Related ArticlesNovel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. Int J Mol Sci. 2020 Mar 07;21(5): Authors: Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W Abstract Melanoma is the deadliest form of skin cancer, and its incidence has continuously increased over the past 20 years. Therefore, the discovery of a novel targeted therapeutic...
Thu Mar 12, 2020 12:53
Related ArticlesGlobular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling. Cancers (Basel). 2020 Mar 06;12(3): Authors: Pham DV, Raut PK, Pandit M, Chang JH, Katila N, Choi DY, Jeong JH, Park PH Abstract Adiponectin, an adipokine predominantly derived from adipose tissue, exhibits potent antitumor properties in breast cancer cells. However, its mechanisms of...
Thu Mar 12, 2020 12:53
Related ArticlesThe Effects of Houttuynia cordata Thunb and Piper ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis. Molecules. 2020 Mar 06;25(5): Authors: Subhawa S, Chewonarin T, Banjerdpongchai R Abstract Houttuynia cordata Thunb. (HCT) and Piper ribesioides Wall. (PR) are common herbs that are widely distributed throughout East Asia and possess various biological properties including anti-cancer...
Thu Mar 12, 2020 12:53
Related ArticlesAnticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29. Foods. 2020 Mar 06;9(3): Authors: Zbakh H, Zubía E, Reyes CL, Calderón-Montaño JM, Motilva V Abstract Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy....
Thu Mar 12, 2020 12:53
Related ArticlesMicroRNA-144 Regulates Cardiomyocyte Proliferation and Apoptosis by Targeting TBX1 through the JAK2/STAT1 Pathway. Cytogenet Genome Res. 2019;159(4):190-200 Authors: Cao ML, Zhu BL, Sun YY, Qiu GR, Fu WN, Jiang HK Abstract It is currently believed that the TBX1 gene is one of the core genes of congenital heart disease (CHD). However, there are few studies on the abnormal regulation of TBX1 gene expression. The purpose of this work was...
Thu Mar 12, 2020 12:53
Related ArticlesCompetitive glucose metabolism as a target to boost bladder cancer immunotherapy. Nat Rev Urol. 2020 02;17(2):77-106 Authors: Afonso J, Santos LL, Longatto-Filho A, Baltazar F Abstract Bladder cancer - the tenth most frequent cancer worldwide - has a heterogeneous natural history and clinical behaviour. The predominant histological subtype, urothelial bladder carcinoma, is characterized by high recurrence rates, progression and both...
Thu Mar 12, 2020 12:53
Related ArticlesLicochalcone H Synthesized by Modifying Structure of Licochalcone C Extracted from Glycyrrhiza inflata Induces Apoptosis of Esophageal Squamous Cell Carcinoma Cells. Cell Biochem Biophys. 2020 Mar;78(1):65-76 Authors: Kwak AW, Cho SS, Yoon G, Oh HN, Lee MH, Chae JI, Shim JH Abstract Esophageal cancer is one of the malignant cancers with a low 5-year survival rate. Licochalcone (LC) H, a chemically synthesized substance, is a regioisomer...
Thu Mar 12, 2020 12:53
Related ArticlesActivity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer. J Exp Clin Cancer Res. 2019 Aug 30;38(1):383 Authors: Noblejas-López MDM, Nieto-Jimenez C, Burgos M, Gómez-Juárez M, Montero JC, Esparís-Ogando A, Pandiella A, Galán-Moya EM, Ocaña A Abstract BACKGROUND: Triple negative breast cancer (TNBC) is an incurable disease where novel therapeutic strategies are needed. Proteolysis targeting chimeric...
Thu Mar 12, 2020 12:53
Related ArticlesAtINO80 and AtARP5 physically interact and play common as well as distinct roles in regulating plant growth and development. New Phytol. 2019 07;223(1):336-353 Authors: Kang H, Zhang C, An Z, Shen WH, Zhu Y Abstract The proper modulation of chromatin structure is dependent on the activities of chromatin-remodeling factors and their interplays. Here, we show that the Arabidopsis chromatin-remodeler AtINO80 interacts with the actin-related...
