Κυριακή 11 Αυγούστου 2019


Protective effect of the “food-microorganism-SCFAs” axis on colorectal cancer: from basic research to practical application
Abstracts Background Recent studies have shown that the short-chain fatty acids (SCFAs) produced by the gut microbiota play a positive role in the development of colorectal cancer (CRC). Aims This study aims to elucidate the “food-microorganism-SCFAs” axis and to provide guidance for prevention and intervention in CRC. ...
Journal of Cancer Research and Clinical Oncology
1d
High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial
Abstract Objective Exercise training is recently considered as a trend in adjuvant therapies for cancer patients, but its mechanisms need to be scrutinized further. This study is aimed to test the hypothesis that the patients who perform the high-intensity interval exercise training (HIIT) during hormone therapy would show improvements in low-grade inflammation and HSP70 compared to the controls receiving standard care. ...
Journal of Cancer Research and Clinical Oncology
1d
Dihydrotestosterone promotes kidney cancer cell proliferation by activating the STAT5 pathway via androgen and glucocorticoid receptors
Abstract Purpose Androgen receptors (ARs) are expressed on a variety of cell types, and AR signaling plays an important role in tumor development and progression in several cancers. This in vitro study evaluated the effect of dihydrotestosterone (DHT) on the proliferation of renal cell carcinoma (RCC) cells in relation to AR status. Methods Steroid hormone...
Journal of Cancer Research and Clinical Oncology
1d
Radiotherapy of patients with cardiac implantable electronic devices according to the DEGRO/DGK guideline—is the risk of relevant errors overestimated?
Abstract Purpose Ionizing radiation is able to cause severe damage to cardiac implantable electronic devices (CIED). In Germany, the DEGRO/DGK guideline recommends close monitoring of patients with CIEDs undergoing radiotherapy (RT). Nevertheless, especially in the era of intensity-modulated techniques and predominant use of 6 MV photons, errors of CIEDs are rare events. Therefore, we performed daily CIED controls and hypothesized that...
Strahlentherapie und Onkologie
2d
Oxidative phosphorylation as a potential therapeutic target for cancer therapy
In contrast to prior belief, cancer cells require oxidative phosphorylation (OXPHOS) to strive, and exacerbated OXPHOS dependency frequently characterizes cancer stem cells, as well as primary or acquired resistance against chemotherapy or tyrosine kinase inhibitors. A growing arsenal of therapeutic agents is being designed to suppress the transfer of mitochondria from stromal to malignant cells, to interfere with mitochondrial biogenesis, to directly inhibit respiratory chain complexes, or to disrupt...
International Journal of Cancer
1d
CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin
Immune checkpoint blockade has proven its efficacy in hypermutated subtypes of metastatic colorectal cancers (mCRC). Immunogenic potential can also be observed with conventional chemotherapies, but this property has never been explored thoroughly in CRC patients. The CRC therapeutic arsenal includes oxaliplatin, a well‐characterized platinum drug already described as immunogenic. Here, we investigated the impact of the oxaliplatin‐based treatment on mCRC immunopeptidome. We demonstrated that oxaliplatin‐resistant...
International Journal of Cancer
1d
BRCA2 loss‐of‐function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese
Esophageal squamous cell carcinoma (ESCC) occurs with highest frequency in China with over 90% mortality, highlighting the need for early detection and improved treatment strategies. We aimed to identify ESCC cancer predisposition gene(s). This study included 4,517 individuals. The discovery phase using whole‐exome sequencing (WES) included 186 familial ESCC patients from high‐risk China. Targeted gene sequencing validation of 598 genes included 3,289 Henan and 1,228 moderate‐risk Hong Kong Chinese....
International Journal of Cancer
1d
CD16‐158‐Valine Chimeric Receptor T Cells Overcome the Resistance of Kras‐Mutated Colorectal Carcinoma Cells to Cetuximab
KRAS mutations hinder therapeutic efficacy of epidermal‐growth‐factor‐receptor (EGFR)‐specific mAbs cetuximab and panitumumab‐based immunotherapy of EGFR+ cancers. Although cetuximab inhibits KRAS‐mutated cancer cell growth in vitro by NK cell‐mediated antibody‐dependent‐cellular‐cytotoxicity‐(ADCC), KRAS‐mutated colorectal carcinoma (CRC) cells escape NK cell immunosurveillance in vivo. To overcome this limitation, we used cetuximab and panitumumab to redirect Fcγ chimeric receptor (CR) T cells...
