Publication date: Available online 8 August 2019Source: American Journal of Infection ControlAuthor(s): Lucas D. Jones, Thriveen S.C. Mana, Jennifer L. Cadnum, Annette L. Jencson, Heba Alhmidi, Sandra Y. Silva, Brigid M. Wilson, Curtis J. Donskey
Publication date: Available online 8 August 2019Source: American Journal of Infection ControlAuthor(s): Terry Grimmond, Linda GoodBackgroundThe annual Exposure Survey of Trends in Occupational Practice (EXPO-S.T.O.P.), conducted by the Association of Occupational Health Professionals in Healthcare, provides a U.S. national overview of sharps injuries (SIs) and mucocutaneous exposures (MCEs). This study presents the 2016 and 2017 surveys.MethodsAn 18-item survey was distributed to Association of Occupational...
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Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11551-9Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shuttling and transcriptional activity of SMAD2 in the diseased heart.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11615-wMetallo-β-lactamases (MBLs) confer resistance to carbapenem antibiotics. Here, López et al. show that the host range of MBLs depends on the efficiency of MBL signal peptide processing and secretion into outer membrane vesicles, which affects bacterial fitness.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11575-1Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11568-0Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by competing with the Mit/TFE transcription factors for occupancy of their target gene promoters.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11589-9Contact between electrons in a nanotube and solvated ions in an electrolyte yield electric fields confined to small dimensions and electrostatics that are affected by quantum density of states. Here the authors measure quantum effects on capacitance in a reduced-dimension system in a liquid electrolyte.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11582-2The definition of regulatory landscape at chronic lymphocytic leukaemia (CLL) risk loci is limited. Here, the authors perform an epigenomic characterisation of 42 known risk loci in CLL and normal B cells at different developmental stages and show active chromatin and target genes in the risk loci.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-10964-wFiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin at the tip to support force transmission through the actin core.
Nature Communications, Published online: 09 August 2019; doi:10.1038/s41467-019-11587-xMolecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.
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In rare cases, some children, often still in the womb, develop urethral strictures that make it difficult or impossible to empty the bladder. Typically, a surgical procedure is performed to remove the narrowed section of the urethra, with the open ends being sewed together. This is traumatic for the children and can be difficult for physicians to perform. Now, scientists at ETH Zurich, a major Swiss science and technology university, have managed to 3D print a malleable stent small enough...
While scientists have a variety of tools on hand to monitor and manipulate living brains, they still lack the ability to observe how large numbers of individual neurons operate in real time. Now, researchers at the Howard Hughes Medical Institute have developed a remarkable technology, published in the journal Science, that illuminates neurons just as they fire off. The technology has already allowed the team to investigate the activity within the brains of mice, flies, and zebrafish. ...
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Related ArticlesHearing loss in inherited peripheral neuropathies: Molecular diagnosis by NGS in a French series. Mol Genet Genomic Med. 2019 Aug 08;:e839 Authors: Lerat J, Magdelaine C, Roux AF, Darnaud L, Beauvais-Dzugan H, Naud S, Richard L, Derouault P, Ghorab K, Magy L, Vallat JM, Cintas P, Bieth E, Arne-Bes MC, Goizet C, Espil-Taris C, Journel H, Toutain A, Urtizberea JA, Boespflug-Tanguy O, Laffargue F, Corcia P, Pasquier L, Fradin M, Napuri S, Ciron J, Boulesteix...
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Publication date: September–October 2019Source: Allergologia et Immunopathologia, Volume 47, Issue 5Author(s): Luis Garcia-Marcos
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Related ArticlesProlactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells. Am J Cancer Res. 2019;9(7):1484-1503 Authors: MacDonald TM, Thomas LN, Daze E, Marignani P, Barnes PJ, Too CK Abstract Previously, we identified a prolactin (PRL)-inducible gene encoding EDD E3 ubiquitin ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-associated...
Related ArticlesSPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation. Am J Cancer Res. 2019;9(7):1469-1483 Authors: Dong Y, Zhang D, Cai M, Luo Z, Zhu Y, Gong L, Lei Y, Tan X, Zhu Q, Han S Abstract Speckle-type POZ protein (SPOP) plays an important role in maintaining genome stability. Disability or mutation of the SPOP gene has been reported to contribute to prostate cancer incidence and prognosis. However, the functions...
