Abstracts Background Recent studies have shown that the short-chain fatty acids (SCFAs) produced by the gut microbiota play a positive role in the development of colorectal cancer (CRC). Aims This study aims to elucidate the “food-microorganism-SCFAs” axis and to provide guidance for prevention and intervention in CRC. ...
Abstract Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity interval exercise training (HIIT) during hormone therapy would show improvements in low-grade inflammation and HSP70 compared to the controls receiving standard care. ...
Abstract Purpose Androgen receptors (ARs) are expressed on a variety of cell types, and AR signaling plays an important role in tumor development and progression in several cancers. This in vitro study evaluated the effect of dihydrotestosterone (DHT) on the proliferation of renal cell carcinoma (RCC) cells in relation to AR status. Methods Steroid hormone...
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Abstract Purpose Ionizing radiation is able to cause severe damage to cardiac implantable electronic devices (CIED). In Germany, the DEGRO/DGK guideline recommends close monitoring of patients with CIEDs undergoing radiotherapy (RT). Nevertheless, especially in the era of intensity-modulated techniques and predominant use of 6 MV photons, errors of CIEDs are rare events. Therefore, we performed daily CIED controls and hypothesized that...
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In contrast to prior belief, cancer cells require oxidative phosphorylation (OXPHOS) to strive, and exacerbated OXPHOS dependency frequently characterizes cancer stem cells, as well as primary or acquired resistance against chemotherapy or tyrosine kinase inhibitors. A growing arsenal of therapeutic agents is being designed to suppress the transfer of mitochondria from stromal to malignant cells, to interfere with mitochondrial biogenesis, to directly inhibit respiratory chain complexes, or to disrupt...
Immune checkpoint blockade has proven its efficacy in hypermutated subtypes of metastatic colorectal cancers (mCRC). Immunogenic potential can also be observed with conventional chemotherapies, but this property has never been explored thoroughly in CRC patients. The CRC therapeutic arsenal includes oxaliplatin, a well‐characterized platinum drug already described as immunogenic. Here, we investigated the impact of the oxaliplatin‐based treatment on mCRC immunopeptidome. We demonstrated that oxaliplatin‐resistant...
Esophageal squamous cell carcinoma (ESCC) occurs with highest frequency in China with over 90% mortality, highlighting the need for early detection and improved treatment strategies. We aimed to identify ESCC cancer predisposition gene(s). This study included 4,517 individuals. The discovery phase using whole‐exome sequencing (WES) included 186 familial ESCC patients from high‐risk China. Targeted gene sequencing validation of 598 genes included 3,289 Henan and 1,228 moderate‐risk Hong Kong Chinese....
KRAS mutations hinder therapeutic efficacy of epidermal‐growth‐factor‐receptor (EGFR)‐specific mAbs cetuximab and panitumumab‐based immunotherapy of EGFR+ cancers. Although cetuximab inhibits KRAS‐mutated cancer cell growth in vitro by NK cell‐mediated antibody‐dependent‐cellular‐cytotoxicity‐(ADCC), KRAS‐mutated colorectal carcinoma (CRC) cells escape NK cell immunosurveillance in vivo. To overcome this limitation, we used cetuximab and panitumumab to redirect Fcγ chimeric receptor (CR) T cells...
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Abstract Gastric cancer is one of the most common cancers, and an increasing number of studies have found that microRNAs (miRNAs) play essential roles in gastric cancer progression; however, the roles of specific miRNAs involved in the immune response to this disease remain unclear. We compared the miRNA expression in tissues from primary gastric cancer patients and healthy controls to find miRNAs dysregulated in gastric cancer and used bioinformatics tools to determine potential...
Abstract The aim of our study is to investigate the efficacy of metronomic cyclophosphamide plus low dose of corticosteroids in advanced or metastatic castration-resistant prostate cancer (CRPC) before, between, and after standard chemotherapy, such as docetaxel and cabazitaxel, and new hormonal treatments, such as abiraterone and enzalutamide. A retrospective analysis was performed on 37 patients. Cyclophosphamide was given orally 50 mg per day together with low dose of corticosteroids,...
