Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 61-year-old…
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Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune, inflammatory disorder of the central nervous system that has a prevalence of 0.5 to 10 persons (predominantly women) per 100,000 population. It is characterized mainly by recurrent optic neuritis and myelitis, and such attacks are…
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Abstract Purpose To investigate immunoglobulin E (IgE)-mediated hypersensitivity to chlorhexidine (CHX), and association between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous...
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Abstract The Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps between initial presentation, through diagnosis, management and tolerance development. Despite its UK focus, it soon became clear that MAP was being accessed internationally and thus an updated International Milk Allergy in Primary Care (iMAP) guideline was published...
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Three medical stories from the week that we didn't cover, explained.Medscape (Source: Medscape Allergy Headlines)
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Find out how the safety profile for abatacept compared with that of other DMARDs for rheumatoid arthritis.Arthritis Research & Therapy (Source: Medscape Allergy Headlines)
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Tiny pieces of plastic have been found in ice cores drilled in the Arctic by a U.S.-led team of scientists, underscoring the threat the growing form of pollution poses to marine life in even the remotest waters on the planet.Reuters Health Information (Source: Medscape Allergy Headlines)
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The International Commission on the Clinical Use of Human Germline Genome Editing met for the first time this week and urged caution.Medscape Medical News (Source: Medscape Allergy Headlines)
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So far this year, the number of global measles cases is surging, reaching numbers that haven't been this high since 2006, according to WHO; measles vaccine uptake is also suboptimal.Medscape Medical News (Source: Medscape Allergy Headlines)
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Treatment of vitiligo can be challenging. Review current and emerging pharmacological, surgical and phototherapy management options in this article.Skin Therapy Letter (Source: Medscape Allergy Headlines)
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The experience with dupilumab, the first biologic for the treatment of atopic dermatitis, has demonstrated some marked contrasts to that seen in clinical trials.Medscape Dermatology (Source: Medscape Allergy Headlines)
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AstraZeneca Plc said on Friday a late-stage study showed its top-selling drug, Tagrisso (osimertinib), had significantly helped patients with a type of lung cancer live longer without the disease worsening.Reuters Health Information (Source: Medscape Allergy Headlines)
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Title: chlorpheniramine, pseudoephedrine (Deconamine - discontinued)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 8/13/2019 12:00:00 AM (Source: MedicineNet Allergies General)
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Abstract Background Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related diseases. We aimed to explore whether sestrin2 was involved in asthma. Methods Seventy-six subjects (44 in the asthma group,...
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Purpose of review Here we review the rheumatologic and autoimmune features of primary immune deficiencies with a focus on recently recognized genetic diseases, the spectrum of autoimmunity in PID, and targeted therapies. Recent findings Primary immune deficiencies (PIDs) were initially described as genetic diseases of the immune system leading to susceptibility to infection. It is now well recognized that immune dysfunction and dysregulation also cause noninfectious complications including...
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Publication date: Available online 17 August 2019Source: Allergology InternationalAuthor(s): Taisuke Ito, Takahiro Suzuki, Jun-ichi Sakabe, Atsuko Funakoshi, Toshiharu Fujiyama, Yoshiki TokuraAbstractBackgroundAlopecia areata (AA) is a tissue-specific autoimmune disease, and interferon (IFN)-γ has been regarded as the key cytokine in the pathogenesis of AA. The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paul J. Maglione, Huaibin M. Ko, Minami Tokuyama, Gavin Gyimesi, Camilia Soof, Mingjie Li, Eric Sanchez, Haiming Chen, Lin Radigan, James Berenson, Charlotte Cunningham-RundlesABSTRACTBackgroundPrimary antibody deficiencies (PAD) are the most prevalent primary immunodeficiencies. More severe forms of PAD, common variable immunodeficiency (CVID) and X-linked agammaglobulinemia...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Alexandra Leonard, Jingya Wang, Li Yu, Hao Liu, Yeriel Estrada, Lydia Greenlees, Roderick McPhee, Alexey Ruzin, Emma Guttman-Yassky, Michael D. HowellAbstractBackgroundAtopic dermatitis (AD) is a chronic inflammatory disease with significant local and systemic inflammation and barrier disruption. AD is associated with increased risk of allergen sensitization and skin colonization...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Melissa D. Gans, Carlos A. Saavedra-Matiz, Larry Bernstein
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Delayed graft function (DGF) is a transplant complication which means a need to dialysis throughout the first week after transplantation. This study aimed to ascertain the relationship between the two immunomodulatory factors of soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble fibrinogen-like protein 2 (sFGL-2) with DGF after transplantation. This case-control study was done in 2 groups of 58 kidney transplant patients with and without DGF. The control group included the patients who didn’t...
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Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defective phagocytic NADPH oxidase, causing a complete lack or significant decrease in the production of microbicidal reactive oxygen metabolites. It mainly affects male children; however, there are scarce reports of adult females diagnosed with X-linked-CGD attributed to an extremely skewed X-chromosome inactivation. This condition is characterized by severe and recurrent infections that usually develop after childhood....
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In this study, we first tried to determine whether the expression level of 9 miRNAs in the peripheral blood CD8+ T cells of asthmatic patients varies from that of controls, and secondly, we investigated the effects of fluticasone furoate and vilanterol on the expression level of these miRNAs. Fifteen subjects including 8 healthy individuals and 7 asthmatic patients were included in this study. CD8+T cells were isolated from participants' peripheral blood by a negative selection method using magnetic-activated...
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Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS). Studies have been shown that Long-term usage of this protein can lead to the development of anti-drug antibodies (ADAs) and this phenomenon cause total loss or reduced efficacy of IFNβ-1b. The aim of this study was to predict and silence IFNβ-1b T-cells epitopes by in silico methods and genetic engineering. Based on bioinformatics studies we identified optimal sets of conservative point mutations...
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Interleukin (IL)-4-producing-CD8 (cytotoxic T cells, Tc) contribute to lung eosinophilia and airway hyper-responsiveness (AHR) to an antigen. CD4+CD25+ regulatory T cells (Tregs) attenuate airway inflammation and AHR. This study investigated whether Tregs decrease Tc2frequencies in ovalbumin (OVA)-induced asthma model of mice. Female C57BL/6 mice were sensitized with OVA intraperitoneally and challenged with OVA intranasally to induce allergic asthma model. Tregs were sorted by fluorescence activated...
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Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. The aim of this review is to comprehensively summarize the various factors impacting AD incidence in...
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The oncogenic role of human cytomegalovirus (HCMV) has been recently shown in different cancers like colorectal cancer (CRC). According to the recent immunotherapy approach to target the CMV-expressing tumor cells, we investigated the CMV peptide-stimulated CD8+T cells functions in CRC patients compared to healthy individuals. All sixteen patients and seven controls were CMV seropositive. Blood samples were obtained from patients without chemotherapy and radiotherapy before surgery. Cytotoxic CD8+...
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Granulocyte colony-stimulating factor (G-CSF) is the major regulator of hemopoiesis and granulopoiesis. However, overexpression of G-CSF has been implicated in several important processes in tumor biology such as tumor growth, angiogenesis, and metastasis. Four different mRNA isoforms resulting from alternative splicing have been reported for G-CSF (transcript variants 1, 2, 3 and 4). The mRNAs and protein products of splice variants 1 and 2 have been isolated for the first time, from tumor cell...
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CXC Chemokine Ligand 8 (CXCL8) plays an important role in gastric inflammation and in the progression of gastric cancer induced by Helicobacter pylori (H. pylori) infection. The association of CXCL8, CXC Chemokine Receptor 1 (CXCR1), and CXC Chemokine Receptor 2 (CXCR2) polymorphisms with H. pylori infection and gastric cancer progression needs to be investigated in a population within an enigma area consisting of multiple ethnicities, such as Thailand. To analyze the relative risk of H. pylori infection...
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Poikiloderma is a hereditary pathologic situation in which the appearance of skin rash is associated with epidermal atrophy, telangiectasia, and reticular dyspigmentation skin symptoms of poikiloderma are usually caused by sun damage. The main reason forpoikiloderma is unknown. We introduce a 14- month-old boy who referred to our center with a complaint of fever and cough. Furthermore, hepatosplenomegaly symptoms had been presented at the time of birth and were continuously observed at age one. He...
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The current study aimed to investigate the effects of vitamin D administration on the markers of inflammation and metabolic damages in the liver of high-fat diet-induced obese rats. Forty male Wistar rats were divided into two groups of control receiving a normal diet (ND) and intervention receiving a high-fat diet (HFD). After 16 weeks, each group was divided into two groups including ND, ND + vitamin D, HFD, and HFD + vitamin D. Vitamin D was administered by oral gavage for five weeks at the dose...
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Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase–positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X–linked CGD (XL-CGD) and carriers, and very few in autosomal recessive CGD (AR-CGD). Here, we present 5 patients with CGD...
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Loss of the keratin cytoskeleton results in upregulation of the pro-inflammatory cytokine Tslp via autocrine Areg-Egfr-Erk1/2 signaling. The Areg-Egfr axis represents a therapeutical target to moderate Tslp, inflammation and itch in EBS. (Source: Journal of Allergy and Clinical Immunology)
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In the phase 2 clinical study, topical delgocitinib, a novel Janus kinase inhibitor, improved clinical signs and symptoms in pediatric patients with atopic dermatitis and was well tolerated. (Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Allergy and Clinical Immunology)
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This study supports a positive benefit-risk profile for long-term mepolizumab treatment in these patients. (Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Allergy and Clinical Immunology)
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IL-8 is an important chemokine implicated in the pathogenesis of chronic rhinosinusitis (CRS), but little is known about epigenetic regulation of IL8 in the pathogenesis of CRS. (Source: Journal of Allergy and Clinical Immunology)
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Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Liat Nachshon, Michael R. Goldberg, Michael B. Levy, Naama Epstein-Rigbi, Michael Y. Appel, Yitzhak Katz, Arnon Elizur
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Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gökçe Özyılmaz-Bozat, Ümit Murat Şahiner, A Betül Büyüktiryaki, Özge Uysal-Soyer, Bülent Enis Şekerel
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Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Amelia Licari, Giuliana Ferrante, Gian Luigi Marseglia, Giovanni Corsello, Stefania La GruttaAbstract:Suboptimal adherence to treatment is a significant issue in the management of pediatric asthma and is a major cause of uncontrolled disease, life-threatening attacks, and increased utilization of healthcare resources. Electronic health (e-Health) solutions have the potential...
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Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Guilherme Constante Preis Sella, Edwin Tamashiro, Juliana Augusta Sella, Davi C. Aragon, Thais Nociti de Mendonça, Luisa Karla de Paula Arruda, Wilma Terezinha Anselmo Lima, Fabiana Cardoso Pereira ValeraAbstractBackgroundFactors associated with recurrence of chronic rhinosinusitis are still poorly recognized.ObjectiveTo evaluate which risk factors could influence the risk...
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Publication date: Available online 16 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Naiya B. Patel, Lyda Cuervo-Pardo, Timothy L. Tan, Roopal V. Kundu, Sergio E. Chiarella
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Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Punita Ponda, Charmi Patel, Seungjun Ahn, Tung Ming Leung, Toni Webster
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Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maxime Cormier, Simone Chaboillez, Catherine Lemière
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Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): James W. Antoon, Jennifer L. Goldman, Brian R. Lee
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Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Amy H. Huang, Kristin L. Chichester, Sarbjit S. Saini
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Publication date: Available online 14 August 2019Source: Allergology InternationalAuthor(s): Minoru Gotoh, Kimihiro Okubo, Atsushi Yuta, Yukiko Ogawa, Hitoshi Nagakura, Shigehiro Ueyama, Tomoyo Ueyama, Kayoko Kawashima, Masashi Yamamoto, Shigeharu Fujieda, Masafumi Sakashita, Hirokazu Sakamoto, Naruhito Iwasaki, Eri Mori, Tomonori Endo, Nobuo Ohta, Hiroshi Kitazawa, Mitsuhiro Okano, Mikiya Asako, Masami TakadaAbstractBackgroundThere have been no studies of dual administration of sublingual immunotherapy...
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Sufficient cell surface expression of CD48 is needed to (i) control inflammation, (ii) ensure correct natural killer cell maturation and function, and (iii) regulate target cell susceptibility to cytotoxicity. (Source: Journal of Allergy and Clinical Immunology)
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