Saumya Sara Sunny, Julie Hephzibah, Nylla Shanthly, Regi Oommen, David Mathew, Aby AbrahamIndian Journal of Nuclear Medicine 2020 35(2):143-146 Objective: The objective of this study is to assess the efficacy of Yttrium-90 (Y-90) radiation synovectomy in decreasing the recurrent bleeding episodes in hemophilic joints. Subjects and Methods: A retrospective analysis of patients who had Y-90 synovectomy from January 2001 to January 2016 was done. Among them, patients with minimum follow-up of 6...
Thu Mar 12, 2020 00:00
Sarthak Tripathy, Asit Ranjan Mirdha, Shamim Ahmed Shamim, Girish Kumar Parida, Kishan SubudhiIndian Journal of Nuclear Medicine 2020 35(2):174-175 Multiple primary malignancies in a single patient are exceedingly rare, but their prevalence has increased in recent decades due to prolonged survival rates supported by the advent of newer and better generation of chemotherapeutic agents as well as advances in cancer detectability facilitated by sophisticated modalities such as positron emission...
Thu Mar 12, 2020 00:00
Mohsen QutbiIndian Journal of Nuclear Medicine 2020 35(2):147-153 Myocardial perfusion single-photon emission computed tomography (SPECT) as a common imaging procedure in nuclear medicine laboratories may encompass findings in the heart or beyond it, in the thorax or abdomen, which may be related or unrelated to the symptoms of the patients. Sometimes, these findings may be discovered incidentally. In the present article, it is aimed to present some less frequent cardiac and extracardiac findings...
Thu Mar 12, 2020 00:00
Nitin Gupta, Abhishek KhareIndian Journal of Nuclear Medicine 2020 35(2):178-180 Isolated mandibular metastasis is very rare from carcinoma urinary bladder with no locoregional lymph node involvement. Here, we present a case where staging fluorodeoxyglucose - positron emission tomography - computed tomography (FDG PET-CT) scan showed an FDG avid primary lesion in carcinoma urinary bladder with FDG avid erosion in the right mandibular condyle. However, since no pelvic lymph nodes were involved,...
Thu Mar 12, 2020 00:00
Mohsen QutbiIndian Journal of Nuclear Medicine 2020 35(2):154-159 Gated imaging, as a technically demanding procedure, requires special attention and effort to fulfill the technical adequacy and accuracy of the study, based on the available standard guidelines. One of the essential requirements to be met by both technologists and physicians, in nuclear cardiology, is triggering and synchronization as a fundamental subject of gating. There are many sources of gating errors that produce imaging...
Thu Mar 12, 2020 00:00
Sarthak Tripathy, Sreedharan Thankarajan Arun Raj, Kishan Subudhi, Prateek Kaushik, Rakesh KumarIndian Journal of Nuclear Medicine 2020 35(2):185-186 Thymomas are rare anterior mediastinal tumors that originate in the epithelial cells of the thymus and have a rare propensity to metastasize to extrathoracic locations unless it is a histologic high-grade neoplasm (type B and above). We describe a case of 50-year-old woman diagnosed with type AB thymoma and the role of18F-fluorodeoxyglucose positron...
Thu Mar 12, 2020 00:00
Girish Kumar Parida, Sarthak Tripathy, Sreedharan Thankarajan Arun, Madhavi Tripathi, Shamim Ahmed ShamimIndian Journal of Nuclear Medicine 2020 35(2):160-161 Melanomas are usually cutaneous in origin but rarely can also arise from the mucosal linings in the body. Sinonasal melanomas arise from the mucosa of the nasal cavity and paranasal sinuses, which account for approximately 50% of mucosal melanomas in the body. 18F fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG...
Thu Mar 12, 2020 00:00
Georgios Meristoudis, Ioannis IliasIndian Journal of Nuclear Medicine 2020 35(2):189-189
Thu Mar 12, 2020 00:00
Abstract Background The ability of a loop to generate a certain moment/force ratio (M/F ratio) can achieve the desired tooth movement in orthodontics. The present study aimed to investigate the effects of elastic modulus, cross-sectional dimensions, loop configuration geometry dimensions, and activation force on the generated M/F ratio of vertical, L- and T-loops. ...
