Related ArticlesOverinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss. J Transl Med. 2019 Aug 14;17(1):269 Authors: Ołdak M, Lechowicz U, Pollak A, Oziębło D, Skarżyński H Abstract BACKGROUND: Hearing loss (HL) is the most common disability of human senses characterized by a great allelic heterogeneity. GJB2 and TMPRSS3 are two well-known HL genes typically...
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Related ArticlesA deafness-associated mitochondrial DNA mutation altered the tRNASer(UCN) metabolism and mitochondrial function. Mitochondrion. 2019 05;46:370-379 Authors: Xue L, Chen Y, Tang X, Yao J, Huang H, Wang M, Ye S, Wang M, Guan MX Abstract Mutations in mitochondrial DNA (mtDNA) have been associated with deafness and their pathophysiology remains poorly understood. In this study, we investigated the pathogenic mechanism of deafness-associated...
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Related ArticlesMolecular pathways disrupted by gestational diabetes mellitus. J Mol Endocrinol. 2019 Aug 01;: Authors: Nguyen-Ngo C, Jayabalan N, Salomon C, Lappas M Abstract Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for mother and baby. An effective therapeutic that can reduce the incidence of GDM and improve long-term maternal and fetal outcomes is a major research priority, crucially important for public...
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Related ArticlesStructure-based identification of novel sirtuin inhibitors against triple negative breast cancer: An in silico and in vitro study. Int J Biol Macromol. 2019 Aug 09;: Authors: Sinha S, Patel S, Athar M, Vora J, Chhabria MT, Jha PC, Shrivastava N Abstract Triple-negative breast cancer (TNBC) is an aggressive disease exemplified by a poor prognosis, greater degrees of relapse, the absence of hormonal receptors for coherent utilization of...
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Related ArticlesNAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer. Front Immunol. 2019;10:1720 Authors: Audrito V, Managò A, Gaudino F, Sorci L, Messana VG, Raffaelli N, Deaglio S Abstract Cancer cells, particularly in solid tumors, are surrounded by non-neoplastic elements, including endothelial and stromal cells, as well as cells of immune origin, which can support...
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Related ArticlesPalmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons. Neurochem Res. 2019 Jul;44(7):1745-1754 Authors: Flores-León M, Pérez-Domínguez M, González-Barrios R, Arias C Abstract Increased levels of circulating fatty acids, such as palmitic acid (PA), are associated with the development of obesity, insulin resistance, type-2 diabetes and metabolic syndrome....
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Related Articles[Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):787-795 Authors: Chen H, Li J, Hu L, Zhao W, Yu H, Liu HZ, Ma ST Abstract To investigate the effects of geniposidic acid( GPA) on hepato-enteric circulation in cholestasis rats,and to explore the mechanism based on the sirtuin 1( Sirt1)-farnesol X receptor( FXR) pathway,sixty SD...
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Related Articles[Qibai Pingfei capsule alleviates inflammation and oxidative stress in a chronic obstructive pulmonary disease rat model with syndromes of Qi deficiency and phlegm and blood stasis by regulating the SIRT1/FoxO3a pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Feb;35(2):115-120 Authors: Wu F, Li Z, Dong C, Tong J, Wang L, Yang Q, Yin Z, Li L Abstract Objective To explore the effect of Qibai Pingfei capsule (QPC) on the inflammation...
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Related ArticlesThe protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation. Int Immunopharmacol. 2019 May;70:520-529 Authors: Peng XP, Li XH, Li Y, Huang XT, Luo ZQ Abstract Overactivation of the N-methyl-d-aspartate (NMDA) receptor promotes oxidative stress, aggravates the inflammatory response and induces excitotoxic lung injury. NMDA is a synthetic agonist...
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Related ArticlesNF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Cell Commun Signal. 2019 03 18;17(1):24 Authors: Szymura SJ, Zaemes JP, Allison DF, Clift SH, D'Innocenzi JM, Gray LG, McKenna BD, Morris BB, Bekiranov S, LeGallo RD, Jones DR, Mayo MW Abstract BACKGROUND: Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion...
