Abstract Selinexor (XPOVIO™) is a first-in-class, oral, small molecule Exportin-1 (XPO1) inhibitor that is being developed by Karyopharm Therapeutics for the treatment of cancer. Selinexor (in combination with dexamethasone) received accelerated approval in the USA in July 2019 for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM). Selinexor is also undergoing clinical development in a wide range of haematological and solid cancers. This article...
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Abstract Purpose Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20–40% of exposed patients, despite any implemented precaution to avoid it. The aim of this work was therefore to identify a relevant nephroprotective method for CIA. Methods We searched Pubmed, Embase, and Web of Science from 1 January 1978 to 1 June 2018,...
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Abstract Bremelanotide (Vyleesi™) is a melanocortin receptor agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty. It is a self-administered, on-demand subcutaneous therapy. Initially developed by Palatin Technologies who sponsored the Phase 3 clinical trials, bremelanotide was subsequently out-licensed...
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Hearing healthcare is evolving at a rapid rate. Origins of this evolution stem, in part, from the recent proliferation of disruptive innovations (e.g., OTCs/PSAPs, pharmaceuticals), along with changes in population dynamics. This course provides participants with evidence and hands-on tools that promote opportunities for increased audiology awareness, and increased adoption of services and technologies in this changing market landscape.
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The incidence of type 2 diabetes in children and adolescents is increasing, with the increase driven by childhood obesity, and type 2 diabetes disproportionately affects disadvantaged minorities. Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in…
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Comparisons of early and delayed abstainers and its effects on long-term smoking cessation in Taiwan
Different quitting trajectories may reflect the stages of behavior change among smokers. The nature of quitting patterns could help the public health sector to design appropriate cessation plans. This study co...
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AbstractFamily caregivers often feel ill-equipped to handle bothersome behavioral and psychological symptoms of dementia, such as agitation, apathy, and sleep disturbances, leading to increased caregiver distress and nursing home placement for people with dementia. Therapies for such symptoms are currently limited and non-pharmacological options are preferred, given potential side effects of medications. Neurologic music therapy (NMT) could provide an additional treatment option for managing behavioral...
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