02:00
Abstract Background The Filling Children’s Teeth: Indicated Or Not? (FiCTION) randomised controlled trial (RCT) aimed to explore the clinical- and cost-effectiveness of managing dental caries in children’s primary teeth. The trial compared three management strategies: conventional caries management with best practice prevention (C + P), biological management with best practice prevention (B + P) and best practice prevention alone...
Thu Mar 12, 2020 02:00
Abstract Background Nurses’ oral assessment and dental referral performance for inpatients are important to provide appropriate oral care services in hospitals. The purpose of this study was to investigate the knowledge, attitudes, and performance of oral assessments and dental referrals for their inpatients among nurses and to identify factors associated with that performance to promote oral health care in hospitals. ...
Thu Mar 12, 2020 02:00
Abstract Background Periodontitis was reported to be associated with inflammatory bowel disease (IBD). However, the association between them has not been firmly established in the existing literature. Therefore, this meta-analysis was conducted to evaluate the relationship between periodontitis and IBD. Methods Electronic databases were...
Thu Mar 12, 2020 02:00
Smoothed cepstral peak prominence (CPPs) has been shown to be an effective indicator of breathiness (Hillenbrand and Houde, 1996). High-speed videoendoscopy (HSV) is frequently being used as a complement to stroboscopy especially when asymmetric or aperiodic vocal fold vibration is present in dysphonic voices. In an HSV image data set obtained with normal (nondisordered) voice subjects, we have observed that some degree of asymmetry is present in many of the vocal fold displacement curves extracted...
Thu Mar 12, 2020 02:00
Exposure to cigarette smoke has significant effects on the respiratory mucosa. However, little is known about the effects of household smoke exposure on children's voice-related quality of life. The aim of this study was to elucidate the effect of parental smoking (PS) on voice-related quality of life in the pediatric population.
Thu Mar 12, 2020 02:00
Interspecific gene flow by hybridization may weaken species barriers and adaptive divergence, but also initiate reinforcement of reproductive isolation trough natural and sexual selection. The extent and consequences of interspecific gene flow in natural systems remain poorly understood. To assess genome-wide patterns of gene flow between the two closely related European dung fly species Sepsis cynipsea and Sepsis neocynipsea (Diptera: Sepsidae), we analyzed whole-genome resequencing data from pooled...
Thu Mar 12, 2020 02:00
Pigmentation is involved in a wide array of biological functions across insect orders, including body patterning, thermoregulation, and immunity. The melanin pathway, in particular, has been characterized in several species. However, molecular evolution of the genes involved in this pathway is poorly characterized, and their roles in pigmentation of early developmental stages are just beginning to be explored in non-model organisms. We traced the molecular evolution of six melanin pathway genes in...
Thu Mar 12, 2020 02:00
A previous study describing the genome of Zostera marina, the most widespread seagrass in the Northern hemisphere, revealed some genomic signatures of adaptation to the aquatic environment. Important features related to the "back-to-the-sea" reverse evolutionary pathway were found, such as the loss of stomatal genes, while other functions like an algal-like cell wall composition were acquired. Beyond these, the genome structure and organization were comparable to the majority of plant genomes sequenced,...
Thu Mar 12, 2020 02:00
The origin of oxygen respiration in bacteria has long intrigued biochemists, microbiologists and evolutionary biologists. The earliest enzymes that consume oxygen to extract energy did not evolve in the same lineages of photosynthetic bacteria that released oxygen on primordial earth, leading to the great oxygenation event (GOE). A widespread type of such enzymes is proton pumping cytochrome c oxidase (COX) that contains heme A, a unique prosthetic group for these oxidases. Here we show that the...
Thu Mar 12, 2020 02:00
Mitochondria and chloroplasts emerged from primary endosymbiosis. Most endosymbiont proteins have subsequently been expressed in the nucleo-cytosol of the host and organelle-targeted via the acquisition of N-terminal presequences, whose evolutionary origin remains enigmatic. Using a quantitative assessment of their physico-chemical properties, we show that organelle targeting peptides, which are distinct from signaling peptides targeting other subcellular compartments, group with a subset of antimicrobial...
