201.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2185-2188.
[Oral Floor Reconstruction with Digastric Muscle Bipedicle Flap for Advanced Tongue Cancer in Very Elderly Patients-Report of Two Cases].
[Article in Japanese]
Abstract
In recent years, the opportunity to treat oral cancer in elderly patients has been increasing because of the increased lifespan of individuals. Standard treatment for advanced tongue cancer involves reconstruction of the tongue with a free vascularized flap. However, this may not always be suitable for elderly patients because the procedure is lengthy and invasive and also because of their medical history. We report 2 cases of elderly patients undergone oral floor reconstruction with digastric muscle bipedicle flap for advanced tongue cancer. In case 1, an 86-year-old woman underwent pull-through ablation surgery with partial glossectomy and modified radical neck dissection for the treatment of left-sided tongue cancer(well-differentiated squamous cell carcinoma, cT3N2bM0, Stage ⅣA). In case 2, a 93-year-old man underwent pull-through ablation surgery with hemiglossectomy and suprahyoid neck dissection for treatment of right-sided tongue cancer(verrucous carcinoma, cT3N0M0, Stage Ⅲ). In both patients, the flap was sutured to the mandibular border, mandibular periosteum and surrounding tissue, and the intraoral mucosa and neck were isolated. Compared to the reconstruction of the tongue with a free vascularized flap, the procedure used in these 2 cases was shorter and caused less bleeding. Moreover, the patients exhibited no postoperative dysfunction, and clinical outcome remained favorable. We believe that oral floor reconstruction with digastric muscle bipedicle flap at the bottom of the mouth was effective in reducing surgical stress and restoring oral function in very elderly patients.
202.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2182-2184.
[Incidence of Catheter-Related Thrombosis in Patients with Long-Term Indwelling Central Venous Port Who Received Chemotherapies for Unresectable Advanced Digestive Cancers].
[Article in Japanese]
Tanioka H1, Asano M, Kawasaki K, Yoshida R, Waki N, Uno F, Ishizaki M, Yamashita K, Katata Y, Sano F, Okawaki M, Yamamura M, Nagasaka T, Yamaguchi Y.
Abstract
BACKGROUND:
Most patients with unresectable advanced digestive cancers require placement of a fully implantable venous access port to facilitate safe delivery of anti-cancer drugs. Anti-VEGF therapies are commonly used even though they increase the risk of thrombosis. The objective of this study was to assess the incidence of radiologically confirmed catheter-related thrombosis(CRT)in patients with advanced digestive cancers.
METHODS:
We retrospectively reviewed 88 patients with advanced digestive cancers who had adapted implantable ports placed in our institution for chemotherapy.
RESULTS:
Thirty-nine patients were diagnosed with colorectal cancer, 26 with gastric cancer, 12 with pancreatic cancer, 8 with esophageal cancer, and 3 with other cancers. During follow-up, 22 patients(25%)received anti-VEGF therapies, while 66 patients(75%)did not. Four out of 88 patients(4.5%)had asymptomatic CRT. The incidence of CRT was the same(4.5%)regardless of whether the patient received anti-VEGF therapy.
CONCLUSIONS:
In patients with digestive cancers who had implantable venous access ports, the incidence of the CRT was 4.5% with no association with anti-VEGF therapies.
203.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2179-2181.
[Two Cases of Surgery Combined with Intraoperative Radiofrequency Ablation for Colorectal Cancer and Synchronous Liver Metastases].
[Article in Japanese]
Shirouzu Y1, Muroya D, Nakame A, Murayama M, Kuratsu S, Kadoya K, Kishimoto Y, Otsuka H, Sakai H, Ishikawa H, Hisaka T, Tayama K, Okabe M, Okuda K, Tanaka H.
Abstract
The therapeutic management of simultaneous liver metastasis of colorectal cancer(SCRLM)remains controversial. Although hepatic metastasectomy is the first choice for resectable liver metastasis of colorectal cancer, radiofrequency ablation (RFA)is one of the least invasive application for patients who refuse more invasive treatment such as hepatectomy and longterm systemic chemotherapy or for whom such treatment is not suitable. We report 2 cases of SCRLM treated by surgery combined with intraoperative RFA and adjuvant chemotherapy, raising the possibility of local control in the liver for selected patients.
204.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2176-2178.
[Digestive Surgery Intervention for Gynecological Malignant Tumor].
[Article in Japanese]
Kameyama H1, Shimada Y, Abe K, Oyanagi H, Nakano M, Nakano M, Ichikawa H, Hanyu T, Takizawa K, Nagahashi M, Sakata J, Kobayashi T, Nishikawa N, Enomoto T, Wakai T.