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Related ArticlesB-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro. Transl Res. 2019 06;208:30-46 Authors: Tsai YT, Lin FY, Lin CS, Loh SH, Li CY, Lin CY, Lin YW, Tsai CS Abstract B-type natriuretic peptide (BNP) was approved by the US Food and Drug Administration in 2001 for the treatment of heart failure. However, the effects of BNP...
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Related ArticlesBaicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats. Phytother Res. 2019 May;33(5):1480-1489 Authors: Yu H, Zhang F, Guan X Abstract Depression is a common and detrimental illness that affects up to 120 million people worldwide. The present study was designed to evaluate the antidepressant-like effects and mechanisms of baicalin on olfactory bulbectomized model of...
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Related ArticlesMelatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats. Can J Physiol Pharmacol. 2019 May;97(5):386-391 Authors: He B, Zhang W, Qiao J, Peng Z, Chai X Abstract The apoptosis of bronchial and alveolar epithelial cells plays a key role in chronic obstructive pulmonary disease (COPD). The endoplasmic reticulum (ER) stress induced by cigarette smoke contributes to...
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Related ArticlesResveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. Inflammopharmacology. 2019 Feb;27(1):47-56 Authors: Yang QB, He YL, Zhong XW, Xie WG, Zhou JG Abstract BACKGROUND: Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1...
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Related ArticlesNext generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease. Mol Genet Metab. 2019 01;126(1):64-76 Authors: Dembic M, Andersen HS, Bastin J, Doktor TK, Corydon TJ, Sass JO, Lopes Costa A, Djouadi F, Andresen BS Abstract Resveratrol (RSV) is a small compound first identified as an activator of sirtuin 1 (SIRT1), a key factor in mediating the effects of caloric restriction. Since...
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Related ArticlesLoss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity. Cardiovasc Res. 2018 07 01;114(8):1178-1188 Authors: Gaul DS, Weber J, van Tits LJ, Sluka S, Pasterk L, Reiner MF, Calatayud N, Lohmann C, Klingenberg R, Pahla J, Vdovenko D, Tanner FC, Camici GG, Eriksson U, Auwerx J, Mach F, Windecker S, Rodondi N, Lüscher TF, Winnik S, Matter CM Abstract Aims:...
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Related ArticlesComparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial. J Am Coll Nutr. 2018 Mar-Apr;37(3):223-233 Authors: Asghari S, Asghari-Jafarabadi M, Somi MH, Ghavami SM, Rafraf M Abstract OBJECTIVE: There is a promising perspective regarding the potential effect of...
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Related Articles[Acute treatment of ischemic stroke : Current standards]. Nervenarzt. 2019 Aug 12;: Authors: Barow E, Thomalla G Abstract Important milestones of acute ischemic stroke (AIS) treatment were achieved in recent years. The results of two randomized controlled trials revealed that intravenous thrombolysis is efficacious for treatment of AIS patients with a symptom onset <9 h or an unknown time of symptom onset in the presence of beneficial...
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Related Articles[New biomarkers for Alzheimer's disease in cerebrospinal fluid and blood]. Nervenarzt. 2019 Aug 12;: Authors: Vogelgsang J, Wiltfang J Abstract In accordance with the current German dementia guidelines, the dementia biomarkers amyloid beta 42, the tau peptides total tau and phosphorylated tau 181 are recommended for cerebrospinal fluid (CSF)-based diagnostics of dementia. Several studies have clearly shown that determination of the amyloid...
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Related Articles[Intracerebral hemorrhage: hot topics]. Nervenarzt. 2019 Aug 12;: Authors: Sprügel MI, Huttner HB Abstract Significant advances in the acute treatment of patients with intracerebral hemorrhage (ICH) have been achieved in recent years. While many randomized trials have provided neutral results, important findings have been generated for the design of follow-up studies. Furthermore, a number of observational studies have been published,...
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Related Articles[ADHD in adult patients with substance use disorders]. Nervenarzt. 2019 Aug 12;: Authors: Luderer M, Kiefer F, Reif A, Moggi F Abstract BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common comorbidity in adult patients with substance use disorders (SUDs). The diagnostics and treatment of ADHD with SUD are often a challenge, also with respect to the prescription of stimulants. Recently, a group of international experts...
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The headlines about late diagnosis of cancers feed into a false narrative that misleads the public to believe that if any chronic disease had been diagnosed a bit earlier, the outcome would have been...