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Publication date: Available online 10 August 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Gregory C. Wilson, David A. Geller
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Cancers, Vol. 11, Pages 1150: Association between PD-1 and PD-L1 Polymorphisms and the Risk of Cancer: A Meta-Analysis of Case-Control Studies Cancers doi: 10.3390/cancers11081150 Authors: Mohammad Hashemi Shima Karami Sahel Sarabandi Abdolkarim Moazeni-Roodi Andrzej Małecki Saeid Ghavami Emilia Wiechec A number of case-control studies regarding the association of the polymorphisms in the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes...
Cancers, Vol. 11, Pages 1151: SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11081151 Authors: Sara Gomes Bartolomeo Bosco Joana B. Loureiro Helena Ramos Liliana Raimundo Joana Soares Nair Nazareth Valentina Barcherini Lucília Domingues Carla Oliveira Alessandra Bisio Silvano Piazza Matthias R. Bauer João P. Brás Maria Inês Almeida Célia Gomes Flávio...
Cancers, Vol. 11, Pages 1152: Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine Cancers doi: 10.3390/cancers11081152 Authors: Claudio Luchini Nicola Veronese Alessia Nottegar Vera Cappelletti Maria G. Daidone Lee Smith Christopher Parris Lodewijk A. A. Brosens Maria G. Caruso Liang Cheng Christopher L. Wolfgang Laura D. Wood Michele Milella Roberto Salvia Aldo Scarpa Liquid...
Cancers, Vol. 11, Pages 1149: ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers Cancers doi: 10.3390/cancers11081149 Authors: Tarek M. A. Abdel-Fatah Reem Ali Maaz Sadiq Paul M. Moseley Katia A. Mesquita Graham Ball Andrew R. Green Emad A. Rakha Stephen Y. T. Chan Srinivasan Madhusudan Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated...
Cancers, Vol. 11, Pages 1148: Integration of Radiomic and Multi-omic Analyses Predicts Survival of Newly Diagnosed IDH1 Wild-Type Glioblastoma Cancers doi: 10.3390/cancers11081148 Authors: Ahmad Chaddad Paul Daniel Siham Sabri Christian Desrosiers Bassam Abdulkarim Predictors of patient outcome derived from gene methylation, mutation, or expression are severely limited in IDH1 wild-type glioblastoma (GBM). Radiomics offers an alternative insight into tumor characteristics...
Cancers, Vol. 11, Pages 1147: Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11081147 Authors: Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30–150...
Cancers, Vol. 11, Pages 1145: KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy Cancers doi: 10.3390/cancers11081145 Authors: Pinto Petriella Lacalamita Montrone Catino Pizzutilo Botticella Zito Del Bene Zonno Tommasi De Summa Non-small-cell lung cancer, histologically classified into adenocarcinoma (AD) and squamous cell carcinoma, is one of the most deadly malignancies worldwide. Lung AD (LUAD) could...
Cancers, Vol. 11, Pages 1146: BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work Cancers doi: 10.3390/cancers11081146 Authors: Bracci Ciarapica Zabaleta Tartaglione Pirozzi Giuliani Piva Valentino Ledda Rapisarda Stevens Santarelli BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk...
Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis Cancers doi: 10.3390/cancers11081143 Authors: Batham Lim Rao The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing...
Cancers, Vol. 11, Pages 1144: Cancer Metabolism and the Evasion of Apoptotic Cell Death Cancers doi: 10.3390/cancers11081144 Authors: Aditi Sharma Lawrence H. Boise Mala Shanmugam Cellular growth and proliferation depend upon the acquisition and synthesis of specific metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential required for duplication of cellular biomass. Multicellular organisms maintain tissue homeostasis by balancing signals promoting...
Cancers, Vol. 11, Pages 1142: Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer Cancers doi: 10.3390/cancers11081142 Authors: Hannah Flebbe Feda H. Hamdan Vijayalakshmi Kari Julia Kitz Jochen Gaedcke B. Michael Ghadimi Steven A. Johnsen Marian Grade Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin...