Abstract
AIM:
This study aimed to determine surgical outcomes in patients with gynecological cancers for whom surgery was performed by gynecologists and digestive surgeons.
METHODS:
Seventy-three patients who underwent surgery for a gynecological malignant tumor from January 2010 to December 2014 were included in this retrospective study. Data on the definitive diagnosis, operative procedures, postoperative complications, stoma settings, length of hospital stay, and prognosis was collected for each patient.
RESULTS:
The median age of this female-only cohort was 60 years. Emergency surgery was performed in 8(11.0%)patients. Ovarian cancer was diagnosed in 56(76.7%)patients, and among these patients, the clinical disease Stage was Ⅰ, Ⅱ, Ⅲ, and Ⅳ in 4, 4, 20, and 11 patients, respectively. Moreover, 17 patients had recurrent ovarian cancer. Intestinal resection with anastomosis was performed in 25(34.2%)patients. Stoma formation was performed in 22 (30.1%)patients, however no patient underwent stoma closure surgery in the current study. The median operative time was 252 minutes, and the median blood loss was 1,190 mL. Regarding postoperative complications, ileus, pelvic abscess, and anastomotic leakage developed in 6(8.2%), 4(5.5%), and 2(2.7%)patients, respectively. The postoperative median survival time in patients with ovarian cancer was 1,399 days.
CONCLUSION:
These results suggest that tumor debulking, including intestinal tract resection, may contribute to the prolonged prognosis of gynecological tumors, although stoma closure is difficult to perform.
205.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2173-2175.
[Neoadjuvant Triplet Combination Chemotherapy(UDON Therapy)in Esophageal Cancer Patients with Impaired Renal Function-A Retrospective Study].
[Article in Japanese]
Kimura Y1, Shiraishi O, Iwama M, Kato H, Kawakami H, Okuno T, Hiraki Y, Yasuda A, Shinkai M, Imano M, Nakagawa K, Yasuda T.
Abstract
BACKGROUND:
In Japan, pre-operative 5-FU and cisplatin(CDDP)(FP)combination therapy has been the standard neoadjuvant chemotherapy(NAC)for advanced resectable esophageal cancer(EC); furthermore, the efficacy of the docetaxel (DTX)-containing triplet regimen, FP plus DTX, has been reported. However, patients with impaired renal function should not receive high-dose CDDP. We have been developing a non-CDDP-containing triplet regimen, comprising 5-FU, DTX, and nedaplatin(NED)(UDON), on a phase Ⅰ/Ⅱtrial basis. This retrospective study aimed to investigate the safety and efficacy of NAC with UDON in advanced EC patients with impaired renal function.
METHODS:
Five patients with advanced resectable EC with impaired renal function were enrolled in this study. Patients received NAC(5-FU, 640mg/m / 2, days 1-5; DTX, 28 mg/m2, days 1 and 15; and NED, 72mg/m2, day 1, q28, 2 courses); following this, they underwent esophagectomy. The primary endpoint was response rate, and the secondary endpoint was adverse event(AE).
RESULTS:
The median age was 79 years (range: 58-80 years). The ECOG performance status was 1/2 : 3/2. The main tumor locations were Ce/Ut/Mt : 1/1/3 and the cStages were ⅡA/ⅢA/ⅢC : 1/2/2. The RR(CR/PR/SD/PD : 0/4/1/0)was 80%. The pathological response was grade 1a/1b : 2/3. Major grade 3 or 4 AEs included neutropenia(40%), febrile neutropenia(20%), diarrhea(20%), and hyponatremia( 40%). There was no treatment-related death or reoperation.
CONCLUSIONS:
NAC with UDON might be feasible and effective in patients with advanced resectable EC with impaired renal function, who are ineligible for high-dose CDDP administration. We are planning a phaseⅡclinical study based on the present results.
206.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2170-2172.
[Differences in Treatment Effect between Local and Distant Lesions in Breast Cancer Patients Administered Neoadjuvant Endocrine TherapyGuided byOncoty pe DX-A Case Report].