Thu Mar 12, 2020 12:53
Related ArticlesBRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. Hum Mol Genet. 2019 03 01;28(5):842-857 Authors: Xu X, Chen E, Mo L, Zhang L, Shao F, Miao K, Liu J, Su SM, Valecha M, Chan UI, Zheng H, Chen M, Chen W, Chen Q, Fu H, Aladjem MI, He Y, Deng CX Abstract The mammary gland undergoes fast cell proliferation during early...
Thu Mar 12, 2020 12:53
Related ArticlesPotential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020. Euro Surveill. 2020 Mar;25(9): Authors: Johnson HC, Gossner CM, Colzani E, Kinsman J, Alexakis L, Beauté J, Würz A, Tsolova S, Bundle N, Ekdahl K Abstract Two months after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the possibility of established and widespread community transmission...
Thu Mar 12, 2020 12:53
Related ArticlesUpdated rapid risk assessment from ECDC on the outbreak of COVID-19: increased transmission globally. Euro Surveill. 2020 Mar;25(9): Authors: Eurosurveillance Editorial Team PMID: 32156331 [PubMed - in process]
Thu Mar 12, 2020 12:53
Related ArticlesRapid establishment of laboratory diagnostics for the novel coronavirus SARS-CoV-2 in Bavaria, Germany, February 2020. Euro Surveill. 2020 Mar;25(9): Authors: Konrad R, Eberle U, Dangel A, Treis B, Berger A, Bengs K, Fingerle V, Liebl B, Ackermann N, Sing A Abstract The need for timely establishment of diagnostic assays arose when Germany was confronted with the first travel-associated outbreak of severe acute respiratory syndrome coronavirus...
Thu Mar 12, 2020 12:53
Related ArticlesEvaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system. Euro Surveill. 2020 Mar;25(9): Authors: Pfefferle S, Reucher S, Nörz D, Lütgehetmann M Abstract Facing the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), high-volume respiratory testing is demanded in laboratories worldwide. We evaluated the performance of a molecular assay for...
Thu Mar 12, 2020 12:53
Related ArticlesOutbreak of gastroenteritis highlighting the diagnostic and epidemiological challenges of enteroinvasive Escherichia coli, County of Halland, Sweden, November 2017. Euro Surveill. 2020 Mar;25(9): Authors: Lagerqvist N, Löf E, Enkirch T, Nilsson P, Roth A, Jernberg C Abstract An outbreak of gastroenteritis with 83 cases occurred at a conference venue in November 2017 in Halland County, Sweden. Stool samples from two venue visitors and...
Thu Mar 12, 2020 12:53
Related ArticlesFirst cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020. Euro Surveill. 2020 Mar;25(9): Authors: Spiteri G, Fielding J, Diercke M, Campese C, Enouf V, Gaymard A, Bella A, Sognamiglio P, Sierra Moros MJ, Riutort AN, Demina YV, Mahieu R, Broas M, Bengnér M, Buda S, Schilling J, Filleul L, Lepoutre A, Saura C, Mailles A, Levy-Bruhl D, Coignard B, Bernard-Stoecklin S, Behillil S, van der Werf S, Valette...
Thu Mar 12, 2020 12:53
Malaria drug resistance is a global public health concern. Though parasite mutations have been associated with resistance, other factors could influence the resistance. A robust surveillance system is required to monitor and help contain the resistance. This study established the role of travel and gender in dispersion of chloroquine resistant genotypes in malaria epidemic zones in Kenya. A total of 1,776 individuals presenting with uncomplicated malaria at hospitals selected from four malaria transmission...
Thu Mar 12, 2020 02:00
Background A wetland is a special ecosystem formed by the interaction of land and water. The moisture content variation will greatly affect the function and structure of the wetland internal system. Method In this paper, three kinds of wetlands with different flooding levels (Phragmites australis wetland (long-term flooding), Calamagrostis epigeios wetland(seasonal flooding) and Ditch millet wetland (rarely flooded))...
Thu Mar 12, 2020 02:00
Background Both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are blood pressure-lowering agents, but they are also being used to control proteinuria in early chronic kidney disease (CKD) patients. However, clinically, some patients present merely proteinuria without hypertension. No guidelines pointed out how to select treatments for proteinuria in normotensive patients. Thus, we conducted a Bayesian network analysis to evaluate the relative...
