Summary Background Checkpoint inhibitors bring marked benefits but only in a minority of patients and may also be associated with severe adverse events. Treatment outcome still cannot be faithfully predicted. The following study hypothesized that host genetics could be applied as predictive biomarkers for checkpoint inhibitor response and immune-related adverse events. We conducted a study based on germinal polymorphisms from genes coding for proteins involved in immune regulation....
Summary Background The 5-year survival rate for extensive-disease small-cell lung carcinoma (ED-SCLC) is only 1%. Recently, apatinib exerted promising effects on cancer patients after failure of first-line chemotherapy. Methods This study enrolled 24 ED-SCLC patients to study the efficacy and toxicity of apatinib in combination with chemotherapy and maintenance therapy. The primary endpoints were overall survival (OS) and progression-free survival (PFS). The secondary endpoints...
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Publication date: Available online 10 August 2019Source: Clinical TherapeuticsAuthor(s): Bradley Tucker, Rahul Kurup, Jennifer Barraclough, Rodney Henriquez, Siân Cartland, Clare Arnott, Ashish Misra, Gonzalo Martínez, Mary Kavurma, Sanjay PatelAbstractPurposeExisting literature reports that colchicine inhibits inflammasome activation and downstream inflammatory cytokine production and stabilizes coronary plaque. However, colchicine's effect on chemokines, which orchestrate multiple atheroinflammatory...
Publication date: Available online 10 August 2019Source: Clinical TherapeuticsAuthor(s): Cory McLaughlin, Anthony I. Squillaro, Shadassa Ourshaliman, Ashley Song, Ashwini Lakshmanan, Giovanni Cucchiaro, Matthew Hall, Rita V. Burke, Lorraine I. Kelley-QuonABSTRACTPurposeThe purpose of this study was to describe the frequency and variation of opioid use across hospitals in infants undergoing pyloromyotomy and to determine the impact of opioid use on postoperative outcomes.MethodsA retrospective cohort...
Publication date: Available online 10 August 2019Source: Clinical TherapeuticsAuthor(s): Jorge Sanchez-Redondo, Gerard Espinosa, David Varillas Delgado, Ricard CerveraAbstractPurposeThe treatment of thrombosis in patients with antiphospholipid syndrome (APS) usually requires long-term anticoagulation with vitamin K antagonists. The effectiveness of direct oral anticoagulants (DOACs) in APS has not been fully addressed. The purpose of this research was to analyze the efficacy (thrombotic event–free...
Publication date: Available online 9 August 2019Source: Clinical TherapeuticsAuthor(s): Merve Duru, Osman Meydan, Mustafa Kaya, Sinem Ezgi Gulmez
Publication date: Available online 8 August 2019Source: Clinical TherapeuticsAuthor(s): J. Russell May, William K. DolenAbstractPurposeAllergic rhinitis (AR) is a highly prevalent disease, affecting the quality of life of millions of Americans. Intranasal corticosteroids (INCs) are widely recommended as first-line therapy for moderate to severe AR. Although these drugs exhibit similar safety and efficacy, a potentially differentiating factor within this class is the varying sensory attributes associated...
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Publication date: Available online 8 August 2019Source: BrachytherapyAuthor(s): Diana J. Lu, Michael Luu, Catheryn M. Yashar, Ann H. Klopp, Mitchell KamravaAbstractPurposeRecent evaluation of female representation in major radiation oncology organizations was published by Knoll et al. (IJROBP, 2018) but did not include information about the American Brachytherapy Society (ABS). The objective of this study is to assess trends in gender diversity in the ABS.Materials and MethodsPublicly available information...
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Publication date: Available online 9 August 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Taku Nakayama, Tatsuya Kobayashi, Otsuka Shimpei, Hideo Fukuhara, Tsutomu Namikawa, Keiji Inoue, Kazumasa Hanasaki, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro OguraAbstractBackgroundPhotodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to control the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), are in common clinical use....
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hanyu Ma, Tian Tian, Xubin Liu, Meng Xia, Cancan Chen, Lianxi Mai, Shule Xie, Li YuAbstractCircular RNAs (circRNAs) are a novel group of noncoding RNAs characterized by a covalently closed loop. An increasing evidence suggests that deregulated circRNAs exert their essential regulatory roles in oncogenesis. However, little is explored on the biological role of novel circRNAs in cervical cancer (CC) progression....