[Article in Japanese]
Abstract
We report different treatment effects between local and distant lesions based on oncotype DX in a patient with breast cancer administered neoadjuvant endocrine therapy. The patient was a 50-year-old woman. Ultrasound(US)showed a mass 16×11×11mm in diameter in the C area of her right breast. Histological examination revealed invasive ductal carcinoma positive for estrogen and progesterone receptor and negative for human epidermal growth factor receptor type 2(HER2), and a Ki-67 index of 38%. The recurrence score(RS)calculated from the core needle biopsy was 4(low-risk group)with a predicted 10-year risk of distant recurrence of 4% after 5 years of endocrine therapy. Oncotype DX showed that this patient would not benefit from chemotherapy. We administered neoadjuvant endocrine therapy. However, the tumor size increased to 26×18×15mm 1 month after treatment initiation. Therefore, right breast-conserving surgery and sentinel lymph node biopsy were performed. Histopathologically, the effect of the endocrine therapy was grade 0 and the surgical margins were negative. Even though RS was low in the breast, the effect of endocrine therapy differed between local and distant lesions such as circulating tumor cells.
207.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2167-2169.
[Pancreatic Leiomyosarcoma with a Difficult Preoperative Diagnosis-A Case Report].
[Article in Japanese]
Mitachi K1, Ishida M, Omori Y, Furukawa T, Ariake K, Masuda K, Ohtsuka H, Mizuma M, Nakagawa K, Morikawa T, Hayashi H, Motoi F, Naitoh T, Kamei T, Unno M.
Abstract
A 43-year-old man was referred to our hospital for examination of a pancreatic tumor. Imaging revealed a mass-like lesion with a cyst in the pancreatic tail. Histological examination by EUS-FNA showed a low grade spindle cell lesion for which laparoscopic distal pancreatectomy was performed. The neoplasm was histologically diagnosed as pancreatic leiomyosarcoma. The postoperative course was uneventful and no signs of recurrence at 8 months after the surgery. Pancreatic leiomyosarcoma is very rare. Only 7 previous cases were reported in Japan. In tumors with diameters exceeding 50 mm, bleeding and necrosis occur inside the tumor and a cyst-like form often develops, which is considered a characteristic imaging finding. Therefore, imaging is important for preoperative differential diagnosis of the disease.
208.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2164-2166.
[A Case of Mesenteric Hematoma Caused by Abdominal Metastasis of Small Cell Lung Carcinoma].
[Article in Japanese]
Sakano Y1, Ohtsuka M, Mikamori M, Saito T, Furukawa K, Suzuki Y, Imasato M, Kishi K, Tanemura M, Akamatsu H.
Abstract
Chemoradiation was performed at Osaka Police Hospital's department of respiratory medicine on a 70-year-old male with small cell lung carcinoma(cT4N3M0, cStage ⅢC). Subsequent to secondary chemotherapy for multiple bone metastases that had been observed, he received care to control the disease. He arrived at the hospital complaining of epigastric pain. He got CT-scan and was referred to our department because of a suspected hematoma around the right gastroepiploic artery. He was treated conservatively because circulatory dynamics were steady and there was no indication that anemia had progressed. However, when a test laparotomy was performed the day after the start of treatment because he presented with decreased blood pressure and progressive anemia, a massive hematoma was found around the right gastroepiploic artery. The hematoma was removed, and hemostasis was performed. Based on the pathological findings of the excised specimen, he was diagnosed with abdominal metastasis of small cell lung carcinoma. This is a report on our experience and a literature review on a case of mesenteric hematoma caused by abdominal metastasis of small cell lung carcinoma.
209.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2161-2163.
[A Case of Appendiceal Neuroendocrine Tumor Diagnosed after Appendectomy].
[Article in Japanese]
Sasaki M1, Wada Y, Ishibashi N, Adachi M, Tomii C, Watanabe Y, Kamiya A, Oshima N, Goto H, Koshiishi H, Yoshimura T.
Abstract
A 25-year-old woman visited our hospital with a complaint of right lower abdominal pain. As a result of the examination, she was diagnosed as having acute appendicitis. After conservative treatment, we planned an elective surgery. At 3 months after discharge, laparoscopic appendectomy was performed. We found a mass of 10mm in diameter at the body of the appendix. Histopathological examination revealed the proliferation of heteromorphic cells with small round nuclei. It was positive for chromogranin A and synaptophysin in immunostaining, so we made a diagnosis of NET G1. Tumor cells infiltrated beyond the intrinsic muscle layer, but no vascular invasion was observed, and the margin was negative. In accordance with the guidelines, we followed up the patient with imaging examination and did not find any signs of recurrence.
210.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2158-2160.
[Palliative Laparoscopic Operation for an Extremely Elderly Patient with Cecum Cancer].
[Article in Japanese]
Abstract
Symptomatic colorectal cancer in extremely elderly patients is difficult to treat. A 97-year-old woman was initially suspected of having appendicitis because of worsening right lower abdominal pain with persistent fatigue. After antimicrobial therapy, advanced cecum cancer with lymph node involvement was found. Palliative laparoscopy-assisted ileocecal resection without radical lymph node dissection was performed to prevent further inflammation. The patient was transferred to another hospital for rehabilitation on postoperative day 24, when she regained walking function. This palliative procedure can be an effective treatment for elderly patients with symptomatic advanced colon cancer.
