Abstract Purpose of Review The purposes of the review are as follows: (1) to define acute rhinosinusitis (ARS) and their phenotypes, (2) to highlight the ARS management according to international guidelines, (3) to compare the physicians’ management with the ARS guideline recommendations, and (4) to report ARS socioeconomic burden. Recent Findings ...
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Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1151-4800 Background Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) has a wide phenotypic spectrum including Kallmann syndrome (KS) and normosmic idiopathic hypogonadotropic hypogonadism (nIHH). FGFR1 mutations have been identified in 3–10% of patients with KS or nIHH. This study was performed to investigate clinical phenotypes and...
Tue Jun 02, 2020 02:00
LaryngorhinootologieDOI: 10.1055/a-1176-1785© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Tue Jun 02, 2020 02:00
Abstract Insulinoma is a rare pancreatic neuroendocrine tumor (pNET) potentially associated with severe hypoglycaemic crisis. The great majority of these tumors are benign. In patients with metastatic malignant insulinoma, systemic therapies aim to control both the syndrome and tumor growth. Everolimus is a drug approved for the management of advanced pNETs that can achieve both these goals. According to international guidelines and regulatory authorities, everolimus in patients...
Tue Jun 02, 2020 03:00
Abstract Purpose The increasing burden of noncommunicable diseases (NCDs) attributable to high body mass index (BMI) represents both a threat and an opportunity for intervention. Estimates of the global latest trend of high BMI-related NCDs and its association with socioeconomic status can facilitate strategic intervention and inform further research. Methods ...
Tue Jun 02, 2020 03:00
Abstract The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is centralizing the interest of the scientific world. In the next months, long-term consequences on the endocrine system may arise following COVID-19. In this article, we hypothesized the effects of SARS-CoV-2 taking into account what learned from the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused SARS in 2003.
Tue Jun 02, 2020 03:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Tue Jun 02, 2020 03:00
Evolutionary Computation, Volume 28, Issue 2, Page 317-338, Summer 2020.
Mon Jun 01, 2020 15:00
Evolutionary Computation, Volume 28, Issue 2, Page 289-316, Summer 2020.
Mon Jun 01, 2020 15:00
Evolutionary Computation, Volume 28, Issue 2, Page 255-288, Summer 2020.
Mon Jun 01, 2020 15:00
Even if adolescence is a window of opportunity to break the intergenerational cycle of malnutrition, adolescents are the neglected age groups. Hence, information regarding the nutritional status of adolescents is lacking, making creating and implementing intervention programs difficult. This study aimed to assess the prevalence and determinants of thinness among school adolescents in Finote Selam Town, Northwest Ethiopia. A school-based cross-sectional study among adolescent students aged 10–19 in...
Tue Jun 02, 2020 12:50
Ameloblastoma is one of the most common benign odontogenic neoplasms. Its surgical excision has the potential to lead to postoperative malocclusion. In this case report, we describe the successful interdiscipl...
Tue Jun 02, 2020 03:00
Zygomatic implants (ZIs) are used for the oral rehabilitation of patients with maxillectomy defects as an alternative to extensive bone grafting surgeries. New technologies such as computer-assisted navigation systems can improve the accuracy and safety of ZI placement. The intraoral anchorage of fiducial markers necessary for navigation registration is not possible in the case of a severe maxillary defect and lack of residual bone. This technical note presents a novel extraoral registration method...
Tue Jun 02, 2020 03:00
Abstract Autozygosity-driven exome analysis has been shown effective for identification of genes underlying recessive diseases especially in countries of the so-called Greater Middle East (GME), where high consanguinity unravels the phenotypic effects of recessive alleles and large family sizes facilitate homozygosity mapping. In Italy, as in most European countries, consanguinity is estimated low. Nonetheless, consanguineous Italian families are not uncommon in publications of...
Tue Jun 02, 2020 03:00
Abstract An inverted duplication with a terminal deletion (inv-dup-del) is one of the complex constitutional structural rearrangements that can occur in a chromosome. Although breakages of dicentric chromosome have been suggested, the precise mechanism of this is yet to be fully understood. In our present study, we investigated the genomic structure of 10 inv-dup-del cases to elucidate this mechanism. Two recurrent 8p inv-dup-del cases harbored a large copy-number-neutral region...
Tue Jun 02, 2020 03:00
Abstract Background The histological differentiation of individual types of vascular anomalies (VA), such as lymphatic malformations (LM), hemangioma (Hem), paraganglioma (PG), venous malformations (VeM), arteriovenous malformations (AVM), pyogenic granulomas (GP), and (not otherwise classified) vascular malformations (VM n.o.c.) is frequently difficult due to the heterogeneity of these anomalies. The aim of the study was to evaluate digital...
Tue Jun 02, 2020 03:00
Abstract Objective To assess the internal consistency, reliability, and clinical validity of a French version of the M.D. Anderson Dysphagia Inventory (Fr-MDADI). Methods Patients addressed in the Swallowing Clinics of CHU Saint-Pierre Hospital (Brussels) and EpiCURA hospital (Ath, Belgium) for dysphagia completed Fr-MDADI, eating assessment tool-10 (EAT-10),...
Tue Jun 02, 2020 03:00
Abstract Purpose To evaluate the effect of the different surgical techniques used in the treatment of obstructive sleep apnea (OSA) on the postoperative voice and nasalance, and to conduct a meta-analysis through the assessment of postoperative changes. Methods Systematic literature review and meta-analysis of published data using the data sources, MEDLINE,...
Tue Jun 02, 2020 03:00
Abstract Purpose Although the prevalence of olfactory dysfunction in children is thought to be lower compared to adults, little is known about the actual frequency of etiologies of smell dysfunction in children. Aim of the study was (i) to describe the epidemiology of olfactory dysfunction in a pediatric population and (ii) to compare the distribution of etiologies to adults. ...
Mon Jun 01, 2020 03:00
Mon Jun 01, 2020 03:00
Abstract Purpose In this study, we aimed to determine whether or not COM leads to loss of spiral and Scarpa ganglion neurons. Methods From the human temporal bone (HTB) collection at the University of Minnesota we selected human temporal bones with COM, defined as the presence of clinically intractable tissue abnormalities in the middle ear (cholesteatoma,...
Mon Jun 01, 2020 03:00
Abstract Objective Lateral and central compartments cervical lymph nodes metastases are common among patients with papillary thyroid carcinoma (PTC). Elective level VI neck dissection during thyroidectomy and lateral neck dissection (LND) for the treatment of PTC with lateral compartment lymph node metastases is controversial because of the uncertain benefit in clinical outcomes and increased risks of surgical morbidity. ...
Tue Jun 02, 2020 03:00
Theater actors are a high risk group for developing voice disorders.
Tue Jun 02, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04442
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05957
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04422
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02808
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02756
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04999
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03244
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b13391
Tue Jun 02, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05548
Tue Jun 02, 2020 07:00
Multigenerational, multicultural, multiethnic. These words describe our increasingly global society as well as many of our organizations, colleagues, communities, and patients. “Intentionally Shaping the Future of Otolaryngology” seeks to provide evidence and insight and to provoke critical thought and conversations regarding issues facing the future of our field.
Tue Jun 02, 2020 03:00
Abstract Object Hydrocephalus diagnosed prenatally or in infancy differs substantially from hydrocephalus that develops later in life. The purpose of this review is to explore hydrocephalus that begins before skull closure and full development of the brain. Understanding the unique biomechanics of hydrocephalus beginning very early in life is essential to explain two poorly understood and controversial issues. The first is why is endoscopic...
Tue Jun 02, 2020 03:00
Tue Jun 02, 2020 03:00
Abstract Physical frailty and sarcopenia (PF&S) is a prototypical geriatric condition characterized by reduced physical function and low muscle mass. The aim of the present study was to provide an initial selection of biomarkers for PF&S using a novel multivariate analytic strategy. Two-hundred community-dwellers, 100 with PF&S and 100 non-physically frail, non-sarcopenic (nonPF&S) controls aged 70 and older were enrolled as part of the BIOmarkers associated with...
Mon Jun 01, 2020 03:00
Abstract Polygenic risk scores (PRSs) discriminate trait risks better than single genetic markers because they aggregate the effects of risk alleles from multiple genetic loci. Constructing pleiotropic PRSs and understanding heterogeneity, and the replication of PRS-trait associations can strengthen its applications. By using variational Bayesian multivariate high-dimensional regression, we constructed pleiotropic PRSs jointly associated with body mass index, systolic and diastolic...
Mon Jun 01, 2020 03:00
Tue Jun 02, 2020 03:00
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