Πέμπτη 5 Μαρτίου 2020


Learning to deal with dual use
Science: Current Issue
Thu Mar 05, 2020 20:39
Bulky lipids for light-harvesting control
Science: Current Issue
Thu Mar 05, 2020 20:39
News at a glance
Science: Current Issue
Thu Mar 05, 2020 20:39
Pervasive functional translation of noncanonical human open reading frames
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based screening strategy to identify hundreds of noncanonical CDSs that are essential for cellular growth and whose disruption elicits specific, robust transcriptomic and phenotypic changes in human cells. Functional characterization of the encoded microproteins reveals distinct cellular localizations, specific protein binding...
Science: Current Issue
Thu Mar 05, 2020 20:39
Can China's COVID-19 strategy work elsewhere?
Science: Current Issue
Thu Mar 05, 2020 20:39
Palmitoylation makes the switch for EGFR
Science: Current Issue
Thu Mar 05, 2020 20:39
Why weather systems are apt to stall
Science: Current Issue
Thu Mar 05, 2020 20:39
It takes a village
Science: Current Issue
Thu Mar 05, 2020 20:39
Unplanned experiment could help save a key farmed fish
Science: Current Issue
Thu Mar 05, 2020 20:39
Single-atom vibrational spectroscopy in the scanning transmission electron microscope
Single-atom impurities and other atomic-scale defects can notably alter the local vibrational responses of solids and, ultimately, their macroscopic properties. Using high-resolution electron energy-loss spectroscopy in the electron microscope, we show that a single substitutional silicon impurity in graphene induces a characteristic, localized modification of the vibrational response. Extensive ab initio calculations reveal that the measured spectroscopic signature arises from defect-induced pseudo-localized...
Science: Current Issue
Thu Mar 05, 2020 20:39
Pentagon's social science research faces threat
Science: Current Issue
Thu Mar 05, 2020 20:39
Learning to say 'yes, and
Science: Current Issue
Thu Mar 05, 2020 20:39
New telescope promises boon for Turkish science
Science: Current Issue
Thu Mar 05, 2020 20:39
Watching defects flow and grow
Science: Current Issue
Thu Mar 05, 2020 20:39
The body's dangerous defenders
Science: Current Issue
Thu Mar 05, 2020 20:39
Tuning band gaps with three halides
Science: Current Issue
Thu Mar 05, 2020 20:39
Understanding the mother-breastmilk-infant "triad"
Science: Current Issue
Thu Mar 05, 2020 20:39
Sniffing out disease
Science: Current Issue
Thu Mar 05, 2020 20:39
Origins of peanut allergy-causing antibodies
Science: Current Issue
Thu Mar 05, 2020 20:39
Wisdom of the crowd
Science: Current Issue
Thu Mar 05, 2020 20:39
Coding functions of "noncoding" RNAs
Science: Current Issue
Thu Mar 05, 2020 20:39
A neurodevelopmental origin of behavioral individuality in the Drosophila visual system
The genome versus experience dichotomy has dominated understanding of behavioral individuality. By contrast, the role of nonheritable noise during brain development in behavioral variation is understudied. Using Drosophila melanogaster, we demonstrate a link between stochastic variation in brain wiring and behavioral individuality. A visual system circuit called the dorsal cluster neurons (DCN) shows nonheritable, interindividual variation in right/left wiring asymmetry and controls object orientation...
Science: Current Issue
Thu Mar 05, 2020 20:39
Rings rule three-dimensional active matter
Science: Current Issue
Thu Mar 05, 2020 20:39
Replay of cortical spiking sequences during human memory retrieval
Episodic memory retrieval is thought to rely on the replay of past experiences, yet it remains unknown how human single-unit activity is temporally organized during episodic memory encoding and retrieval. We found that ripple oscillations in the human cortex reflect underlying bursts of single-unit spiking activity that are organized into memory-specific sequences. Spiking sequences occurred repeatedly during memory formation and were replayed during successful memory retrieval, and this replay was...
Science: Current Issue
Thu Mar 05, 2020 20:39
Frank Press (1924-2020)
Science: Current Issue
Thu Mar 05, 2020 20:39
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies
The regulation of messenger RNA levels in mammalian cells can be achieved by the modulation of synthesis and degradation rates. Metabolic RNA-labeling experiments in bulk have quantified these rates using relatively homogeneous cell populations. However, to determine these rates during complex dynamical processes, for instance during cellular differentiation, single-cell resolution is required. Therefore, we developed a method that simultaneously quantifies metabolically labeled and preexisting unlabeled...
Science: Current Issue
Thu Mar 05, 2020 20:39
Overcoming obstacles to experiments in legal practice
Science: Current Issue
Thu Mar 05, 2020 20:39
Erratum for the Report: "A room-temperature single-photon source based on strongly interacting Rydberg atoms" by F. Ripka, H. Kübler, R. Löw, T. Pfau
Science: Current Issue
Thu Mar 05, 2020 20:39
Evolution makes a splash
Science: Current Issue
Thu Mar 05, 2020 20:39
A major psychosocial stress circuit
Science: Current Issue
Thu Mar 05, 2020 20:39
The landmark case that almost never was
Science: Current Issue
Thu Mar 05, 2020 20:39
Porin' through the wax
Science: Current Issue
Thu Mar 05, 2020 20:39
Protect Australia's Gondwana Rainforests
Science: Current Issue
Thu Mar 05, 2020 20:39
PAX1 in the thymus
Science: Current Issue
Thu Mar 05, 2020 20:39
Post-2020 goals overlook genetic diversity
Science: Current Issue
Thu Mar 05, 2020 20:39
Seeing single silicon atom vibrations
Science: Current Issue
Thu Mar 05, 2020 20:39
Outreach that sticks
Science: Current Issue
Thu Mar 05, 2020 20:39
Sulfurous glue for heterocycles
Science: Current Issue
Thu Mar 05, 2020 20:39
Growing perovskite on textured silicon
Science: Current Issue
Thu Mar 05, 2020 20:39

