Reinforced Composite and high‐density polymer blocks using CAD/CAM technology on the bond strength to root canal dentin compared with prefabricated fiber posts, and to evaluate the influence of thermocycling on the push out bond strength of the tested materials. Materials and methods Eighty extracted single‐rooted premolars, endodontically treated and prepared to receive the...
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Abstract Coffin–Lowry syndrome (CLS) is a well‐described syndrome characterized by intellectual disability, growth retardation, recognizable dysmorphic features, and skeletal changes. It is an X‐linked syndrome where males are more severely affected and females have high variability in clinical presentations. This case series reports nine molecularly confirmed Chinese CLS patients from six unrelated families (three with familial variants and three with de novo variants). There is a wide genotypic...
Abstract Histone Gene Cluster 1 Member E, HIST1H1E, encodes Histone H1.4, is one of a family of epigenetic regulator genes, acts as a linker histone protein, and is responsible for higher order chromatin structure. HIST1H1E syndrome (also known as Rahman syndrome, OMIM #617537) is a recently described intellectual disability (ID) syndrome. Since the initial description of five unrelated individuals with three different heterozygous protein‐truncating variants (PTVs) in the HIST1H1E gene in 2017,...
The cover image is based on the Genetic Syndromes in Adults Phenotype evolution and health issues of adults with Beckwith‐Wiedemann Syndrome by Alessandro Mussa et al., DOI: 10.1002/ajmg.a.61301.
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Abstract Objectives Two major classifications of frontoethmoidal cells, Lee and Kuhn’s and the IFAC (International Frontal Sinus Anatomy Classification), distinguish anterior, posterior and medial cells. The European anatomical position paper includes also lateral cells. According to the IFAC, anterior cells push the frontal sinus drainage pathway (FSDP) medially, posteriorly or posteromedially. Posterior cells push the FSDP anteriorly. The only medial cell, pushing the FSDP laterally is the...
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Abstract Background Evidence for the efficacy of low-volume high-intensity interval training (HIIT) for the modulation of body composition is unclear. Objectives We examined the effect of low-volume HIIT versus a non-exercising control and moderate-intensity continuous training (MICT) on body composition and cardiorespiratory fitness in normal weight, overweight...
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Abstract Objectives Andean and Tibetan high‐altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as partial pressure of several additional high‐altitude native populations in order to examine the possibility that this putative adaptive trait, that is, high exhaled NO, is universal. Methods We recruited two geographically diverse highland...
Abstract Objectives Invertebrates are important foods for many primates and provide valuable nutrients often unavailable from plant sources. We examine the diet of white‐faced capuchins (Cebus capucinus imitator) to determine: (a) timing and types of invertebrate food consumption; (b) whether invertebrate consumption varies with availability of plant foods; and (c) how invertebrates contribute to energy and protein intake of females during different reproductive states. Materials and methods...
Abstract Objectives Around the aim of gaining knowledge on the secular trends in nutritional status of the Spanish population, we found a collection of historical records compiled by La Institución Libre de Enseñanza and their alumni association along 47 years. These data had been collected from boys and girls attending summer camps, with a policy of improving health of children with unfavorable socioeconomic conditions. The objective is to extract all possible information about growth changes,...
Abstract Objectives This article documents an incomplete child's mandible found in H. Obermaier's excavation campaign (in 1912) in El Castillo Cave, Spain. This fossil was assigned to what was then considered a phase of the “Aurignacian‐delta”. Materials and Methods We exhaustively analyzed the original Obermaier documents, with particular attention to those corresponding to the year of the discovery. We extracted a bone sample to radiocarbon date the fossil directly. We also followed established...
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Abstract Home monitoring is the most practical means of collecting sleep data in large‐scale research investigations. Because the portion of recording time with poor‐quality data is higher than in attended polysomnography, a quantitative assessment of the quality of each signal should be recommended. Currently, only qualitative or semi‐quantitative assessments are carried out, likely because of the lack of computer‐based applications to carry out this task efficiently. This paper presents an innovative...
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Abstract Pathogenic MAGEL2 variants result in the phenotypes of Chitayat‐Hall (CHS), Schaaf‐Yang (SYS) and Prader‐Willi (PWS) syndromes. We present five patients with mutations in MAGEL2, including the first patient reported with a missense variant, adding to the limited literature. Further, we performed a systematic review of the CHS and SYS literature, assess the overlap between CHS, SYS and PWS, and analyze genotype‐phenotype correlations among them. We conclude that there is neither...
