Related ArticlesNeoplastic plasma cells with azurophilic crystalline inclusions mimicking promyelocytes. Blood. 2018 11 01;132(18):1999 Authors: Gralewski J, Pina-Oviedo S PMID: 30385493 [PubMed - indexed for MEDLINE]
15m
Related ArticlesDimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Biochim Biophys Acta Gen Subj. 2019 01;1863(1):232-240 Authors: Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR Abstract Nucleic Acid Aptamers (NAAs) are a class of synthetic DNA or RNA molecules that bind specifically to their target. We recently introduced an aptamer...
15m
Related ArticlesExosome-derived miRNAs as predictive biomarkers for diffuse large B-cell lymphoma chemotherapy resistance. Epigenomics. 2019 01;11(1):35-51 Authors: Feng Y, Zhong M, Zeng S, Wang L, Liu P, Xiao X, Liu Y Abstract AIM: To analyze the expression profiles, clinicopathological features and chemotherapeutic efficacies of exosome-derived miRNAs in diffuse large B-cell lymphoma (DLBCL). MATERIALS & METHODS: Next-generation sequencing...
15m
Related ArticlesMurine pre-B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor. Blood. 2018 11 01;132(18):1899-1910 Authors: Qin H, Ishii K, Nguyen S, Su PP, Burk CR, Kim BH, Duncan BB, Tarun S, Shah NN, Kohler ME, Fry TJ Abstract Adoptive transfer of patient-derived T cells modified to express chimeric antigen receptors (CARTs) has demonstrated dramatic success in relapsed/refractory pre-B-cell acute...
15m
Related ArticlesBiology and management of primary effusion lymphoma. Blood. 2018 11 01;132(18):1879-1888 Authors: Shimada K, Hayakawa F, Kiyoi H Abstract Primary effusion lymphoma (PEL) is a rare B-cell malignancy that most often occurs in immunocompromised patients, such as HIV-infected individuals and patients receiving organ transplantation. The main characteristic of PEL is neoplastic effusions in body cavities without detectable tumor masses. The...
15m
Related ArticlesA cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. Blood. 2018 11 01;132(18):1911-1921 Authors: Hu Z, Anandappa AJ, Sun J, Kim J, Leet DE, Bozym DJ, Chen C, Williams L, Shukla SA, Zhang W, Tabbaa D, Steelman S, Olive O, Livak KJ, Kishi H, Muraguchi A, Guleria I, Stevens J, Lane WJ, Burkhardt UE, Fritsch EF, Neuberg D, Ott PA, Keskin DB, Hacohen N, Wu CJ Abstract Recent studies...
15m
Related ArticlesRituximab addition to chemotherapy in real world patients with chronic lymphocytic leukemia: effective in first line but indication of lack of efficacy in subsequent lines of therapy. Leuk Lymphoma. 2018 11;59(11):2757-2761 Authors: van der Straten L, Dinmohamed AG, Westerweel PE, Langerak AW, Riedl J, Doorduijn JK, Kater AP, Levin MD PMID: 29616852 [PubMed - indexed for MEDLINE]
15m
Related ArticlesComparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods. Proteomics. 2018 06;18(12):e1700251 Authors: Lanoix J, Durette C, Courcelles M, Cossette É, Comtois-Marotte S, Hardy MP, Côté C, Perreault C, Thibault P Abstract Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility...
15m
Jian Wei, Zhenchang WangJournal of Cancer Research and Therapeutics 2019 15(4):941-946 Objective: This study aimed to establish a predictive model for the presence of transcatheter arterial chemoembolization (TACE) resistance in hepatocellular carcinoma (HCC) Barcelona Clinic Liver Cancer classification stage B or stage C4 (BCLC B/C) and further verify its accuracy, enabling clinicians to accurately predict the efficacy of TACE and propose individualized therapy to further optimize multidisciplinary...
15m
Qin Qin, Baosheng LiJournal of Cancer Research and Therapeutics 2019 15(4):743-750 The development of inhibitors of immune checkpoints has revolutionized the treatment for a subset of patients with advanced nonsmall cell lung cancer (NSCLC), resulting in promising clinical outcomes and durable responses. Pembrolizumab, a humanized anti-programmed cell death-1 (PD-1) antibody, has been approved as a first-line treatment for patients with advanced NSCLC with PD-L1 expression of ≥50% and as a second-line...
15m
Yan Li, Ke Tang, Lulu Huang, Chunxia Liu, Qianqian Du, Tiegang Li, Chen Yan, Zhiqiang Feng, Xueji LiJournal of Cancer Research and Therapeutics 2019 15(4):889-898 Background: The hedgehog (HH) signaling pathway is abnormally activated in glioblastoma (GBM); thus, its downstream effector GLI1 may be a suitable target for the treatment of GBM. The aim of the present study was to evaluate the antitumor activities of a novel compound, FL34, in GBM through the inhibition of GLI1. Methods: The...