Related ArticlesDual-labeled pertuzumab for multimodality image-guided ovarian tumor resection. Am J Cancer Res. 2019;9(7):1454-1468 Authors: Lee HJ, Ehlerding EB, Jiang D, Barnhart TE, Cao T, Wei W, Ferreira CA, Huang P, Engle JW, Cai W Abstract Pertuzumab is clinically employed in the treatment of cancers over-expressing human epidermal growth factor receptor 2 (HER2). Herein, we developed dual-labeled pertuzumab with a radionuclide (89Zr) and a near-infrared...
Related ArticlesMonocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model. Am J Cancer Res. 2019;9(7):1439-1453 Authors: Park S, Zhu J, Altan-Bonnet G, Cheng SY Abstract Thyroid cancer is the most common endocrine malignancy. Although an association between inflammation and thyroid cancer has long been recognized, a cause-effect relationship at the molecular level has yet to be elucidated. We explored...
Related ArticlesRadiomics signature for the preoperative assessment of stage in advanced colon cancer. Am J Cancer Res. 2019;9(7):1429-1438 Authors: Li Y, Eresen A, Lu Y, Yang J, Shangguan J, Velichko Y, Yaghmai V, Zhang Z Abstract The purpose of this study was to develop a radiomics signature for distinguishing stage in advanced colon cancer (CC). 195 colon cancer patients were enrolled in this study (stage III, n = 146 vs. stage IV, n = 49) and divided...
Related ArticlesNatriuretic peptide receptor a promotes breast cancer development by upregulating MMP9. Am J Cancer Res. 2019;9(7):1415-1428 Authors: Qu J, Zhao X, Liu X, Sun Y, Wang J, Liu L, Wang J, Zhang J Abstract Natriuretic peptide receptor A (NPRA), one of the natriuretic peptide receptors, plays important roles in circulatory system. Recently some studies showed that NPRA was involved in tumorigenesis, however, its role in the development of...
Related ArticlesTrends in incidence and survival in patients with melanoma, 1974-2013. Am J Cancer Res. 2019;9(7):1396-1414 Authors: Che G, Huang B, Xie Z, Zhao J, Yan Y, Wu J, Sun H, Ma H Abstract Melanoma is a rare malignancy that invades the skin and the mucosa. Research has been conducted on melanoma incidence and the survival of patients with melanoma; however, no studies in melanoma incidence and the survival spanning 40 years and based on a large...
Related ArticlesLenvatinib promotes antitumor immunity by enhancing the tumor infiltration and activation of NK cells. Am J Cancer Res. 2019;9(7):1382-1395 Authors: Zhang Q, Liu H, Wang H, Lu M, Miao Y, Ding J, Li H, Gao X, Sun S, Zheng J Abstract Based on previous reports, the efficacy of lenvatinib against cancer is mainly attributed to its antiangiogenic activity and its ability to suppress tumor proliferation, which are mediated by targeting receptor...
Related ArticlesLong noncoding RNAs, emerging and versatile regulators of tumor-induced angiogenesis. Am J Cancer Res. 2019;9(7):1367-1381 Authors: Zhao J, Li L, Han ZY, Wang ZX, Qin LX Abstract Angiogenesis is an essential step in maintaining tumor growth and facilitating metastasis. The regulatory mechanisms of tumor-induced angiogenesis are extremely complicated, and include sophisticated crosstalk between tumors and surrounding microenvironment cells,...
Related ArticlesEmerging roles of lncRNA in cancer and therapeutic opportunities. Am J Cancer Res. 2019;9(7):1354-1366 Authors: Jiang MC, Ni JJ, Cui WY, Wang BY, Zhuo W Abstract Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have diverse roles in regulating gene expression at both the transcriptional and translational levels...
Related ArticlesNew insights into autophagy in hepatocellular carcinoma: mechanisms and therapeutic strategies. Am J Cancer Res. 2019;9(7):1329-1353 Authors: Yang S, Yang L, Li X, Li B, Li Y, Zhang X, Ma Y, Peng X, Jin H, Li H Abstract Autophagy is a mechanism by which cellular substances are transported to lysosomes for degradation, allowing the basic transformation of cellular components, and providing energy and macromolecular precursors. In cancer,...
Related ArticlesResearch landscape of liquid biopsies in prostate cancer. Am J Cancer Res. 2019;9(7):1309-1328 Authors: Campos-Fernández E, Barcelos LS, de Souza AG, Goulart LR, Alonso-Goulart V Abstract Studies show that liquid biopsies are efficient in the detection of circulating cancer products. However, scientific community has not yet implemented this technology in routine clinical practice. Liquid biopsies are less invasive than traditional surgical...
