Spin ices are exotic phases of matter characterized by frustrated spins obeying local "ice rules," in analogy with the electric dipoles in water ice. In two dimensions, one can similarly define ice rules for in-plane Ising-like spins arranged on a kagome lattice. These ice rules require each triangle plaquette to have a single monopole and can lead to different types of orders and excitations. Using experimental and theoretical approaches including magnetometry, thermodynamic measurements, neutron...
Thu Mar 12, 2020 19:40
How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation element–binding (CPEB) protein, is a putative substrate of long-lasting memories. We isolated aggregated Drosophila CPEB, Orb2, from adult heads and determined its activity and atomic structure, at 2.6-angstrom resolution, using cryo–electron microscopy. Orb2 formed ~75-nanometer-long threefold-symmetric amyloid filaments. Filament formation transformed...
Thu Mar 12, 2020 19:40
In neurons, the loading of neurotransmitters into synaptic vesicles uses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases). These membrane protein complexes possess numerous subunit isoforms, which complicates their analysis. We isolated homogeneous rat brain V-ATPase through its interaction with SidK, a Legionella pneumophila effector protein. Cryo–electron microscopy allowed the construction of an atomic model, defining the enzyme’s ATP:proton ratio as...
Thu Mar 12, 2020 19:40
The sensitivity of river discharge to climate-system warming is highly uncertain, and the processes that govern river discharge are poorly understood, which impedes climate-change adaptation. A prominent exemplar is the Colorado River, where meteorological drought and warming are shrinking a water resource that supports more than 1 trillion dollars of economic activity per year. A Monte Carlo simulation with a radiation-aware hydrologic model resolves the longstanding, wide disparity in sensitivity...
Thu Mar 12, 2020 19:40
The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a 3.5-angstrom-resolution cryo–electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding...
Thu Mar 12, 2020 19:40
Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue...
Thu Mar 12, 2020 19:40
At the body surface, skin’s stratified squamous epithelium is challenged by environmental extremes. The surface of the skin is composed of enucleated, flattened surface squames. They derive from underlying, transcriptionally active keratinocytes that display filaggrin-containing keratohyalin granules (KGs) whose function is unclear. Here, we found that filaggrin assembles KGs through liquid-liquid phase separation. The dynamics of phase separation governed terminal differentiation and were disrupted...
Thu Mar 12, 2020 19:40
Neuroendocrine carcinomas mainly affect the bronchopulmonary and the gastrointestinal systems. Breast localizations are very rare. They represent less than 0.1% of all breast cancers. A definitive diagnosis re...
Tue Mar 10, 2020 02:00
Publication date: Available online 12 March 2020Source: Cancer/RadiothérapieAuthor(s): I. Menoux, D. Antoni, C. Mazzara, A. Labani, A. Charloux, E. Quoix, P.-E. Falcoz, P. Truntzer, G. Noël
Thu Mar 12, 2020 19:21
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): I. Zawati, O. Adouni, P. Finetti, Ma. Manai, M. Manai, A. Gamoudi, D. Birnbaum, F. Bertucci, A. Mezlini
Thu Mar 12, 2020 19:21
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): Claire Lemanski, Celine Bourgier, Roxanna Draghici, Simon Thezenas, Aurélie Morel, Philippe Rouanet, Pierre-Emmanuel Colombo, Anne Mourregot, Laure Delmond, Pascal Fenoglietto, Norbert Ailleres, David Azria, Marian Gutowski
Thu Mar 12, 2020 19:21
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): J.P. Gérard, C. Dejean, L. Montagne, K. Benezery, J. Doyen, J.M. Hannoun Levi
Thu Mar 12, 2020 19:21
Evidence of Possible Irritable Larynx Syndrome in Obstructive Sleep Apnea: An Epidemiologic Approach
Publication date: Available online 11 March 2020Source: Journal of VoiceAuthor(s): Nelson Roy, Ray M. Merrill, Jenny Pierce, Krishna M. Sundar
Thu Mar 12, 2020 19:17
Condition: PsoriasisInterventions: Drug: Brodalumab; Drug: Ustekinumab; Drug: PlaceboSponsor: LEO PharmaNot yet recruiting
Thu Mar 12, 2020 18:00
Condition: Psoriasis VulgarisIntervention: Biological: BrodalumabSponsor: LEO PharmaNot yet recruiting
Thu Mar 12, 2020 18:00
Conditions: Head and Neck Squamous Cell Carcinoma; Cutaneous Squamous Cell CarcinomaInterventions: Drug: Pembrolizumab 200mg Intravenous infusion for HNSCC; Drug: Cemiplimab 350mg Intravenous infusion for cuSCC; Combination Product: ASP-1929 Photoimmunotherapy Light TreatmentSponsor: Rakuten Medical, Inc.Not yet recruiting
Thu Mar 12, 2020 18:00
Conditions: Headache; Cervicogenic HeadacheInterventions: Procedure: Dry Needling; Other: Upper extremity stretching programSponsor: Emory UniversityRecruiting
Thu Mar 12, 2020 18:00
Condition: DementiaInterventions: Procedure: Comprehensive acupuncture therapy (CAT) (Hwato®/ Dongbang®); Procedure: Comfy Acupressure for the Elderly (CAE)Sponsor: The University of Hong KongNot yet recruiting
Thu Mar 12, 2020 18:00
Condition: Squamous Cell Carcinoma of Head and NeckIntervention: Other: Tissue collectionSponsors: University of Colorado, Denver; National Cancer Institute (NCI)Recruiting
Thu Mar 12, 2020 18:00
Abstract Objective Multiple sclerosis (MS) is a neurological disease with a substantial genetic component and immune‐mediated neurodegeneration. Patients with MS show structural brain differences relative to individuals without MS, including smaller regional volumes and alterations in white matter (WM) microstructure. Whether genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear. In this study, we explore the association between MS polygenic risk...
Thu Mar 12, 2020 19:01
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Thu Mar 12, 2020 18:59
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Thu Mar 12, 2020 18:59
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Thu Mar 12, 2020 18:59
Thu Mar 12, 2020 02:00
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