International Journal of Cancer
1d
Issue Information
International Journal of Cancer
1d
Issue Information
International Journal of Cancer
1d
Osimertinib confers potent binding affinity to EGFR Kinase Domain Duplication
International Journal of Cancer
2d
MicroRNA expression profiling provides novel insights into immune-related pathways involved in gastric cancer
Abstract Gastric cancer is one of the most common cancers, and an increasing number of studies have found that microRNAs (miRNAs) play essential roles in gastric cancer progression; however, the roles of specific miRNAs involved in the immune response to this disease remain unclear. We compared the miRNA expression in tissues from primary gastric cancer patients and healthy controls to find miRNAs dysregulated in gastric cancer and used bioinformatics tools to determine potential...
Medical Oncology
2d
Metronomic chemotherapy with cyclophosphamide plus low dose of corticosteroids in advanced castration-resistant prostate cancer across the era of taxanes and new hormonal drugs
Abstract The aim of our study is to investigate the efficacy of metronomic cyclophosphamide plus low dose of corticosteroids in advanced or metastatic castration-resistant prostate cancer (CRPC) before, between, and after standard chemotherapy, such as docetaxel and cabazitaxel, and new hormonal treatments, such as abiraterone and enzalutamide. A retrospective analysis was performed on 37 patients. Cyclophosphamide was given orally 50 mg per day together with low dose of corticosteroids,...
Medical Oncology
2d
Evolving Surgical Options for Hepatocellular Carcinoma
Publication date: Available online 10 August 2019Source: Surgical Oncology Clinics of North AmericaAuthor(s): Gregory C. Wilson, David A. Geller
Surgical Oncology Clinics of North America
1d
Cancers, Vol. 11, Pages 1150: Association between PD-1 and PD-L1 Polymorphisms and the Risk of Cancer: A Meta-Analysis of Case-Control Studies
Cancers, Vol. 11, Pages 1150: Association between PD-1 and PD-L1 Polymorphisms and the Risk of Cancer: A Meta-Analysis of Case-Control Studies Cancers doi: 10.3390/cancers11081150 Authors: Mohammad Hashemi Shima Karami Sahel Sarabandi Abdolkarim Moazeni-Roodi Andrzej Małecki Saeid Ghavami Emilia Wiechec A number of case-control studies regarding the association of the polymorphisms in the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes...
Cancers
1d
Cancers, Vol. 11, Pages 1151: SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma
Cancers, Vol. 11, Pages 1151: SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11081151 Authors: Sara Gomes Bartolomeo Bosco Joana B. Loureiro Helena Ramos Liliana Raimundo Joana Soares Nair Nazareth Valentina Barcherini Lucília Domingues Carla Oliveira Alessandra Bisio Silvano Piazza Matthias R. Bauer João P. Brás Maria Inês Almeida Célia Gomes Flávio...
Cancers
1d
Cancers, Vol. 11, Pages 1152: Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine
Cancers, Vol. 11, Pages 1152: Liquid Biopsy as Surrogate for Tissue for Molecular Profiling in Pancreatic Cancer: A Meta-Analysis Towards Precision Medicine Cancers doi: 10.3390/cancers11081152 Authors: Claudio Luchini Nicola Veronese Alessia Nottegar Vera Cappelletti Maria G. Daidone Lee Smith Christopher Parris Lodewijk A. A. Brosens Maria G. Caruso Liang Cheng Christopher L. Wolfgang Laura D. Wood Michele Milella Roberto Salvia Aldo Scarpa Liquid...