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OBJECTIVES: To investigate the relationship between the serum levels of NLRP3 and HMGB-1 and the prognosis of patients with severe blunt abdominal trauma. METHODS: In total, 299 patients were included in the current study from July 2014 to December 2015. All patients were divided into the mild/moderate blunt abdominal trauma group and the severe blunt abdominal trauma group according to their injury severity scores. Serum levels of NLRP3 and HMGB-1 were measured upon admission (0 h) and at 12 h,...
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OBJECTIVE: The reliability of heart rate variability (HRV) analysis is not yet fully understood, especially considering different body positions and the mathematical influence of heart rate. The aim of this study was to evaluate the reliability of HRV in supine and standing positions, with and without mathematical adjustment of HRV by the average R-R interval (iRR). METHODS: We evaluated 37 young males (23.1±4 years; 25.1±3 kg/m2). A 5-min segment of the iRR was collected in the supine and standing...
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OBJECTIVES: Evaluate the use of probiotics as an additional therapy in the treatment of children and adolescents with asthma in Belo Horizonte, MG-Brazil. METHODS: A pilot longitudinal, experimental and nonrandomized study with 30 patients from six to 17 years old from Belo Horizonte. In the baseline appointment, all patients received beclomethasone, and one group also received a probiotic containing Lactobacillus reuteri (n=14). The patients were reassessed after at least 60 days with the Asthma...
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Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a life-threatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy...
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Keywords systemtic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, systemic sclerosis, vasculitis, temporal arteritis, Takayasu arteritis, Behçet syndrome The diseases discussed in this chapter are linked by their inflammatory mechanisms...
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Keywords amyotrophic lateral sclerosis, de-efferented state, dementia, end-of-life care, minimally conscious state, persistent vegetative state With the advent of increasingly sophisticated technology and more powerful pharmacologic agents, it has...
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Keywords dementia, Alzheimer disease, Parkinson disease, dysphagia, aspiration, delirium, falls, sleep Dementia is a common problem among the elderly and is associated with a number of important systemic complications....
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Keywords Seizures, epilepsy, uremia, hepatic failure, critical illness, porphyria, transplant recipients, connective tissue diseases, HIV infection, diabetes, hypoglycemia, thyroid disease, sodium, magnesium, alcohol, cocaine, medication-induced seizures, trauma Seizures commonly...
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Keywords consciousness, coma, metabolic encephalopathy, brain death, vegetative state, minimally conscious state Consciousness is a complex and elusive concept that has been the subject of extensive thought and speculation...
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Keywords motor neuron, radiculopathy, dorsal root ganglia, plexopathy, peripheral neuropathy, polyneuropathy, vasculitic neuropathy, critical illness polyneuropathy, uremic neuropathy, paraneoplastic neuropathies, nutritional neuropathy, toxic neuropathy, hereditary neuropathy, neuromuscular junction disorders, botulism,...
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Keywords sepsis, septic encephalopathy, critical illness neuropathy, critical illness myopathy, critical illness polyneuropathy Injury to other organ systems may have direct or remote neurologic effects. Hepatic, cardiac, pulmonary, pancreatic,...
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Keywords concussion, postconcussion syndrome, diagnosis, treatment, chronic traumatic encephalopathy, sports participation, headache Postconcussion syndrome (PCS) is a common condition that includes physical, cognitive, and affective symptoms. PCS has a...
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Keywords anesthesia, regional anesthesia, general anesthesia, spinal anesthesia, neurologic complications, seizures, neuropathy Current rates of anesthetic complications are low regardless of the type of anesthesia (general, regional, or local)....
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Keywords preoperative evaluation, perioperative stroke, postoperative recovery, anesthesia, surgery, neuromuscular disorders, seizures, delirium, multiple sclerosis, movement disorders Introduction Perioperative care of the patient with neurologic disease provides practitioners with...
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Journal of Exposure Science & Environmental Epidemiology, Published online: 16 August 2019; doi:10.1038/s41370-019-0161-2Weight of epidemiological evidence for titanium dioxide risk assessment: current state and further needs
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Journal of Exposure Science & Environmental Epidemiology, Published online: 12 August 2019; doi:10.1038/s41370-019-0159-9Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers
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