211.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2155-2157.
[A Case of Nephrotic Syndrome Induced by FOLFIRI plus Ramucirumab for Metastatic Descending Colon Cancer].
[Article in Japanese]
Shingai T1, Fukuzaki T, Okimura S, Ito Y, Taniguchi Y, Fukata T, Nishida H, Takayama O, Yoshioka S, Hojo S, Ohigashi H.
Abstract
We report a case of multiple lung metastases of RAS mutant type descending colon cancer with development of nephrotic syndrome after the introduction of FOLFIRI plus ramucirumab(RAM). A female patient in her 50s underwent adjuvant chemotherapy with capecitabine and oxaliplatin after primary tumor and partial lung resection. For recurrent multiple lung metastases, 4 years of capecitabine and bevacizumab therapy was administered. FOLFIRI plus RAM therapy was introduced because of tumor progression. After treatment, the patient showed increased urine protein content, decreased serum albumin levels, marked hypertension, and increased edema, and was diagnosed with nephrotic syndrome. The patient's condition improved with prednisolone, additional doses of antihypertensive, and diuretics. Even in cases where it is possible to control proteinuria during bevacizumab administration, it is necessary to keep in mind that RAM administration as second-line therapy may cause nephrotic syndrome.
212.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2152-2154.
[A Case of Locally Advanced Breast Cancer Successfully Treated with Epirubicin/Cyclophosphamide].
[Article in Japanese]
Abstract
A 66-year-old woman was referred to our hospital with the chief complaint of a huge exposed left breast mass with bleeding. Triple-negative invasive ductal carcinoma of the breast was diagnosed by core needle biopsy. Computed tomogra- phy showed axillary and infraclavicular lymph node metastases. Epirubicin/cyclophosphamide(EC)therapy was started. We reduced the dose to 80%during courses 2-4. After 4 courses of treatment, CT showed a complete response. We reduced the dose to 50% during courses 5-12 and stopped chemotherapy. Five years have passed without recurrence since the first treatment.
213.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2149-2151.
[A Case Report of a Patient Over 90 Years of Age with Liver Metastasis after Sigmoid Colectomy Controlled by a Combination Oral UFT/LV Chemotherapy Regimen].
[Article in Japanese]
Abstract
A92 -year-old woman underwent laparoscopic sigmoid colectomy with D3 lymphadenectomy. Histological examination confirmed a pT3(SS), pN0, pM0, pStageⅡ tumor. Abdominal CT 6 months after surgery revealed liver metastasis close to the right branch of the portal vein in the S6 region of the liver. There were no indications for transcatheter arterial embolization, radiofrequency ablation, or hepatectomy. Although she had Grade 3 neutropenia, the patient received 15 courses of oral UFT/LV. Three courses of UFT/LV plus bevacizumab were also administered. She was judged to have achieved stable disease (SD); however, Grade 4 proteinuria was observed. After she was administered 2 courses of TAS-102, we shifted to best supportive care. She died of a sigmoid cancer 32 months after UFT/LV initiation. Careful adaptation of chemotherapy can be used to control a patient's condition during certain periods, even in patients with super-advanced age.
214.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2146-2148.
[A Case of Two-Stage Combined Resection of Cervical Esophageal Cancer with Bulky Right Supraclavicular Lymph Node Metastasis Invading the Right Common Carotid Artery].
[Article in Japanese]
Yamamoto K1, Makino T, Yamasaki M, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Nakajima K, Mori M, Doki Y.
Abstract
R0 resection has been reported to be an important prognostic factor for the treatment of T4 esophageal cancer, Here, we report a resected case of cervical esophageal cancer with bulky right supraclavicular lymph node metastasis infiltrating the right brachiocephalic trunk. A combined arterial resection of metastatic lymph node with artificial vessel replacement preceded the primary tumor resection because simultaneous resection or reconstruction of the digestive tract could cause a fatal infection at the replaced artificial vessel. R0 resection was eventually achieved without any postoperative infectious complications. In the combined arterial resection of locally advanced esophageal cancer, a two-stage operation with a different surgical field setting might be useful to prevent fatal infection at the replaced artificial vessel.
215.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2143-2145.
[Effectiveness of Chemoradiotherapy for the Treatment of Local Recurrence in Rectal Cancer-A Case Report].
