Publication date: Available online 10 August 2019Source: Journal of Neuroscience MethodsAuthor(s): M.L. Machado, N. Lefèvre, B. Philoxene, A. Le Gall, S. Madeleine, P. Fleury, P.F. Smith, S. BesnardAbstractBackgroundcompared to previous neuropsychological investigations with standard paper-pen tests limited to test complex spatial learning and memory processes, 3-D virtual immersive technology might offer new tools for research purposes and for diagnosis in patients suffering from mild cognitive...
Publication date: Available online 10 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Xiaoyan Wei, Lin Zhou, Zhen Zhang, Ziyi Chen, Yi ZhouAbstractBackgroundA seizure prediction system can detect seizures prior to their occurrence and allow clinicians to provide timely treatment for patients with epilepsy. Research on seizure prediction has progressed from signal processing analyses to machine learning. However, most prediction methods are hand-engineered and have high computational...
Publication date: Available online 10 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, Gregory A. JichaAbstractBackgroundDisparate research sites using identical or near-identical magnetic resonance imaging (MRI) acquisition techniques often produce results that demonstrate significant variability regarding volumetric quantification of white matter hyperintensities...
Publication date: Available online 9 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Aarti Nagayach, Anshuman Singh, Alfred I. GellerABSTRACTBackgroundWithin a circuit, specific neurons and synapses are hypothesized to have essential roles in circuit physiology and learning, and dysfunction in these neurons and synapses causes specific disorders. These critical neurons and synapses are embedded in complex circuits containing many neuron and synapse types.New MethodWe established technology...
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Abstract Cerebral arteriovenous malformations (AVMs) are frequently associated with concurrent aneurysms. These aneurysms are commonly haemodynamically related to the AVM and can be classified into extranidal or intranidal in reference to the AVM nidus. An aneurysm arising from an artery that does not angiographically contribute to the blood flow to the AVM is uncommon. A distal middle cerebral artery (dMCA) aneurysm itself is also a rare presentation, especially...
Abstract Purpose To investigate white matter microstructural abnormality based on diffusion tensor imaging (DTI) in pediatric patients with fetal repair for myelomeningocele (MMC). Methods This was a retrospective analysis of DTI data from 8 pediatric patients with prenatal MMC repair (age range 1.64–33.70 months; sex 3F/5M) and 8 age-matched controls (age...
Abstract Purpose The aim of this study is to prove the efficacy and safety of intrathecal baclofen therapy in infants and children below 6 years of age by retrospective analysis of our pediatric cohort of 135 primary pump implantations. Methods Between 2007 and 2018, 17 patients with pump implantations were below 6 years of age. Data were acquired retrospectively...
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Publication date: Available online 10 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jordan Court, Charles J Touchette, Christian Iorio-Morin, Harrison J. Westwick, François Belzile, Khaled EffendiABSTRACTChronic subdural hematomas (cSDH) are one of the most frequent reasons for consultation in neurosurgery. Multiple authors have proposed middle meningeal artery embolization (MMAE) as an option in cSDH patients to manage recurrence or avoid surgery altogether. Although many articles...
Publication date: Available online 10 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Tetsutaro Abe, Masashi Miyazaki, Toshinobu Ishihara, Shozo Kanezaki, Naoki Notani, Masashi Kataoka, Hiroshi TsumuraAbstractObjectiveThis study examined the association of spinal epidural lipomatosis (SEL) with liver fat deposition and any other liver dysfunction, except steroid involvement.Patients and MethodsWe analyzed 102 patients (62 men and 40 women; mean age 73.3 years) who underwent spinal...
Publication date: Available online 10 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Samon Tavakoli, John Lacci, Timothy Wong, Daniel A. Godoy, Neveda Murugesan, Ali SeifiAbstractObjectivesOver the last two decades, various studies have evaluated the impact of weekend admission to the hospital on inpatient mortality. Our study sought to identify whether or not the “weekend effect” was true for patients with Intracranial Hemorrhage (ICH) admitted to United States hospitals and whether...
Publication date: September 2019Source: Clinical Neurology and Neurosurgery, Volume 184Author(s):
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jun Chen, Yifeng Zheng, Zirong Chen, Fanfan Fan, Yu WangAbstractObjectivePrimary spinal intradural malignant peripheral nerve sheath tumors (MPNSTs) are exceedingly rare, and there is limited published information regarding these lesions. The purpose of this study was to analyze the clinical course, treatment, and outcome of primary spinal intradural MPNSTs.Patients and MethodsA retrospective study...