Cancers
1d
Cancers, Vol. 11, Pages 1149: ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers
Cancers, Vol. 11, Pages 1149: ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers Cancers doi: 10.3390/cancers11081149 Authors: Tarek M. A. Abdel-Fatah Reem Ali Maaz Sadiq Paul M. Moseley Katia A. Mesquita Graham Ball Andrew R. Green Emad A. Rakha Stephen Y. T. Chan Srinivasan Madhusudan Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated...
Cancers
1d
Cancers, Vol. 11, Pages 1148: Integration of Radiomic and Multi-omic Analyses Predicts Survival of Newly Diagnosed IDH1 Wild-Type Glioblastoma
Cancers, Vol. 11, Pages 1148: Integration of Radiomic and Multi-omic Analyses Predicts Survival of Newly Diagnosed IDH1 Wild-Type Glioblastoma Cancers doi: 10.3390/cancers11081148 Authors: Ahmad Chaddad Paul Daniel Siham Sabri Christian Desrosiers Bassam Abdulkarim Predictors of patient outcome derived from gene methylation, mutation, or expression are severely limited in IDH1 wild-type glioblastoma (GBM). Radiomics offers an alternative insight into tumor characteristics...
Cancers
1d
Cancers, Vol. 11, Pages 1147: Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target
Cancers, Vol. 11, Pages 1147: Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11081147 Authors: Koji Nakamura Kenjiro Sawada Masaki Kobayashi Mayuko Miyamoto Aasa Shimizu Misa Yamamoto Yasuto Kinose Tadashi Kimura Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30–150...
Cancers
2d
Cancers, Vol. 11, Pages 1145: KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy
Cancers, Vol. 11, Pages 1145: KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy Cancers doi: 10.3390/cancers11081145 Authors: Pinto Petriella Lacalamita Montrone Catino Pizzutilo Botticella Zito Del Bene Zonno Tommasi De Summa Non-small-cell lung cancer, histologically classified into adenocarcinoma (AD) and squamous cell carcinoma, is one of the most deadly malignancies worldwide. Lung AD (LUAD) could...
Cancers
2d
Cancers, Vol. 11, Pages 1146: BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work
Cancers, Vol. 11, Pages 1146: BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work Cancers doi: 10.3390/cancers11081146 Authors: Bracci Ciarapica Zabaleta Tartaglione Pirozzi Giuliani Piva Valentino Ledda Rapisarda Stevens Santarelli BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk...
Cancers
2d
Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis
Cancers, Vol. 11, Pages 1143: SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis Cancers doi: 10.3390/cancers11081143 Authors: Batham Lim Rao The full epigenetic repertoire governing breast cancer metastasis is not completely understood. Here, we discuss the histone methyltransferase SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and its role in breast cancer metastasis. SETDB1 serves as an exemplar of the difficulties faced when developing...
Cancers
2d
Cancers, Vol. 11, Pages 1144: Cancer Metabolism and the Evasion of Apoptotic Cell Death
Cancers, Vol. 11, Pages 1144: Cancer Metabolism and the Evasion of Apoptotic Cell Death Cancers doi: 10.3390/cancers11081144 Authors: Aditi Sharma Lawrence H. Boise Mala Shanmugam Cellular growth and proliferation depend upon the acquisition and synthesis of specific metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential required for duplication of cellular biomass. Multicellular organisms maintain tissue homeostasis by balancing signals promoting...
Cancers
2d
Cancers, Vol. 11, Pages 1142: Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer
Cancers, Vol. 11, Pages 1142: Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer Cancers doi: 10.3390/cancers11081142 Authors: Hannah Flebbe Feda H. Hamdan Vijayalakshmi Kari Julia Kitz Jochen Gaedcke B. Michael Ghadimi Steven A. Johnsen Marian Grade Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin...
Cancers
2d
Cancers, Vol. 11, Pages 1141: PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around
Cancers, Vol. 11, Pages 1141: PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around Cancers doi: 10.3390/cancers11081141 Authors: Anastasios Gkountakos Giulia Sartori Italia Falcone Geny Piro Ludovica Ciuffreda Carmine Carbone Giampaolo Tortora Aldo Scarpa Emilio Bria Michele Milella Rafael Rosell Vincenzo Corbo Sara Pilotto Lung cancer is the most common malignancy and cause of cancer deaths worldwide,...