15m
Qingchun Li, Yun Liang, Ye Zhao, Baodong GaiJournal of Cancer Research and Therapeutics 2019 15(4):751-754 Owing to the location of the pancreas and its complex anatomical relationship, it is difficult to perform radioactive Iodine-125 seed implantation in patients with pancreatic cancer as it can cause surgical side effects and further complications. To standardize the procedure of radioactive Iodine-125 seed implantation in the treatment of pancreatic cancer and reduce the occurrence of adverse...
15m
Gang Liu, Zhi Li Wang, Meng Ke Zhang, Yan He, Yuan LiuJournal of Cancer Research and Therapeutics 2019 15(4):864-870 Aims: To present the ultrasound (US), shear-wave elastography (SWE), and contrast-enhanced ultrasonography (CEUS) features of breast hamartomas. Subjects and Methods: In this retrospective analysis, we included 36 breast hamartomas of 36 female patients who had been scheduled for US-guided vacuum-assisted biopsy (VAB) or surgical excision between May 2013 and October 2016....
15m
Jiao Wang, Yang Ni, Xia Yang, Guanghui Huang, Zhigang Wei, Wenhong Li, Xiaoying Han, Min Meng, Xin Ye, Jiayun LeiJournal of Cancer Research and Therapeutics 2019 15(4):755-759 Objectives: The objective of this study is to determine the diagnostic ability of percutaneous core biopsy immediately after microwave ablation (MWA) for lung ground-glass opacity (GGO). Materials and Methods: Seventy-four patients with 74 lung GGOs were enrolled and treated with MWA. A percutaneous core needle biopsy...
15m
Ke Han, Yi ZhangJournal of Cancer Research and Therapeutics 2019 15(4):914-920 Objective: The objective of this study is to investigate the relationship between programmed cell death ligand 1 (PD-L1) expression and the mutation status of epidermal growth factor receptor (EGFR) in lung adenocarcinoma, as well as the correlation between the clinical features of patients and mRNA levels of PD-L1 and components of the phosphatidylinositol 3-kinase (PI3K)/ protein kinase B (AKT)/phosphatase and tensin...
15m
Jingjing Liu, Wei Huang, Zhiyuan Wu, Zhongmin Wang, Xiaoyi DingJournal of Cancer Research and Therapeutics 2019 15(4):760-765 Background: The aim of the study is to evaluate the technique, safety, efficacy, and clinical value of computed tomography (CT)-guided percutaneous coaxial biopsy combined with microwave ablation (MWA) therapy for pulmonary tumors. Materials and Methods: CT-guided percutaneous coaxial biopsy combined with MWA was performed on 27 tumors in 23 patients who received treatment...
15m
Wanrong Jiang, Xiangdong Sun, Bin Zhou, Chenglong Han, Feng Liu, Jingwei Zheng, Xinchen SunJournal of Cancer Research and Therapeutics 2019 15(4):849-856 Purpose: This study investigated the outcome of elderly patients (≥65 years) with thoracic esophageal squamous cell carcinoma (TESCC) treated with esophagectomy and postoperative radiotherapy (PORT) or definitive radiotherapy (DRT). Patients and Methods: One hundred and ninety patients (median age of 72 years) who received PORT (n = 68)...
15m
Mengfei Wu, Shanshan Gao, Huadan Song, Zihan Zhang, Jianhua Wang, Rong Liu, Xiaolin Wang, Jiemin Cheng, Jianjun Luo, Qingxin Liu, Yi Chen, Zhiping Yan, Lingxiao LiuJournal of Cancer Research and Therapeutics 2019 15(4):766-772 Background/Aim: Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous thermal ablation combined...
15m
Li Pan, Hailong Wang, Chengwen Jiang, Wei Li, Yongzi Chen, Guoguang YingJournal of Cancer Research and Therapeutics 2019 15(4):876-881 Aims: Lung cancer is one of the leading causes of cancer-related mortality. Tobacco usage is considered as associated with the carcinogenesis, progression, and prognosis of lung cancer. Previous studies have demonstrated that the smoking inhibited medical therapy results from K-Ras gene mutation through suppressing the epidermal growth factor receptor (EGFR) pathway....
15m
Wei Yang, Jung-Chieh Lee, Min-Hua Chen, Zhong-Yi Zhang, Xiu-Mei Bai, Shan-Shan Yin, Kun Cao, Song Wang, Wei Wu, Kun YanJournal of Cancer Research and Therapeutics 2019 15(4):773-783 Background: Lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox) consists of doxorubicin encapsulated contained within a heat-sensitive liposome. Aims and Objectives: We sought to evaluate whether the use of combined radiofrequency ablation (RFA) and LTLD would result in larger coagulation volume and longer...