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Summary Distress, suffering, and care‐seeking behavior are characteristics of pain‐related disease and illness. Pain that transitions from an acute to a chronic phase carries with it the potential of further effects: these include a worsening of the disease or illness; high‐impact chronic pain; and substantial personal, societal, and economic burden. The biopsychosocial model directly addresses these multiple processes, yet clinical frameworks supporting this model are not universally implemented....
Abstract Background Phantom bite syndrome (PBS) is characterized by occlusal discomfort without corresponding dental abnormalities. Despite repeated, failed dental treatments, PBS patients persist in seeking bite correction. PBS has been regarded as a mental disorder. However, we have reported that PBS patients with a dental trigger tend to have less psychiatric history than those without. Hence, the symptoms of PBS cannot be explained by a mental disorder alone, and it is unclear if mental disorders...
Abstract Background Two‐point discrimination (2‐PD) is a valuable test for measuring tactile acuity that provides relevant information about cortical reorganization and somatosensory function. Objectives The main objectives of the present study were to assess intra‐ and interexaminer reliability of the 2‐PD test in the trigeminal region in asymptomatic individuals and only intraexaminer reliability in patients with temporomandibular disorders (TMD). The secondary objective was to observe...
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Abstract Purpose To determine the detailed computed tomography angiography (CTA) features of isolated superior mesenteric artery dissection (ISMAD), aiming to improve the current understanding of ISMAD. Materials and methods We retrospectively analyzed 57 patients with confirmed diagnoses of ISMAD with CTA from June 2011 to June 2018 in our hospital. The...
Abstract Purpose We aimed to explore the relationship among baseline perfusion CT parameters, clinical, and pathological factors with post-nephrectomy long-term progression-free survival in localized clear cell renal cell carcinoma. Materials and methods This study retrospectively collected 127 patients from March 2005 to May 2007 who undertook perfusion...
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Journal of International Medical Research, Ahead of Print.
Journal of International Medical Research, Ahead of Print.
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Surgical Infections, Ahead of Print.
Surgical Infections, Ahead of Print.
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The original version of this article incorrectly listed the second author’s name. It should be Stephanie J. Nahas, not Stephanie J. Nahas-Geiger. The author name is corrected in this erratum.
Abstract Purpose of Review People with headache usually experienced significantly lower health-related quality of life (HRQoL) than the healthy subjects. The goal of this systematic review was to evaluate the effectiveness of manual therapy on HRQoL in patients with tension-type headache (TTH), migraine (MH) or cervicogenic headache (CGH). Recent Findings ...
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Facial plast SurgDOI: 10.1055/s-0039-1694722The purpose of this study was to present surgical techniques for the reconstruction of medial canthal defects with and without the involvement of the eyelid. This study included 31 patients who underwent medial canthal reconstruction after tumor excision during a 6-year period. Data regarding patient demographics, defect size, tumor pathology, surgery techniques, functional and cosmetic outcomes, and complications were recorded. The reconstructive methods...
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Related ArticlesProposal for a new nomenclature of tracheo-oesophageal puncture: a different perspective. Acta Otorhinolaryngol Ital. 2019 Aug 08;: Authors: Leone CA, Capasso P, Russo G PMID: 31392972 [PubMed - as supplied by publisher]
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Abstract Maintenance is a crucial subject in medical equipment life cycle management. Evidence-based maintenance consists of the continuous performance monitoring of equipment, starting from the evidence—the current state in terms of failure history—and improvement of its effectiveness by making the required changes. This process is very important for optimizing the use and allocation of the available resources by clinical engineering departments. Medical equipment maintenance...
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Related ArticlesCancer stem cells equipped with powerful hedgehog signaling and better epigenetic memory: Avenues to look for cancer therapeutics. Curr Cancer Drug Targets. 2019 Aug 08;: Authors: Tandon I, Waghmode A, Sharma NK Abstract Complex nature of the tumor is depicted at the cellular landscape by showing heterogeneity in the presence of cancer cells, cancer-associated stromal cells, mesenchymal stem cells and cancer stem cells (CSCs). One of...
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Nature, Published online: 09 August 2019; doi:10.1038/d41586-019-02411-zHuge amphibians’ engineering works protect their offspring from predators and swift currents.
Nature, Published online: 09 August 2019; doi:10.1038/d41586-019-02430-w‘Lokiarchaea’, previously known only from DNA, is isolated and grown in culture.
Nature, Published online: 09 August 2019; doi:10.1038/d41586-019-02423-9Helen Currie has shared her fish-migration research at several UK festivals, including Glastonbury.
Nature, Published online: 09 August 2019; doi:10.1038/d41586-019-02422-wTeamwork between neural networks and a swivelling robot churns out new compounds.
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We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with low...
