Antibiotics, Vol. 8, Pages 117: Put a Bow on It: Knotted Antibiotics Take Center Stage Antibiotics doi: 10.3390/antibiotics8030117 Authors: Stephanie Tan Gaelen Moore Justin Nodwell Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products produced across all domains of life. The lasso peptides, a subclass of RiPPs with a lasso-like structure, are structurally and functionally unique compared to other known peptide antibiotics...
Antibiotics, Vol. 8, Pages 116: Vitamin C in the Presence of Sub-Inhibitory Concentration of Aminoglycosides and Fluoroquinolones Alters Proteus mirabilis Biofilm Inhibitory Rate Antibiotics doi: 10.3390/antibiotics8030116 Authors: Joanna Kwiecińska-Piróg Krzysztof Skowron Tomasz Bogiel Agata Białucha Jana Przekwas Eugenia Gospodarek-Komkowska Vitamin C has antimicrobial activity and is often used as an oral supplement accompanying antibiotic treatment in urinary tract...
Antibiotics, Vol. 8, Pages 115: The Clinical and Economic Impact of Antibiotic Resistance in China: A Systematic Review and Meta-Analysis Antibiotics doi: 10.3390/antibiotics8030115 Authors: Zhen Lundborg Sun Hu Dong Antibiotic resistance (ABR) is one of the biggest threats to global health, especially in China. This study aims to analyze the published literature on the clinical and economic impact of ABR or multi-drug resistant (MDR) bacteria compared to susceptible...
Antibiotics, Vol. 8, Pages 114: Antimicrobial Drug Interactions: Systematic Evaluation of Protein and Nucleic Acid Synthesis Inhibitors Antibiotics doi: 10.3390/antibiotics8030114 Authors: Yilancioglu Antimicrobial multidrug resistance and its transmission among strains are serious problems. Success rate is decreased and treatment options are narrowed due to increasing bacterial multidrug resistance. On the other hand, the need for long-term efforts to discover new antibiotics and difficulties...
Antibiotics, Vol. 8, Pages 113: Intermittent colonisation with Methicillin-Resistant Staphylococcal aureus can be eradicated from the Airways of Adults with Cystic Fibrosis Antibiotics doi: 10.3390/antibiotics8030113 Authors: Ranzenbacher Song Merchant Middleton The airways of people with cystic fibrosis (CF) are chronically colonised with different pathogens. With recent interest in methicillin-resistant Staphylococcus aureus (MRSA), we have recently examined the rates...
Antibiotics, Vol. 8, Pages 112: Antibiofilm Activity of Three Different Irrigation Techniques: An in Vitro Study Antibiotics doi: 10.3390/antibiotics8030112 Authors: Eneide Castagnola Martini Grande Bugli Patini Cordaro Sanguinetti Olivi Isola Marigo The microbial infection of the endodontic space occurs in a necrotic tooth as a result of dental caries, trauma, periodontal disease, or previous root canal therapy. The disruption of the biofilms...
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Antioxidants, Vol. 8, Pages 300: Chemistry and Pharmacology of the Kazakh Crataegus Almaatensis Pojark: An Asian Herbal Medicine Antioxidants doi: 10.3390/antiox8080300 Authors: Sabrina S. Soares Elmira Bekbolatova Maria Dulce Cotrim Zuriyadda Sakipova Liliya Ibragimova Wirginia Kukula-Koch Thais B. Sardella Giorno Patrícia D. Fernandes Diogo André Fonseca Fabio Boylan Crataegus almaatensis, an endemic ornamental plant in Kazakhstan is used in popular medicine...
Antioxidants, Vol. 8, Pages 299: Antioxidant and Potentially Anti-Inflammatory Activity of Anthocyanin Fractions from Pomace Obtained from Enzymatically Treated Raspberries Antioxidants doi: 10.3390/antiox8080299 Authors: Urszula Szymanowska Barbara Baraniak Raspberry pomace was obtained from raspberries subjected to enzymatic maceration using three commercial pectinolytic preparations (Pectinex Ultra SP-L, Pectinex Yield Mash, and Ultrazym AFP-L). Phenolic compounds were extracted...
Antioxidants, Vol. 8, Pages 298: Characterization and Antioxidant Activities of Yellow Strain Flammulina velutipes (Jinhua Mushroom) Polysaccharides and Their Effects on ROS Content in L929 Cell Antioxidants doi: 10.3390/antiox8080298 Authors: Yu-Ning Hu Tzu-Jung Sung Chun-Hsu Chou Kai-Lun Liu Liang-Po Hsieh Chang-Wei Hsieh Yellow strain Flammulina velutipes, which is known as Jinhua mushroom in Taiwan, has become popular among customers due to its distinct texture that...
Antioxidants, Vol. 8, Pages 297: Antioxidants: Terminology, Methods, and Future Considerations Antioxidants doi: 10.3390/antiox8080297 Authors: Khiena Brainina Natalia Stozhko Marina Vidrevich Unreliable terminology and incompatible units of antioxidant activity/concentration expression lead to the failure of antioxidant clinical trials, ambiguity of conclusions about the effect of a chosen therapy in medicine and evaluation of food quality, diet, difficulties using information...
Antioxidants, Vol. 8, Pages 296: Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Moringa oleifera from Kenya and Their Correlations with Flavonoids Antioxidants doi: 10.3390/antiox8080296 Authors: Yong-Bing Xu Gui-Lin Chen Ming-Quan Guo Moringa oleifera Lam. (M. oleifera) is commonly distributed and utilized in tropical and sub-tropical areas. There has been a large number of reports on the antioxidant and anti-inflammatory activity of its leaves, but only...