15m
IJMS, Vol. 20, Pages 4039: miR526b and miR655 Induce Oxidative Stress in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20164039 Authors: Bonita Shin Riley Feser Braydon Nault Stephanie Hunter Sujit Maiti Kingsley Chukwunonso Ugwuagbo Mousumi Majumder In eukaryotes, overproduction of reactive oxygen species (ROS) causes oxidative stress, which contributes to chronic inflammation and cancer. MicroRNAs (miRNAs) are small, endogenously produced...
1h
IJMS, Vol. 20, Pages 4038: Tetracycline Analogs Inhibit Osteoclast Differentiation by Suppressing MMP-9-Mediated Histone H3 Cleavage International Journal of Molecular Sciences doi: 10.3390/ijms20164038 Authors: Yeojin Kim Jinman Kim Hyerim Lee Woo-Ri Shin Sheunghun Lee Jisu Lee Jae-Il Park Byung Hak Jhun Yang-Hoon Kim Sun-Ju Yi Kyunghwan Kim Osteoporosis is a common disorder of bone remodeling, caused by the imbalance between bone resorption by osteoclasts...
1h
IJMS, Vol. 20, Pages 4036: Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood–Brain Barrier Alterations after Cerebral Photothrombosis in Rats International Journal of Molecular Sciences doi: 10.3390/ijms20164036 Authors: Michael K. Schuhmann Guido Stoll Lena Papp Arne Bohr Jens Volkmann Felix Fluri Blood–brain barrier (BBB) disruption is a critical event after ischemic stroke, which results in edema formation and hemorrhagic...
1h
IJMS, Vol. 20, Pages 4037: Consistent Biomarkers and Related Pathogenesis Underlying Asthma Revealed by Systems Biology Approach International Journal of Molecular Sciences doi: 10.3390/ijms20164037 Authors: Xiner Nie Jinyi Wei Youjin Hao Jingxin Tao Yinghong Li Mingwei Liu Boying Xu Bo Li Asthma is a common chronic airway disease worldwide. Due to its clinical and genetic heterogeneity, the cellular and molecular processes in asthma are highly complex and relatively...
1h
IJMS, Vol. 20, Pages 4034: Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1 International Journal of Molecular Sciences doi: 10.3390/ijms20164034 Authors: Wolfgang Stremmel Simone Staffer Ralf Weiskirchen Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative...
2h
IJMS, Vol. 20, Pages 4035: Novel Insights into Regulation of Human Teeth Biomineralization: Deciphering the Role of Post-Translational Modifications in a Tooth Protein Extract International Journal of Molecular Sciences doi: 10.3390/ijms20164035 Authors: Vaibhav Sharma Komal Rani Ajoy Roychoudhury Amita Chawla Fredrik Nikolajeff Saroj Kumar The importance of whole protein extracts from different types of human teeth in modulating the process of teeth biomineralization...
2h
IJMS, Vol. 20, Pages 4033: Gonadotropin-Releasing Hormone in Regulation of Thymic Development in Rats: Profile of Thymic Cytokines International Journal of Molecular Sciences doi: 10.3390/ijms20164033 Authors: Victoria I. Melnikova Nadezhda V. Lifantseva Svetlana N. Voronova Liudmila A. Zakharova An increasing body of recent experimental data confirms the impact of neurohormones on fetal development and function of different body systems. The synthesis of many neurohormones...
3h
IJMS, Vol. 20, Pages 4031: The Effects of Rebamipide 2% Ophthalmic Solution Application on Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress International Journal of Molecular Sciences doi: 10.3390/ijms20164031 Authors: Cem Simsek Takashi Kojima Shigeru Nakamura Murat Dogru Kazuo Tsubota Rebamipide ophthalmic solution is a mucin secretagogue which is an important therapeutic agent in the treatment of dry eye. It has been noted that dry eye in office workers...
19h
IJMS, Vol. 20, Pages 4032: A Concise Review on the Molecular Structure and Function Relationship of β-Glucan International Journal of Molecular Sciences doi: 10.3390/ijms20164032 Authors: Bin Du Maninder Meenu Hongzhi Liu Baojun Xu β-glucan is a non-starch soluble polysaccharide widely present in yeast, mushrooms, bacteria, algae, barley, and oat. β-Glucan is regarded as a functional food ingredient due to its various health benefits. The high molecular weight...
19h
IJMS, Vol. 20, Pages 4028: Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20164028 Authors: Davide Ceresa Francesco Alessandrini Lorenzo Bosio Daniela Marubbi Daniele Reverberi Paolo Malatesta Irene Appolloni The high invasive phenotype of glioblastoma is one of the main causes of therapy inefficacy and tumor relapse. Cell adhesion molecules of the cadherin...