Cancers, Vol. 11, Pages 1141: PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around Cancers doi: 10.3390/cancers11081141 Authors: Anastasios Gkountakos Giulia Sartori Italia Falcone Geny Piro Ludovica Ciuffreda Carmine Carbone Giampaolo Tortora Aldo Scarpa Emilio Bria Michele Milella Rafael Rosell Vincenzo Corbo Sara Pilotto Lung cancer is the most common malignancy and cause of cancer deaths worldwide,...
Cancers, Vol. 11, Pages 1140: Mining Prognosis Index of Brain Metastases Using Artificial Intelligence Cancers doi: 10.3390/cancers11081140 Authors: Shigao Huang Jie Yang Simon Fong Qi Zhao This study is to identify the optimum prognosis index for brain metastases by machine learning. Seven hundred cancer patients with brain metastases were enrolled and divided into 446 training and 254 testing cohorts. Seven features and seven prediction methods were selected to evaluate the...
Cancers, Vol. 11, Pages 1139: Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors Cancers doi: 10.3390/cancers11081139 Authors: Veronika Liskova Sona Hudecova Lubomira Lencesova Filippo Iuliano Marta Sirova Karol Ondrias Silvia Pastorekova Olga Krizanova Hypoxia and acidosis are among the key microenvironmental factors that contribute to cancer progression. We have explored...
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The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about TrmD in Pseudomonas aeruginosa (PaTrmD), an important human pathogen. Here we present detailed structural, substrate and kinetic properties of PaTrmD. Mass spectrometric analysis confirmed the G36G37-containing tRNAs Leu(GAG), Leu(CAG), Leu(UAG), Pro(GGG),...
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Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to i...
Over the past decade, newly designed cancer therapies have not significantly improved the survival of patients diagnosed with Malignant Pleural Mesothelioma (MPM). Among a limited number of genes that are freq...
RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland. Consistent evidence indicates that RUNX...
Pancreatic cancer is a highly lethal malignancy with poor prognosis. Anillin (ANLN), an actin binding protein, is upregulated and plays an important role in many malignant tumors. However, the precise role of ...
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Abstract Translocation renal cell carcinoma (tRCC) affects younger patients and often has poor outcomes. Accurate diagnosis is required to guide clinical management. Here we evaluate the RNA‐sequencing FusionPlex platform with a 115‐gene panel including TFE3 and TFEB for tRCC diagnosis and correlate molecular findings with clinicopathological features. We reviewed 996 consecutive RCC cases from our institution over the preceding 7 years and retrieved 17 cases with histological and immunohistochemical...
ABSTRACT The tumor suppressor gene TP53 is one of the most frequently mutated genes in human cancer. The central role of the TP53 protein in several fundamental processes such as cancer, aging, senescence and DNA repair have ensured enormous attention. However, the role of TP53 in acute myeloid leukemia (AML) is enigmatic. Unlike many other human cancers, a vast majority of AMLs display no genomic TP53 alterations. There is now growing appreciation of the fact that the unaltered TP53 status of tumor...
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Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Wiebke Sondermann, Jochen Sven Utikal, Alexander H. Enk, Dirk Schadendorf, Joachim Klode, Axel Hauschild, Michael Weichenthal, Lars E. French, Carola Berking, Bastian Schilling, Sebastian Haferkamp, Stefan Fröhling, Christof von Kalle, Titus J. BrinkerAbstractRecent research revealed the superiority of artificial intelligence over dermatologists to diagnose melanoma from images. However, 30–50% of all melanomas...
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Titus J. Brinker, Achim Hekler, Alexander H. Enk, Carola Berking, Sebastian Haferkamp, Axel Hauschild, Michael Weichenthal, Joachim Klode, Dirk Schadendorf, Tim Holland-Letz, Christof von Kalle, Stefan Fröhling, Bastian Schilling, Jochen S. UtikalAbstractBackgroundMelanoma is the most dangerous type of skin cancer but is curable if detected early. Recent publications demonstrated that artificial intelligence...