Although infant mortality because of birth defect has increased in both developed and developing countries, had not got attention like other health issues at national, regional, or local levels. Documenting th...
Glyphosate (N-phosphonomethyl glycine) and its commercial herbicide formulations have been shown to exert toxicity via various mechanisms. It has been asserted that glyphosate substitutes for glycine in polypepti...
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b02495
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01945
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02386
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02328
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02857
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02697
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01884
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02044
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06831
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06803
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05899
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06889
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07033
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06622
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05894
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05355
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05357
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05318
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05516
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03646
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06004
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The detrimental effects of synthetic fungicides have increased the emphasis for biological control as an effective and safe sustainable alternative method. In the present work, a potent rhizospheric actinobact...
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Ghost Surgery, Including Neurosurgery and Other Surgical Subspecialties Category: Article Type: Nancy E. EpsteinProfessor of Clinical Neurosurgery, School of Medicine, State University of New York at Stony Brook, New York, and Chief of Neurosurgical Spine and Education, NYU Winthrop Hospital, NYU Winthrop NeuroScience/Neurosurgery, Mineola, New York 11501, United States.DOI:10.25259/SNI_421_2019Copyright:...
Missed thoracic myelopathy: Do not throw the hammer away yet Category: Article Type: Lisa B. E. Shields, Vasudeva G. Iyer, Yi Ping Zhang, Christopher B. ShieldsNorton Neuroscience Institute, Norton Healthcare, University of Louisville School of Medicine, Louisville, Kentucky, USA.Neurodiagnostic Center of Louisville, University of Louisville School of Medicine, Louisville, Kentucky, USA.Department...
Computed tomography perfusion in detecting malignant middle cerebral artery infarct Category: Article Type: Chun Lin Lee, Regunath Kandasamy, Mohammed Azman Bin Mohammad RaffiqDepartment of Neurosurgery, Hospital Kuala Lumpur, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur,Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.Correspondence...
Viruses and tumor cell microenvironment: A brief summary Category: Article Type: Russell L. BlaylockTheoretical Neuroscience Research, LLC, Ridgeland, MS, United States.DOI:10.25259/SNI_351_2019Copyright: © 2019 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others...
Pituitary carcinomas: Rare and challenging Category: Article Type: Georges Sinclair, Martin Olsson, Hamza Benmakhlouf, Yahya Al-saffar, Philippa Johnstone, Mustafa Aziz Hatiboglu, Alia ShamikhDepartments of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden,Department of Oncology, Royal Berkshire NHS Foundation Trust, Reading, United Kingdom,Department of Neurosurgery, Bezmialem Vakif...
A surgical case of cerebellar tuberculoma caused by a paradoxical reaction while on therapy for tuberculosis spondylitis Category: Article Type: Atsuhiko Ninomiya, Atsushi Saito, Tomohisa Ishida, Tomoo Inoue, Takashi Inoue, Masayuki Ezura, Shinsuke Suzuki, Hiroshi Uenohara, Teiji TominagaDepartment of Neurosurgery, Sendai Medical Centre,Department of Neurosurgery, Graduate School of Medicine,...
Professional Medical Associations Exert Undue Influence Despite Conflicts of Interest Category: Article Type: Nancy E. EpsteinProfessor of Clinical Neurosurgery, School of Medicine, State University of New York at Stony Brook, New York, and Chief of Neurosurgical Spine and Education, NYU Winthrop Hospital, NYU Winthrop NeuroScience/Neurosurgery, Mineola, New York 11501, United States.DOI:10.25259/SNI_420_2019Copyright:...
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Purpose of review The establishment of long-term clinical tolerance in AIT requires the involvement of basophils, mast cells, allergen-specific regulatory T and B cells, downregulation of effector type 2 responses, and increase in production of specific IgG, particularly immunglobulin G4 (IgG4) antibodies. This review aims to provide an overview of the role of B cells in AIT, their mechanism of action, and their potential for improving AIT. Recent findings In-depth research of B cells has...
Purpose of review Although allergen immunotherapy (AIT) for fungi has been performed for many years, evidence clearly demonstrating its clinical benefit are still lacking. Here, we reviewed the available studies assessing efficacy and safety of AIT for molds. Recent findings Studies on AIT for fungi were performed only for the two predominating mold species in the external environment, namely Cladosporium and Alternaria. There is no evidence for other mold species. Recent finding in the literature...