Thu Mar 12, 2020 02:00
Tumour-associated macrophages (TAMs) are associated with both the progression and poor prognosis of a variety of solid tumours. This study aimed to investigate and clarify the tumour-promoting role of CXCL8 secreted by TAMs in the urothelial carcinoma microenvironment of the bladder. Immunohistochemistry (n = 55) was used to detect Chemokine (C-X-C motif) ligand 8 (CXCL8), CD163 (a TAM marker), Matrixmetalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), and E-cadherin in cancerous...
Thu Mar 12, 2020 02:00
With the purpose of discovering new anticancer molecules that might have fewer side effects or reduce resistance to current antitumor drugs, a bioprospecting study of the microalgae of the Cuatro Cienegas Basin (CCB), an oasis in the Chihuahuan desert in Mexico was conducted. A microalgae was identified as Granulocystopsis sp. through sequencing the rbcL gene and reconstruction of a phylogenetic tree, and its anticancer activities were assessed using various in vitro assays and different cell lines...
Thu Mar 12, 2020 02:00
Impact of the antidepressant citalopram on the behaviour of two different life stages of brown trout
Background Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among the antidepressants detected in the environment citalopram, a selective serotonin reuptake inhibitor, is one of the most commonly found. Given citalopram is specifically designed to alter mood and behaviour in humans, there is growing concern it...
Thu Mar 12, 2020 02:00
Histopathological images contain rich phenotypic descriptions of the molecular processes underlying disease progression. Convolutional neural networks, state-of-the-art image analysis techniques in computer vision, automatically learn representative features from such images which can be useful for disease diagnosis, prognosis, and subtyping. Hepatocellular carcinoma (HCC) is the sixth most common type of primary liver malignancy. Despite the high mortality rate of HCC, little previous work has made...
Thu Mar 12, 2020 02:00
Related ArticlesLow Radiation Doses: Small Risks? No Risks? Or Risks to Only a Few? Radiology. 2020 Mar 10;:200212 Authors: Brenner DJ PMID: 32159453 [PubMed - as supplied by publisher]
Thu Mar 12, 2020 12:43
Related ArticlesThe Long Route to Standardized Radiomics: Unraveling the Knot from the End. Radiology. 2020 Mar 10;:200059 Authors: Kuhl CK, Truhn D PMID: 32159452 [PubMed - as supplied by publisher]
Thu Mar 12, 2020 12:43
Related ArticlesUse of Early T1 Mapping for MRI in Acute Myocarditis. Radiology. 2020 Mar 10;:200171 Authors: De Cecco CN, Monti CB PMID: 32159451 [PubMed - as supplied by publisher]
Thu Mar 12, 2020 12:43
Related ArticlesConsecutive Screening Rounds with Digital Breast Tomosynthesis Enable Detection of Breast Cancers with Poor Prognosis. Radiology. 2020 Mar 10;:192762 Authors: Moy L, Heller SL PMID: 32159450 [PubMed - as supplied by publisher]
Thu Mar 12, 2020 12:43
Related ArticlesCervical Laminoplasty for Resection of Hemorrhagic Cavernous Malformation Using a Biportal Technique. World Neurosurg. 2020 Mar 07;: Authors: Couldwell WT, Schmidt MH, Mortimer V Abstract This video presents the surgical management of a 36-year-old woman who presented with progressive weakness in her right arm associated with a pins-and-needles sensation. Magnetic resonance imaging of the cervical spine revealed a likely hemorrhagic cavernous...
Thu Mar 12, 2020 12:42
Related ArticlesSyringomyelia in a patient with concurrent post-traumatic hydrocephalus and tethered spinal cord: implications for surgical management. World Neurosurg. 2020 Mar 07;: Authors: Li Y, Green B PMID: 32156596 [PubMed - as supplied by publisher]
Thu Mar 12, 2020 12:42
Related ArticlesPenetrating Spinal Column Injuries (pSI): An Institutional Experience with 100 consecutive cases in an urban trauma center. World Neurosurg. 2020 Mar 07;: Authors: Su YS, Gutierrez A, Vaughan KA, Miranda S, Chen HI, Petrov D, Malhotra NR, Schuster JM Abstract BACKGROUND: Gunshot wound (GSW) injuries are among the leading causes of penetrating spinal column injury (pSI). pSI patients often have concurrent polytrauma that complicate management....
