Salivary duct carcinoma (SDC) is a rare, aggressive malignancy that histologically resembles high-grade mammary duct carcinoma. Because of the rarity of this entity, data verifying the association between histologic features and patient survival are limited. We conducted a comprehensive histologic review of 151 SDC cases and performed an analysis of the association between various histomorphologic parameters and the clinical outcome with the aim of developing a histologic risk stratification model...
08:46
Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is a rare subtype of extranodal DLBCL. Because of the rarity of this disease, its morphologic and genetic features are not comprehensively studied. Here, we systematically reviewed the clinicopathologic features of 42 cases of PA-DLBCL from our institution and investigated the frequency of MYD88 L265P and CD79B (exon 5) mutation in 29 eligible cases using Sanger sequencing. Clinically, PA-DLBCL was predominant in elderly male patients with...
08:46
Endometrial mesonephric-like carcinomas (MLCa) are uncommon with 50% myometrial invasion, 20/23; lymphovascular space invasion, 16/23; cervical stromal invasion, 7/23. Twenty patients had adjuvant therapy (7 radiation only; 13 chemotherapy±radiation), whereas 3 patients had either unknown or declined therapy. Follow-up was known for 21 patients: 17 patients had recurrences or never achieved remission with the lung being the most common recurrence site (n=9); 7 patients died of disease. The median...
08:46
A malignant gastrointestinal neuroectodermal tumor (GNET) is rare, and it is therefore yet to be completely understood. This study aimed to present the clinicopathologic features of GNET, including treatment information. We included 19 patients with GNET with a mean tumor size of 4.2 cm. The most common site of tumor origin was the small intestine (57.9%), followed by the stomach (15.8%), colon (10.5%), ileocecal junction (5.3%), lower esophagus (5.3%), and anal canal (5.3%). Microscopically, the...
08:46
Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominantly cribriform and solid patterns with glomeruloid structures and optically clear nuclei. Opinions diverge on whether CASG represents a separate entity or a variant of PAC. We aimed to assess the level of agreement among 25 expert Head and Neck pathologists in classifying these tumors. Digital slides of 48 cases were reviewed...
08:46
There is no systematic histopathologic analysis of non-neoplastic polyps in the gallbladder. In this study, in addition to a computer search for cases designated as “polyp,” a systematic review of 2533 consecutive routinely sampled archival and 203 totally submitted prospective cholecystectomies were analyzed for >2 mm polyps (cut-off was based on radiologic sensitivity). A total of 447 non-neoplastic polyps were identified. The frequency was 3% in archival cases and 5% in totally submitted cases....
08:46
No abstract available
08:46
Xp11 renal cell carcinoma (RCC) with different gene fusions may have different clinicopathologic features. We sought to identify variant fusions in TFEB translocation RCC. A total of 31 cases of TFEB RCCs were selected for the current study; MALAT1-TFEB fusion was identified in 25 cases (81%, 25/31) using fusion probes. The remaining 6 cases (19%, 6/31) were further analyzed by RNA sequencing and 5 of them were detected with TFEB-associated gene fusions, including 2 ACTB-TFEB, 1 EWSR1-TFEB, 1 CLTC-TFEB,...
08:46
Trophoblastic neoplasms involving the ovary are uncommon and include gestational tumors, which are either metastatic from the uterus or ectopic and nongestational tumors, which include those of germ cell type/origin and somatic tumors with trophoblastic differentiation; in all these types, most are pure choriocarcinoma. Intermediate trophoblastic tumors, which include placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT), are rare in the ovary, with most assumed to be...
08:46
Patients undergoing transthoracic needle core lung biopsy (TTNB) are at risk for biopsy-related pneumothorax. Instilling pleural sealant at the pleural puncture site reduces this risk. The impact of histologic changes associated with pleural sealant on assessing the histologic type and pathologic stage in lung cancer resection specimens has not been previously evaluated. All lung cancer resection specimens from 2015 to 2018 in which polyethylene glycol hydrogel pleural sealant was instilled during...
08:46
The presence of increased tumor-infiltrating lymphocytes (TILs) is established as a positive prognostic factor in many malignancies including colorectal carcinoma (CRC). However, multiple different approaches have been used to assess TILs. In 2014, the International TILs Working Group (ITWG) proposed a standardized methodology for evaluating TILs, initially in the context of breast cancer, but subsequently expanded to other malignancies. To date, the efficacy of the ITWG system has not been investigated...
08:46
Mesonephric carcinoma is a rare malignancy, thought to derive from Wolffian remnants. To date, no targeted molecular therapeutic options have been identified. On the basis of limited case reports, c-KIT immunohistochemical expression has been reported in female adnexal tumors of Wolffian origin, and targeted therapy with Imatinib has been attempted with mixed success. Currently, it is unclear whether c-KIT immunohistochemical expression is seen in mesonephric carcinoma, a tumor that is thought to...
08:46
Keratocystic odontogenic tumors (KCOTs) are locally aggressive odontogenic neoplasms with recurrence rates of up to 60%. Approximately 5% of KCOTs are associated with nevoid basal cell carcinoma (Gorlin) syndrome and 90% of these show genomic inactivation of the PTCH1 gene encoding Patched 1. Sporadic KCOTs reportedly have PTCH1 mutations in 30% of cases, but previous genomic analyses have been limited by low tumor DNA yield. The aim of this study was to identify recurrent genomic aberrations in...
