Pharmaceutics, Vol. 11, Pages 380: Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart Pharmaceutics doi: 10.3390/pharmaceutics11080380 Authors: Maryam Oroujeni Ayman Abouzayed Fanny Lundmark Bogdan Mitran Anna Orlova Vladimir Tolmachev Ulrika Rosenström Radiolabelled antagonistic bombesin analogues are successfully used for targeting...
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Pharmaceutics, Vol. 11, Pages 379: Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications Pharmaceutics doi: 10.3390/pharmaceutics11080379 Authors: Marcus Hill Matthew Twigg Emer A. Sheridan John G. Hardy J. Stuart Elborn Clifford C. Taggart Christopher J. Scott Marie E. Migaud Cystic fibrosis (CF) is a complex, potentially life-threatening disease that is most effectively treated through the administration of antibiotics (e.g., colistimethate...
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Pharmaceutics, Vol. 11, Pages 381: Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications Pharmaceutics doi: 10.3390/pharmaceutics11080381 Authors: Parveen Kumar Peipei Huo Bo Liu The folate receptor (FR) is a tumor-associated antigen that can bind with folic acid (FA) and its conjugates with high affinity and ingests the bound molecules inside the cell via the endocytic mechanism. A wide variety of payloads can be delivered to FR-overexpressed cells...
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Pharmaceutics, Vol. 11, Pages 378: Retinol-Containing Graft Copolymers for Delivery of Skin-Curing Agents Pharmaceutics doi: 10.3390/pharmaceutics11080378 Authors: Justyna Odrobińska Katarzyna Niesyto Karol Erfurt Agnieszka Siewniak Anna Mielańczyk Dorota Neugebauer The new polymeric systems for delivery in cosmetology applications were prepared using self-assembling amphiphilic graft copolymers. The synthesis based on “click” chemistry reaction included...
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Pharmaceutics, Vol. 11, Pages 377: Comparison of Target Features for Predicting Drug-Target Interactions by Deep Neural Network Based on Large-Scale Drug-Induced Transcriptome Data Pharmaceutics doi: 10.3390/pharmaceutics11080377 Authors: Hanbi Lee Wankyu Kim Uncovering drug-target interactions (DTIs) is pivotal to understand drug mode-of-action (MoA), avoid adverse drug reaction (ADR), and seek opportunities for drug repositioning (DR). For decades, in silico predictions for DTIs...
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Pharmaceutics, Vol. 11, Pages 382: Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection Pharmaceutics doi: 10.3390/pharmaceutics11080382 Authors: Dong-Gyun Han Jinsook Kwak Seong-Wook Seo Ji-Min Kim Jin-Wook Yoo Yunjin Jung Yun-Hee Lee Min-Soo Kim Young-Suk Jung Hwayoung Yun In-Soo Yoon Since diabetes mellitus and osteoarthritis...
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Pharmaceutics, Vol. 11, Pages 375: Mucosal Vaccination via the Respiratory Tract Pharmaceutics doi: 10.3390/pharmaceutics11080375 Authors: Hellfritzsch Scherließ Vaccine delivery via mucosal surfaces is an interesting alternative to parenteral vaccine administration, as it avoids the use of a needle and syringe. Mucosal vaccine administration also targets the mucosal immune system, which is the largest lymphoid tissue in the human body. The mucosal immune response involves systemic,...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 376: Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases Pharmaceutics doi: 10.3390/pharmaceutics11080376 Authors: Puttemans Lahoutte D’Huyvetter Devoogdt Brain tumors are notoriously difficult to treat. The blood-brain barrier provides a sanctuary site where residual and metastatic cancer cells can evade most therapeutic modalities. The delicate nature of the brain further complicates the decision of eliminating...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 371: Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes Pharmaceutics doi: 10.3390/pharmaceutics11080371 Authors: Christin Henein Sahar Awwad Nkiruka Ibeanu Stavros Vlatakis Steve Brocchini Peng Tee Khaw Yann Bouremel Intravitreal injections have become the cornerstone of retinal care and one of the most commonly performed procedures across all medical specialties. The impact of hydrodynamic forces of intravitreal...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 373: Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice Pharmaceutics doi: 10.3390/pharmaceutics11080373 Authors: Chawanphat Muangnoi Pahweenvaj Ratnatilaka Na Bhuket Ponsiree Jithavech Wisut Wichitnithad Onsiri Srikun Chakkrapan Nerungsi Suthiluk Patumraj Pornchai Rojsitthisak Previously, we synthesized curcumin and a succinate ester prodrug of curcumin...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 372: Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development Pharmaceutics doi: 10.3390/pharmaceutics11080372 Authors: Djordje Medarević Jelena Djuriš Panagiotis Barmpalexis Kyriakos Kachrimanis Svetlana Ibrić The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 374: Topical Inserts: A Versatile Delivery Form for HIV Prevention Pharmaceutics doi: 10.3390/pharmaceutics11080374 Authors: M. Melissa Peet Vivek Agrahari Sharon M. Anderson Homaira Hanif Onkar N. Singh Andrea R. Thurman Gustavo F. Doncel Meredith R. Clark The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 368: Sex Differences in Medicine Acceptability: A New Factor to Be Considered in Medicine Formulation Pharmaceutics doi: 10.3390/pharmaceutics11080368 Authors: Fabrice Ruiz Alexander Keeley Patrick Léglise Catherine Tuleu Célia Lachuer Jean-Paul Rwabihama Nathalie Bachalat Imad Boulaich Fattima Abdallah Maité Rabus Annie-Claude Ribemont Hugues Michelon Amélie Dufaÿ Wojcicki Mine Orlu Thibault Vallet Vincent Boudy ...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 369: Designing Fast-Dissolving Orodispersible Films of Amphotericin B for Oropharyngeal Candidiasis Pharmaceutics doi: 10.3390/pharmaceutics11080369 Authors: Dolores R. Serrano Raquel Fernandez-Garcia Marta Mele Anne Marie Healy Aikaterini Lalatsa Amphotericin B possesses high activity against Candida spp. with low risk of resistance. However, Amphotericin B’s high molecular weight compared to other antifungal drugs, such as miconazole...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 370: Pharmacokinetics of B-Ring Unsubstituted Flavones Pharmaceutics doi: 10.3390/pharmaceutics11080370 Authors: Robert Ancuceanu Mihaela Dinu Cristina Dinu-Pirvu Valentina Anuţa Vlad Negulescu B-ring unsubstituted flavones (of which the most widely known are chrysin, baicalein, wogonin, and oroxylin A) are 2-phenylchromen-4-one molecules of which the B-ring is devoid of any hydroxy, methoxy, or other substituent. They may be found naturally...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 367: Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650 Pharmaceutics doi: 10.3390/pharmaceutics11080367 Authors: Simone Ladel Patrick Schlossbauer Johannes Flamm Harald Luksch Boris Mizaikoff Katharina Schindowski Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal...
Thu Aug 01, 2019 03:00
Pharmaceutics, Vol. 11, Pages 366: Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Methoxy Poly(ethylene glycol)-b-Poly(d,l-Lactide) Polymeric Micelles Encapsulating Alpinumisoflavone Extracted from Unripe Cudrania tricuspidata Fruit Pharmaceutics doi: 10.3390/pharmaceutics11080366 Authors: Min Jeong Jo Yang Hee Jo Yu Jin Lee Chun-Woong Park Jin-Seok Kim Jin Tae Hong Youn Bok Chung Mi Kyeong Lee Dae Hwan Shin Alpinumisoflavone, a major compound in...
Thu Aug 01, 2019 03:00
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