Abstract Background Thyroid-stimulating hormone (TSH) plays an important role in the regulation of lipid metabolism. However, little is known about the role that exosomes play in the process of TSH-induced lipotoxicity in non-alcoholic fatty liver disease (NAFLD). As a preliminary step, the present study set out to investigate alterations in protein expression in exosomes derived from TSH-stimulated HepG2 cells. ...
Thu Mar 12, 2020 02:00
Abstract Purpose This retrospective study aimed to assess the association between obesity, gender, and specific clinicopathological features in patients with papillary thyroid cancer (PTC) and whether diagnostic ultrasonography (US) is adversely affected by obesity in these patients. Materials and methods This study retrospectively analyzed 13,995...
Thu Mar 12, 2020 02:00
Abstract Purpose To retrospectively evaluate the clinical outcomes of percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) in treatment of adrenal metastasis (AM), and to compare with adrenalectomy (Adx). Methods From June 2008 to August 2018, a total of 60 patients with AM treated at our hospital were retrospectively reviewed, of whom...
Thu Mar 12, 2020 02:00
Abstract Purpose The study aimed to investigate whether repeat number in the androgen receptor (AR) gene has any contribution to phenotypes of the disease of androgen excess (polycystic ovary syndrome (PCOS), idiopathic hyperandrogenemia (IHA) and idiopathic hirsutism (IH) in a cohort of Turkish women. Methods Three hundred and fifty-four voluntary...
Thu Mar 12, 2020 02:00
We describe a protocol to assess heart morphology and function in adult zebrafish using high-frequency echocardiography. The method allows visualization of the heart and subsequent quantification of functional parameters, such as heart rate (HR), cardiac output (CO), fractional area change (FAC), ejection fraction (EF), and blood inflow and outflow velocities.
Thu Mar 12, 2020 21:44
Obtaining a pure population of fibroblasts is crucial to studying their role in wound repair and fibrosis. Described here is a detailed method to isolate fibroblasts and myofibroblasts from uninjured and injured mouse hearts followed by characterization of their purity and functionality by immunofluorescence, RTPCR, fluorescence-assisted cell sorting, and collagen gel contraction.
Thu Mar 12, 2020 20:44
Drosophila is a widely used experimental model suitable for screening drugs with potential applications for cancer therapy. Here, we describe the use of Drosophila variegated eye color phenotypes as a method for screening small-molecule compounds that promote heterochromatin formation.
Thu Mar 12, 2020 20:44
A mass spectrometry-guided genome mining protocol is established and described here. It is based on genome sequence information and LC-MS/MS analysis and aims to facilitate identification of molecules from complex microbial and plant extracts.
Thu Mar 12, 2020 19:45
Pneumothorax is a common emergency and critical disease in newborn infants that needs rapid, clear diagnosis and timely treatment. Diagnosis and treatment based on chest X-rays are associated with delayed management and radiation damage. Lung ultrasound (US) provides useful guidance for rapid, accurate diagnosis and the precise thoracentesis of pneumothorax.
Thu Mar 12, 2020 19:45
The protocol presents a complete validated TNBS-induced murine model of Crohn's disease and methods for visualization of estrogen receptors by immunohistochemistry using immunofluorescence of formalin-fixed colon sections embedded in paraffin.
Thu Mar 12, 2020 18:46
EEG-methods are applied for extracting biomarkers of brain dysfunctions. The focus is on multi-channel event-related potentials (ERPs) recorded in a cued GO/NOGO task. Non-brain artifacts are corrected and ERPs are compared with the normative data. Examples relate to biomarkers for ADHD diagnosis and prediction of medication response.
Thu Mar 12, 2020 18:46
Publication date: Available online 12 March 2020Source: Gait & PostureAuthor(s): MM Mañago, PW Kline, E Alvarez, CL Christiansen
Thu Mar 12, 2020 21:28
Publication date: Available online 12 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Duy Quoc Ngo, Quy Xuan Ngo, Quang Van Le
Thu Mar 12, 2020 21:27
Publication date: Available online 12 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Yi-Chun Carol Liu, Sameer Kini, Geran Barton, Tien Pham, Jessie Marcet-Gonzalez, Barbra Novak
Thu Mar 12, 2020 21:27
Scientists have discovered that gorillas really are territorial -- and their behavior is very similar to our own.
Thu Mar 12, 2020 18:36
Since the origin of life, metabolic networks provide cells with nutrition and energy. Modern networks require thousands of enzymes that perform catalysis. Such networks must have arisen from simpler precursors. Investigating the metabolism of modern cells, Xavier et al. have identified ancient and conserved autocatalytic networks at the core of microbial metabolism that require only co-factors and metals as catalysts.
Thu Mar 12, 2020 16:10
Pig pluripotent stem cells have tremendous potential because the pig is a valuable animal as both an agricultural resource and as a preclinical model of human therapy. To date, a lack of understanding of pig p...
Wed Mar 11, 2020 02:00
Cisplatin, the most common chemotherapeutic drug for the treatment of advanced stage cervical cancers has limitations in terms of drugs resistance observed in patients partly due to functional DNA damage repai...
Wed Mar 11, 2020 02:00
The aim was to investigate the prevalence of and factors associated with periodontal disease among pregnant Sudanese women. A cross-sectional study was conducted at the Antenatal Care Clinic of Saad Abualila H...
Wed Mar 11, 2020 02:00
Gene- nutrient interaction might possibly be involved in the pathogenesis of metabolic syndrome and its components. In the current report, the association between antioxidant potential of the diet with 6P21 rs...
Wed Mar 11, 2020 02:00
Future Oncology, Ahead of Print.
Thu Mar 12, 2020 13:09
Thu Mar 12, 2020 20:49
ABSTRACT Background Verrucae are benign proliferations seen in skin due to infection with papillomaviruses. There are different treatment strategies for warts but all of these treatments are painful, time consuming, expensive and recurrence is common. Aim To evaluate and compare the efficacy of intra‐lesional 2% zinc sulfate solution versus vitamin D3 in the treatment of plantar warts, as well as reporting the side effects. Methods This three armed randomized clinical trial included...
Thu Mar 12, 2020 20:49
Abstract Studies conducted on isotretinoin have shown that it may indirectly lead to atherosclerosis. The objective of this study was to determine the effect of systemic isotretinoin on subclinical atherosclerosis. The present study included 63 patients with acne vulgaris who had used isotretinoin for 6 months. Glucose, insulin, and homeostatic model assessment of insulin resistance levels; body mass index; waist circumference; blood pressure; lipid profile; and lectin‐like oxidized low‐density...
Thu Mar 12, 2020 20:49
Abstract Primary localized cutaneous amyloidosis (PLCA) is a recalcitrant sporadic dermatological condition and most treatments have failed so far. We studied the efficacy of topical Dimethyl sulfoxide (DMSO) 50% solution in comparison with tretinoin 0.5% cream in treatment of macular amyloidosis. In this split‐side within‐person single‐blinded randomized clinical trial, 18 patients with bilateral macular amyloidosis received topical DMSO 50% solution and tretinoin 0.5% cream either on their right...
Thu Mar 12, 2020 20:49
Abstract Accurate staging is very important for determining a prognosis and appropriate treatment for malignant melanoma (MM). The aim of this study is to determine the effectiveness of PET/CT imaging in staging MM. Patients diagnosed with MM who then underwent PET/CT metastasis before treatment were assessed retrospectively. For each patient, the following variables were recorded: Breslow thickness, Clark's level, number of mitoses and presence of ulceration detected in the pathology report and...
Thu Mar 12, 2020 20:49
British Journal of Cancer, Published online: 12 March 2020; doi:10.1038/s41416-020-0801-2Correction: A case of malignant hyperlactaemic acidosis appearing upon treatment with the mono-carboxylase transporter 1 inhibitor AZD3965
Thu Mar 12, 2020 02:00
Thu Mar 12, 2020 02:00
British Journal of Cancer, Published online: 12 March 2020; doi:10.1038/s41416-020-0767-0Correction: External validation of risk prediction models for incident colorectal cancer using UK Biobank
Thu Mar 12, 2020 02:00
Thu Mar 12, 2020 02:00
Publication date: June 2020Source: International Immunopharmacology, Volume 83Author(s): Huijing Huang, Xuesong Liu, Dandan Chen, Yikang Lu, Jia Li, Fang Du, Chunyan Zhang, Liangjing Lu
Thu Mar 12, 2020 20:27
Publication date: June 2020Source: International Immunopharmacology, Volume 83Author(s): Rui Tang, Jiangfan Yu, Yaqian Shi, Puyu Zou, Zhuotong Zeng, Bingsi Tang, Yaoyao Wang, Guanghui Ling, Mei Luo, Rong Xiao
Thu Mar 12, 2020 20:27
Publication date: June 2020Source: International Immunopharmacology, Volume 83Author(s): Guangyuan Yu, Shi Mo, Leiqiong Gao, Xiang Wen, Shenglin Chen, Xiaoru Long, Xiaohong Xie, Yu Deng, Luo Ren, Na Zang, Sisi Chen, Enmei Liu
Thu Mar 12, 2020 20:27
Publication date: June 2020Source: International Immunopharmacology, Volume 83Author(s): Darren J. Lee
Thu Mar 12, 2020 20:27
Abstract The classic view of cochlear partition (CP) motion, generalized to be for all mammals, was derived from basal-turn measurements in laboratory animals. Recently, we reported motion of the human CP in the cochlear base that differs substantially from the classic view. We described a human soft tissue “bridge” (non-existent in the classic view) between the osseous spiral lamina (OSL) and basilar membrane (BM), and showed how OSL and bridge move in response to sound. Here,...
Thu Mar 12, 2020 02:00
Abstract The cochlea’s wave-based signal processing allows it to efficiently decompose a complex acoustic waveform into frequency components. Because cochlear responses are nonlinear, the waves arising from one frequency component of a complex sound can be altered by the presence of others that overlap with it in time and space (e.g., two-tone suppression). Here, we investigate the suppression of basilar-membrane (BM) velocity responses to a transient signal (a test click) by another...
Thu Mar 12, 2020 02:00
The measured nitrogen-to-carbon ratio in comets is lower than for the Sun, a discrepancy which could be alleviated if there is an unknown reservoir of nitrogen in comets. The nucleus of comet 67P/Churyumov-Gerasimenko exhibits an unidentified broad spectral reflectance feature around 3.2 micrometers, which is ubiquitous across its surface. On the basis of laboratory experiments, we attribute this absorption band to ammonium salts mixed with dust on the surface. The depth of the band indicates that...
Thu Mar 12, 2020 19:40
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