[Article in Japanese]
Hara K1, Yamada T, Koizumi M, Shinji S, Matsuda A, Oota R, Takahashi G, Hotta M, Takeda K, Ueda K, Kuriyama S, Yoshida H.
Abstract
Chemoradiotherapy(CRT)for locally recurrent rectal cancer can shrink the tumor and permit R0 resection; however, its effectiveness and safety have not been established. Herein, we report a case of a 60s man with locally recurrent rectal cancer invading the surrounding organs who was administered CRT followed by R0 laparoscopic-assisted abdominoperineal resection( APR). Local recurrence was detected 11 months after laparoscopic-assisted low anterior resection(pT3N0M0, pStage Ⅱ). After tumor shrinkage by CRT(capecitabine 3,000mg/day plus 45 Gy/25 Fr), laparoscopic-assisted APR was performed. The pathological findings showed a pathological complete response(pCR). The patient had not experienced recurrent disease at 6 months after the second surgery. CRT may improve the prognosis of patients with locally recurrent rectal cancer, especially those with possibly unresectable tumors.
216.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2140-2142.
[A Case with Long Survival after Total Remnant Pancreatectomy for Recurrence of Pancreatic Body Cancer].
[Article in Japanese]
Omi K1, Matsuo Y, Ueda G, Hayashi Y, Imafuji H, Saito K, Tsuboi K, Morimoto M, Ogawa R, Takahashi H, Takiguchi S.
Abstract
A 56-year-old man underwent distal pancreatectomy due to pancreatic body carcinoma in 2009, at the age of 46. There had been no sign of metastasis and recurrence until levels of tumor markers began to increase in January 2014. PET scan, CT scan, and other examinations showed a possible carcinoma in the pancreas head. The patient underwent total remnant pancreatectomy. The tumor was located in the uncinate process of the pancreas with infiltration of the portal vein. The pathological diagnosis of the tumor was moderately differentiated adenocarcinoma. The ductal lumen structure was relatively maintained and the cytoplasm was comparatively clear. Since its pathological findings were similar to those observed in 2009, the tumor appeared to be a recurrence of the tumor resected at that time. The patient had received postoperative chemotherapy and remains alive in 2019 without recurrence. While there is evidence that surgical resection for the recurrence of other cancers such as colon cancer may improve patient survival, it remains unclear if surgical resection of recurrence in the remnant pancreas after pancreatectomy of pancreatic cancer is feasible. We report a case with long survival after surgical resection of a pancreatic carcinoma recurrence in the remnant pancreas.
217.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2137-2139.
[A Case of Metaplastic Squamous Cell Carcinoma of the Breast Successfully Treated with S-1].
[Article in Japanese]
Abstract
Metaplastic squamous cell carcinoma(MSCC)of the breast is very unusual and is histologically characterized by rapid progression. Conventionalchemotherapy for ductalcarcinoma of the breast is ineffective against MSCC. Here, we report a case of MSCC of the breast successfully treated with S-1. A 57-year-old woman was admitted to our hospital because of a left breast tumor. A tumor approximately 10 cm in diameter was palpable in the lower-outer quadrant(D region)of the left breast. Core needle biopsy indicated estrogen receptor(ER)-negative, progesterone receptor(PR)-negative, and human epidermalgrowth factor receptor 2(HER2)-negative MSCC of the breast. Computed tomography(CT)showed left axillary lymph node metastases but did not indicate distant metastasis. A diagnosis of T4N3cM0, Stage ⅢC, MSCC of the left breast was made. Each treatment course consisted of the administration of S-1(120mg/body/day)for 4weeks, followed by 2 drugfree weeks. After the second course, significant tumor and lymph node reduction was observed. We concluded that S-1 chemotherapy seems to be effective for patients with MSCC of the breast.
218.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2134-2136.
[A Case Report of Gastrointestinal Bleeding with Difficulty in Diagnosis].
[Article in Japanese]
Abstract
The authors report a case involving a 55-year-old female patient who presented with melena and anemia 8 years ago. Esophagogastroduodenoscopy, colonoscopy, and CT did not reveal any sign of lesions except multiple uterine myoma. On reevaluation after the onset of melena, we did not find any lesions. However, the patient had a recurrent episode of melena with progressive anemia(Hb level 12.8 g/dL→9.8 g/dL). CT revealed a 29mm mass in the right side of the pelvis, which was retrospectively observed in the past CT scan, although its position had changed. We suspected gastrointestinal stromal tumor (GIST). Small intestine fluoroscopy revealed the tumor with effusion of barium inside the translucent areas of the ileum. For diagnostic treatment, laparoscopic partial jejunum resection was performed. Pathological diagnostic examination revealed that the tumor consisted of spindle cell disarray with moderate density, fewer heterocysts, and rare mitosis. The tumor cells were c-kit positive and CD34 negative in immunohistochemistry. All the results were consistent with GIST. Eight years had passed before diagnosis and surgical treatment were performed. This case report emphasizes the difficulty of diagnose of GIST because of its low malignancy and slow progression.