Thu Mar 12, 2020 02:00
In this study we further discuss the relationship between the rate of protein evolution and the misfolding avoidance hypothesis (MAH), and clarify the use of experimental data to test the hypothesis. We demonstrate, in Escherichia coli and Homo sapiens, the lack of a substantial negative correlation between protein evolutionary rates and Gibbs free energies of unfolding, a direct measure of protein stability. We also analyze genome-scale data describing protein aggregation and interaction propensities,...
Thu Mar 12, 2020 02:00
Characterising the distribution of fitness effects (DFE) for new mutations is central in evolutionary genetics. Analysis of molecular data under the McDonald-Kreitman test has suggested that adaptive substitutions make a substantial contribution to between-species divergence. Methods have been proposed to estimate the parameters of the distribution of fitness effects for positively selected mutations from the unfolded site frequency spectrum (uSFS). However, when beneficial mutations are strongly...
Thu Mar 12, 2020 02:00
BackgroundEver decreasing costs along with advances in sequencing and library preparation technologies enable even small research groups to generate chromosome-level assemblies today. Here we report the generation of an improved chromosome-level assembly for the Siamese fighting fish (Betta splendens) that was carried out during a practical university Masters course. The Siamese fighting fish is a popular aquarium fish and an emerging model species for research on aggressive behaviour. We updated...
Thu Mar 12, 2020 02:00
Purpose: Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of combined AXL and HDAC inhibition in these tumors to reverse their mesenchymal, therapy-resistant, phenotype. Experimental design: We used public databases and patient-derived DIPG cells to identify putative drivers of the mesenchymal transition in these...
Thu Mar 12, 2020 15:22
Many studies exclude loci that exhibit linkage disequilibrium (LD); however, high LD can signal reduced recombination around genomic features such as chromosome inversions or sex-determining regions. Chromosome inversions and sex-determining regions are often involved in adaptation, allowing for the inheritance of co-adapted gene complexes and for the resolution of sexually antagonistic selection through sex-specific partitioning of genetic variants. Genomic features such as these can escape detection...
Thu Mar 12, 2020 21:50
The Jianchang duck is mainly distributed in Southwest China, and has the characteristics of fast growth rate and strong abilities in lipid deposition in the liver. In order to investigate the effects of domestication process on formation of the unique characteristics of Jianchang duck, the whole genome of sixteen individuals and three pooling of Jianchang duck were re-sequenced, and genome data of 70 mallards and 83 domestic ducks from thirteen different places in China were obtained from NCBI. The...
Thu Mar 12, 2020 21:50
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1114-5871 Background Children with migration background and from low socio-economic status are at higher risk for overweight. To determine appropriate media channels to possibly reach children with targeted health information, it has to be considered that the media and information behavior of children has changed during the last decades. Objective We examined the media and information behavior of children in low socio-economic districts, focusing on those...
Thu Mar 12, 2020 01:00
Comparative sequence analyses have been used to discover numerous classes of structured noncoding RNAs, some of which are riboswitches that specifically recognize small-molecule or elemental ion ligands and influence expression of adjacent downstream genes. Determining the correct identity of the ligand for a riboswitch candidate typically is aided by an understanding of the genes under its regulatory control. Riboswitches whose ligands were straightforward to identify have largely been associated...
Thu Mar 12, 2020 17:46
Does unsettled sleep lead to later emotional problems? Should parents take a hard line and do what is necessary to build up more "settled" or solitary sleep?
03:30
2-fluorofucose (2FF) inhibits protein and cellular fucosylation. Afucosylation of IgG antibodies enhances antibody-dependent cell-mediated cytotoxicity by modulating antibody affinity for FcyRIIIa which can impact secondary T-cell activation. Immune responses towards most common solid tumors are dominated by a humoral immune response rather than the presence of tumor infiltrating cytotoxic T-cells. IgG antibodies directed against numerous tumor-associated proteins are found in the sera of both...
Thu Mar 12, 2020 15:42
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12824
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01290
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00813
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01171
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00459
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00467
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01416
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13796
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13347
Thu Mar 12, 2020 06:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b12929
Thu Mar 12, 2020 06:00
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