Cancers
2d
Cancers, Vol. 11, Pages 1140: Mining Prognosis Index of Brain Metastases Using Artificial Intelligence
Cancers, Vol. 11, Pages 1140: Mining Prognosis Index of Brain Metastases Using Artificial Intelligence Cancers doi: 10.3390/cancers11081140 Authors: Shigao Huang Jie Yang Simon Fong Qi Zhao This study is to identify the optimum prognosis index for brain metastases by machine learning. Seven hundred cancer patients with brain metastases were enrolled and divided into 446 training and 254 testing cohorts. Seven features and seven prediction methods were selected to evaluate the...
Cancers
2d
Cancers, Vol. 11, Pages 1139: Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors
Cancers, Vol. 11, Pages 1139: Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors Cancers doi: 10.3390/cancers11081139 Authors: Veronika Liskova Sona Hudecova Lubomira Lencesova Filippo Iuliano Marta Sirova Karol Ondrias Silvia Pastorekova Olga Krizanova Hypoxia and acidosis are among the key microenvironmental factors that contribute to cancer progression. We have explored...
Cancers
2d
Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa [Article]
The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about TrmD in Pseudomonas aeruginosa (PaTrmD), an important human pathogen. Here we present detailed structural, substrate and kinetic properties of PaTrmD. Mass spectrometric analysis confirmed the G36G37-containing tRNAs Leu(GAG), Leu(CAG), Leu(UAG), Pro(GGG),...
RNA In Advance
2d
TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to i...
Journal of Experimental & Clinical Cancer Research - Latest Articles
2d
Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
Over the past decade, newly designed cancer therapies have not significantly improved the survival of patients diagnosed with Malignant Pleural Mesothelioma (MPM). Among a limited number of genes that are freq...
Journal of Experimental & Clinical Cancer Research - Latest Articles
2d
HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms
RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland. Consistent evidence indicates that RUNX...
Journal of Experimental & Clinical Cancer Research - Latest Articles
2d
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis
Pancreatic cancer is a highly lethal malignancy with poor prognosis. Anillin (ANLN), an actin binding protein, is upregulated and plays an important role in many malignant tumors. However, the precise role of ...
Journal of Experimental & Clinical Cancer Research - Latest Articles
2d
Gene fusion analysis in renal cell carcinoma by fusionplex RNA sequencing and correlations of molecular findings with clinicopathological features
Abstract Translocation renal cell carcinoma (tRCC) affects younger patients and often has poor outcomes. Accurate diagnosis is required to guide clinical management. Here we evaluate the RNA‐sequencing FusionPlex platform with a 115‐gene panel including TFE3 and TFEB for tRCC diagnosis and correlate molecular findings with clinicopathological features. We reviewed 996 consecutive RCC cases from our institution over the preceding 7 years and retrieved 17 cases with histological and immunohistochemical...
Genes, Chromosomes and Cancer
22h
The Role of TP53 in Acute Myeloid Leukemia: Challenges and Opportunities
ABSTRACT The tumor suppressor gene TP53 is one of the most frequently mutated genes in human cancer. The central role of the TP53 protein in several fundamental processes such as cancer, aging, senescence and DNA repair have ensured enormous attention. However, the role of TP53 in acute myeloid leukemia (AML) is enigmatic. Unlike many other human cancers, a vast majority of AMLs display no genomic TP53 alterations. There is now growing appreciation of the fact that the unaltered TP53 status of tumor...
Genes, Chromosomes and Cancer
2d
Prediction of melanoma evolution in melanocytic nevi via artificial intelligence: A call for prospective data
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Wiebke Sondermann, Jochen Sven Utikal, Alexander H. Enk, Dirk Schadendorf, Joachim Klode, Axel Hauschild, Michael Weichenthal, Lars E. French, Carola Berking, Bastian Schilling, Sebastian Haferkamp, Stefan Fröhling, Christof von Kalle, Titus J. BrinkerAbstractRecent research revealed the superiority of artificial intelligence over dermatologists to diagnose melanoma from images. However, 30–50% of all melanomas...
