Παρασκευή 13 Μαρτίου 2020


Inducing mortality by targeting mortalin
Science: Current Issue
Thu Mar 12, 2020 19:40
Genome analyses help track coronavirus' moves
Science: Current Issue
Thu Mar 12, 2020 19:40
Enantioselective remote C-H activation directed by a chiral cation
Chiral cations have been used extensively as organocatalysts, but their application to rendering transition metal–catalyzed processes enantioselective remains rare. This is despite the success of the analogous charge-inverted strategy in which cationic metal complexes are paired with chiral anions. We report here a strategy to render a common bipyridine ligand anionic and pair its iridium complexes with a chiral cation derived from quinine. We have applied these ion-paired complexes to long-range...
Science: Current Issue
Thu Mar 12, 2020 19:40
Airport screening is largely futile, research shows
Science: Current Issue
Thu Mar 12, 2020 19:40
Evaporating futures
Science: Current Issue
Thu Mar 12, 2020 19:40
Madagascar's mysterious, murderous cats identified
Science: Current Issue
Thu Mar 12, 2020 19:40
Contracting disease-causing repeat expansions
Science: Current Issue
Thu Mar 12, 2020 19:40
Publishers try out alternative pathways to open access
Science: Current Issue
Thu Mar 12, 2020 19:40
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
Cluster of differentiation 20 (CD20) is a B cell membrane protein that is targeted by monoclonal antibodies for the treatment of malignancies and autoimmune disorders but whose structure and function are unknown. Rituximab (RTX) has been in clinical use for two decades, but how it activates complement to kill B cells remains poorly understood. We obtained a structure of CD20 in complex with RTX, revealing CD20 as a compact double-barrel dimer bound by two RTX antigen-binding fragments (Fabs), each...
Science: Current Issue
Thu Mar 12, 2020 19:40
EPA expands controversial 'transparency plan
Science: Current Issue
Thu Mar 12, 2020 19:40
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling
In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent but infrequent "long tail" mutations are often unknown. We focused on 484 long tail genes in head and neck squamous cell carcinoma (HNSCC) and used in vivo CRISPR to screen for genes that, upon mutation, trigger tumor development in mice. Of the 15 tumor-suppressor genes identified, ADAM10 and AJUBA suppressed HNSCC in a haploinsufficient manner...
Science: Current Issue
Thu Mar 12, 2020 19:40
New electrolyzer splits water on the cheap
Science: Current Issue
Thu Mar 12, 2020 19:40
Spreading edema after stroke
Science: Current Issue
Thu Mar 12, 2020 19:40
Saving grace
Science: Current Issue
Thu Mar 12, 2020 19:40
Cancer drivers converge on NOTCH
Science: Current Issue
Thu Mar 12, 2020 19:40
Science at Sundance 2020
Science: Current Issue
Thu Mar 12, 2020 19:40
What becomes of fragmented forests?
Science: Current Issue
Thu Mar 12, 2020 19:40
Threatening the vigor of the Colorado River
Science: Current Issue
Thu Mar 12, 2020 19:40
Tying together common plastics
Science: Current Issue
Thu Mar 12, 2020 19:40
Liquid droplets in the skin
Science: Current Issue
Thu Mar 12, 2020 19:40
Quantum-nondemolition state detection and spectroscopy of single trapped molecules
Trapped atoms and ions, which are among the best-controlled quantum systems, find widespread applications in quantum science. For molecules, a similar degree of control is currently lacking owing to their complex energy-level structure. Quantum-logic protocols in which atomic ions serve as probes for molecular ions are a promising route for achieving this level of control, especially for homonuclear species that decouple from blackbody radiation. Here, a quantum-nondemolition protocol on single trapped...
Science: Current Issue
Thu Mar 12, 2020 19:40
Opening the floodgates to the brain
Science: Current Issue
Thu Mar 12, 2020 19:40
Persistent influence of obliquity on ice age terminations since the Middle Pleistocene transition
Radiometric dating of glacial terminations over the past 640,000 years suggests pacing by Earth’s climatic precession, with each glacial-interglacial period spanning four or five cycles of ~20,000 years. However, the lack of firm age estimates for older Pleistocene terminations confounds attempts to test the persistence of precession forcing. We combine an Italian speleothem record anchored by a uranium-lead chronology with North Atlantic ocean data to show that the first two deglaciations of the...
Science: Current Issue
Thu Mar 12, 2020 19:40
Seeking new, highly effective thermoelectrics
Science: Current Issue
Thu Mar 12, 2020 19:40
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence
T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the "quiescent state" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation....
Science: Current Issue
Thu Mar 12, 2020 19:40
Treating sickle cell anemia
Science: Current Issue
Thu Mar 12, 2020 19:40
Erratum for the Report: "An sp-hybridized molecular carbon allotrope, cyclo[18]carbon" by K. Kaiser, L. M. Scriven, F. Schulz, P. Gawel, L. Gross, H. L. Anderson
Science: Current Issue
Thu Mar 12, 2020 19:40
Rethink the expansion of access and benefit sharing
Science: Current Issue
Thu Mar 12, 2020 19:40
Do us a favor
Science: Current Issue
Thu Mar 12, 2020 19:40
Ease conflict in Asia with snow leopard peace parks
Science: Current Issue
Thu Mar 12, 2020 19:40
Ammonium salts on comet 67P
Science: Current Issue
Thu Mar 12, 2020 19:40
Mass mortality of migratory birds in Iran
Science: Current Issue
Thu Mar 12, 2020 19:40
Snapshots of a rotary pump
Science: Current Issue
Thu Mar 12, 2020 19:40
NIH progress toward inclusive excellence
Science: Current Issue
Thu Mar 12, 2020 19:40
Deadenylate or activate?
Science: Current Issue
Thu Mar 12, 2020 19:40
Aging eyes and the immune system
Science: Current Issue
Thu Mar 12, 2020 19:40
Clustering for the kill
Science: Current Issue
Thu Mar 12, 2020 19:40
Stem cells to help the heart
Science: Current Issue
Thu Mar 12, 2020 19:40
Tree diversity relieves drought impacts
Science: Current Issue
Thu Mar 12, 2020 19:40

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