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Sagar B. Sharma, Guang-Xun Lin, Hussam Jabri, Naveen D Sidappa, Myung Soo Song, Kyung Chul Choi, Jin-Sung KimAbstractObjectivesLarge Central disc herniations (occupying more than 50% of canal area) are notorious as they are generally associated with worse outcomes and are technically difficult to manage. Transforaminal endoscopy (TELD) has evolved to become an interesting alternative for lumbar disc...
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Ashley Laurence Bharat Raghu, Anthony Wiggins, Jothy KandasamyABSTRACTLumbar disc herniation (LDH) is a rare cause of morbidity in the paediatric population that can result in disruption to education and participation in social and athletic activities. Modern minimally invasive techniques have increasingly been adopted in paediatric spine surgery. The purpose of this review was to assess characteristics...
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Raf Brouns, Alexis Valenzuela Espinoza, Lisa Goudman, Maarten Moens, Jan VerlooyAbstractOnly a disappointingly low proportion of patients successfully engage in professional activities after ischaemic stroke. This systematic review maps all contemporary evidence regarding interventions aiming to promote return-to-work in survivors of ischaemic stroke. We performed a search according to Preferred...
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jie Zang, Wei Guo, Yi Yang, Ran WeiAbstractObjectiveFew studies have reported on the effects of surgery on giant benign sacral neurogenic tumors since these tumors represent a major challenge for surgical oncologists. In the present study, we retrospectively reviewed our experiences in performing resections of giant benign sacral neurogenic tumors using the posterior-only approach via “fishing” method,...
Publication date: Available online 9 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Alankrita Raghavan, James M. Wright, Christina Huang Wright, Berje H. Shammassian, Louisa Onyewadume, Hasina Momotaz, Christopher J. Burant, Martha Sajatovic, Raphael Carandang, Anthony Furlan, Leonard Calabrese, Michael DeGeorgiaAbstractObjectivePrimary CNS Vasculitis (PCNSV) is a rare disease that is often challenging to diagnose. Cerebral angiography and biopsy have been utilized in the diagnostic...
Publication date: Available online 8 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Fabio Pilato, Rosalinda Calandrelli, Marisa Distefano, Marco Panfili, Giacomo Della Marca, Cesare ColosimoAbstractObjective: Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of acute or subacute onset characterized by varied neurological symptoms including headache, impaired visual acuity or visual field deficits, confusion, disorders of consciousness, seizures, and...
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Abstract Introduction Measurement of tumor growth rates over time for patients with meningiomas has important prognostic and therapeutic implications. Our objective was to compare two methods of measuring meningioma volume: (1) the simplified ellipsoid (ABC/2) method; and (2) perimetric volume measurements using imaging software modules. Methods Patients...
Abstract Introduction We conducted a phase Ib study (NCT02345824) to determine whether ribociclib, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), penetrates tumor tissue and modulates downstream signaling pathways including retinoblastoma protein (Rb) in patients with recurrent glioblastoma (GBM). Methods Study participants received ribociclib...
Abstract Purpose Cyclin-dependent kinase (CDK) 4/6 inhibitors are becoming increasingly utilized in the setting of advanced, hormone receptor (HR+) positive breast cancer. Pre-clinical data suggests a potential synergy between radiation therapy (RT) and CDK4/6 inhibitors. We assessed clinical outcomes of patients treated at our institution with the use of CDK4/6 inhibitors and stereotactic radiation in the management of HR+ breast brain...
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Background: Migraine is a chronic disabling neurologic condition that can be treated with a combination of both pharmacologic and complementary and integrative health options. Evidence Acquisition: With the growing interest in the US population in the use of nonpharmacologic treatments, we reviewed the evidence for supplements and behavioral interventions used for migraine prevention. Results: Supplements reviewed included vitamins, minerals, and certain herbal preparations. Behavioral...
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Publication date: October 2019Source: Current Opinion in Neurobiology, Volume 58Author(s): Maoz ShamirRhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top–down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity. We argue that even though the specifics of...
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Publication date: Available online 9 August 2019Source: Brain Research BulletinAuthor(s): Meng-Ru Wang, Xiao-Jian Zhang, Hong-Chun Liu, Wen-Di Ma, Ming-Liang Zhang, Yuan Zhang, Xing Li, Meng-Meng Dou, Yi-Lei Jing, Yao-Juan Chu, Lin ZhuAbstractStressed oligodendrocytes (OLGs) activate microglia to produce an inflammatory response, and the impairment of mitochondria further aggravates OLG damage, which is the earliest pathological change in multiple sclerosis (MS), an inflammatory demyelinating disease...