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Related ArticlesAcne vulgaris: new evidence in pathogenesis and future modalities of treatment. J Dermatolog Treat. 2019 Aug 08;:1-33 Authors: Hazarika N Abstract Acne vulgaris, a common and chronic disorder of the pilosebaceous unit, affects upto 85% of adolescent and young adults. While a lot is already known about acne and its treatment, still the gaps in our understanding of acne remains. This article will review the emerging evidence in the complex...
Related ArticlesIs the concept of clinical equipoise maintained in psoriasis research? J Dermatolog Treat. 2019 Aug 08;:1-5 Authors: Nguyen C, Housholder A, Fleischer A Abstract Psoriasis is a chronic autoinflammatory disease which significantly impacts the quality of life of patients. Recently, the therapeutic realm of psoriasis has greatly expanded, with agents offering complete clearance of lesions in up to 37% of patients. With the advent of such...
Related ArticlesEfficacy of 0.1% tacrolimus in long-term management of erosive lichen planus. J Dermatolog Treat. 2019 Aug 08;:1-16 Authors: Kiyani A, Sohail K, Saeed MHB Abstract OBJECTIVES: This study documented the response of erosive oral lichen planus to exclusive treatment with 0.1% topical tacrolimus over a 12-month period or until the patient became unresponsive to therapy. MATERIALS AND METHODS: A retrospective cohort design was used to acquire...
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Related ArticlesHuman Induced Pluripotent Stem Cells : Clinical Significance and Applications in Neurologic Diseases. J Korean Neurosurg Soc. 2019 Aug 09;: Authors: Chang EA, Jin SW, Nam MH, Kim SD Abstract The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development....
Related ArticlesErratum to "Minimally Invasive Surgery without Decompression for Hepatocellular Carcinoma Spinal Metastasis with Epidural Spinal Cord Compression Grade 2" by Jung JM, et al. (J Korean Neurosurg Soc 62 : 467-475, 2019). J Korean Neurosurg Soc. 2019 Aug 08;: Authors: AbstractPMID: 31392876 [PubMed - as supplied by publisher]
Related ArticlesIntradural Transpetrosectomy for Petrous Apex Meningiomas. J Korean Neurosurg Soc. 2019 Aug 09;: Authors: Han S, Zhang XH, Han DH, Jin YC Abstract Objective: This study aimed to assess the surgical results of the intradural transpetrosectomy for petrous apex meningiomas (PAMs). In addition, we describe the methods and techniques used to expose and manage superior petrous vein and greater superficial petrosal nerve. Methods: The...
Related ArticlesUpper Cervical Subluxation and Cervicomedullary Junction Compression in Patients with Rheumatoid Arthritis. J Korean Neurosurg Soc. 2019 Aug 09;: Authors: Chung J, Bak KH, Yi HJ, Chun HJ, Ryu JI, Han MH Abstract Objective: Rheumatoid arthritis (RA) is known to involve the cervical spine up to 86%. It often causes cervical instability like atlantoaxial subluxation (AAS), subaxial subluxation, and vertical subluxation (VS). In order to...
Related ArticlesSurgical Reconstruction Using a Flanged Mesh Cage without Plating for Cervical Spondylotic Myelopathy and a Symptomatic Ossified Posterior Longitudinal Ligament. J Korean Neurosurg Soc. 2019 Aug 09;: Authors: Kang JH, Im SB, Yang SM, Chung M, Jeong JH, Kim BT, Hwang SC, Shin DS, Park JH Abstract Objective: We introduce innovative method of cervical column reconstruction and performed the reconstruction with a flanged titanium mesh cage...
Related ArticlesVasa Vasorum Densities in Human Carotid Atherosclerosis Is Associated with Plaque Development and Vulnerability. J Korean Neurosurg Soc. 2019 Aug 09;: Authors: Joo SP, Lee SW, Cho YH, Kim YS, Seo BR, Kim HS, Kim TS Abstract Objective: The extensive vasa vasorum network functions as a conduit for the entry of inflammatory cells or factors that promote the progression of angiogenesis and plaque formation. Therefore, we investigated the...
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Related ArticlesDevelopment of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT). Colloids Surf B Biointerfaces. 2019 Aug 01;183:110387 Authors: Wu CY, Lin JJ, Chang WY, Hsieh CY, Wu CC, Chen HS, Hsu HJ, Yang AS, Hsu MH, Kuo WY Abstract Successful boron neutron capture therapy (BNCT) requires sufficient and specific delivery of boron atoms to malignant cells. Gold nanoparticles (AuNPs) have been...