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Theodora Kanaki, Andreas Stang, Ralf Gutzmer, Lisa Zimmer, Eleftheria Chorti, Antje Sucker, Selma Ugurel, Eva Hadaschik, Nikolai S. Gräger, Imke Satzger, Dirk Schadendorf, Elisabeth LivingstoneAbstractObjectiveThe American Joint Committee on Cancer (AJCC) 8th staging system introduced several revisions. To assess the impact of the 8th edition American Joint Committee on Cancer (AJCC8) staging system on subgrouping...
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Future Oncology, Ahead of Print.
Future Oncology, Ahead of Print.
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Abstract Objective Cancer in young adulthood is a non‐normative and critical life event. The experience of having cancer can have a strong impact on the mental health of young adults. This study investigated anxiety and depression in young adult cancer patients, examining changes over time and determining associated factors. Methods Young cancer patients (18‐39 years at time of diagnosis, diagnosis <4 years) were examined. Anxiety and depression were measured at two time points (t2=12...
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Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy which has demonstrated sensitivity to immune checkpoint inhibitor therapy. Here, we perform the largest genomics study in MCC to date to characterize the molecular landscape and evaluate for clinical and molecular correlates to immune checkpoint inhibitor response. Experimental Design: Comprehensive molecular profiling was performed on 317 tumors from patients with MCC including the evaluation of oncogenic mutations,...
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Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...
Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...
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Related ArticlesEthnic disparity in clinical performance between multivariate index assay and CA125 in detection of ovarian malignancy. Future Oncol. 2019 Aug 09;: Authors: Dunton C, Bullock RG, Fritsche H Abstract Aim: Based on evidence that African-American (AA) women have lower CA125 values than Caucasian (C) women, we investigated this to see if this disparity would have an impact on ovarian cancer detection using CA125 and multivariate index assay...
Related ArticlesHumanistic and economic impact of subcutaneous versus intravenous administration of oncology biologics. Future Oncol. 2019 Aug 09;: Authors: Anderson KC, Landgren O, Arend RC, Chou J, Jacobs IA Abstract More oncology biologics are becoming available for subcutaneous (sc.) administration and are expected to provide useful therapeutic options. We evaluated evidence published in the past 5 years to assess the humanistic and economic impact...
Related ArticlesEfficacy and safety of lenvatinib in an elderly patient with metastatic papillary thyroid carcinoma and cardiological comorbidity: a case report. Future Oncol. 2019 Aug 08;: Authors: Latorre A, Fioretti AM, Giotta F, Lorusso V Abstract Lenvatinib significantly prolonged progression-free survival versus placebo in patients with radio-iodine refractory differentiated thyroid carcinoma. However, the primary adverse effects of any grade that...
Related ArticlesCorrigendum. Future Oncol. 2019 Aug 08;: Authors: PMID: 31393164 [PubMed - as supplied by publisher]
Related ArticlesPoor survival of non-small-cell lung cancer patients with main bronchus tumor: a large population-based study. Future Oncol. 2019 Aug 08;: Authors: Li C, Liu J, Lin J, Li Z, Shang X, Wang H Abstract Aim: In this study, we evaluated the association between tumor location and prognosis in non-small-cell lung cancer patients. Patients & methods: The SEER database was used to screen for suitable patients using our inclusion criteria....
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Abstract Cascade testing for hereditary breast/ovarian cancer is an important public health priority. Increasing attention has been paid to the relevance of testing for men within BRCA1/2-positive families given that such testing may provide important information about their cancer risks, particularly for prostate cancer, and risks to their offspring. However, men are much less likely to seek genetic counseling and testing than their at-risk female relatives. To facilitate access...
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Background Several studies have investigated the relationship between experience measured by caseload and oncological outcomes, economics, and access to care for prostate cancer care. Oncological outcomes have been limited to biochemical failure after radical prostatectomy. Questions remain regarding the more definitive measures of outcomes and their relationship with caseload. Methods The National Cancer Database was used to investigate the outcomes of radical prostatectomy in the United...