Publication date: Available online 8 August 2019Source: Brain Research BulletinAuthor(s): Angelina Rakovska, Daniel Javitt, Polina Petkova-Kirova, Andrea Balla, Rosalind Ang, Reni KalfinA B S T R A C TElevated striatal dopamine release is thought to be one of the hallmarks of schizophrenia and correlates with its positive symptoms. Cysteamine (2-aminoethane-1-thiol), a compound naturally found in mammalian cells, inhibits amphetamine-induced dopamine-mediated increases in locomotor activity and behavior...
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Stereotact Funct Neurosurg 2019;97:139–139
Stereotact Funct Neurosurg 2019;97:138–138
Stereotact Funct Neurosurg 2019;97:137–137
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Journal of Neurotrauma, Ahead of Print.
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Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Valeria Marques Figueira Muoio, Miyuki Uno, Sueli Oba-Shinjo, Roseli da Silva, Benedito Jamilson Araújo Pereira, Carlos Clara, Hamilton Matushita, Suely K.N. Marie
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Brahim Kammoun, Houda Belmabrouk, Fatma Kolsi, Omar Kammoun, Rim Kallel, Mouna Ammar, Mouna Kallel, Mohamed Amine Mseddi, Mohamed Zaher BoudawaraBackgroundPheochromocytoma brain metastasis is extremely rare. Few cases have been reported in the literature. Therefore, diagnosis and effective treatment of these lesions are difficult.Case DescriptionHere, we report the case of 29-year-old woman, who was operated on for a right...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Hrishikesh Dadhich, Ravi Sharma, Sachin Anil Borkar, Atmanranjan Dash, Swati Mahajan, Mehar Chand SharmaBackgroundPleomorphic xanthoastrocytomas (PXAs) are a rare type of astrocytoma, which, similar to other gliomas, can rarely arise from glial nests in the meninges, manifesting as an extra-axial mass. We describe a solitary extra-axial intracranial primary meningeal PXA in the pediatric age group, which was masquerading...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Cédric Baltus, Sébastien Toffoli, Frédéric London, Paul Delrée, Claude Gilliard, Thierry GustinBackgroundChromothripsis is characterized by a multitude of chromosomal rearrangements during a unique cataclysmic event in a cell life. Disintegration of one or several chromosomes is followed by a chaotic rearrangement of generated fragments. It might play a role in oncogenesis and tumor progression. It is observed in 2%–3%...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Rahil Rafiq, Ravi Sharma, Sachin A. BorkarVestibular schwannomas (VSs) are rare in children and, when present, are usually part of neurofibromatosis 2 and bilateral. Sporadic unilateral VSs in the pediatric age group itself are rare in medical literature and giant sporadic unilateral pediatric VSs (>4 cm) are extremely rare. Herein, we describe the largest reported case of giant sporadic left-sided VS in a 10-year-old...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Neil D. Almeida, Andrea L. Klein, Elizabeth A. Hogan, Samantha J. Terhaar, Jayanidhi Kedda, Prayerna Uppal, Kenneth Sack, Michael Keidar, Jonathan H. ShermanGlioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in adults. GBM carries a dismal prognosis because of its proliferative, invasive, and angiogenic capabilities and because of its ability to downregulate the immune system. Immune-based...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Whitfield Lewis, Hamidreza Saber, Mahsa Sadeghi, Gary Rajah, Sandra NarayananBackgroundIn patients who have failed systemic anticoagulation therapy, various endovascular approaches may assist in emergent recanalization.MethodsWe searched the PubMed database from January 1999 to August 2018 for studies that reported endovascular treatment modalities and associated clinical outcomes including recanalization, functional independence,...
Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Hiroshi Kondo, Yoshihiro Kiura, Shinichiro Takeshita, Takuro Magaki, Tetsuhiko Sakoguchi, Tomoya Mukai, Yuyo Maeda, Atsushi Tominaga, Kaoru KurisuBackgroundUse of angioscopy to directly observe the stent lumen in the chronic phase after carotid artery stenting (CAS) has not been reported to date. Here we report 3 patients in whom angioscopy helped confirm the stent lumen during retreatment after CAS.Case DescriptionCase...