Related ArticlesCorrelation of radioiodine doses for 6-hr and 24-hour iodine-131 thyroid uptake values for Graves' hyperthyroidism. Endocr J. 2019 Aug 07;: Authors: Horn-Lodewyk J Abstract The destruction of thyroid follicular cells by iodine-131 treatment for Graves' hyperthyroidism to a large extent depends on the amount of intrathyroidal activity absorbed (IAA). A thyroid weighing 50 g should receive an iodine-131 therapeutic dosage of between 110...
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Publication date: Available online 8 August 2019Source: Sleep MedicineAuthor(s): Bertien Buyse, David Cassiman, Dries Testelmans
Publication date: Available online 8 August 2019Source: Sleep MedicineAuthor(s): Jaana K. Huhtakangas, Juha Huhtakangas, Risto Bloigu, Tarja SaaresrantaAbstractObjectivesWe aimed to compare the feasibility of automatically and manually scored cardiorespiratory polygraphy results for sleep apnea screening in the acute phase of ischemic stroke.MethodsProspective study included 204 ischemic stroke patients, who underwent nocturnal unattended portable monitoring with three-channel device during 48 hours...
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Related ArticlesLINC01133 promotes the progression of cervical cancer by sponging miR-4784 to up-regulate AHDC1. Cancer Biol Ther. 2019 Aug 07;:1-9 Authors: Feng Y, Qu L, Wang X, Liu C Abstract Cervical cancer, as the deadliest gynecological tumor with high risk of incidence, manifests aberrantly expressed lncRNAs in the malignant cellular processes. Long intergenic non-protein coding RNA 1133 (LINC01133) has been acknowledged to actively participate...
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Related Articles[Patients-at home alone : Current legal questions on remote treatment]. HNO. 2019 Aug 07;: Authors: Hübner L, Wienke A PMID: 31392343 [PubMed - as supplied by publisher]
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Related ArticlesHearing loss in inherited peripheral neuropathies: Molecular diagnosis by NGS in a French series. Mol Genet Genomic Med. 2019 Aug 08;:e839 Authors: Lerat J, Magdelaine C, Roux AF, Darnaud L, Beauvais-Dzugan H, Naud S, Richard L, Derouault P, Ghorab K, Magy L, Vallat JM, Cintas P, Bieth E, Arne-Bes MC, Goizet C, Espil-Taris C, Journel H, Toutain A, Urtizberea JA, Boespflug-Tanguy O, Laffargue F, Corcia P, Pasquier L, Fradin M, Napuri S, Ciron J, Boulesteix...
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Related ArticlesLINC01133 promotes the progression of cervical cancer by sponging miR-4784 to up-regulate AHDC1. Cancer Biol Ther. 2019 Aug 07;:1-9 Authors: Feng Y, Qu L, Wang X, Liu C Abstract Cervical cancer, as the deadliest gynecological tumor with high risk of incidence, manifests aberrantly expressed lncRNAs in the malignant cellular processes. Long intergenic non-protein coding RNA 1133 (LINC01133) has been acknowledged to actively participate...
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Related ArticlesImpact of Therapeutic Drug Monitoring of Antiretroviral Drugs in Routine Clinical Management of People Living with HIV: a narrative review. Ther Drug Monit. 2019 Aug 05;: Authors: Cattaneo D, Baldelli S, Cozzi V, Clementi E, Marriott DJ, Gervasoni C Abstract PURPOSE: The treatment of human immunodeficiency virus (HIV) infection has evolved significantly since the advent of highly active antiretroviral therapy. As a result, a response...
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Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. One uncommon type of ischemic stroke is occlusion of the artery of Percheron (AOP) leading to infarction of the paramedian thalami and mesencephalon. There are several variants of thalamic blood supply, and identifying the potential presence and infarction of an AOP is important in diagnosis and treatment of ischemic strokes affecting the thalami and mesencephalon, especially because of the unusual...
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Primary spinal cord giant cell glioblastoma multiforme of the thoracic spinal cord is a rarely-diagnosed primary spinal cord tumor in comparison to neoplasms in intracranial locations. In this article, we highlight a young adult who was diagnosed with intramedullary giant cell glioblastoma, IDH wild-type, World Health Organization grade IV/IV of the thoracic spinal cord. This case report describes...
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Abstract Introduction Skeletal muscle abnormalities, such as low skeletal muscle mass, measured by skeletal muscle index (SMI), and low skeletal muscle quality, measured by skeletal muscle density (SMD), are associated with poor prognosis in cancer. There has been little investigation of their impact on tolerance to radiation therapy and overall outcome in gynaecologic cancers. We examined the effect of low SMI and SMD on treatment tolerance and survival outcomes in patients with endometrial...