219.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2131-2133.
[Locally Advanced Breast Cancer Treated with Mohs' Paste and Neoadjuvant Chemotherapy-A Case Report].
[Article in Japanese]
Abstract
Cutaneous infiltration by breast cancer significantly reduces patient quality of life(QOL)due to bleeding, exudate, and pain. We report a case of combined treatment using Mohs' paste and neoadjuvant chemotherapy for locally advanced breast cancer. Mohs' paste decreased bleeding and exudate from the tumor and neoadjuvant chemotherapy combined with bevacizumab down-staged a large tumor to a volume that permitted mastectomy. Good local control using Mohs' paste and neoadjuvant chemotherapy can improve patient QOL and reduce the physical burden.
220.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2128-2130.
[A Case Report of Long-Term Survival of Metastatic Breast Cancer Treated with Mohs Paste and Systemic Therapy].
[Article in Japanese]
Takahashi M1, Okazaki S, Fukahori M, Taguchi K, Minoshima K, Suematsu Y, Yan M, Saito H, Teranishi N, Wakabayashi K, Itoh Y.
Abstract
The patient was a 75-year-old woman who had experienced left breast cancer(BT plus AX)in 1988. Local recurrences in the skin of the left chest wall appeared and were treated with operation, radiotherapy, and systemic therapy. Twenty-four years later, she developed continuous bleeding due to skin metastasis of the breast cancer and received Mohs chemosurgery and continued systemic therapy. After using Mohs paste 10 times, the skin surface healed and dried up. Improving the quality of life of patients with several symptoms such as skin cancer or metastatic skin lesions is essential in multidisciplinary therapy and Mohs paste was useful for the local control of the unresectable skin lesion.
221.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2125-2127.
[A Case of Peritoneal Metastasis of Appendiceal Mucinous Carcinoma Successfully Managed by Multidisciplinary Treatment].
[Article in Japanese]
Yamamoto E1, Muta Y, Itou T, Chikatani K, Yamamoto A, Muramatsu S, Toyomasu Y, Hatano S, Suzuki O, Amano K, Ishiguro T, Kumagai Y, Ishibashi K, Mochiki E, Ishida H.
Abstract
There is no established treatment for appendiceal mucinous adenocarcinoma. When this condition is complicated by pseudomyxoma peritonei(PMP), multidisciplinary treatment is often administered. A 40-year-old woman was diagnosed with right ovarian cancer for which laparotomy was performed. At the time of laparotomy, we considered the tumor to be an appendiceal carcinoma infiltrating the right ovary and performed ileocecal resection with lymph node dissection(D3)and right salpingo-oophorectomy. The pathological diagnosis was stage pT3, pN0, pM0, pStage Ⅱ mucinous adenocarcinoma of the appendix. Fourteen months later, the patient underwent abdominal total hysterectomy and left salpingo-oophorectomy because a CT scan suggested recurrence in the uterus, left fallopian tube, and ovary. Seventeen months after the second operation, despite adjuvant chemotherapy, CT revealed a peritoneal nodule in the pelvic cavity. Therefore, we administered chemotherapy comprising 5 lines for 32 months, which resulted in failure. CT showed an enlarged tumor and ascites and the patient became terminally ill. We repeatedly performed cytoreduction surgery and intraperitoneal chemotherapy, which improved her QOL. One year after discharge, abdominal CT showing an abdominal wall and intraperitoneal mass. We performed again cytoreduction surgery and intraperitoneal chemotherapy. Her postoperative course is good and she is currently an outpatient.
222.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2122-2124.
[A Case of Jejunal Ectopic Pancreatic Cancer with Intestinal Perforation].
[Article in Japanese]
Abstract
This patient was a 96-year-old woman. She was referred to our hospital with abdominal pain and vomiting. The levels of the tumor markers CEA and CA19-9 were elevated, at 39.47 ng/mL and 918.5 U/mL, respectively. She was diagnosed with peritonitis with digestive tract perforation by abdominal CT and an emergency operation was performed. At laparotomy, dirty ascites was observed in the peritoneal cavity. A perforation, 1 cm in diameter was found in the jejunum 15 cm from the Treitz ligament, and a mass, 2 cm in diameter was also palpated on the mesentery side. We performed jejunectomy including the tumor. The submucosal tumor was 2 cm in size and the mucosal surface of the perforation was ulcerated. Pathohistological inspection of the extracted sample revealed no heteromorphism in the small intestine mucosal plane. A moderately differentiated adenocarcinoma was diagnosed in the submucosal layer of the heterotopic pancreas of Heinrich typeⅡ. No tumor cells were found in the perforation. Thirteen previous cases of ectopic pancreatic cancer have been reported and this was the 14th case.