Humans on a chip
Science: Current Issue
Thu Mar 05, 2020 20:39
Gauge invariance with cold atoms
Science: Current Issue
Thu Mar 05, 2020 20:39
Closing the loop on sequencing
Science: Current Issue
Thu Mar 05, 2020 20:39
Clearing a path for an HIV cure
Science: Current Issue
Thu Mar 05, 2020 20:39
Microenvironment mapping via Dexter energy transfer on immune cells
Many disease pathologies can be understood through the elucidation of localized biomolecular networks, or microenvironments. To this end, enzymatic proximity labeling platforms are broadly applied for mapping the wider spatial relationships in subcellular architectures. However, technologies that can map microenvironments with higher precision have long been sought. Here, we describe a microenvironment-mapping platform that exploits photocatalytic carbene generation to selectively identify protein-protein...
Science: Current Issue
Thu Mar 05, 2020 20:39
Expanding the human proteome
Science: Current Issue
Thu Mar 05, 2020 20:39
A central master driver of psychosocial stress responses in the rat
The mechanism by which psychological stress elicits various physiological responses is unknown. We discovered a central master neural pathway in rats that drives autonomic and behavioral stress responses by connecting the corticolimbic stress circuits to the hypothalamus. Psychosocial stress signals from emotion-related forebrain regions activated a VGLUT1-positive glutamatergic pathway from the dorsal peduncular cortex and dorsal tenia tecta (DP/DTT), an unexplored prefrontal cortical area, to the...
Science: Current Issue
Thu Mar 05, 2020 20:39
RNA life span at single-cell resolution
Science: Current Issue
Thu Mar 05, 2020 20:39
Topological structure and dynamics of three-dimensional active nematics
Topological structures are effective descriptors of the nonequilibrium dynamics of diverse many-body systems. For example, motile, point-like topological defects capture the salient features of two-dimensional active liquid crystals composed of energy-consuming anisotropic units. We dispersed force-generating microtubule bundles in a passive colloidal liquid crystal to form a three-dimensional active nematic. Light-sheet microscopy revealed the temporal evolution of the millimeter-scale structure...
Science: Current Issue
Thu Mar 05, 2020 20:39
Pinpointing proteins
Science: Current Issue
Thu Mar 05, 2020 20:39
A scalable realization of local U(1) gauge invariance in cold atomic mixtures
In the fundamental laws of physics, gauge fields mediate the interaction between charged particles. An example is the quantum theory of electrons interacting with the electromagnetic field, based on U(1) gauge symmetry. Solving such gauge theories is in general a hard problem for classical computational techniques. Although quantum computers suggest a way forward, large-scale digital quantum devices for complex simulations are difficult to build. We propose a scalable analog quantum simulator of...
Science: Current Issue
Thu Mar 05, 2020 20:39
Diversity from development
Science: Current Issue
Thu Mar 05, 2020 20:39
Efficient tandem solar cells with solution-processed perovskite on textured crystalline silicon
Stacking solar cells with decreasing band gaps to form tandems presents the possibility of overcoming the single-junction Shockley-Queisser limit in photovoltaics. The rapid development of solution-processed perovskites has brought perovskite single-junction efficiencies >20%. However, this process has yet to enable monolithic integration with industry-relevant textured crystalline silicon solar cells. We report tandems that combine solution-processed micrometer-thick perovskite top cells with...
Science: Current Issue
Thu Mar 05, 2020 20:39
Human brain activity during memory
Science: Current Issue
Thu Mar 05, 2020 20:39
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
Mycobacterium tuberculosis has an unusual outer membrane that lacks canonical porin proteins for the transport of small solutes to the periplasm. We discovered that 3,3-bis-di(methylsulfonyl)propionamide (3bMP1) inhibits the growth of M. tuberculosis, and resistance to this compound is conferred by mutation within a member of the proline-proline-glutamate (PPE) family, PPE51. Deletion of PPE51 rendered M. tuberculosis cells unable to replicate on propionamide, glucose, or glycerol. Growth was restored...
Science: Current Issue
Thu Mar 05, 2020 20:39
Paths to understanding breastmilk
Science: Current Issue
Thu Mar 05, 2020 20:39
New Products
Science: Current Issue
Thu Mar 05, 2020 20:39
Commencing oogenesis
Science: Current Issue
Thu Mar 05, 2020 20:39
ZGLP1 is a determinant for the oogenic fate in mice
Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation...
Science: Current Issue
Thu Mar 05, 2020 20:39
Mapping the mammalian brain
Science: Current Issue
Thu Mar 05, 2020 20:39

An atlas of the protein-coding genes in the human, pig, and mouse brain
The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. This analysis was carried out in the human, pig, and mouse brain to allow the identification of regional expression profiles,...
Science: Current Issue
Thu Mar 05, 2020 20:39

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