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Abstract Maize MON 87427 ×MON 87460 × MON 89034 × MIR162 × NK603 (five‐event stack maize) was produced by conventional crossing to combine five single events: MON 87427, MON 87460, MON 89034, MIR162 and NK603. The GMO Panel previously assessed the five single maize events and eleven of the subcombinations and did not identify safety concerns. No new data on the single maize events or the 11 subcombinations that could lead to modification of the original conclusions on their safety were identified....
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐histidine monohydrochloride monohydrate produced by fermentation with Escherichia coli (NITE BP‐02526) when used as a nutritional additive or as a feed flavouring compound in feed and water for drinking for all animal species. The product under assessment is l‐histidine HCl H2O produced by fermentation with a genetically...
Abstract Following the request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the proposed modification of the terms of the authorisation regarding the maximum inclusion level of Maxiban® G160. The FEEDAP Panel cannot conclude on the safety of Maxiban® G160 at a dose level of 70 + 70 mg/kg feed for the target species. The use of Maxiban® G160 in diets for chickens for fattening at the maximum...
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on Bacillus licheniformis DSM 32457 as a silage additive for all animal species. Bacillus licheniformis DSM 32457 is presumed safe for the target species, consumers of products from animals fed treated silage and the environment. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive...
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British Journal of Nursing, Volume 28, Issue 15, Page 985-992, August 2019.
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Background Recently, there has been growing interest in using smartphone applications to assess gait speed and quantify isometric core stability exercise intensity. The purpose of this study was to investigate the between-session reliability and minimal detectable change of a smartphone app for two dynamic exercise tests of the lumbopelvic complex. Methods Thirty-three healthy young and active students (age: 22.3 ± 5.9...
High variability (HV) training has been found to be more effective than low variability (LV) training when learning various non-native phonetic contrasts. However, little research has considered whether this applies to the learning of tone contrasts. The only two relevant studies suggested that the effect of HV training depends on the perceptual aptitude of participants (Perrachione et al., 2011; Sadakata & McQueen, 2014). The present study extends these findings by examining the interaction...
The geographical range of the orchid genus Cranichis extends from USA, Central America, and the Caribbean to Bolivia and Argentina—with the greatest diversity observed in the Andean region. This taxon embraces herbs with the scape and basal leaves developing from a single, terminal bud and having the scape enclosed in several sheaths. The small, non-resupinate, flowers are arranged in a racemose inflorescence. The petals and lip are free from the column part and their gynostemium is short and massive....
Global warming can significantly affect many aspects of the biology of animal species, including their thermal physiology and physiological performance. Thermal performance curves provide a heuristic model to evaluate the impacts of temperature on the ecophysiology of ectotherms. When integrated with other thermal biology parameters, they can be used to predict the impacts of climate change on individual fitness and population viability. In this study, we combine holistic measures of thermal physiology...
The transitory and long-term elasticities of the Bay of Biscay ecosystem to density-independent and density-dependent influences were estimated within a state space model that accounted for both process and observation uncertainties. A functional group based model for the Bay of Biscay fish ecosystem was fit to time series obtained from scientific survey and commercial catch and effort data. The observation model parameters correspond to the unknown catchabilities and observation error variances...
Introduction Knowledge of internal finger loading during human and non-human primate activities such as tool use or knuckle-walking has become increasingly important to reconstruct the behaviour of fossil hominins based on bone morphology. Musculoskeletal models have proven useful for predicting these internal loads during human activities, but load predictions for non-human primate activities are missing due to a lack of suitable finger models. The main goal of this study was to...
Background Many horse breeds in the world are reserved as genetic resources; however, their characteristics seem to be insufficiently clarified, especially in terms of horse performance. Two jumping ability evaluation methods have been used to compare different types of performance breeds and on this basis their applicability for precision phenotyping has been determined. Methods Jumping data of 186 young Polish Warmblood...
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Abstract Many nonhuman primates adjust their behavior and thrive in human-altered habitats, including towns and cities. Studying anthropogenic influences from an animal’s perspective can increase our understanding of their behavioral flexibility, presenting important information for human–wildlife cohabitation management plans. Currently, research on anthropogenically disturbed wildlife considers either positive or negative aspects of human–wildlife encounters independently, highlighting...
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Abstract Rationale and objectives Rimcazole, a σ-receptor antagonist with affinity for the dopamine transporter (DAT), decreases rates of cocaine self-administration at doses lower than those that affect food-reinforced responding. As response rates are multiply determined, behavioral-economic analyses were used to provide measures of the reinforcing effectiveness of cocaine and food after rimcazole treatment. Further, effects of combinations...
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