European Journal of Cancer
2d
Deep neural networks are superior to dermatologists in melanoma image classification
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Titus J. Brinker, Achim Hekler, Alexander H. Enk, Carola Berking, Sebastian Haferkamp, Axel Hauschild, Michael Weichenthal, Joachim Klode, Dirk Schadendorf, Tim Holland-Letz, Christof von Kalle, Stefan Fröhling, Bastian Schilling, Jochen S. UtikalAbstractBackgroundMelanoma is the most dangerous type of skin cancer but is curable if detected early. Recent publications demonstrated that artificial intelligence...
European Journal of Cancer
2d
Impact of American Joint Committee on Cancer 8th edition classification on staging and survival of patients with melanoma
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Theodora Kanaki, Andreas Stang, Ralf Gutzmer, Lisa Zimmer, Eleftheria Chorti, Antje Sucker, Selma Ugurel, Eva Hadaschik, Nikolai S. Gräger, Imke Satzger, Dirk Schadendorf, Elisabeth LivingstoneAbstractObjectiveThe American Joint Committee on Cancer (AJCC) 8th staging system introduced several revisions. To assess the impact of the 8th edition American Joint Committee on Cancer (AJCC8) staging system on subgrouping...
European Journal of Cancer
2d
Humanistic and economic impact of subcutaneous versus intravenous administration of oncology biologics
Future Oncology, Ahead of Print.
Future Oncology
2d

Ethnic disparity in clinical performance between multivariate index assay and CA125 in detection of ovarian malignancy
Future Oncology, Ahead of Print.
Future Oncology
2d
Anxiety and depression in young adult German cancer patients: time course and associated factors
Abstract Objective Cancer in young adulthood is a non‐normative and critical life event. The experience of having cancer can have a strong impact on the mental health of young adults. This study investigated anxiety and depression in young adult cancer patients, examining changes over time and determining associated factors. Methods Young cancer patients (18‐39 years at time of diagnosis, diagnosis <4 years) were examined. Anxiety and depression were measured at two time points (t2=12...
Psycho-Oncology
1d
The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy which has demonstrated sensitivity to immune checkpoint inhibitor therapy. Here, we perform the largest genomics study in MCC to date to characterize the molecular landscape and evaluate for clinical and molecular correlates to immune checkpoint inhibitor response. Experimental Design: Comprehensive molecular profiling was performed on 317 tumors from patients with MCC including the evaluation of oncogenic mutations,...
Clinical Cancer Research Online First Articles
2d
A treatment planning study comparing IMRT techniques and cyber knife for stereotactic body radiotherapy of low-risk prostate carcinoma
Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...
Radiation Oncology - Latest Articles
1d
Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity
Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...
Radiation Oncology - Latest Articles
1d
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...
Radiation Oncology - Latest Articles
2d
Ethnic disparity in clinical performance between multivariate index assay and CA125 in detection of ovarian malignancy.
Related ArticlesEthnic disparity in clinical performance between multivariate index assay and CA125 in detection of ovarian malignancy. Future Oncol. 2019 Aug 09;: Authors: Dunton C, Bullock RG, Fritsche H Abstract Aim: Based on evidence that African-American (AA) women have lower CA125 values than Caucasian (C) women, we investigated this to see if this disparity would have an impact on ovarian cancer detection using CA125 and multivariate index assay...
Future Oncology.
1d
Humanistic and economic impact of subcutaneous versus intravenous administration of oncology biologics.
Related ArticlesHumanistic and economic impact of subcutaneous versus intravenous administration of oncology biologics. Future Oncol. 2019 Aug 09;: Authors: Anderson KC, Landgren O, Arend RC, Chou J, Jacobs IA Abstract More oncology biologics are becoming available for subcutaneous (sc.) administration and are expected to provide useful therapeutic options. We evaluated evidence published in the past 5 years to assess the humanistic and economic impact...
Future Oncology.
1d
Efficacy and safety of lenvatinib in an elderly patient with metastatic papillary thyroid carcinoma and cardiological comorbidity: a case report.