Thu Mar 12, 2020 12:42
Related ArticlesBlind-alley formation and occipital artery-posterior inferior cerebellar artery bypass for the treatment of unclippable vertebral artery aneurysms with posterior inferior cerebellar artery involvement. World Neurosurg. 2020 Mar 07;: Authors: Wongsuriyanan S Abstract BACKGROUND: and importance: Unclippable vertebral artery aneurysms (UVAs) are difficult to treat with direct clipping, especially in cases involving the origin of the posterior...
Thu Mar 12, 2020 12:42
Related ArticlesMicrosurgery "Under the Eaves" using ORBEYE: A Case of dAVF of the Anterior Cranial Fossa. World Neurosurg. 2020 Mar 07;: Authors: Iwata T, Toyota S, Kudo A, Nakagawa K, Shimizu T, Murakami T, Mori K, Taki T, Kishima H Abstract BACKGROUND: One of the merits of exoscopes, including ORBEYE, is that they are superior to a microscope in terms of ergonomic features. We report a case of dural arteriovenous fistula (dAVF) that was cured by direct...
Thu Mar 12, 2020 12:42
Related ArticlesStability evaluation of oblique lumbar interbody fusion constructs with various fixation options: A finite element analysis based on three-dimensional scanning models. World Neurosurg. 2020 Mar 07;: Authors: Guo HZ, Tang YC, Guo DQ, Luo PJ, Li YX, Mo GY, Ma YH, Peng JC, Liang, Zhang SC Abstract BACKGROUND: The oblique lumbar interbody fusion (OLIF) procedure may reduce many of the risks and limitations associated with lateral lumbar interbody...
Thu Mar 12, 2020 12:42
Related ArticlesPosterior fossa dimensions of Chiari malformation patients compared with normal subjects: systematic review and metanalysis. World Neurosurg. 2020 Mar 07;: Authors: Botelho RV, Heringer LC, Botelho PB, Lopes RA, Waisberg J Abstract BACKGROUND: Chiari malformation (CM) is defined as a herniation of cerebellar tonsils below foramen magnum and is considered as secondary to the underdevelopment of posterior fossa bone components. There is...
Thu Mar 12, 2020 12:42
Related ArticlesIntervertebral Displacement of the Thoracic Spine with and without Loading: Radiographic and in vitro Measurements. World Neurosurg. 2020 Mar 07;: Authors: Seaman SC, Zanaty M, Holland MT, Gillies GT, Howard MA, Yamaguchi S Abstract INTRODUCTION: We are developing an intradural approach to spinal cord stimulation, where the thin electrode array is affixed stably to the underside of the thoracic spinal dura mater without leakage of cerebrospinal...
Thu Mar 12, 2020 12:42
Related ArticlesTheranostic approaches in nuclear medicine: current status and future prospects. Expert Rev Med Devices. 2020 Mar 11;: Authors: Filippi L, Chiaravalloti A, Schillaci O, Cianni R, Bagni O Abstract Introduction: Theranostics is an emerging field in which diagnosis and specific targeted therapy are combined to achieve a personalized treatment approach to the patient. In nuclear medicine clinical practice, theranostics is often performed...
Thu Mar 12, 2020 12:41
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00477D, PaperEstefanía Núñez, M.Teresa Fernández-AbedulThere is a growing interest in the development of simple, fast, sustainable and low-cost analytical methodologies on paper-based platforms. However, sensitive detection strategies that fit properly with these devices are...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Mar 12, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00325E, PaperAleksei Chudinov, Marco Rosenbusch, Vyacheslav Kozlovskiy, Valeriy Raznikov, Peter Schury, Michiharu Wada, Hermann WollnikA procedure is introduced to extract the time-of-flight probability density distribution for ions of one type using an accumulated ion peak as a template for use in the fitting of...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Mar 12, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00305K, PaperZhongbao Han, Xiaoyu Gu, Shirong Wang, Liyan Liu, Ying Wang, Zhen Zhao, Zhan YuProbe electrospray ionization mass spectrometry (PESI-MS) has been demonstrated as a useful in situ and online analysis tool for monitoring of various reactions. In this work, PESI-MS with a surface-modified...The content of this RSS Feed (c) The Royal Society of Chemistry
Thu Mar 12, 2020 02:00
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