223.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2119-2121.
[A Case of Rectal Obstruction Due to Gastric Cancer Dissemination for Which Rectal Stenting Was Performed Twice].
[Article in Japanese]
Miyazawa M1, Katsube T, Nishiguchi R, Asaka S, Yamaguchi K, Usui T, Yokomizo H, Shiozawa S, Shimakawa T, Naritaka Y.
Abstract
Malignant colorectal obstruction results in a worse quality of life and makes it difficult for patients to continue chemotherapy. In this paper, we present a case of rectal obstruction caused by gastric cancer dissemination for which rectal stent insertions were performed twice. The patient was a 72-year-old woman. She underwent gastrectomy for Stage Ⅳ gastric cancer (ypT3, N1, M1, P0, H0, CY+). Twenty-eight months after gastrectomy, she experienced rectal obstruction due to peritoneal dissemination. A rectal stent was placed at the stenosis site. She was administered chemotherapy after stenting. Seven months later, she developed rectal obstruction due to tumor in-growth. Rectal stenting was performed again. Subsequently, the patient had no abdominal symptoms until she died, 2 months after the second stenting.
224.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2116-2118.
[A Case of Solitary Right Adrenal Metastasis from Rectal Cancer].
[Article in Japanese]
Abstract
An 86-year-old woman underwent laparoscopic high anterior resection for RS rectal cancer. Histological examination showed tub2-por, pT3, pN2a, Stage ⅢB disease. Given the age of the patient, adjuvant chemotherapy was not administered. Five months after the surgery, her carcinoembryonic antigen(CEA)level was elevated and a 42×25mm mass was detected in the right adrenalby computed tomography(CT). Metastasis from rectalcancer was suspected but no other lesions were detected by positron-emission tomography(PET)-CT. Nine months after the surgery, laparoscopic right adrenalectomy was performed. Histological examination revealed that the right adrenal tumor had moderately-differentiated adenocarcinoma very similar to the primary rectalcancer; therefore, the right adrenall esion was diagnosed as metastasis from the previous rectalcancer. The tumor marker levelreturned to normall evelafter the second surgery. The patient was discharged on the 8th post-operative day but declined adjuvant chemotherapy due to her age. Six months later, liver, lung, and peritoneal metastasis were identified by CT. We report this case of solitary adrenalmetastasis from rectalcancer resected by laparoscopic right adrenalectomy.
225.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2113-2115.
[A Case of Robot-Assisted Laparoscopic Lower Anterior Resection and Total Hysterectomy with Transvaginal NOSE].
[Article in Japanese]
Wada T1, Enomoto M, Kasahara K, Watanabe M, Okazaki N, Mazaki J, Ishizaki T, Nagakawa Y, Seshimo A, Katsumata K, Tsuchida A.
Abstract
Natural orifice specimen extraction(NOSE)can be considered a minimally invasive treatment method. We performed robotassisted laparoscopic lower anterior resection and total hysterectomy with transvaginal NOSE. The patient was a 44-year-old woman. When she underwent CS in the blood in 2017, the rectal Rs had a mass-like lesion. On pathological examination, sarcoma from the endometrial stroma was suspected, and an operation was planned. The surgical findings included the following: The camera port was inserted 4 cm from the navel, the first arm on the right side at the same height, the second arm on the left, the third arm in the lower left abdomen, and the 12mm port in the lower right abdomen. First, the uterus was removed, the vagina was opened, and the uterus was removed. Vacuum was maintained, and the operation for the anterior resection was performed without changing the arrangement of the arms. The IMAwas treated; the descending colon was also sufficiently peeled for NOSE surgery, and then the lower rectum was peeled until the levator muscle was exposed to secure the AW. The inter-rectal membrane was treated to secure the AW. The intestinal tract was induced from the vaginal stump, the anvil head of ILS 29 was inserted, and anal anastomosis was performed again by insufflation. The vaginal stump was closed with continuous sutures and covered with the bladder peritoneum.
226.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2110-2112.
[Two Cases of Liver Metastasis from Gastric Cancer Achieving Long-Term Survival Successfully Treated with Stereotactic Body Radiotherapy(SBRT)].
