Παρασκευή 13 Μαρτίου 2020


Hope for hematological diseases
Science: Current Issue
Thu Mar 12, 2020 19:40
Cells gone rogue
Science: Current Issue
Thu Mar 12, 2020 19:40
An underground record of past deglaciations
Science: Current Issue
Thu Mar 12, 2020 19:40
Catalyzing heavy haze
Science: Current Issue
Thu Mar 12, 2020 19:40
Looking for a crystalline 2D spin ice
Science: Current Issue
Thu Mar 12, 2020 19:40
Self-organizing floral pigmentation patterns
Science: Current Issue
Thu Mar 12, 2020 19:40
Structure of the nCoV trimeric spike
Science: Current Issue
Thu Mar 12, 2020 19:40
Realization of the kagome spin ice state in a frustrated intermetallic compound
Spin ices are exotic phases of matter characterized by frustrated spins obeying local "ice rules," in analogy with the electric dipoles in water ice. In two dimensions, one can similarly define ice rules for in-plane Ising-like spins arranged on a kagome lattice. These ice rules require each triangle plaquette to have a single monopole and can lead to different types of orders and excitations. Using experimental and theoretical approaches including magnetometry, thermodynamic measurements, neutron...
Science: Current Issue
Thu Mar 12, 2020 19:40
Asymmetry on the plus side
Science: Current Issue
Thu Mar 12, 2020 19:40
Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila
How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation element–binding (CPEB) protein, is a putative substrate of long-lasting memories. We isolated aggregated Drosophila CPEB, Orb2, from adult heads and determined its activity and atomic structure, at 2.6-angstrom resolution, using cryo–electron microscopy. Orb2 formed ~75-nanometer-long threefold-symmetric amyloid filaments. Filament formation transformed...
Science: Current Issue
Thu Mar 12, 2020 19:40
How amyloid can be a substrate of memory
Science: Current Issue
Thu Mar 12, 2020 19:40
Structure of V-ATPase from the mammalian brain
In neurons, the loading of neurotransmitters into synaptic vesicles uses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases). These membrane protein complexes possess numerous subunit isoforms, which complicates their analysis. We isolated homogeneous rat brain V-ATPase through its interaction with SidK, a Legionella pneumophila effector protein. Cryo–electron microscopy allowed the construction of an atomic model, defining the enzyme’s ATP:proton ratio as...
Science: Current Issue
Thu Mar 12, 2020 19:40
Revisiting memory
Science: Current Issue
Thu Mar 12, 2020 19:40
Colorado River flow dwindles as warming-driven loss of reflective snow energizes evaporation
The sensitivity of river discharge to climate-system warming is highly uncertain, and the processes that govern river discharge are poorly understood, which impedes climate-change adaptation. A prominent exemplar is the Colorado River, where meteorological drought and warming are shrinking a water resource that supports more than 1 trillion dollars of economic activity per year. A Monte Carlo simulation with a radiation-aware hydrologic model resolves the longstanding, wide disparity in sensitivity...
Science: Current Issue
Thu Mar 12, 2020 19:40
Strategic lumbar support
Science: Current Issue
Thu Mar 12, 2020 19:40
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a 3.5-angstrom-resolution cryo–electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding...
Science: Current Issue
Thu Mar 12, 2020 19:40
Reading a molecule without destroying it
Science: Current Issue
Thu Mar 12, 2020 19:40
Teamwork, the Cuban way
Science: Current Issue
Thu Mar 12, 2020 19:40
New therapies for sickle cell disease
Science: Current Issue
Thu Mar 12, 2020 19:40
Cerebrospinal fluid influx drives acute ischemic tissue swelling
Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue...
Science: Current Issue
Thu Mar 12, 2020 19:40
Phase separation can be skin deep
Science: Current Issue
Thu Mar 12, 2020 19:40
Liquid-liquid phase separation drives skin barrier formation
At the body surface, skin’s stratified squamous epithelium is challenged by environmental extremes. The surface of the skin is composed of enucleated, flattened surface squames. They derive from underlying, transcriptionally active keratinocytes that display filaggrin-containing keratohyalin granules (KGs) whose function is unclear. Here, we found that filaggrin assembles KGs through liquid-liquid phase separation. The dynamics of phase separation governed terminal differentiation and were disrupted...
Science: Current Issue
Thu Mar 12, 2020 19:40
Primary neuroendocrine tumors of the breast: two case reports and review of the literature
Neuroendocrine carcinomas mainly affect the bronchopulmonary and the gastrointestinal systems. Breast localizations are very rare. They represent less than 0.1% of all breast cancers. A definitive diagnosis re...
Journal of Medical Case Reports - Latest Articles
Tue Mar 10, 2020 02:00
Radiation-induced lung toxicity predictors: Retrospective analysis of 90 patients treated with stereotactic body radiation therapy for stage I non-small-cell lung carcinoma
Publication date: Available online 12 March 2020Source: Cancer/RadiothérapieAuthor(s): I. Menoux, D. Antoni, C. Mazzara, A. Labani, A. Charloux, E. Quoix, P.-E. Falcoz, P. Truntzer, G. Noël
Cancer/Radiothérapie
Thu Mar 12, 2020 19:21
Adolescents and young adults with classical Hodgkin lymphoma in North Tunisia: Insights from an adult single-institutional study
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): I. Zawati, O. Adouni, P. Finetti, Ma. Manai, M. Manai, A. Gamoudi, D. Birnbaum, F. Bertucci, A. Mezlini
Cancer/Radiothérapie
Thu Mar 12, 2020 19:21
Intraoperative partial irradiation for highly selected patients with breast cancer: Results of the INTRAOBS prospective study
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): Claire Lemanski, Celine Bourgier, Roxanna Draghici, Simon Thezenas, Aurélie Morel, Philippe Rouanet, Pierre-Emmanuel Colombo, Anne Mourregot, Laure Delmond, Pascal Fenoglietto, Norbert Ailleres, David Azria, Marian Gutowski
Cancer/Radiothérapie
Thu Mar 12, 2020 19:21
A brief history of contact X-ray brachytherapy 50 kVp
Publication date: Available online 11 March 2020Source: Cancer/RadiothérapieAuthor(s): J.P. Gérard, C. Dejean, L. Montagne, K. Benezery, J. Doyen, J.M. Hannoun Levi
Cancer/Radiothérapie
Thu Mar 12, 2020 19:21
Evidence of Possible Irritable Larynx Syndrome in Obstructive Sleep Apnea: An Epidemiologic Approach
Publication date: Available online 11 March 2020Source: Journal of VoiceAuthor(s): Nelson Roy, Ray M. Merrill, Jenny Pierce, Krishna M. Sundar
Voice
Thu Mar 12, 2020 19:17
Efficacy and Safety of Brodalumab in Adolescents From 12 to 17 Years of Age With Moderate-to-severe Plaque Psoriasis
Condition:   PsoriasisInterventions:   Drug: Brodalumab;   Drug: Ustekinumab;   Drug: PlaceboSponsor:   LEO PharmaNot yet recruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
Adjusted Brodalumab Dose Compared With Standard Brodalumab Dose in Subjects With Moderate-to-severe Plaque Psoriasis and ≥120 kg Body Weight
Condition:   Psoriasis VulgarisIntervention:   Biological: BrodalumabSponsor:   LEO PharmaNot yet recruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
Phase 1b/2, Open-label Study of ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
Conditions:   Head and Neck Squamous Cell Carcinoma;   Cutaneous Squamous Cell CarcinomaInterventions:   Drug: Pembrolizumab 200mg Intravenous infusion for HNSCC;   Drug: Cemiplimab 350mg Intravenous infusion for cuSCC;   Combination Product: ASP-1929 Photoimmunotherapy Light TreatmentSponsor:   Rakuten Medical, Inc.Not yet recruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
Dry Needling for Cervicogenic Headache
Conditions:   Headache;   Cervicogenic HeadacheInterventions:   Procedure: Dry Needling;   Other: Upper extremity stretching programSponsor:   Emory UniversityRecruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
Combining Acupuncture and Acupressure for Community-dwelling Elderly With Dementia
Condition:   DementiaInterventions:   Procedure: Comprehensive acupuncture therapy (CAT) (Hwato®/ Dongbang®);   Procedure: Comfy Acupressure for the Elderly (CAE)Sponsor:   The University of Hong KongNot yet recruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
MicroRNA Markers in Head and Neck Cancers
Condition:   Squamous Cell Carcinoma of Head and NeckIntervention:   Other: Tissue collectionSponsors:   University of Colorado, Denver;   National Cancer Institute (NCI)Recruiting
ClinicalTrials
Thu Mar 12, 2020 18:00
Polygenic multiple sclerosis risk and population‐based childhood brain imaging.
Abstract Objective Multiple sclerosis (MS) is a neurological disease with a substantial genetic component and immune‐mediated neurodegeneration. Patients with MS show structural brain differences relative to individuals without MS, including smaller regional volumes and alterations in white matter (WM) microstructure. Whether genetic risk for MS is associated with brain structure during early neurodevelopment remains unclear. In this study, we explore the association between MS polygenic risk...
Annals of Neurology
Thu Mar 12, 2020 19:01
Editorial Board
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Cranio-Maxillofacial Surgery
Thu Mar 12, 2020 18:59
EACMFS Awards
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Cranio-Maxillofacial Surgery
Thu Mar 12, 2020 18:59
Announcements
Publication date: March 2020Source: Journal of Cranio-Maxillofacial Surgery, Volume 48, Issue 3Author(s):
Cranio-Maxillofacial Surgery
Thu Mar 12, 2020 18:59
Histopathologic Changes and SARS–CoV-2 Immunostaining in the Lung of a Patient With COVID-19
Annals of Internal Medicine Online First
Thu Mar 12, 2020 02:00

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