Antioxidants, Vol. 8, Pages 295: Antioxidant Properties of a Traditional Vine Tea, Ampelopsis grossedentata Antioxidants doi: 10.3390/antiox8080295 Authors: Kun Xie Xi He Keyu Chen Jihua Chen Kozue Sakao De-Xing Hou Ampelopsis grossedentata, also called vine tea, has been used as a traditional beverage in China for centuries. Vine tea contains rich polyphenols and shows benefit to human health, but the chemical and antioxidant properties of vine tea polyphenols from different...
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Atmosphere, Vol. 10, Pages 457: East Asian Summer Atmospheric Moisture Transport and Its Response to Interannual Variability of the West Pacific Subtropical High: An Evaluation of the Met Office Unified Model Atmosphere doi: 10.3390/atmos10080457 Authors: José M. Rodríguez Sean F. Milton In this study, the atmospheric moisture transport involved in the East Asian summer monsoon (EASM) water cycle is examined. Observational estimates are contrasted with the Met Office Unified Model...
Atmosphere, Vol. 10, Pages 456: Comparison of Anthropogenic Aerosol Climate Effects among Three Climate Models with Reduced Complexity Atmosphere doi: 10.3390/atmos10080456 Authors: Xiangjun Shi Wentao Zhang Jiaojiao Liu The same prescribed anthropogenic aerosol forcing was implemented into three climate models. The atmosphere components of these participating climate models were the GAMIL, ECHAM, and CAM models. Ensemble simulations were carried out to obtain a reliable estimate...
Atmosphere, Vol. 10, Pages 455: Impacts of Climate Change on the Eastern Mediterranean and the Middle East and North Africa Region and the Water–Energy Nexus Atmosphere doi: 10.3390/atmos10080455 Authors: Manfred A. Lange The present paper aims to elucidate impacts of climate change on the availability and security of water and energy in the Middle East and North Africa region (MENA region; including the Eastern Mediterranean) in the context of the water–energy nexus. It largely...
Atmosphere, Vol. 10, Pages 454: Riding the Plumes: Characterizing Bubble Scavenging Conditions for the Enrichment of the Sea-Surface Microlayer by Transparent Exopolymer Particles Atmosphere doi: 10.3390/atmos10080454 Authors: Tiera-Brandy Robinson Helge-Ansgar Giebel Oliver Wurl Transparent exopolymer particles (TEP) act as a major transport mechanism for organic matter (OM) to the sea surface microlayer (SML) via bubble scavenging, and into the atmosphere via bubble bursting....
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Behavioral Sciences, Vol. 9, Pages 85: Peer Status Position within School-Based Hierarchies and Excessive Fat Accumulation in Adulthood—A 30 Year Follow up of a Stockholm Cohort Behavioral Sciences doi: 10.3390/bs9080085 Authors: Rojas Almquist Disadvantaged socioeconomic status is arguably the one exposure that has most consistently been linked to obesity, even more strongly so than diet and physical inactivity, which are the two main perceived root causes of weight gain. However,...
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Biomedicines, Vol. 7, Pages 58: Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers Biomedicines doi: 10.3390/biomedicines7030058 Authors: Mitsuru Konishi Yoku Hayakawa Kazuhiko Koike In the tumor microenvironment, various stromal and immune cells accumulate and interact with cancer cells to contribute to tumor progression. Among stromal players, nerves have recently been recognized as key regulators of tumor growth. More neurotransmitters, such as catecholamines...
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Biomolecules, Vol. 9, Pages 357: Phytochemical Composition, Antioxidant, and Antimicrobial Attributes of Different Solvent Extracts from Myrica esculenta Buch.-Ham. ex. D. Don Leaves Biomolecules doi: 10.3390/biom9080357 Authors: Kabra Sharma Hano Kabra Martins Baghel Background: Plant diversity is a basic source of food and medicine for local Himalayan communities. The current study was designed to assess the effect of different solvents (methanol, ethyl acetate,...
Biomolecules, Vol. 9, Pages 355: KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis Biomolecules doi: 10.3390/biom9080355 Authors: Paradowska-Gorycka Stypinska Pawlik Malinowski Romanowska-Prochnicka Manczak Olesinska We investigated kinase insert domain-containing receptor (KDR) polymorphisms and protein levels in relation to susceptibility to and severity of Rheumatoid Arthritis (RA). 641 RA patients and 340 controls (HC) were...
Biomolecules, Vol. 9, Pages 356: Insights on the Use of α-Lipoic Acid for Therapeutic Purposes Biomolecules doi: 10.3390/biom9080356 Authors: Bahare Salehi Yakup Berkay Yılmaz Gizem Antika Tugba Boyunegmez Tumer Mohamad Fawzi Mahomoodally Devina Lobine Muhammad Akram Muhammad Riaz Esra Capanoglu Farukh Sharopov Natália Martins William C. Cho Javad Sharifi-Rad α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,...
Biomolecules, Vol. 9, Pages 354: Cyclodextrins Can Entrap Zearalenone-14-Glucoside: Interaction of the Masked Mycotoxin with Cyclodextrins and Cyclodextrin Bead Polymer Biomolecules doi: 10.3390/biom9080354 Authors: Zelma Faisal Eszter Fliszár-Nyúl Luca Dellafiora Gianni Galaverna Chiara Dall’Asta Beáta Lemli Sándor Kunsági-Máté Lajos Szente Miklós Poór Zearalenone (ZEN) is a Fusarium-derived xenoestrogenic mycotoxin. In plants, zearalenone-14-O-β-d-glucoside...
Biomolecules, Vol. 9, Pages 353: Whole Conversion of Soybean Molasses into Isomaltulose and Ethanol by Combining Enzymatic Hydrolysis and Successive Selective Fermentations Biomolecules doi: 10.3390/biom9080353 Authors: Zhi-Peng Wang Lin-Lin Zhang Song Liu Xiao-Yan Liu Xin-Jun Yu Isomaltulose is mainly produced from sucrose by microbial fermentation, when the utilization of sucrose contributes a high production cost. To achieve a low-cost isomaltulose production, soy molasses...
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Brain Sciences, Vol. 9, Pages 197: Manual Therapy Reduces Pain Behavior and Oxidative Stress in a Murine Model of Complex Regional Pain Syndrome Type I Brain Sciences doi: 10.3390/brainsci9080197 Authors: Afonso S. I. Salgado Juliana Stramosk Daniela D. Ludtke Ana C. C. Kuci Daiana C. Salm Lisandro A. Ceci Fabricia Petronilho Drielly Florentino Lucineia G. Danielski Aline Gassenferth Luana R. Souza Gislaine T. Rezin Adair R. S. Santos Leidiane Mazzardo-Martins...
Brain Sciences, Vol. 9, Pages 196: α-Tocopherol Modulates Non-Amyloidogenic Pathway and Autophagy in an In Vitro Model of Alzheimer’s Disease: A Transcriptional Study Brain Sciences doi: 10.3390/brainsci9080196 Authors: Agnese Gugliandolo Luigi Chiricosta Serena Silvestro Placido Bramanti Emanuela Mazzon Alzheimer’s disease (AD) is the most common form of dementia worldwide. The hallmarks of AD are the extracellular amyloid plaques, which are formed by amyloid β...
Brain Sciences, Vol. 9, Pages 195: Improved Central Nervous System Symptoms in People with HIV without Objective Neuropsychiatric Complaints Switching from Efavirenz to Rilpivirine Containing cART Brain Sciences doi: 10.3390/brainsci9080195 Authors: Vera Bracchi Alagaratnam Lwanga Fox Winston Boffito Nelson Objective: Occult central nervous system (CNS) symptoms not recognized by people living with HIV (PLWH) receiving efavirenz or their clinicians could...
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Cancers, Vol. 11, Pages 1150: Association between PD-1 and PD-L1 Polymorphisms and the Risk of Cancer: A Meta-Analysis of Case-Control Studies Cancers doi: 10.3390/cancers11081150 Authors: Mohammad Hashemi Shima Karami Sahel Sarabandi Abdolkarim Moazeni-Roodi Andrzej Małecki Saeid Ghavami Emilia Wiechec A number of case-control studies regarding the association of the polymorphisms in the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes...
Cancers, Vol. 11, Pages 1151: SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11081151 Authors: Sara Gomes Bartolomeo Bosco Joana B. Loureiro Helena Ramos Liliana Raimundo Joana Soares Nair Nazareth Valentina Barcherini Lucília Domingues Carla Oliveira Alessandra Bisio Silvano Piazza Matthias R. Bauer João P. Brás Maria Inês Almeida Célia Gomes Flávio...
Cancers, Vol. 11, Pages 1152: Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine Cancers doi: 10.3390/cancers11081152 Authors: Claudio Luchini Nicola Veronese Alessia Nottegar Vera Cappelletti Maria G. Daidone Lee Smith Christopher Parris Lodewijk A. A. Brosens Maria G. Caruso Liang Cheng Christopher L. Wolfgang Laura D. Wood Michele Milella Roberto Salvia Aldo Scarpa Liquid...
Cancers, Vol. 11, Pages 1149: ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers Cancers doi: 10.3390/cancers11081149 Authors: Tarek M. A. Abdel-Fatah Reem Ali Maaz Sadiq Paul M. Moseley Katia A. Mesquita Graham Ball Andrew R. Green Emad A. Rakha Stephen Y. T. Chan Srinivasan Madhusudan Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated...
Cancers, Vol. 11, Pages 1148: Integration of Radiomic and Multi-omic Analyses Predicts Survival of Newly Diagnosed IDH1 Wild-Type Glioblastoma Cancers doi: 10.3390/cancers11081148 Authors: Ahmad Chaddad Paul Daniel Siham Sabri Christian Desrosiers Bassam Abdulkarim Predictors of patient outcome derived from gene methylation, mutation, or expression are severely limited in IDH1 wild-type glioblastoma (GBM). Radiomics offers an alternative insight into tumor characteristics...
Cancers, Vol. 11, Pages 1147: Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11081147 Authors: Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30–150...
Cancers, Vol. 11, Pages 1145: KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy Cancers doi: 10.3390/cancers11081145 Authors: Pinto Petriella Lacalamita Montrone Catino Pizzutilo Botticella Zito Del Bene Zonno Tommasi De Summa Non-small-cell lung cancer, histologically classified into adenocarcinoma (AD) and squamous cell carcinoma, is one of the most deadly malignancies worldwide. Lung AD (LUAD) could...
Cancers, Vol. 11, Pages 1146: BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work Cancers doi: 10.3390/cancers11081146 Authors: Bracci Ciarapica Zabaleta Tartaglione Pirozzi Giuliani Piva Valentino Ledda Rapisarda Stevens Santarelli BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk...
Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis Cancers doi: 10.3390/cancers11081143 Authors: Batham Lim Rao The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing...
Cancers, Vol. 11, Pages 1144: Cancer Metabolism and the Evasion of Apoptotic Cell Death Cancers doi: 10.3390/cancers11081144 Authors: Aditi Sharma Lawrence H. Boise Mala Shanmugam Cellular growth and proliferation depend upon the acquisition and synthesis of specific metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential required for duplication of cellular biomass. Multicellular organisms maintain tissue homeostasis by balancing signals promoting...
Cancers, Vol. 11, Pages 1142: Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer Cancers doi: 10.3390/cancers11081142 Authors: Hannah Flebbe Feda H. Hamdan Vijayalakshmi Kari Julia Kitz Jochen Gaedcke B. Michael Ghadimi Steven A. Johnsen Marian Grade Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin...
Cancers, Vol. 11, Pages 1141: PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around Cancers doi: 10.3390/cancers11081141 Authors: Anastasios Gkountakos Giulia Sartori Italia Falcone Geny Piro Ludovica Ciuffreda Carmine Carbone Giampaolo Tortora Aldo Scarpa Emilio Bria Michele Milella Rafael Rosell Vincenzo Corbo Sara Pilotto Lung cancer is the most common malignancy and cause of cancer deaths worldwide,...
Cancers, Vol. 11, Pages 1140: Mining Prognosis Index of Brain Metastases Using Artificial Intelligence Cancers doi: 10.3390/cancers11081140 Authors: Shigao Huang Jie Yang Simon Fong Qi Zhao This study is to identify the optimum prognosis index for brain metastases by machine learning. Seven hundred cancer patients with brain metastases were enrolled and divided into 446 training and 254 testing cohorts. Seven features and seven prediction methods were selected to evaluate the...
Cancers, Vol. 11, Pages 1139: Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors Cancers doi: 10.3390/cancers11081139 Authors: Veronika Liskova Sona Hudecova Lubomira Lencesova Filippo Iuliano Marta Sirova Karol Ondrias Silvia Pastorekova Olga Krizanova Hypoxia and acidosis are among the key microenvironmental factors that contribute to cancer progression. We have explored...
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Cells, Vol. 8, Pages 876: Oligosaccharides Modulate Rotavirus-Associated Dysbiosis and TLR Gene Expression in Neonatal Rats Cells doi: 10.3390/cells8080876 Authors: Ignasi Azagra-Boronat Malén Massot-Cladera Karen Knipping Belinda van‘t Land Sebastian Tims Bernd Stahl Jan Knol Johan Garssen Àngels Franch Margarida Castell Francisco J. Pérez-Cano Maria J. Rodríguez-Lagunas Colonization of the gut in early life can be altered through multiple environmental...
Cells, Vol. 8, Pages 874: MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes Cells doi: 10.3390/cells8080874 Authors: Sara Cheleschi Sara Tenti Nicola Mondanelli Claudio Corallo Marcella Barbarino Stefano Giannotti Ines Gallo Antonio Giordano Antonella Fioravanti Current evidence suggests a complex interaction between adipokines and microRNA (miRNA) in osteoarthritis (OA)...
Cells, Vol. 8, Pages 873: Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model Cells doi: 10.3390/cells8080873 Authors: Zoë P. Van Acker Geert A. Van Raemdonck Emilie Logie Sara I. Van Acker Geert Baggerman Wim Vanden Berghe Peter Ponsaerts Sylvia Dewilde Neuroglobin is a heme protein of which increased levels provide neuroprotection against amyloid proteinopathy and hemorrhagic damage....
Cells, Vol. 8, Pages 875: Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice Cells doi: 10.3390/cells8080875 Authors: Leonardo Sandrini Alessandro Ieraci Patrizia Amadio Marta Zarà Nico Mitro Francis S. Lee Elena Tremoli Silvia Stella Barbieri Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical...
Cells, Vol. 8, Pages 871: The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament Cells doi: 10.3390/cells8080871 Authors: Jorge Monserrat Cristina Bohórquez Ana María Gómez Lahoz Atusa Movasat Ana Pérez Lucía Ruíz David Díaz Luis Chara Ana Isabel Sánchez Fernando Albarrán Ignacio Sanz Melchor Álvarez-Mon Patients with long-term, treated, rheumatoid arthritis (RA)...
Cells, Vol. 8, Pages 870: Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells Cells doi: 10.3390/cells8080870 Authors: Nicole C. Bilz Edith Willscher Hans Binder Janik Böhnke Megan L. Stanifer Denise Hübner Steeve Boulant Uwe G. Liebert Claudia Claus The study of congenital virus infections in humans requires suitable ex vivo platforms for the species-specific events during embryonal development. A prominent...
Cells, Vol. 8, Pages 872: Molecular Imaging of the Dopamine Transporter Cells doi: 10.3390/cells8080872 Authors: Palermo Ceravolo Dopamine transporter (DAT) single-photon emission tomography (SPECT) with (123)Ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian syndromes, as it assists with differentiating between Parkinson’s disease (PD) or atypical parkinsonisms and conditions without a presynaptic dopaminergic deficit such as essential...
Cells, Vol. 8, Pages 868: Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies Cells doi: 10.3390/cells8080868 Authors: Sonja C. Buisman Gerald de Haan Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of red blood cells and decreased generation...
Cells, Vol. 8, Pages 869: The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies Cells doi: 10.3390/cells8080869 Authors: Carl C. Correll Jiri Bartek Miroslav Dundr The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved in the biogenesis of ribosomes, essential macromolecular machines responsible for synthesizing all proteins required by the cell. The assembly of...
Cells, Vol. 8, Pages 867: Analysis of Catecholamines and Pterins in Inborn Errors of Monoamine Neurotransmitter Metabolism—From Past to Future Cells doi: 10.3390/cells8080867 Authors: Jung-Klawitter Hübschmann Inborn errors of monoamine neurotransmitter biosynthesis and degradation belong to the rare inborn errors of metabolism. They are caused by monogenic variants in the genes encoding the proteins involved in (1) neurotransmitter biosynthesis (like tyrosine hydroxylase (TH) and...
Cells, Vol. 8, Pages 863: Current and Future Trends on Diagnosis and Prognosis of Glioblastoma: From Molecular Biology to Proteomics Cells doi: 10.3390/cells8080863 Authors: Silantyev Falzone Libra Gurina Kardashova Nikolouzakis Nosyrev Sutton Panayioti Tsatsakis Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous system. Due to the absence of effective pharmacological and surgical treatments, the identification of...
Cells, Vol. 8, Pages 865: Calcitriol Attenuates Doxorubicin-Induced Cardiac Dysfunction and Inhibits Endothelial-to-Mesenchymal Transition in Mice Cells doi: 10.3390/cells8080865 Authors: Tsai Lin Hang Chen Doxorubicin (Dox) is an effective anti-neoplasm drug, but its cardiac toxicity limits its clinical use. Endothelial-to-mesenchymal transition (EndMT) has been found to be involved in the process of heart failure. It is unclear whether EndMT contributes to Dox-induced...
Cells, Vol. 8, Pages 864: Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer Cells doi: 10.3390/cells8080864 Authors: Chen Song Li Xie Guo Su Tang Chang Liang Huang Prostate cancer is a common carcinoma in males, the development of which involves the androgen receptor (AR) as a key regulator. AR transactivation induces the high expression of androgen-regulated genes, including transmembrane...
Cells, Vol. 8, Pages 866: Construction and Comprehensive Analysis of a Molecular Association Network via lncRNA–miRNA –Disease–Drug–Protein Graph Cells doi: 10.3390/cells8080866 Authors: Guo Yi You One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput “omics” technologies, the achieved ability to detect and characterize...
Cells, Vol. 8, Pages 860: Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer Cells doi: 10.3390/cells8080860 Authors: Jacob J. Adashek Rohit K. Jain Jingsong Zhang The approval of upfront abiraterone for castration-sensitive prostate cancer and the approval of enzalutamide and apalutamide for non-metastatic castration-resistant prostate cancer have led to early utilization of potent androgen receptor (AR) signaling inhibitors in...
Cells, Vol. 8, Pages 862: The Prospect and Challenges to the Flow of Liquid Biopsy in Africa Cells doi: 10.3390/cells8080862 Authors: Dada Oluwaseyi Temilola Martha Wium Tangbadioa Herve Coulidiati Henry Ademola Adeola Giuseppina Maria Carbone Carlo Vittorio Catapano Luiz Fernando Zerbini Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment...
Cells, Vol. 8, Pages 859: MicroRNAs in Obesity and Related Metabolic Disorders Cells doi: 10.3390/cells8080859 Authors: Jean-François Landrier Adel Derghal Lourdes Mounien Metabolic disorders are characterized by the inability to properly use and/or store energy. The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through a complex interplay between genetics and epigenetics predisposition, environment and nutrition. Therefore, understanding the...
Cells, Vol. 8, Pages 858: The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition Cells doi: 10.3390/cells8080858 Authors: Burcu Sengez Ilkin Aygün Huma Shehwana Neslihan Toyran Sanem Tercan Avci Ozlen Konu Marc P. Stemmler Hani Alotaibi The epithelial to mesenchymal transition (EMT) and the mesenchymal to epithelial transition (MET) are two critical biological processes that are involved in both physiological events such...
Cells, Vol. 8, Pages 861: Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis Cells doi: 10.3390/cells8080861 Authors: Nadia Y. Edelsztein Rodolfo A. Rey Androgens are key for pubertal development of the mammalian testis, a phenomenon that is tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling affects Sertoli cell function and morphology by concomitantly inhibiting...
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Climate, Vol. 7, Pages 98: Investigation on the Use of Passive Microclimate Frames in View of the Climate Change Scenario Climate doi: 10.3390/cli7080098 Authors: Elena Verticchio Francesca Frasca Fernando-Juan Garcìa-Diego Anna Maria Siani Passive microclimate frames are exhibition enclosures able to modify their internal climate in order to comply with paintings’ conservation needs. Due to a growing concern about the effects of climate change, future policies in...
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Clocks & Sleep, Vol. 1, Pages 367-384: Napping Behaviors and Extracurricular Club Activities in Japanese High School Students: Associations with Daytime Sleep Problems Clocks & Sleep doi: 10.3390/clockssleep1030030 Authors: Koh Mizuno Kazue Okamoto-Mizuno Kazuki Iwata Although engaging in evening naps and extracurricular activities are popular among Japanese high school students, the associations between these behaviors and daytime sleep problems were unclear. A questionnaire...
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Cosmetics, Vol. 6, Pages 50: The Influence of Facial Muscle Training on the Facial Soft Tissue Profile: A Brief Review Cosmetics doi: 10.3390/cosmetics6030050 Authors: Takashi Abe Jeremy P. Loenneke In this review, we summarize recent literature investigating facial-exercise-induced changes in facial soft tissue. A literature search was performed in PubMed for the terms facial exercise, rejuvenation, muscle, skin, and aging. Four studies were identified from the search and were subject...
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Diversity, Vol. 11, Pages 129: Endemic Infection of Batrachochytrium dendrobatidis in Costa Rica: Implications for Amphibian Conservation at Regional and Species Level Diversity doi: 10.3390/d11080129 Authors: Héctor Zumbado-Ulate Kiersten N. Nelson Adrián García-Rodríguez Gerardo Chaves Erick Arias Federico Bolaños Steven M. Whitfield Catherine L. Searle Batrachochytrium dendrobatidis (Bd) has been associated with the severe declines and extinctions of amphibians...
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Epigenomes, Vol. 3, Pages 16: Application of the High-Throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma Epigenomes doi: 10.3390/epigenomes3030016 Authors: Chang Zeng Zhou Zhang Jun Wang Brian C-H Chiu Lifang Hou Wei Zhang The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate of less than 5%. Early detection and prognostic approaches,...
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Fermentation, Vol. 5, Pages 74: Immobilization of Saccharomyces cerevisiae on Apple Pieces to Produce Cider Fermentation doi: 10.3390/fermentation5030074 Authors: Clelia Altieri Daniela Campaniello Barbara Speranza Milena Sinigaglia Maria Rosaria Corbo Antonio Bevilacqua Three yeasts (Saccharomyces cerevisiae var. boulardii, a commercial probiotic yeast; S. cerevisiae W13, a wild yeast able to remove ochratoxin A; and S. cerevisiae 17, a wild yeast with promising probiotic...
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Foods, Vol. 8, Pages 337: Tempering Improves Flour Properties of Refined Intermediate Wheatgrass (Thinopyrum intermedium) Foods doi: 10.3390/foods8080337 Authors: Catrin Tyl Radhika Bharathi Tonya Schoenfuss George Amponsah Annor Progress in breeding of intermediate wheatgrass (Thinopyrum intermedium), a perennial grain with environmental benefits, has enabled bran removal. Thus, determination of optimum milling conditions for production of refined flours is warranted. This...
Foods, Vol. 8, Pages 335: The Postharvest Quality of Fresh Sweet Cherries and Strawberries with an Active Packaging System Foods doi: 10.3390/foods8080335 Authors: Chiabrando Garavaglia Giacalone This study assessed the effect of the recently-introduced Life+ (ILIP, Valsamoggia, Italy) active packaging system on the postharvest quality of sweet cherries and strawberries. This system uses Equilibrium Modified Atmosphere Packaging (EMAP) to achieve specific intra-package conditions...
Foods, Vol. 8, Pages 336: Potential of Cooperage Byproducts Rich in Ellagitannins to Improve the Antioxidant Activity and Color Expression of Red Wine Anthocyanins Foods doi: 10.3390/foods8080336 Authors: María Luisa Escudero-Gilete Dolores Hernanz Celia Galán-Lorente Francisco J. Heredia María José Jara-Palacios Cooperage byproducts are an important source of phenolic compounds that could be used for wine technology applications. The effects of the addition of two types...
Foods, Vol. 8, Pages 334: Phytosterol Contents of Edible Oils and Their Contributions to Estimated Phytosterol Intake in the Chinese Diet Foods doi: 10.3390/foods8080334 Authors: Ruinan Yang Li Xue Liangxiao Zhang Xuefang Wang Xin Qi Jun Jiang Li Yu Xiupin Wang Wen Zhang Qi Zhang Peiwu Li Phytosterols are important micronutrients in human diets. Evidence has shown that phytosterols play an essential role in the reduction of cholesterol in blood and therefore...
Foods, Vol. 8, Pages 333: Rheological Properties of Wheat–Flaxseed Composite Flours Assessed by Mixolab and Their Relation to Quality Features Foods doi: 10.3390/foods8080333 Authors: Georgiana Gabriela Codină Ana Maria Istrate Ioan Gontariu Silvia Mironeasa The effect of adding brown and golden flaxseed variety flours (5%, 10%, 15% and 20% w/w) to wheat flours of different quality for bread-making on Mixolab dough rheological properties and bread quality was studied. The flaxseed–wheat...
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Heritage, Vol. 2, Pages 2384-2397: Combined Methodologies for the Survey and Documentation of Historical Buildings: The Castle of Scalea (CS, Italy) Heritage doi: 10.3390/heritage2030146 Authors: Eugenio Donato Dario Giuffrida In the last few years, new technologies have become indispensable tools for specialists in the field of cultural heritage for the analysis, reconstruction and interpretation of data but also for promotion of artefacts or buildings sometimes inaccessible or in...
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Humanities, Vol. 8, Pages 137: Shirley Jackson’s ‘The Lottery,’ and William Empson’s Seven Types of Ambiguity Humanities doi: 10.3390/h8030137 Authors: Teresa Hakaraia Shirley Jackson’s, ‘The Lottery,’ is without doubt her most famous work. It is one of the most anthologized short stories in America. However, despite the popularity of the short story, very few critics have attempted to delve deeper into the story’s meaning. Those few critics who...
Humanities, Vol. 8, Pages 136: The Averted Gaze: Audre Lorde’s Zami and the Death of Emmett Till Humanities doi: 10.3390/h8030136 Authors: Rachel Watson This essay considers Audre Lorde’s Zami: A New Spelling of My Name (1982) as an example of the neoliberal turn to memoir that both complicates and exemplifies important aspects of the relationship between literary form and ideological expressions of racial and sexual identity. By examining a hitherto un-noted omission from...
Humanities, Vol. 8, Pages 135: “Have You Ever Seen the Crowd Goin’ Apeshit?”: Disrupting Representations of Animalistic Black Femininity in the French Imaginary Humanities doi: 10.3390/h8030135 Authors: Elodie Silberstein 16 June 2018. London Stadium. Beyoncé and Jay–Z revealed the premiere of the music video Apeshit. Filmed inside the Louvre Museum in Paris, Beyoncé’s sexual desirability powerfully dialogues with Western canons of high art that...
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IJERPH, Vol. 16, Pages 2873: Anaerobic Dechlorination by a Humin-Dependent Pentachlorophenol-Dechlorinating Consortium under Autotrophic Conditions Induced by Homoacetogenesis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162873 Authors: Laskar Awata Kasai Katayama Anoxic aquifers suffer from energy limitations due to the unavailability of organic substrates, as dictated by hydrogen (H2) for various electron-accepting processes. This...
IJERPH, Vol. 16, Pages 2872: Comparison of Short-Term Associations between PM2.5 Components and Mortality across Six Major Cities in South Korea International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162872 Authors: Si-Eun Yoo Jin-Soo Park Soo Hyun Lee Choong-Hee Park Chul-Woo Lee Sang-Bo Lee Seung Do Yu Sun-Young Kim Ho Kim Association between short-term exposure to fine particulate matter (PM2.5) and mortality or morbidity varies...
IJERPH, Vol. 16, Pages 2871: Corruption, Hidden Economy and Environmental Pollution: A Spatial Econometric Analysis Based on China’s Provincial Panel Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162871 Authors: Shi Wang Yizhou Yuan Hua Wang Previous studies show that the environmental quality is significantly influenced by corruption and the hidden economy separately. However, what is the impact of their interaction effect on environmental...
IJERPH, Vol. 16, Pages 2870: Lay People Training in CPR and in the Use of an Automated External Defibrillator, and Its Social Impact: A Community Health Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162870 Authors: Felipe Villalobos Albert Del Pozo Cristina Rey-Reñones Ester Granado-Font David Sabaté-Lissner Carme Poblet-Calaf Josep Basora Antoni Castro Gemma Flores-Mateo Out-of-hospital cardiac arrest (OHCA) mortality...
IJERPH, Vol. 16, Pages 2869: The Dynamic and Correlation of Skin Temperature and Cardiorespiratory Fitness in Male Endurance Runners International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162869 Authors: Jonathan Galan-Carracedo Andrea Suarez-Segade Myriam Guerra-Balic Guillermo R. Oviedo During endurance exercise, skin temperature (Tsk) plays a fundamental role in thermoregulatory processes. Environmental temperature is the biggest determinant...
IJERPH, Vol. 16, Pages 2867: The Dilemma of Medical Reimbursement Policy in Rural China: Spatial Variability between Reimbursement Region and Medical Catchment Area International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162867 Authors: Yongqing Dong Liping Fu Ronghui Tan Liman Ding Since the initiation of the New Rural Cooperative Medical Scheme (NCMS) in 2003 in China, medical reimbursement plays an increasingly important role in reducing the...
IJERPH, Vol. 16, Pages 2868: A Multicriteria Model for the Assessment of Countries’ Environmental Performance International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162868 Authors: Francisco Guijarro Countries are encouraged to integrate environmental performance metrics by covering the key value-drivers of sustainable development, such as environmental health and ecosystem vitality. The proper measurement of environmental trends provides a foundation...
IJERPH, Vol. 16, Pages 2866: Antifungal Properties of Two Volatile Organic Compounds on Barley Pathogens and Introduction to Their Mechanism of Action International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162866 Authors: Amine Kaddes Marie-Laure Fauconnier Khaled Sassi Bouzid Nasraoui M. Haïssam Jijakli This study evaluated the antifungal effects of various volatile organic compounds (VOCs) against two common pathogens: Fusarium culmorum and...
IJERPH, Vol. 16, Pages 2863: Mortality and Morbidity in a Population Exposed to Emission from a Municipal Waste Incinerator. A Retrospective Cohort Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162863 Authors: Anna Maria Romanelli Fabrizio Bianchi Olivia Curzio Fabrizio Minichilli In the present research, we evaluated the health effects of exposure to the municipal waste incinerator (MWI) in Pisa, Italy, through a population-based...
IJERPH, Vol. 16, Pages 2864: Changes in Undergraduate Students’ Psychological Well-Being as They Experience University Life International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162864 Authors: Xinqiao Liu Siqing Ping Wenjuan Gao The onset of most lifetime mental disorders occurs during adolescence, and the years in college, as the final stage of adolescence in a broad sense, deserve attention in this respect. The psychological well-being of undergraduate...
IJERPH, Vol. 16, Pages 2862: Correlates of Children’s Independent Mobility in Canada: A Multi-Site Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162862 Authors: Negin A. Riazi Sébastien Blanchette François Trudeau Richard Larouche Mark S. Tremblay Guy Faulkner Globally, physical inactivity is a concern, and children’s independent mobility (CIM) may be an important target behavior for addressing the physical inactivity...
IJERPH, Vol. 16, Pages 2865: Dermatologic Vasculature Diseases as a Risk Factor of Subconjunctival Hemorrhage International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162865 Authors: Chia-Yi Lee Hung-Chi Chen Jing-Yang Huang Chi-Chin Sun Chao-Bin Yeh Hung-Yu Lin Shun-Fa Yang To evaluate the relationship between subconjunctival hemorrhage (SCH) and dermatologic vasculature diseases (DVDs) via the national health insurance research database...
IJERPH, Vol. 16, Pages 2860: Smart Approaches to Food Waste Final Disposal International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162860 Authors: Franco Cecchi Cristina Cavinato Food waste, among the organic wastes, is one of the most promising substrates to be used as a renewable resource. Wide availability of food waste and the high greenhouse gas impacts derived from its inappropriate disposal, boost research through food waste valorization. Several...
IJERPH, Vol. 16, Pages 2861: Distribution and Potential Ecological Risk of Heavy Metals in Water, Sediments, and Aquatic Macrophytes: A Case Study of the Junction of Four Rivers in Linyi City, China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162861 Authors: Xiuling Li Henglun Shen Yongjun Zhao Weixing Cao Changwei Hu Chen Sun The Yi River, the second longest river in Shandong Province, China, flows through Linyi City and is fed...
IJERPH, Vol. 16, Pages 2859: Investigating Effects of Cold Water Hand Immersion on Selective Attention in Normobaric Hypoxia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162859 Authors: Hayden D. Gerhart Yongsuk Seo Jung-Hyun Kim Brittany Followay Jeremiah Vaughan Tyler Quinn John Gunstad Ellen L. Glickman This study investigated the effect of cold-water hand immersion on selective attention as measured by the Stroop Color...
IJERPH, Vol. 16, Pages 2856: An Empirical Study on the Influence Path of Environmental Risk Perception on Behavioral Responses In China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162856 Authors: Shan Gao Weimin Li Shuang Ling Xin Dou Xiaozhou Liu In recent years, the outbreak of numerous environmental risk incidents aroused widespread public concern about the amplification mechanism of environmental risk in China. However, few studies...
IJERPH, Vol. 16, Pages 2857: Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162857 Authors: Tiago Miranda Luis R. Vieira Lúcia Guilhermino Microplastics (MPs) were found to modulate the toxicity of...
IJERPH, Vol. 16, Pages 2858: The ‘Merry-Go-Round’ of Habitual Relapse: A Qualitative Study of Relapse in Electronic Gaming Machine Problem Gambling International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162858 Authors: Jane Oakes Rene Pols Sharon Lawn Background: Our understanding of gambling relapse is limited despite the damaging consequences affecting many aspects of the gambler’s life. Paradoxically, regardless of these negative consequences...
IJERPH, Vol. 16, Pages 2855: Prevalence and Predictors of Vitamin D Deficiency among African Immigrants Living in Australia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162855 Authors: Kahlea Horton-French Eleanor Dunlop Robyn M. Lucas Gavin Pereira Lucinda J. Black Vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol/L) is a public health issue in Australia and internationally. Those with darker...
IJERPH, Vol. 16, Pages 2854: Effects of Telephone Follow-Up Intervention on %Body Fat, Inflammatory Cytokines, and Oxidative Stress in Obese Hispanic Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162854 Authors: Hyun-Seung Rhyu Kyung-Shin Park This study investigated whether 10 month telephone follow-up intervention effectively stabilizes reductions in %body fat, and markers of inflammation and oxidative stress obtained from summer...
IJERPH, Vol. 16, Pages 2853: Use of Simple Telemetry to Reduce the Health Impacts of Fuel Poverty and Living in Cold Homes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162853 Authors: Adam Pollard Tim Jones Stephen Sherratt Richard A. Sharpe Introduction: In Great Britain, roughly half of people with at least one long-standing illness (LSI) live in low-income households. Lower-income households are at risk of fuel poverty and living...
IJERPH, Vol. 16, Pages 2852: Validation of the CIMI-Ethiopia Program and Seasonal Variation in Maternal Nutrient Intake in Enset (False Banana) Growing Areas of Southern Ethiopia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162852 Authors: Tafese Bosha Christine Lambert Simon Riedel Ute Gola Aberra Melesse Hans K. Biesalski Background: Tools for the rapid and accurate analysis of nutrient intakes from diets of individuals in Southern...
IJERPH, Vol. 16, Pages 2850: Comfort and Time-Based Walkability Index Design: A GIS-Based Proposal International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162850 Authors: Tarek Al Shammas Francisco Escobar Encouraging people to walk as a means of transport throughout their daily lives has obvious benefits for the environment, the economy, and personal health. Specific features of the built environment have a significant influence on encouraging or discouraging...
IJERPH, Vol. 16, Pages 2851: What If Pregnancy Is Not Seventh Heaven? The Influence of Specific Life Events during Pregnancy and Delivery on the Transition of Antenatal into Postpartum Anxiety and Depression International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162851 Authors: Judith Aris-Meijer Claudi Bockting Ronald Stolk Tjitte Verbeek Chantal Beijers Mariëlle van Pampus Huibert Burger Introduction: Postpartum symptoms of anxiety...
IJERPH, Vol. 16, Pages 2849: Metals in Occluded Water: A New Perspective for Pollution in Drinking Water Distribution Systems International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162849 Authors: Huiyan Tong Zhongyue Li Xingshuai Hu Weiping Xu Zhengkun Li Occluded water is water that remains inside corrosion scales within deteriorating distribution pipes. The accumulation of iron and manganese in the occluded water is a potential risk for...
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