Background Melanoma brain metastases (MBM) occur in up to 50% of patients with metastatic melanoma (MM) and represent a frequent site of systemic treatment failure for targeted therapies. However, to the authors' knowledge, little is known regarding the incidence, patterns of disease progression, and outcomes of MBM in patients treated with anti–PD‐1 immunotherapy. Methods A total of 320 patients with MM who were treated with anti–PD‐1 at The University of Texas MD Anderson Cancer Center in...
Background After controlling for baseline disease factors, researchers have found that black women have worse breast cancer survival, and this suggests that treatment differences may contribute to poorer outcomes. Delays in initiating and completing treatment are one proposed mechanism. Methods Phase 3 of the Carolina Breast Cancer Study involved a large, population‐based cohort of women with incident breast cancer. For this analysis, we included black women (n = 1328) and white women (n = 1331)...
Background Postmenopausal obese women demonstrate an elevated breast cancer risk and experience increased breast cancer morbidity and mortality compared with women with a normal body mass index (BMI). However, to the authors' knowledge, prior studies have yielded inconclusive results regarding the effects of obesity on mammography screening adherence. Using national cross‐sectional survey data, the objective of the current study was to assess the current association between increasing BMI and use...
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Publication date: Available online 10 August 2019Source: European Journal of Surgical OncologyAuthor(s): Julius de Vries, Anne N. Heirman, Linda Bras, Boudewijn E.C. Plaat, Emoke Rácz, Marloes S. van Kester, Suzanne Festen, Geertruida H. de Bock, Bernard F.A.M. van der Laan, Gyorgy B. HalmosAbstractIntroductionAs cutaneous head and neck malignancies are highly prevalent especially in older patients, the risk of surgical complications is substantial in this potentially vulnerable population. The objective...
Publication date: Available online 8 August 2019Source: European Journal of Surgical OncologyAuthor(s): Kadri Altundag
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British Journal of Cancer, Published online: 09 August 2019; doi:10.1038/s41416-019-0545-zCorrection: Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy
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Publication date: Available online 10 August 2019Source: Practical Radiation OncologyAuthor(s): Miriam A. Knoll
Publication date: Available online 10 August 2019Source: Practical Radiation OncologyAuthor(s): Vikram Jairam, Holly Lincoln, Derek Brown, Henry S. Park, Suzanne B. EvansAbstractBackgroundMedical devices in radiation therapy (RT) undergo a complex process of Food and Drug Administration (FDA) approval. Little is known about which processes within the RT medical device industry are most prone to events involving wrong dose, volume, or targeting in radiotherapy treatment.MethodsWe carried out a retrospective...
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Abstract Yes‐associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has been verified in different types of human cancers. However, the molecular mechanism of YAP1 upregulation in cancer is still unclear. Here we demonstrated that the E3 ubiquitin ligase STUB1 ubiquitinates and...
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Abstract Recent studies have indicated that using statins to inhibit the mevalonate pathway induces mutant p53 degradation by impairing the interaction of mutant p53 with DnaJ subfamily A member 1 (DNAJA1). However, the role of the C‐terminus of DNAJA1 with a CAAX box for farnesylation in the binding, folding, and translocation of client proteins such as mutant p53 is not known. In the present study, we used a genetically engineered mouse model of pancreatic carcinoma and showed that atorvastatin...
Abstract Carboxypeptidase A4 (CPA4) is a member of the metallocarboxypeptidase family. A previous study indicated that CPA4 may participate in the modulation of peptide hormone activity and hormone‐regulated tissue growth and differentiation. However, the role of CPA4 in lung tumorigenesis remains unclear. Our study revealed that CPA4 expression was higher in both lung cancer cells and tumor tissues. We performed 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assays, colony‐formation...
Abstract A major concern in the clinical application of tumor necrosis factor related apoptosis‐inducing ligand (TRAIL) in tumors is the development of resistance. Therefore, agents that can potentially restore TRAIL sensitivity are important therapeutic targets for cancer treatment. Herein, we evaluated lanatoside c and digoxin, both of which are widely used cardiac glycosides (CGs), for their ability to sensitize human hepatocellular carcinoma cells (Huh‐7 and HepG2) through TRAIL‐induced apoptosis....
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