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Abstract Gerstmann‐Sträussler‐Scheinker syndrome (GSS) with the P102L mutation is a rare genetic prion disease caused by a pathogenic mutation at codon 102 in the prion protein gene. Cluster analysis encompassing data from seven Czech patients and 87 published cases suggests the existence of four clinical phenotypes (“typical GSS,” “GSS with areflexia and paresthesia,” “pure dementia GSS,” and “Creutzfeldt‐Jakob disease‐like GSS”); GSS may be more common than previously estimated. In making a clinical...
ABSTRACT Objective To evaluate the effect of a decrease in blood pressure (BP) fulfilling the diagnostic criteria for orthostatic hypotension (OH) on performance in each domain of cognitive function in patients with type 2 diabetes mellitus using a cross‐sectional and within‐group design. Methods Subjects were individuals without dementia and with type 2 diabetes mellitus, including 107 individuals without OH and 94 with OH (DMOH); 95 control participants were also included. Blood pressure...
Abstract Objective Vagus nerve stimulation (VNS) is a common treatment for medically‐intractable epilepsy, but response rates are highly variable with no pre‐operative means of identifying good candidates. This study aimed to predict VNS response using structural and functional connectomic profiling. Methods Fifty‐six children, comprising Discovery (N = 38) and Validation (N = 18) Cohorts, were recruited from three separate institutions. Diffusion tensor imaging was used to identify group...
Abstract Objectives CLN3 disease is the commonest form of neuronal ceroid lipofuscinoses (NCLs), a group of pediatric neurodegenerative disorders. Functions of the CLN3 protein (CLN3p) include anti‐apoptotic properties, and, facilitating anterograde transport of galactosylceramide from Golgi to lipids rafts. This study confirms the beneficial effects of long‐term exogenous galactosylceramide supplementation on longevity, neurobehavioral parameters, neuronal cell counts, astrogliosis, and diminution...
ABSTRACT Objective To establish the effects induced by long‐term, unilateral stimulation of parvalbumin‐positive (PV) interneurons on seizures, interictal spikes and high‐frequency oscillations (80‐500 Hz) occurring after pilocarpine‐induced status epilepticus (SE) ‐ a proven model of mesial temporal lobe epilepsy (MTLE) ‐ in transgenic mice expressing or not expressing ChR2. Methods PV‐ChR2 (n = 6) and PV‐Cre (n = 6) mice were treated with pilocarpine to induce SE. Three hours after SE...
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Related ArticlesEndovascular stenting for rescue of a failed donor graft during superficial temporal artery to middle cerebral artery bypass surgery: case report. J Neurosurg Pediatr. 2019 Aug 09;:1-5 Authors: LoPresti MA, Srinivasan VM, North RY, Ravindra VM, Johnson J, Burkhardt JK, Lam SK, Kan P Abstract Direct bypass has been used to salvage failed endovascular treatment; however, little is known of the reversed role of endovascular management for...
Related ArticlesMechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series. J Neurosurg Pediatr. 2019 Aug 09;:1-14 Authors: Bhatia K, Kortman H, Blair C, Parker G, Brunacci D, Ang T, Worthington J, Muthusami P, Shoirah H, Mocco J, Krings T Abstract OBJECTIVE: The role of mechanical thrombectomy in pediatric acute ischemic stroke is uncertain, despite extensive evidence of benefit in adults....
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Abstract We outline what we believe could be an improvement in future discussions of the brain acting as a Bayesian‐Laplacian system. We do so by distinguishing between two broad classes of priors on which the brain's inferential systems operate: in one category are biological priors (β priors) and in the other artifactual ones (α priors). We argue that β priors, of which colour categories and faces are good examples, are inherited or acquired very rapidly after birth, are highly or relatively resistant...
Abstract Although steroids are suggested as the treatment of choice for infantile spasms, the mechanism of action is still unclear. Using a rat model of malformation of cortical development with refractory infantile spasms, we evaluated the efficacy of methylprednisolone on spasms susceptibility and behaviors. Additionally, we investigated the in vivo electrophysiological and neurochemical changes of the brain after methylprednisolone treatment. Infant rats with prenatal exposure of methylazoxymethanol...
Abstract Motor cortical contribution was shown to be important for balance control and for ballistic types of movements. However, little is known about the role of cortical inhibitory mechanisms and even less about long(er)‐term adaptations of these inhibitory processes. Therefore, the aim of the present study was to investigate the role of intracortical inhibition before and after four weeks of explosive or balance training. Two groups of subjects participated for four weeks either in an explosive...
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