08:46
The distinction of metastatic melanoma from melanocytic nevi in lymph nodes can on occasion be difficult. As diffuse immunohistochemical (IHC) PRAME (PReferentially expressed Antigen in MElanoma) expression is detected in the majority of primary and metastatic melanomas, but rarely in nevi, we reasoned that PRAME could be a useful adjunct marker for the diagnosis of melanocytes in lymph nodes. In this study, we examined 45 nodal melanocytic deposits comprising 30 nodal nevi and 15 melanoma metastases....
08:46
No abstract available
08:46
Bronchopulmonary dysplasia (BPD) is usually seen in premature infants who require mechanical ventilation and oxygen therapy for acute respiratory distress. Although most patients wean from oxygen therapy by the ages of 2 to 3, rehospitalization for respiratory problems is common in these patients in adulthood. There have been few studies that document the long-term outcomes of BPD survivors and information about the pulmonary function and radiographic findings of adult BPD are limited. Data on pathologic...
08:46
No abstract available
08:46
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00208
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05858
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00470
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00631
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00016
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00199
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04313
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03676
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00250
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05604
Thu Mar 12, 2020 06:00
[ASAP] Multifunctional Detection of Extracellular Vesicles with Surface Plasmon Resonance Microscopy
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04622
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00185
Thu Mar 12, 2020 06:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05285
Thu Mar 12, 2020 06:00
A 29-year-old man with perinatally acquired human immunodeficiency virus (HIV) infection presented to the hospital with abdominal pain and drenching night sweats. He had a history of intermittent adherence to antiretroviral therapy; on presentation, the CD4 count was 18 cells per cubic millimeter…
Thu Mar 12, 2020 02:00
A 48-year-old man who had recently immigrated to France and had not yet established routine medical care presented to the emergency department with shortness of breath. He had a history of end-stage renal disease for which hemodialysis had been initiated 10 years earlier. A physical examination…
Thu Mar 12, 2020 02:00
Bermuda grass is a prevalent allergen that flourishes in tropical climates. Bermuda grass exposure is traditionally believed to be low in Ontario due to the colder environment. However, high rates of Bermuda grass sensitization have been observed in Kingston, Ontario.
Thu Mar 12, 2020 02:00
Storage space can be at a premium no matter what your console. (Nikita Kachanovsky/Unsplash/)When you’re ready for another gaming session, the last message you want to see on your console is that you’re running out of space. Help is at hand, though—the PlayStation 4 and Xbox One consoles all come with options for freeing up space on your existing internal drive and adding extra storage with a new external disk.How to get extra space on a PlayStation 4Go to the Storage section of your PS4’s Settings...
00:39
The Isle of Skye was once more like the Isle of Dinosaurs. (Jon Hoad./)When you think about Scotland, the first images that pop into your mind are probably of gorgeous cliffs and men in kilts. But rewind a few million years, and Scotland was hardly the place we know it as today. Its inhabitants were wildly different as well.The Isle of Skye, for example, is one of the most picturesque spots in the modern Scottish Highlands, but it’s also home to a diverse array of tracks and fossils from middle-Jurassic...
Thu Mar 12, 2020 19:30
Please don't freeze the entire chicken like this when you store this soup. There's a process. (Jenny Huang/)Follow all of PopSci’s COVID-19 coverage here, including travel advice, pregnancy concerns, and the latest findings on the virus itself.As humanity responds to the COVID-19 pandemic by canceling large events, working from home, self-quarantining, and locking down portions of countries where the virus has spread quickly, there’s a chance you might be stuck inside for a while. And you gotta eat....
Thu Mar 12, 2020 18:41
A weather satellite picked up on the string of violent tornadoes that blew through Tennessee early last week. (NOAA /)On March 3, seven devastating tornadoes tore across a 50-mile-plus swath of Tennessee, killing around 25 people and destroying hundreds of buildings. The winds reached up to 165 miles an hour during the worst storm, which was categorized as a “Strong” EF3 twister—one notch below the EF4 and EF5 “Violent” category.In addition to dangerously high speeds, the tornadoes took Tennesseans...
Thu Mar 12, 2020 17:00
The FCC's coverage map shows how many internet provider options exist for different parts of the country. Many locations have one cable provider and rely on more niche satellite options beyond that. (FCC/)Working from home is often more complicated than it sounds. When your job consists mostly of typing away on your laptop and fending off a never-ending parade of Slack messages, it seems easy enough to do it from just about anywhere. But in reality, not every home is set up to double as a workplace.Internet...
Thu Mar 12, 2020 17:56
At the airport, wash your hands more than you think you should. (Pexels/)Washing your hands prevents the spread of many diseases. Public health officials and doctors know it, and there’s studies to back it up. That includes one as recent as December 2019 which showed that if a small fraction of the people who pass through airports wash their hands with more regularity it could have a huge impact on the spread of a new disease such as COVID-19. But getting people to actually perform this illness-preventing...
Thu Mar 12, 2020 14:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου