The faster-X effect, namely the rapid evolution of protein-coding genes on the X chromosome, has been widely reported in metazoans. However, the prevalence of this phenomenon across diverse systems and its potential causes remain largely unresolved. Analysis of sex-biased genes may elucidate its possible mechanisms: for example, in systems with X/Y males a more pronounced faster-X effect in male-biased genes than in female-biased or unbiased genes may suggest fixation of recessive beneficial mutations...
Thu Mar 05, 2020 18:53
Repair of damaged DNA is required for the viability of all organisms. Studies in Drosophila melanogaster, driven by the power of genetic screens, pioneered the discovery and characterization of many genes and pathways involved in DNA repair in animals. However, fewer than half of the alleles identified in these screens have been mapped to a specific gene, leaving a potential for new discoveries in this field. Here we show that the previously uncharacterized mutagen sensitive gene mus302 codes for...
Thu Mar 05, 2020 18:53
Abstract Introduction High-turnover bone disease is a major consequence of SHPT and may explain the high risk for fracture in patients with advanced chronic kidney disease (CKD). Bisphosphonates suppress bone turnover and improve bone strength, but their effects have not been fully characterized in advanced CKD with severe SHPT. Bisphosphonates also increase 1,25-dihydroxyvitamin D levels in normal and uremic rats, but the underlying...
Thu Mar 05, 2020 02:00
Abstract Introduction Eldecalcitol increases bone mineral density (BMD) and reduces vertebral fracture in patients with primary osteoporosis. However, the effect of eldecalcitol on BMD and fracture in glucocorticoid-induced osteoporosis (GIO) patients is unknown. This study was undertaken to compare the effect of eldecalcitol on BMD and fracture with that of alfacalcidol in GIO patients. ...
Thu Mar 05, 2020 02:00
Dear Editor, difficult-to-control asthma may be associated with continuous exposure to allergens, particularly professional ones, presence of comorbidities and lack of adherence to therapy. A component-resolved approach can provide an invaluable support to the diagnosis of allergic asthma.1 On the other hand, molecular diagnosis also underlines new questions, as described here.An otherwise healthy nurse, aged 28 years, experienced onset of asthma symptoms soon after being located to a healthcare...
Thu Mar 05, 2020 19:00
In tropical Africa, trypanosomiasis is present in endemic areas with many other diseases including malaria. Because malaria vectors become more anthropo-zoophilic under the current insecticide pressure, they m...
Wed Mar 04, 2020 02:00
This study aimed to assess the availability of adequately iodized salt at a household level and associated factors in Arba Minch town, South Ethiopia using the gold standard technique, the iodometric titration.
Wed Mar 04, 2020 02:00
Retirement from work may trigger various changes in everyday life that affect mental health. The current cross-sectional study, conducted with 231 veterans, examines the relationship between socio-demographic ...
Tue Mar 03, 2020 02:00
Publication date: Available online 4 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Kristen Glisinski, Jonathan S. Kurman, Adam Spandorfer, Nicholas J. Pastis, Septimiu Murgu, George Z. Cheng
Thu Mar 05, 2020 19:49
Publication date: Available online 4 March 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Aziz ul Rehman, Iftikhar Ahmad, Shahzad Ahmad Qureshi
Thu Mar 05, 2020 19:49
The possible mechanism of the 11 cytokines and chemokines in the pathogenesis of achalasia. Both pro‐and anti‐inflammatory pathways are activated in achalasia, while proinflammatory pathways dominate in the immune imbalance. Besides, the fibroplasia accelerates the progress of the immune reaction. Abstract Background Achalasia is an esophageal motility disorder with unknown etiology. Previous findings indicate that immune‐mediated inflammatory process causes inhibitory neuronal degeneration....
Thu Mar 05, 2020 19:45
For residents of long-term care facilities (LTCFs), antimicrobial-resistant bacteria (ARB) are a risk factor, yet their oral colonisation, potentially leading to aspiration pneumonia, remains unclear. This stu...
Wed Mar 04, 2020 02:00
Biomarkers of clinical efficacy for subcutaneous immunotherapy (SCIT) on allergic rhinitis (AR) have not been identified yet. This study aims to assess the clinical relevance of serum inhibitory activity for I...
Wed Mar 04, 2020 02:00
Food allergy is a growing global health concern, with limited studies conducted in developing countries. High-risk behavior regarding allergies is common among young adults, making them prone to severe allergi...