Related ArticlesEfficacy and safety of lenvatinib in an elderly patient with metastatic papillary thyroid carcinoma and cardiological comorbidity: a case report. Future Oncol. 2019 Aug 08;: Authors: Latorre A, Fioretti AM, Giotta F, Lorusso V Abstract Lenvatinib significantly prolonged progression-free survival versus placebo in patients with radio-iodine refractory differentiated thyroid carcinoma. However, the primary adverse effects of any grade that...
Future Oncology.
2d
Corrigendum.
Related ArticlesCorrigendum. Future Oncol. 2019 Aug 08;: Authors: PMID: 31393164 [PubMed - as supplied by publisher]
Future Oncology.
2d
Poor survival of non-small-cell lung cancer patients with main bronchus tumor: a large population-based study.
Related ArticlesPoor survival of non-small-cell lung cancer patients with main bronchus tumor: a large population-based study. Future Oncol. 2019 Aug 08;: Authors: Li C, Liu J, Lin J, Li Z, Shang X, Wang H Abstract Aim: In this study, we evaluated the association between tumor location and prognosis in non-small-cell lung cancer patients. Patients & methods: The SEER database was used to screen for suitable patients using our inclusion criteria....
Future Oncology.
2d
The Genetic Education for Men (GEM) Trial: Development of Web-Based Education for Untested Men in BRCA1/2- Positive Families
Abstract Cascade testing for hereditary breast/ovarian cancer is an important public health priority. Increasing attention has been paid to the relevance of testing for men within BRCA1/2-positive families given that such testing may provide important information about their cancer risks, particularly for prostate cancer, and risks to their offspring. However, men are much less likely to seek genetic counseling and testing than their at-risk female relatives. To facilitate access...
Journal of Cancer Education
1d
Influence of the facility caseload on the subsequent survival of men with localized prostate cancer undergoing radical prostatectomy
Background Several studies have investigated the relationship between experience measured by caseload and oncological outcomes, economics, and access to care for prostate cancer care. Oncological outcomes have been limited to biochemical failure after radical prostatectomy. Questions remain regarding the more definitive measures of outcomes and their relationship with caseload. Methods The National Cancer Database was used to investigate the outcomes of radical prostatectomy in the United...
Cancer
1d
Incidence, patterns of progression, and outcomes of preexisting and newly discovered brain metastases during treatment with anti–PD‐1 in patients with metastatic melanoma
Background Melanoma brain metastases (MBM) occur in up to 50% of patients with metastatic melanoma (MM) and represent a frequent site of systemic treatment failure for targeted therapies. However, to the authors' knowledge, little is known regarding the incidence, patterns of disease progression, and outcomes of MBM in patients treated with anti–PD‐1 immunotherapy. Methods A total of 320 patients with MM who were treated with anti–PD‐1 at The University of Texas MD Anderson Cancer Center in...
Cancer
1d
Race and delays in breast cancer treatment across the care continuum in the Carolina Breast Cancer Study
Background After controlling for baseline disease factors, researchers have found that black women have worse breast cancer survival, and this suggests that treatment differences may contribute to poorer outcomes. Delays in initiating and completing treatment are one proposed mechanism. Methods Phase 3 of the Carolina Breast Cancer Study involved a large, population‐based cohort of women with incident breast cancer. For this analysis, we included black women (n = 1328) and white women (n = 1331)...
Cancer
1d
Obesity and breast cancer screening: Cross‐sectional survey results from the behavioral risk factor surveillance system
Background Postmenopausal obese women demonstrate an elevated breast cancer risk and experience increased breast cancer morbidity and mortality compared with women with a normal body mass index (BMI). However, to the authors' knowledge, prior studies have yielded inconclusive results regarding the effects of obesity on mammography screening adherence. Using national cross‐sectional survey data, the objective of the current study was to assess the current association between increasing BMI and use...