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Fan-Yen Lee, Chi-Wen Luo, Christopher Glenn Wallace, Kuan-Hung Chen, Jiunn-Jye Sheu, Tsung-Cheng Yin, Han-Tan Chai, Hon-Kan YipAbstractBackgroundThis study tested the hypothesis that intramuscular injections of erythropoietin (EPO) and endothelial progenitor cells (EPC) to critical limb ischemia (CLI; primary treatment site) could also improve heart function in rat after acute myocardial infarction (AMI;...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Haixia Yuan, Xinqiang Ni, Min Zheng, Xinmin Han, Yuchen Song, Minfeng YuAbstractStudies suggest that abnormal neurodevelopment of prefrontal striatal circuits is implicated in the pathogenesis of attention deficit hyperactivity disorder (ADHD). In the present study, we investigated the effect of catalpol, an active ingredient of Rehmanniae radix preparata, which is the most frequently used Chinese medicinal...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Gong Mei-jiao, Li Shi-fang, Chang Yan-yan, Shao Jun-jun, Sun Yue-feng, Ren Ting-ting, Zhang Yong-guang, Chang Hui-yunAbstractFoot-and-mouth disease virus (FMDV) is an important pathogen that affects livestock breeding and causes huge economic losses worldwide. Currently, the development of antiviral agents to combat FMDV infection at the early stages is being explored. As viral replication critically depends...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yang Zhang, Wu Yu, Dong Han, Jing Meng, Hongjun Wang, Guangke CaoAbstractSepsis is a severe, life-threatening condition caused primarily by the cellular response to infection. Sepsis leads to increased tissue damage and mortality in patients in the intensive care unit. L-Lysine is an essential amino acid required for protein biosynthesis and is abundant in lamb, pork, eggs, red meat, fish oil, cheese, beans,...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jing Liu, Xinhua Huang, Siping Hu, Huanzhong He, Zhipeng MengAbstractObjectiveToll-like receptor 4(TLR-4)/nuclear factor-kappa B(NF-κB) pathway plays an important role in inducing acute lung injury (ALI). Studies have proved Dexmedetomidine (Dex) inhibits inflammatory response to mitigate lipopolysaccharide (LPS)‐induced ALI and protect against multiorgan injury in various scenarios via restraining TLR-4/NF-κB...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Junnan Ma, Xianglong Meng, Seok Yong Kang, Jie Zhang, Hyo Won Jung, Yong-Ki ParkAbstractOur study was conducted to investigate the effects of the fruits of Lycium chinense Mill. (Lycii Fructus, LF) and its bioactive compound, betaine, on muscle differentiation and mitochondrial biogenesis in C2C12 cells. LF extract and betaine was analyzed by high-performance liquid chromatography (HPLC). The expression...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yang Zhang, Neil Gross, Zufei Li, Gaofei Yin, Qi Zhong, Chuan Liu, Zhigang HuangAbstractPurposeThe BTF3 is involved in oncogenesis, while the biological roles in HSCC remain unclear. The aim of this study was to explore the impact of BTF3 knockdown on biological phenotypes of human HSCC in vivo and in vitro.MethodsThe expression of BTF3 was assessed in HSCC and normal tissues. In vitro experiments were performed...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zikuan Song, Haoyu Wang, Shuang ZhangAbstractSignificant advances in the treatment of non-small cell lung cancer (NSCLC) have been made over the past decade, and they predominantly involve molecular targets such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. However, despite the initial good response, drug resistance eventually develops. The Wnt...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zhi-Bin Wang, Jun-Yan Liu, Xiao-Jing Xu, Xiao-Yuan Mao, Wei Zhang, Hong-Hao Zhou, Zhao-Qian LiuAbstractNBIA (Neurodegeneration with brain iron accumulation) is a group of inherited neurologic disorders characterized by marked genetic heterogeneity, in which iron atypical accumulates in basal ganglia resulting in brain magnetic resonance imaging changes, histopathological abnormalities, and neuropsychiatric...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): James M. Brimson, Nattawat Onlamoon, Tewin Tencomnao, Premrutai ThitilertdechaAbstractClerodendrum petasites S. Moore has been prescribed in Thai traditional medicine for over 30 years for the treatment of ailments including asthma, inflammation, fever, cough, vomiting, and skin disorders. The phytochemicals from this plant have been identified as phenolic acids, flavones, flavone glycosides, glycosides,...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xinli Ouyang, Yangyang Han, Yongfang Xie, Yide Wu, Shaojia Guo, Min Cheng, Guohui WangAbstractPurposeTo increase the understanding of collagen metabolism as related to scleral remodeling in the process of emmetropization and myopization.MethodsAn eyelid suture that lasted 60 days was performed on one-month-old rabbits to establish an experimental monocular visual deprivation myopia model and the axial length...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Junma Yu, Ke Chen, Lining Wu, Xuesheng Liu, Yao LuAbstractRemote preconditioning of trauma (RPCT) by surgical incision is an effective cardioprotective strategy via the transient receptor potential vanilloid 1 (TRPV1) channel as a form of remote ischemic preconditioning (RIPC). However, cardioprotection by RIPC has been shown to be completely blocked by propofol. We thus hypothesized that propofol may interfere...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Renjie Wang, Lina Zhao, Linlin Ji, Lin Bai, Qiang WenAbstractThe long noncoding RNA myocardial infarction associated transcript (MIAT) was reported to be involved in the progression of multiple cancers. However, the exact roles and molecular mechanisms of MIAT in papillary thyroid cancer (PTC) progression are still unknown. We examined the expression levels of lncRNA MIAT in 50 paired PTC tissue specimens...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hongguang Xia, Xiangyu Zhu, Xiaoyan Zhang, Haiyan Jiang, Biao Li, Zhihao Wang, Dalang Li, Yong JinAbstractNon-alcoholic fatty liver disease (NAFLD) is a chronic liver disease. The literature suggests that the aryl hydrocarbon receptor (AHR) may be a key player in the pathogenesis of NAFLD, and it can modulate the synthesis of cytochrome P450 1A1 (CYP1A1) and tumor necrosis factor-α (TNF-α). Previous studies...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Chengzhi Xie, Guoxing Liu, Min Li, Yu Fang, Ke Qian, Yu Tang, Xiaolong Wu, Xiaohua Lei, Xiaocheng Li, Qiang Liu, Gao Liu, Jiefeng Liu, Yueming Zhang, Zhao Huang, Zecheng Hu, Zhenyu Cao, Jixiong Hu, Shengfu Huang, Dewu Zhong, Jiangsheng HuangAbstractThe landscape of cellular plasticity and sources with relevant niche signals in hepatocellular carcinoma is still obscure. Transient receptor potential vanilloid...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Angelina Sampson, Brian G. Peterson, Kee W. Tan, Surtaj H. IramAbstractMultidrug resistance protein 1 (MRP1/ABCC1) actively transports a variety of drugs, toxic molecules and important physiological substrates across the plasma membrane. It can confer broad-spectrum multidrug resistance and can decrease the bioavailability of many important drugs. Substrates of MRP1 include anti-cancer agents, antibiotics,...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hadi Tavakkoli, Reza Attaran, Ahmad Khosravi, Zohreh Salari, Ehsan Salarkia, Shahriar Dabiri, Seyedeh Saedeh MosallanejadAbstractFosfomycin residues are found in the egg following administration in the layer hen. In this regard, some aspects of embryo-toxicity of fosfomycin have been documented previously. The exact mechanism by which fosfomycin causes embryo-toxicity is not clearly understood. We hypothesis...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yiyu Qin, Yang Zhou, Anxing Ge, Li Chang, Haiyan Shi, Yang Fu, Qiong LuoAbstractBackgroundGallbladder cancer (GBC) ranks fifth in the most common malignancy of the gastrointestinal tract worldwide. It is reported many small nucleolar RNAs (SNORNs) could regulate the progression of GBC. To identify potential therapeutic targets for GBC, we conducted microarray analysis in GBC tissues and adjacent normal tissues....
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jamie R. Friedman, Stephen D. Richbart, Justin C. Merritt, Kathleen C. Brown, Krista L. Denning, Maria T. Tirona, Monica A. Valentovic, Sarah L. Miles, Piyali DasguptaAbstractCancer progression is a complex multistep process comprising of angiogenesis of the primary tumor, its invasion into the surrounding stroma and its migration to distant organs to produce metastases. Nutritional compounds of the “capsaicinoid”...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jing-Ze Yu, Yi Ying, Yang Liu, Chun-Bin Sun, Chen Dai, Shan Zhao, Shou-Zheng Tian, Jing Peng, Ni-Ping Han, Jia-Li Yuan, Jin-Yuan Yan, Zhong-Shan YangAbstractPulmonary fibrosis (PF) is a crippling disease characterized by progressive dyspnea and associated with a high mortality rate, but its origin is unknown and there is no effective treatment. Yifei Sanjie formula (YFSJF) is a Chinese medicine that is widely...
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Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Yuxuan Li, Lin Yuan, Shenyi Jiang, Siyan Liu, Liping Xia, Hui Shen, Jing LuAbstractInterleukin (IL)-35 plays an important role in the pathogenesis of rheumatoid arthritis (RA), which is characterized by tumor necrosis factor (TNF)-α activated bone loss beginning early and persisting over time. The aim of this study was to explore the effects and signaling pathway of IL-35 on osteoblasts differentiation in...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Yuangang Wu, Xiaoxi Lu, Mingyang Li, Junfeng Zeng, Jun Zeng, Bin Shen, Yi ZengAbstractOsteoarthritis (OA) is one of the most common chronic joint diseases. However, the mechanism remains unclear. The traditional renin-angiotensin system (RAS) is an important system for regulating homeostasis and controlling balance. In recent years, RAS-related components have played an important role in the occurrence of...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Ruizhe Wang, Yi Zhang, Fengping ShanAbstractEndogenous opioids are neuro-peptides with multifunctional properties. Historically, opioids are used to mediate pain; however, excess opiate consumption can lead to addiction. One endogenous opioid, methionine enkephalin (MENK), was reported to modulate cell growth, MENK was identified as an opioid growth factor (OGF) that interacts with the OGF receptor (OGFr)...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Ying Xiong, Yan Ma, Nandani Darshika Kodithuwakku, Weirong Fang, Lifang Liu, Fengwen Li, Yahui Hu, Yunman LiAbstractClematichinenoside AR (AR), a major active ingredient extracted from traditional Chinese herb Clematis chinensis Osbeck, has been demonstrated to possess anti-inflammatory and immune-modulatory activities in the treatment of experimental rheumatoid arthritis (RA). The therapeutic potential of...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Yannong Dou, Jinque Luo, Juntao Yu, Yufeng Xia, Yue DaiAbstractOur previous studies demonstrated that oral administration of madecassoside could markedly attenuate collagen-induced arthritis in rats, a rodent model of rheumatoid arthritis. As the autonomic nervous system is critically involved in the modulation of peripheral inflammation and immune response, the present study aims to explore the possible involvement...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Miao-Miao Hou, Yu-Feng Li, Ling-Ling He, Xiao-Qiong Li, Yu Zhang, Sheng-Xiao Zhang, Xin-Yi LiAbstractBackgroundT helper (Th17) cells play an important role in many autoimmune diseases. In this meta-analysis, we aimed to specify the proportion of Th17 cells and the levels of Th17-related cytokines in neuromyelitis optica spectrum disorders (NMOSD) patients, we did this meta-analysis.MethodsUsing previously...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Ping Zhang, Yi Fu, Jihui Ju, Dapeng Wan, Hao Su, Zhaodong Wang, Huajuan Rui, Qianheng Jin, Yingying Le, Ruixing HouAbstractEstrogen has been reported to inhibit neutrophil infiltration related inflammation and suppress neutrophils migration in vitro, but the underlying mechanism is not fully understood. By using HL-60 differentiated neutrophil-like cells (dHL-60) and human neutrophils, we examined the effect...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Yanhao He, Guangde Yang, Feng Yao, Yushan Xian, Guan Wang, Lifang Chen, Xiaohan Lv, Hongqian Gao, Zihan Zheng, Lijing Sun, Weirong Wang, Rong LinAbstractSitagliptin has recently been shown to inhibit inflammatory response in cardiovascular disease. Sirtuin6 (SIRT6), a NAD+-dependent class III histone deacetylase, participates in the regulation of cellular inflammation. We hypothesized that sitagliptin could...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Lihua Tan, Yongfu Wang, Gaoxiang Ai, Chaodan Luo, Hanbin Chen, Cailan Li, Huifang Zeng, Jianhui Xie, Jiannan Chen, Ziren SuAbstractDihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. Nowadays most researches on PC focus on its main components like BBR, however, the role of its naturally-occurring derivatives...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Na Qu, Xiaobin Wang, Yiming Meng, Fengping ShanAbstractThe standard treatments for neoplasia include surgery, chemotherapy, hormone antagonists and radiotherapy, which can prolong survival, but rarely cure the tumors of gynecological cancer patients. OGF - OGFr expression, in various gynecologic cells and tissues, is an intersection point between cell development, neuroendocrine function and immune modulation....
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Tissue Engineering Part A, Ahead of Print.
Tissue Engineering Part A, Ahead of Print.
Tissue Engineering Part A, Ahead of Print.
Suppression of SPRY4 Promotes Osteogenic Differentiation and Bone Formation of Mesenchymal Stem Cell
Tissue Engineering Part A, Ahead of Print.
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