Wed Mar 04, 2020 02:00
The problem of nonadherence to therapy is a key reason of insufficient asthma control. Evaluating the beliefs about asthma medication, cognitive and emotional perceptions may help to identify patients with poo...
Wed Mar 04, 2020 02:00
Publication date: Available online 5 March 2020Source: Hearing ResearchAuthor(s): Michelle L. Hastings, John V. Brigande
Thu Mar 05, 2020 19:15
Publication date: Available online 4 March 2020Source: Hearing ResearchAuthor(s): Gwenaelle G.S. Géléoc, Aziz El-Amraoui
Thu Mar 05, 2020 19:15
Publication date: February 2020Source: Cancer/Radiothérapie, Volume 24, Issue 1Author(s):
Thu Mar 05, 2020 19:14
Publication date: February 2020Source: Cancer/Radiothérapie, Volume 24, Issue 1Author(s):
Thu Mar 05, 2020 19:14
Publication date: February 2020Source: Cancer/Radiothérapie, Volume 24, Issue 1Author(s):
Thu Mar 05, 2020 19:14
In this issue of JAMA Otolaryngology-Head and Neck Surgery, Kondamuri et al illustrate the extensive informational gap limiting the ability of patients to understand just how much their health care costs. As of August 2019, only 8 states sponsored price transparency (PT) websites with cost data from all-payer claims databases, with half of these including data pertaining to otolaryngologic procedures. These data, which were of uneven quantity and quality, demonstrated substantial price variation...
Thu Mar 05, 2020 02:00
This propensity score–matched cohort study of pediatric tympanic cholesteatoma resections investigates the association between the surgical method—transcanal endoscopic or postauricular approach—and rates of residual disease at follow-up.
Thu Mar 05, 2020 02:00
This cohort study uses medical records from October 2001 to March 2019 to analyze the revision surgery rate, reasons for revision surgery, and device failure and survival rates of different device models in recipients of cochlear implant.
Thu Mar 05, 2020 02:00
This cross-sectional study examines the information provided by state-sponsored price transparency websites for outpatient otolaryngologic procedures.
Thu Mar 05, 2020 02:00
Authors: Flores Ruelas, Yunue / Del Toro Equihua, Mario / Alejandra Jiménez Solís, Norma / Baltazar Rodríguez, Luz Margarita / Delgado Enciso, Ivan / Sánchez Ramírez, Carmen Alicia
Sat Feb 29, 2020 02:00
Authors: Sinopidis, Xenophon / Panagidis, Antonios / Kourea, Eleni / Kostopoulou, Eirini / Rojas-Gil, Andrea Paola / Skiadopoulos, Spyros / Georgiou, George / Spiliotis, Bessie E.
Fri Feb 28, 2020 02:00
Authors: Zhao, Dehua / Tian, Yuan / Li, Xiaole / Ni, Min / Zhu, Xinyun / Jia, Liting
Fri Feb 28, 2020 02:00
Authors: Lippi, Giuseppe / Plebani, Mario
Tue Feb 18, 2020 02:00
Authors: Loh, Tze Ping / Bietenbeck, Andreas / Cervinski, Mark A. / van Rossum, Huub H. / Katayev, Alex / Badrick, Tony /
Wed Feb 12, 2020 02:00
Authors: Nutt, Stephen L. / Keenan, Christine / Chopin, Michaël / Allan, Rhys S.
Fri Feb 28, 2020 02:00
Authors: Orban, Axel / Hennicke, Florian / Rühl, Martin
Tue Feb 11, 2020 02:00
The use of monoclonal antibodies in various settings has been linked to the development of progressive multifocal leukoencephalopathy (PML). Whilst this association is well-described with agents such as rituxi...
Tue Mar 03, 2020 02:00
Thu Mar 05, 2020 02:00
Publication date: Available online 4 March 2020Source: TalantaAuthor(s): Chang-Seuk Lee, Da Eun Oh, Tae Hyun Kim
Thu Mar 05, 2020 18:50
Publication date: Available online 4 March 2020Source: TalantaAuthor(s): Ke Li, Wangyan Hu, Yingyan Zhou, Xiangnan Dou, Xiayan Wang, Bo Zhang, Guangsheng Guo
Thu Mar 05, 2020 18:50
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