[Article in Japanese]
Akamaru Y1, Wada N, Adachi S, Hokkoku D, Eguchi S, Wada R, Ikeshima R, Munakata K, Takiuchi D, Morimoto O, Ota H, Shibata K.
Abstract
We report 2 cases with long-term survival following stereotactic body radiotherapy(SBRT)for liver metastasis from gastric cancer. Case 1 was a 65-year-old man. We performed distal gastrectomy for gastric cancer with liver metastasis prior to chemotherapy due to pyloric stenosis. Postoperative S-1 chemotherapy was administered. Two liver metastases observed before the operation were temporarily reduced in size but subsequently enlarged; therefore, SBRT was performed 13 months postoperatively. The liver metastases showed a complete response(CR)and the patient is alive 4 years and 11 months after SBRT(6 years postoperatively). Case 2 was a 71-year-old woman. After performing distal gastrectomy, liver metastasis emerged during postoperative S-1 adjuvant chemotherapy; therefore, SBRT was performed 11 months postoperatively. She was then administered weekly paclitaxel. However, she underwent a right hepatic lobectomy 13 months after SBRT for suspected remnant or marginal recurrence by abdominal enhanced CT. Histopathological examination showed that the tumors contained fibrotic connective tissue with no viable cancer cell remnants; therefore, the therapeutic effect was determined to be of Grade 3. The patient is alive without recurrence in the remnant liver 4 years and 7 months after SBRT(5 years and 6 months after the operation of gastric cancer). Thus, SBRT for liver metastasis from gastric cancer may be considered an effective local treatment.
227.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2107-2109.
[Results of Neoadjuvant Chemotherapy with S-1 plus CDDP for Gastric Cancer-The Number of Therapeutic Coursers and Therapeutic Effects].
[Article in Japanese]
Abstract
Neoadjuvant chemotherapy(NAC)with S-1 plus CDDP(SP)followed by gastrectomy has been used for the treatment of patients with locally advanced gastric cancer. We examined the number of treatment courses, histologic effects, ypStage, and prognosis to estimate the utility and define the best treatment course of SP NAC. The patients were divided into 1 course(A: 54 cases), 2 courses(B: 50 cases), and incomplete first course(C: 12 cases). The rates of Grade 2 or more in histological effect were 24.1% in group A, 34.0% in B, and 0% in C. Four patients achieved pathological CR(1 case in group A and 3 cases in group B). The pathological response by NAC was more effective in group B than in group A. In down-staging cases by NAC, survival curves were obtained according to ypStage. The 5-year survival rates in R0 cases were 67.0%in the effective therapeutic group and 51.0%in the non-effective group; the results being significantly different. According to the number of therapeutic courses of NAC, the 5-year survival rates were 57.9% in group A, 65.2% in group B, and 20.0% in group C, demonstrating a significantly better prognosis in group B. Although the pathological response appeared in 1 course, it was significant in 2 courses of NAC. The results indicate that the completion of at least 2 courses of NAC are necessary in locally advanced gastric cancer.
228.
Gan To Kagaku Ryoho. 2019 Dec;46(13):2104-2106.
[Study of Eight Cases of Retroperitoneal Liposarcoma].
[Article in Japanese]
Matsunaga T1, Yamaguchi T, Kaida S, Takebayashi K, Murata S, Shimizu T, Sonoda H, Miyake T, Ueki T, Iida H, Kitamura N, Maehira H, Matsubara A, Kushima R, Tani M.
Abstract
Retroperitoneal liposarcoma is a relatively rare disease, with a high recurrence rate and poor prognosis. We encountered 8 patients with retroperitoneal liposarcoma who underwent surgery in Shiga University of Medical Science Hospital. We often encounter elderly male patients without symptoms. Of the 8 patients, 6 received extensive resection that included the surrounding organs or tissues; however, 3 patients demonstrated positive surgical margins, which resulted in liposarcoma recurrence. Despite the additional resection in the 3 recurrent cases, all the patients had a tumor relapse. One patient with an unresectable tumor received chemotherapy. The other patients received surgical treatment 3 times. One patient developed an unresectable relapse after receiving chemotherapy. Another patient attained long-term survival by adjuvant chemoradiotherapy combined with 3 surgeries. Aggressive surgical resection to achieve a negative surgical margin and careful postoperative follow-up seem important for the treatment of retroperitoneal liposarcoma. This study suggests that postoperative adjuvant therapy may contribute to the improvement of prognosis. Further findings must be accumulated to clarify the significance of postoperative adjuvant therapies in the future.
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