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The Journal of Antibiotics, Published online: 09 August 2019; doi:10.1038/s41429-019-0219-3Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch
The Journal of Antibiotics, Published online: 09 August 2019; doi:10.1038/s41429-019-0218-4Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human
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Οι αισιόδοξοι άνθρωποι έχουν καλύτερο και πιο ποιοτικό ύπνο για μακρύτερο χρονικό διάστημα αποκαλύπτει νέα έρευνα του Πανεπιστημίου του Ιλινόις. Καλύτερα και περισσότερο κοιμούνται οι ενήλικες που έχουν αισιόδοξη στάση ζωής αποκαλύπτει νέα έρευνα επικεφαλής της οποίας ήταν η καθηγήτρια κοινωνικής εργασίας Δρ. Rosalba Hernandez. Στο δείγμα της έρευνας συμπεριελήφθησαν περισσότεροι από 3.50ο ενήλικες 32-51 ετών. «Τα αποτελέσματα της έρευνα έδειξαν σημαντικό συσχετισμό ανάμεσα στην αισιοδοξία και...
Η θεραπεία ορμονικής υποκατάστασης χορηγείται συχνά για την αντιμετώπιση των συμπτωμάτων της εμμηνόπαυσης και σύμφωνα με μία νέα μελέτη από τη Σχολή Δημόσιας Υγείας του Πανεπιστημίου του Πίτσμπουργκ ενισχύεται η σημασία της εξατομικευμένης ορμονοθεραπείας βάσει των ατομικών παραγόντων καρδιαγγειακού κινδύνου κάθε γυναίκας. Σε μελέτη που δημοσιεύθηκε στο Journal of the American Heart Association, οι ερευνητές έδειξαν για πρώτη φορά ότι η θεραπεία ορμονικής υποκατάστασης επηρεάζει τη συσσώρευση του...
Περισσότερες πιθανότητες να εκδηλώσουν νεφροπάθεια έχουν οι έγκυες που πάσχουν από προεκλαμψία. Σε αυτό το συμπέρασμα κατέληξαν επιστήμονες από το Πανεπιστημιακό Κολέγιο Cork σε έρευνα που δημοσιεύθηκε στο PLOS Medicine. Τα δεδομένα από 1,3 εκατομμύρια γυναίκες έδειξαν πως οι μητέρες που αντιμετώπιζαν την εν λόγω επιπλοκή ήταν 4,96 φορές πιο πιθανό να εμφανίσουν νεφρική νόσο τελικού σταδίου αργότερα στη ζωή τους. Οι επιστήμονες σημείωσαν πως παραμένει ασαφής ο λόγος που προκαλεί αυτή τη σχέση. Τα...
Η απώλεια της ακοής αυξάνει τον κίνδυνο άνοιας κατά 17% επιταχύνοντας τη γήρανση του εγκεφάλου. Σε αυτό το συμπέρασμα κατέληξε έρευνα από το Εθνικό Πανεπιστήμιο της Ταϊβάν που δημοσιεύθηκε στο Journal of the American Medical Association. Στη μελέτη βρέθηκε ότι ο κίνδυνος ήταν κατά 40% μεγαλύτερος στους ανθρώπους ηλικίας 45-64 ετών. Στην έρευνα συμμετείχαν 8.135 άνθρωποι οι οποίοι διαγνώσθηκαν με απώλεια ακοής και ίσος αριθμός ατόμων χωρίς απώλεια ακοής ως ομάδα ελέγχου. Από τους 16.270 εθελοντές,...
Τριπλάσιος είναι ο κίνδυνος εκδήλωσης άνοιας κατά τη γήρανση για τους ανθρώπους με υψηλή χοληστερόλη. Σε αυτό το συμπέρασμα κατέληξε νέα μελέτη που πραγματοποίησε το Πανεπιστήμιο της Ινδονησίας και δημοσιεύθηκε στο Enfermería Clínica. Οι ερευνητές μελέτησαν δεδομένα 106 ατόμων άνω των 60 ετών στην Τζακάρτα για να προσδιορίσουν τι ήταν πιο πιθανό να επηρεάσει τον κίνδυνο εκδήλωσης άνοιας. Τα υποψήφια κριτήρια ήταν: το επίπεδο μόρφωσης, το ιστορικό για σακχαρώδη διαβήτη, το επίπεδο χοληστερόλης,...
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Related ArticlesSREDA: A Rare but Confusing Benign EEG Variant. J Clin Neurophysiol. 2019 Aug 05;: Authors: Azman Iste F, Tezer Filik FI, Saygi S Abstract INTRODUCTION: Subclinical rhythmic EEG discharges in adults (SREDA) is a very rare benign EEG pattern. The electrophysiological features and atypical variants of SREDA has wide spectrum and they are poorly known. It resembles ictal discharges, and overinterpretation of SREDA may lead to misdiagnosis...
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