Cancer
2d
A spotlight on cancer researchers in Spain: new paradigms and disruptive ideas
Clinical and translational oncology
2d
Geriatric assessment of patients treated for cutaneous head and neck malignancies in a tertiary referral center: Predictors of postoperative complications
Publication date: Available online 10 August 2019Source: European Journal of Surgical OncologyAuthor(s): Julius de Vries, Anne N. Heirman, Linda Bras, Boudewijn E.C. Plaat, Emoke Rácz, Marloes S. van Kester, Suzanne Festen, Geertruida H. de Bock, Bernard F.A.M. van der Laan, Gyorgy B. HalmosAbstractIntroductionAs cutaneous head and neck malignancies are highly prevalent especially in older patients, the risk of surgical complications is substantial in this potentially vulnerable population. The objective...
European Journal of Surgical Oncology (EJSO)
16h
Complete response to systemic treatment might predict better survival rates regardless of their metastatic patterns in de novo stage IV breast cancer patients undergoing primary surgery
Publication date: Available online 8 August 2019Source: European Journal of Surgical OncologyAuthor(s): Kadri Altundag
European Journal of Surgical Oncology (EJSO)
2d
Correction: Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy
British Journal of Cancer, Published online: 09 August 2019; doi:10.1038/s41416-019-0545-zCorrection: Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy
Cancer
2d

Correction: Targeting CXCL12/CXCR4 and myeloid cells to improve the therapeutic ratio in patient-derived cervical cancer models treated with radio-chemotherapy
Cancer
2d
Where Society and Medicine Meet: The Identity of Motherhood
Publication date: Available online 10 August 2019Source: Practical Radiation OncologyAuthor(s): Miriam A. Knoll
Practical Radiation Oncology
15h
Error Types and Associations of Clinically Significant Events within FDA Recalls of Linear Accelerators and Related Products
Publication date: Available online 10 August 2019Source: Practical Radiation OncologyAuthor(s): Vikram Jairam, Holly Lincoln, Derek Brown, Henry S. Park, Suzanne B. EvansAbstractBackgroundMedical devices in radiation therapy (RT) undergo a complex process of Food and Drug Administration (FDA) approval. Little is known about which processes within the RT medical device industry are most prone to events involving wrong dose, volume, or targeting in radiotherapy treatment.MethodsWe carried out a retrospective...
Practical Radiation Oncology
15h
STUB1 suppress tumorigenesis and chemoresistance through antagonizing YAP1 signaling
Abstract Yes‐associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has been verified in different types of human cancers. However, the molecular mechanism of YAP1 upregulation in cancer is still unclear. Here we demonstrated that the E3 ubiquitin ligase STUB1 ubiquitinates and...
Cancer Science
2d
Inhibition of mutant Kras and p53‐driven pancreatic carcinogenesis by atorvastatin: Mainly via targeting of the farnesylated DNAJA1 in chaperoning mutant p53
Abstract Recent studies have indicated that using statins to inhibit the mevalonate pathway induces mutant p53 degradation by impairing the interaction of mutant p53 with DnaJ subfamily A member 1 (DNAJA1). However, the role of the C‐terminus of DNAJA1 with a CAAX box for farnesylation in the binding, folding, and translocation of client proteins such as mutant p53 is not known. In the present study, we used a genetically engineered mouse model of pancreatic carcinoma and showed that atorvastatin...
Molecular Carcinogenesis
1d
Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway
Abstract Carboxypeptidase A4 (CPA4) is a member of the metallocarboxypeptidase family. A previous study indicated that CPA4 may participate in the modulation of peptide hormone activity and hormone‐regulated tissue growth and differentiation. However, the role of CPA4 in lung tumorigenesis remains unclear. Our study revealed that CPA4 expression was higher in both lung cancer cells and tumor tissues. We performed 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assays, colony‐formation...
Molecular Carcinogenesis
1d
Cardiac glycoside sensitized hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK, mitochondrial transition, and autophagy mediation
Abstract A major concern in the clinical application of tumor necrosis factor related apoptosis‐inducing ligand (TRAIL) in tumors is the development of resistance. Therefore, agents that can potentially restore TRAIL sensitivity are important therapeutic targets for cancer treatment. Herein, we evaluated lanatoside c and digoxin, both of which are widely used cardiac glycosides (CGs), for their ability to sensitize human hepatocellular carcinoma cells (Huh‐7 and HepG2) through TRAIL‐induced apoptosis....
Molecular Carcinogenesis
2d

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