21h
IJMS, Vol. 20, Pages 4030: Dynamic Changes in Metabolite Accumulation and the Transcriptome during Leaf Growth and Development in Eucommia ulmoides International Journal of Molecular Sciences doi: 10.3390/ijms20164030 Authors: Long Li Minhao Liu Kan Shi Zhijing Yu Ying Zhou Ruishen Fan Qianqian Shi Eucommia ulmoides Oliver is widely distributed in China. This species has been used mainly in medicine due to the high concentration of chlorogenic acid (CGA), flavonoids,...
21h
IJMS, Vol. 20, Pages 4029: Multi-Omics Approach for Studying Tears in Treatment-Naïve Glaucoma Patients International Journal of Molecular Sciences doi: 10.3390/ijms20164029 Authors: Claudia Rossi Ilaria Cicalini Maria Concetta Cufaro Luca Agnifili Leonardo Mastropasqua Paola Lanuti Marco Marchisio Vincenzo De Laurenzi Piero Del Boccio Damiana Pieragostino Primary open-angle glaucoma (POAG) represents the leading cause of irreversible blindness worldwide and...
22h
Tianxiao Wang, Xiaohong Liu, Jun WangJournal of Cancer Research and Therapeutics 2019 15(4):904-908 Objectives: Increasing evidence suggests that Wnt5a plays an important role in tumorigenesis. In particular, its expression is downregulated in hepatocellular carcinoma (HCC). The aim of this study was to explore the effect of Wnt5a overexpression on HCC cells. Materials and Methods: We transfected the human HCC cell line SMMC-7721 with pcDNA3.1-Wnt5a overexpression vectors or empty pcDNA3.1...
16m
Chunwang Yuan, Zhuhui Yuan, Xiongwei Cui, Wenfeng Gao, Peng Zhao, Ning He, Shichang Cui, Yang Wang, Yonghong Zhang, Wei Li, Jiasheng ZhengJournal of Cancer Research and Therapeutics 2019 15(4):784-792 Purposes: This study aimed to investigate the efficacy of ultrasound (US)-, computed tomography (CT)-, and magnetic resonance imaging (MRI)-guided radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC). Materials and Methods: This retrospective study included 141 patients...
16m
Zihao Zhang, Xiaoming Huang, Jie Li, Haitao Fan, Fan Yang, Rui Zhang, Yihang Yang, Shaobin Feng, Dong He, Wei Sun, Tao XinJournal of Cancer Research and Therapeutics 2019 15(4):927-932 Objective: Glioma is one of the leading causes of death worldwide with high incidence, recurrence, and mortality. Interleukin-10 (IL-10) is a cytokine with dual function in many types of tumors. Although IL-10 is overexpressed and promotes tumor progression in human primary brain tumor, the mechanisms are largely...
16m
Hongtao Zhang, Devjoy Dev, Huimin Yu, Xuemin Di, Yansong Liang, Lijuan Zhang, Xiaoli Liu, Jinxin Zhao, Zezhou Liu, Aixia Sui, Juan Wang, Man HuJournal of Cancer Research and Therapeutics 2019 15(4):793-800 Objective: The objective of the study is to test whether three-dimensional (3D)-printed template can be used reproducibly for guiding malignant tumors brachytherapy and study the dosimetric consistency and adequacy between pre- and post-plan. Materials and Methods: Between January and December...
16m
Yang Ni, Xin YeJournal of Cancer Research and Therapeutics 2019 15(4):741-742
16m
Hongtao Zhang, Huimin Yu, Yansong Liang, Zeyang Wang, Xuemin Di, Lijuan Zhang, Jinxin Zhang, Zezhou Liu, Aixia Sui, Juan WangJournal of Cancer Research and Therapeutics 2019 15(4):801-806 Objectives: The objective of this study is to assess the technical feasibility, safety, and efficacy of computed tomography (CT)-guided iodine-125 (125 I) seed implantation to treat malignant iliac lymph node metastases. Materials and Methods: In this retrospective study, 11 patients with a total of 11 iliac...
16m
Jian-Shu Chen, Gang Liu, Tian-Ran Li, Jian-Yu Chen, Qi-Ming Xu, Yan-Zhen Guo, Ming Li, Li YangJournal of Cancer Research and Therapeutics 2019 15(4):857-863 Purpose: Postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) is a worrisome and life-threatening complication. This study aimed to investigate the risk factors and preventive strategies for POPF after PD. Materials and Methods: We retrospectively reviewed 301 consecutive patients who underwent PD at our hospitals...
16m
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου