Biomolecules, Vol. 9, Pages 378: There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives Biomolecules doi: 10.3390/biom9080378 Authors: Eric D. Salomaki Martin Kolisko The phylum Apicomplexa (Alveolates) comprises a group of host-associated protists, predominately intracellular parasites, including devastating parasites like Plasmodium falciparum, the causative agent of malaria. One of the more fascinating characteristics of Apicomplexa...
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Cancers, Vol. 11, Pages 1203: Baseline Genomic Features in BRAFV600-Mutated Metastatic Melanoma Patients Treated with BRAF Inhibitor + MEK Inhibitor in Routine Care Cancers doi: 10.3390/cancers11081203 Authors: Baptiste Louveau Fanelie Jouenne Coralie Reger de Moura Aurelie Sadoux Barouyr Baroudjian Julie Delyon Florian Herms Adele De Masson Laetitia Da Meda Maxime Battistella Nicolas Dumaz Celeste Lebbe Samia Mourah In BRAFV600mut metastatic melanoma,...
Sun Aug 18, 2019 03:00
Cells, Vol. 8, Pages 925: The uPAR System as a Potential Therapeutic Target in the Diseased Eye Cells doi: 10.3390/cells8080925 Authors: Maurizio Cammalleri Massimo Dal Monte Vincenzo Pavone Mario De Rosa Dario Rusciano Paola Bagnoli Dysregulation of vascular networks is characteristic of eye diseases associated with retinal cell degeneration and visual loss. Visual impairment is also the consequence of photoreceptor degeneration in inherited eye diseases with a major...
Sun Aug 18, 2019 03:00
Cells, Vol. 8, Pages 927: Targeting the CD40-CD154 Signaling Pathway for Treatment of Autoimmune Arthritis Cells doi: 10.3390/cells8080927 Authors: Jenn-Haung Lai Shue-Fen Luo Ling-Jun Ho Full activation of T lymphocytes requires signals from both T cell receptors and costimulatory molecules. In addition to CD28, several T cell molecules could deliver costimulatory signals, including CD154, which primarily interacts with CD40 on B-cells. CD40 is a critical molecule regulating several...
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Cells, Vol. 8, Pages 926: Cancer Stem Cells and Targeting Strategies Cells doi: 10.3390/cells8080926 Authors: Luisa Barbato Marco Bocchetti Anna Di Biase Tarik Regad Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms that counteract the effect of chemotherapeutic compounds, leading to relapse and the development of more aggressive cancers that contribute to poor prognosis and survival rates of treated patients. Cancer stem cells (CSCs) play...
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Healthcare, Vol. 7, Pages 98: Perspectives of Healthcare Professionals on Meaningful Activities for Persons with Dementia in Transition from Home to a Nursing Home: An Explorative Study Healthcare doi: 10.3390/healthcare7030098 Authors: Mari Groenendaal Anne Loor Manja Trouw Wilco P. Achterberg Monique A.A. Caljouw Meaningful activities can enhance quality of life, a sense of connectedness, and personhood for persons with dementia. Healthcare professionals play an important...
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IJERPH, Vol. 16, Pages 2879: Physiological Demands of Extreme Obstacle Course Racing: A Case Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162879 Authors: Timothy Baghurst Steven L. Prewitt Tyler Tapps Obstacle course races are a popular source of recreation in the United States, providing additional challenges over traditional endurance events. Despite their popularity, very little is known about the physiological or cognitive demands...
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IJERPH, Vol. 16, Pages 2973: European Rural Development Policy Approaching Health Issues: An Exploration of Programming Schemes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162973 Authors: Antonella Samoggia Aldo Bertazzoli Arianna Ruggeri Malnutrition, obesity, type 2 diabetes, micronutrient deficiencies, and the increase in non-communicable diseases are among the future European key challenges in health and welfare. Agriculture and rural...
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IJMS, Vol. 20, Pages 4039: miR526b and miR655 Induce Oxidative Stress in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20164039 Authors: Bonita Shin Riley Feser Braydon Nault Stephanie Hunter Sujit Maiti Kingsley Chukwunonso Ugwuagbo Mousumi Majumder In eukaryotes, overproduction of reactive oxygen species (ROS) causes oxidative stress, which contributes to chronic inflammation and cancer. MicroRNAs (miRNAs) are small, endogenously produced...
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IJMS, Vol. 20, Pages 4038: Tetracycline Analogs Inhibit Osteoclast Differentiation by Suppressing MMP-9-Mediated Histone H3 Cleavage International Journal of Molecular Sciences doi: 10.3390/ijms20164038 Authors: Yeojin Kim Jinman Kim Hyerim Lee Woo-Ri Shin Sheunghun Lee Jisu Lee Jae-Il Park Byung Hak Jhun Yang-Hoon Kim Sun-Ju Yi Kyunghwan Kim Osteoporosis is a common disorder of bone remodeling, caused by the imbalance between bone resorption by osteoclasts...
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IJMS, Vol. 20, Pages 4036: Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood–Brain Barrier Alterations after Cerebral Photothrombosis in Rats International Journal of Molecular Sciences doi: 10.3390/ijms20164036 Authors: Michael K. Schuhmann Guido Stoll Lena Papp Arne Bohr Jens Volkmann Felix Fluri Blood–brain barrier (BBB) disruption is a critical event after ischemic stroke, which results in edema formation and hemorrhagic...
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IJMS, Vol. 20, Pages 4035: Novel Insights into Regulation of Human Teeth Biomineralization: Deciphering the Role of Post-Translational Modifications in a Tooth Protein Extract International Journal of Molecular Sciences doi: 10.3390/ijms20164035 Authors: Vaibhav Sharma Komal Rani Ajoy Roychoudhury Amita Chawla Fredrik Nikolajeff Saroj Kumar The importance of whole protein extracts from different types of human teeth in modulating the process of teeth biomineralization...
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IJMS, Vol. 20, Pages 4037: Consistent Biomarkers and Related Pathogenesis Underlying Asthma Revealed by Systems Biology Approach International Journal of Molecular Sciences doi: 10.3390/ijms20164037 Authors: Xiner Nie Jinyi Wei Youjin Hao Jingxin Tao Yinghong Li Mingwei Liu Boying Xu Bo Li Asthma is a common chronic airway disease worldwide. Due to its clinical and genetic heterogeneity, the cellular and molecular processes in asthma are highly complex and relatively...
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IJMS, Vol. 20, Pages 4034: Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1 International Journal of Molecular Sciences doi: 10.3390/ijms20164034 Authors: Wolfgang Stremmel Simone Staffer Ralf Weiskirchen Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative...
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IJMS, Vol. 20, Pages 4033: Gonadotropin-Releasing Hormone in Regulation of Thymic Development in Rats: Profile of Thymic Cytokines International Journal of Molecular Sciences doi: 10.3390/ijms20164033 Authors: Victoria I. Melnikova Nadezhda V. Lifantseva Svetlana N. Voronova Liudmila A. Zakharova An increasing body of recent experimental data confirms the impact of neurohormones on fetal development and function of different body systems. The synthesis of many neurohormones...
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JCM, Vol. 8, Pages 1250: Mechanical Ventilation Strategies Targeting Different Magnitudes of Collapse and Tidal Recruitment in Porcine Acid Aspiration-Induced Lung Injury Journal of Clinical Medicine doi: 10.3390/jcm8081250 Authors: Juliane Haase Dorina C. Buchloh Sören Hammermüller Peter Salz Julia Mrongowius Nadja C. Carvalho Alessandro Beda Anna Rau Henning Starke Peter M. Spieth Claudia Gittel Thomas Muders Hermann Wrigge Andreas W. Reske Reducing...
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Medicina, Vol. 55, Pages 498: Component-Resolved Diagnosis in Food Allergies Medicina doi: 10.3390/medicina55080498 Authors: Elisabetta Calamelli Lucia Liotti Isadora Beghetti Valentina Piccinno Laura Serra Paolo Bottau Component-resolved diagnostics (CRD) in food allergies is an approach utilized to characterize the molecular components of each allergen involved in a specific IgE (sIgE)-mediated response. In the clinical practice, CRD can improve diagnostic accuracy and...
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Medicina, Vol. 55, Pages 497: Subclinical and Asymptomatic Atrial Fibrillation: Current Evidence and Unsolved Questions in Clinical Practice Medicina doi: 10.3390/medicina55080497 Authors: Andrea Ballatore Mario Matta Andrea Saglietto Paolo Desalvo Pier Paolo Bocchino Fiorenzo Gaita Gaetano Maria De Ferrari Matteo Anselmino Atrial Fibrillation (AF) may be diagnosed due to symptoms, or it may be found as an incidental electrocardiogram (ECG) finding, or by implanted...
Sun Aug 18, 2019 03:00
Microorganisms, Vol. 7, Pages 270: Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms Microorganisms doi: 10.3390/microorganisms7080270 Authors: Koulenti Xu Mok Song Karageorgopoulos Armaganidis Lipman SotiriosTsiodras Increasing multidrug-resistance to Gram-positive pathogens, particularly to staphylococci, enterococci and streptococci, is a major problem, resulting in significant morbidity, mortality and healthcare costs. In recent years,...
Sun Aug 18, 2019 03:00
Molecules, Vol. 24, Pages 2997: Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests Molecules doi: 10.3390/molecules24162997 Authors: Rim Wehbe Jacinthe Frangieh Mohamad Rima Dany El Obeid Jean-Marc Sabatier Ziad Fajloun Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or...
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Molecules, Vol. 24, Pages 2996: Facile Formation of Anatase/Rutile TiO2 Nanocomposites with Enhanced Photocatalytic Activity Molecules doi: 10.3390/molecules24162996 Authors: Jing He Yi-en Du Yang Bai Jing An Xuemei Cai Yongqiang Chen Pengfei Wang Xiaojing Yang Qi Feng Anatase/rutile mixed-phase TiO2 nanoparticles were synthesized through a simple sol-gel route with further calcination using inexpensive titanium tetrachloride as a titanium source, which effectively...
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Molecules, Vol. 24, Pages 2994: Optimization of Ultrasonic-Assisted Extraction and Purification of Zeaxanthin and Lutein in Corn Gluten Meal Molecules doi: 10.3390/molecules24162994 Authors: Litao Wang Weihang Lu Jiali Li Jinxia Hu Ruifang Ding Mei Lv Qibao Wang Zeaxanthin and lutein have a wide range of pharmacological applications. In this study, we conducted systematic experimental research to optimize antioxidant extraction based on detection, extraction, process...
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Nanomaterials, Vol. 9, Pages 1180: Structural Characterization of Graphene Oxide: Surface Functional Groups and Fractionated Oxidative Debris Nanomaterials doi: 10.3390/nano9081180 Authors: Elvin Aliyev Volkan Filiz Muntazim M. Khan Young Joo Lee Clarissa Abetz Volker Abetz The purpose of this work is the structural analysis of graphene oxide (GO) and by means of a new structural model to answer the questions arising from the Lerf–Klinowski and the Lee structural...
Sun Aug 18, 2019 03:00
Religions, Vol. 10, Pages 486: Redemption of ‘Fallen’ Hero-Athletes: Lance Armstrong, Isaiah, and Doing Good while Being Bad Religions doi: 10.3390/rel10080486 Authors: Andrew R. Meyer Lance Armstrong’s achievements in cycling will forever be overshadowed by his admittance of using unethical performance enhancing means to win. However, Armstrong’s positive social impact of raising awareness, hundreds of millions of dollars, and support for the cancer community are...
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Toxics, Vol. 7, Pages 41: Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions Toxics doi: 10.3390/toxics7030041 Authors: Jingchuan Xue Yunjia Lai Chih-Wei Liu Hongyu Ru The proposal of the “exposome” concept represents a shift of the research paradigm in studying exposure-disease relationships from an isolated and partial way to a systematic and agnostic approach. Nevertheless, exposome implementation is...
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Water, Vol. 11, Pages 1717: Regional Flood Frequency Analysis for a Poorly Gauged Basin Using the Simulated Flood Data and L-Moment Method Water doi: 10.3390/w11081717 Authors: Do-Hun Lee Nam Won Kim The design of hydraulic structures and the assessment of flood control measures require the estimation of flood quantiles. Since observed flood data are rarely available at the specific location, flood estimation in un-gauged or poorly gauged basins is a common problem in engineering...
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Water, Vol. 11, Pages 1718: Application of Set Pair Analysis in a Comprehensive Evaluation of Water Resource Assets: A Case Study of Wuhan City, China Water doi: 10.3390/w11081718 Authors: Jingdong Zhang Yanan Li Chaoyang Liu Zhiguang Qu Fei Li Zhaofei Yang Luping Jiang Jiatian Fu With the rapid development of the social economy, China is suffering from severe water scarcity due to improper management. Evaluation of water resource value is a crucial issue for innovative...
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Water, Vol. 11, Pages 1719: Development of Failure Cause–Impact–Duration (CID) Plots for Water Supply and Distribution System Management Water doi: 10.3390/w11081719 Authors: Seungyub Lee Sueyeun Oak Donghwi Jung Hwandon Jun Understanding the impact and duration (consequences) of different component failures (cause) in a water supply and distribution system (WSDS) is a critical task for water utilities to develop effective preparation and response plans. During the last three...
Sun Aug 18, 2019 03:00
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