Mon Jun 01, 2020 03:00
Mon Jun 01, 2020 03:00
Abstract Background Despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, patients suffering from primary adrenal insufficiency (AI) have an increased mortality, mainly due to cardiovascular diseases. Only little knowledge exists on the contribution of MC substitution to the cardiovascular risk. Therefore, this study investigates the impact of plasma renin concentration on parameters of micro- and macrovascular...
Mon Jun 01, 2020 03:00
Abstract IL6 is an inflammatory cytokine with pleiotropic functions in both immune and nonimmune cells, and its expression level is inversely correlated with disease prognosis in patients with cancer. However, blocking IL6 alone has only yielded minimal efficacy in human cancer patients. We aimed at defining IL6 expression profiles under inflammatory conditions and cancer, and elucidating the mechanism underlying IL6 intrinsic signaling in colon carcinoma. We report here that...
Mon Jun 01, 2020 03:00
Boston Scientific is releasing in the United States its DIRECTSENSE Technology for live monitoring of cardiac tissue during radiofrequency ablation procedures. The capability is designed for use on the company’s RHYTHMIA HDx Mapping System along with the INTELLANAV MiFi Open-Irrigated ablation catheter and it works by measuring the change in electrical impedance of the tissue around the catheter as it is being irradiated. It is currently very difficult to create sufficient lesions that alleviate...
Tue Jun 02, 2020 22:36
Testing people for COVID-19 typically involves performing a throat swab to collect a sample for processing. Clinicians performing this task have to wear a complete package of personal protective equipment (PPE), something that can be very uncomfortable over long periods of time. Moreover, since sampling is now widely performed outside of a clinical facility and the weather is hitting summer temperatures in the northern hemisphere, the discomfort for clinical staff can be harrowing. Now, a team of...
Tue Jun 02, 2020 18:45
Aesculap, a part of B.Braun, and Miethke are releasing the M.blue adjustable gravitational hydrocephalus valve. The device features a valve that has both gravitational capability and a fixed differential pressure component, the only one of this kind. This allows the M.blue to automatically adjust the valve, within a certain range, based on the orientation of the patient at any given time. When the patient is most active, which typically happens when someone is upright, the opening pressure...
Tue Jun 02, 2020 16:09
Publication date: August 2020Source: Critical Reviews in Oncology/Hematology, Volume 152Author(s): Ambica Parmar, Beate Sander, Georg A. Bjarnason, Kelvin K.W. Chan
Tue Jun 02, 2020 22:48
Publication date: Available online 2 June 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Ridong Feng, Hai Zhao, Jianguo Xu, Chongyang Shen
Tue Jun 02, 2020 22:48
Abstract The dosimetric effect of artefacts caused by metal hip prostheses in computed tomography imaging is most commonly encountered in the planning of prostate cancer treatment. In this study, a phantom, containing a metal with high atomic number, was prepared for intensity-modulated radiotherapy (IMRT) treatment plans to be used in quality assurance (QA) procedures. Two sets of image files, one without metal artefact correction (ORG) and another with MAR correction (MAR+),...
Mon Jun 01, 2020 03:00
Abstract Many experimental studies are carried out to compare biological effectiveness of high dose rate (HDR) with that of low dose rate (LDR). The rational for this is the uncertainty regarding the value of the dose rate effectiveness factor (DREF) used in radiological protection. While a LDR is defined as 0.1 mGy/min or lower, anything above that is seen as HDR. In cell and animal experiments, a dose rate around 1 Gy/min is usually used as representative for HDR. However, atomic...
Mon Jun 01, 2020 03:00
Abstract Salivary duct carcinoma with rhabdoid features (SDCRF) is a rare salivary tumor with poor prognosis and is proposed as a salivary counterpart of pleomorphic lobular carcinoma of the breast (PLCB). Here, we report three cases of SDC with rhabdoid features (SDCRF) mimicking PLCB. Pleomorphic adenoma (PA) component was accompanied in all the cases confirming carcinoma ex PA. One patient had frequent rhabdoid features and showed invasive growth into the surrounding tissue....
Tue Jun 02, 2020 03:00
Publication date: Available online 2 June 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): So Hyun, Hyung Sub, Taeseng Lee
Tue Jun 02, 2020 22:33
Publication date: Available online 1 June 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Yan-Yan Zhang, Lin Zhang, Yan-Zhen Liu, Rui Zhang, Guang-Hui Zhang
Tue Jun 02, 2020 22:28
Publication date: Available online 1 June 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Carla Guerreiro, Luísa Albuquerque, Sofia Reimão
Tue Jun 02, 2020 22:28
Publication date: Available online 1 June 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Mauro Dobran, Davide Nasi, Gabriele Polonara, Riccardo Paracino, Fabrizio Mancini, Martina Della Costanza, Gjino Jonis, Serena Campa, Simona Lattanzi, Maurizio Iacoangeli
Tue Jun 02, 2020 22:28
Publication date: Available online 1 June 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Hazem I. Assi, Lara Hilal, Ibrahim Abu-Gheida, Juliett Berro, Fares Sukhon, Ghassan Skaf, Fady Geara, Fouad Boulos, Maya Charafeddine, Abeer Tabbarah, Jessica Khoury, Marwan Najjar
Tue Jun 02, 2020 22:28
Publication date: Available online 2 June 2020Source: Dental MaterialsAuthor(s): Abdullah Sadeghyar, David C. Watts, Andreas Schedle
Tue Jun 02, 2020 22:27
Publication date: Available online 2 June 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Robert K. Bush
Tue Jun 02, 2020 22:25
Abstract This paper identifies a tension between the commitment to forming rationally justified emotions and the happy life. To illustrate this tension I begin with a critical evaluation of the positive psychology technique known as ‘gratitude training’. I argue that gratitude training is at odds with the kind of critical monitoring that several philosophers have claimed is regulative of emotional rationality. More...
Mon Jun 01, 2020 03:00
Abstract Many philosophers believe that there is a causal condition on perception, and that this condition is a conceptual truth about perception. A highly influential argument for this claim is based on intuitive responses to Gricean-style thought experiments. Do the folk share the intuitions of philosophers? Roberts et al. (2016) presented participants with two kinds of cases: Blocker cases (similar to Grice’s case involving a mirror and a pillar) and Non-Blocker cases (similar...
Tue Jun 02, 2020 03:00
Abstract Originally understood as memory for the “what”, the “when”, and the “where” of experienced past events, episodic memory has, in recent years, been redefined as a form of past-oriented mental time travel. Following a brief review of empirical research on memory as mental time travel, this introduction provides an overview of the contributions to the special issue, which explore the theoretical implications of that research.
Tue Jun 02, 2020 03:00
Background/Aim: Neoadjuvant chemoradiation/radiation therapy in locally advanced (LA) upper rectal adenocarcinoma management remains unclear. The aim of this study was to compare outcomes between neoadjuvant chemoradiation therapy (CRT) and upfront surgery (US). Patients and Methods: A total of 127 patients were retrospectively included from 5 centers (79 treated with US and 48 with CRT). CRT and US groups were compared in terms of postoperative complications and long-term oncological and functional...
Tue Jun 02, 2020 20:04
Background/Aim: We evaluated urinary levels of porphyrin metabolites, such as uroporphyrin (UP) and coproporphyrin (CP), after 5-Aminolevulinic acid (ALA) administration in patients with or without pancreatic cancer (PaC). Patients and Methods: Sixty-seven subjects with PaC, 11 with pancreatitis, and 9 with normal pancreas (NP) were enrolled. Urine samples from all subjects were collected prior to ALA administration and at more than 4 hours after ALA administration. We measured the urinary levels...
Tue Jun 02, 2020 20:04
Background/Aim: We aimed to elucidate the clinical implication of the epithelial–mesenchymal plasticity of circulating tumor cells (CTCs) in patients with head and neck squamous cell carcinoma (HNSCC). Patients and Methods: CTCs isolated from 44 patients with non-recurrent/metastatic HNSCC and 42 with recurrent/metastatic (R/M) HNSCC were classified into four epithelial–mesenchymal transition (EMT) statuses based on the expression of epithelial (keratin 19) and mesenchymal (vimentin) markers and...
Tue Jun 02, 2020 20:04
Background/Aim: Previous studies have identified pelvic tumors as a risk factor for surgical site infections (SSI). However, risk factors for extremity tumors are still unclear. This study investigated risk factors for postoperative deep infection in malignant bone tumors of the extremities. Patients and Methods: Data from 238 patients with 256 malignant bone tumor surgeries were reviewed. Univariate analysis and multiple logistic regression determined risk factors for deep infection. Results: Deep...
Tue Jun 02, 2020 20:04
Background/Aim: We conducted a phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy in patients with cervical cancer with para-aortic node metastasis. Patients and Methods: Thirty-seven women with stage IB1-IVA cervical cancer were enrolled. Results: The median age was 52 years. Thirty-four patients other than 3 progressive disease, proceeded to extended field concurrent chemoradiotherapy. The 3-year overall survival and progression-free survival rates...
Tue Jun 02, 2020 20:04
Background/Aim: Inflammation is known to promote the progression of cancer, and there is increasing evidence that inflammation caused by the antitumor response of the host and post-operative infectious complications worsens the prognosis for colorectal cancer. However, the impact of post-operative inflammation caused by surgical stress on long-term survival is unclear. Patients and Methods: A total of 274 patients who underwent curative operation for stage II/III colorectal cancer were enrolled and...
Tue Jun 02, 2020 20:04
Background/Aim: To compare the diagnostic reliability, accuracy and safety of ultrasound-guided biopsy (Tru-Cut biopsy) and ascites puncture in patients with a primarily inoperable malignant ovarian tumor. Patients and Methods: This is a retrospective analysis of the studied methods in consecutively examined patients and a prospective validation of these methods. 79 women with a suspected primarily inoperable ovarian tumor underwent Tru-Cut biopsies and were included in the ultrasound-guided biopsy...
Tue Jun 02, 2020 20:04
Background/Aim: A retrospective study was performed in 246 breast cancer patients to define whether tumor-to-nipple distance (TND) assessment by breast MRI may select patients eligible to nipple-sparing mastectomy (NSM) as compared to permanent section assessment of retroareolar margin. Patients and Methods: Pre- and post-operative parameters including imaging data, histology of the primary tumor, biologic prognostic factors, and adjuvant regimens were retrieved; patients with close/positive retroareolar...
Tue Jun 02, 2020 20:04
Background/Aim: The development of treatment-related neuroendocrine prostate cancer (t-NEPC) is an increasing clinical concern. The objectives were to clarify the clinical features of t-NEPC. Patients and Methods: A total of 9 patients with histologically confirmed t-NEPC were reviewed. Results: Of these 9 patients, 2 patients were diagnosed with t-NEPC by a histological examination without elevation in blood tumor marker levels. Immunohistochemistry revealed an acquired Rb loss in 5 patients. All...
Tue Jun 02, 2020 20:04
Background/Aim: The treatment outcome of locally advanced non-small cell lung cancer (LA-NSCLC) has been improved over the past years but local failure is still common for these patients. The purpose of this study is to analyze the pattern of local failure and its risk factor of concurrent chemo-radiotherapy (CCRT) for locally advanced LA-NSCLC. Patients and Methods: We evaluated 77 patients treated with CCRT for LA-NSCLC from July 2007 to December 2017 at our institution. Most of the patients were...
Tue Jun 02, 2020 20:04
Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of somatic mutation and the phenotype is correspondingly diverse. This report describes histological and genetic findings in a case of mosaic NF1, the clinical control of which documents...
Tue Jun 02, 2020 20:04
Background/Aim: The combination of paclitaxel and carboplatin is the standard chemotherapy for ovarian cancer. Previous studies have implied that vitamin D (1,25-D3) may have growth inhibitory effects in ovarian cancer. This study aimed to investigate the effect of paclitaxel, carboplatin and 1,25-D3 on the growth of ovarian cancer cells in vitro, based on the hypothesis that 1,25-D3 might potentiate the effect of paclitaxel and/or carboplatin. Materials and Methods: Three non-commercial ovarian...
Tue Jun 02, 2020 20:04
Background/Aim: We evaluated whether splenic volume (SV) predicts sinusoidal obstruction syndrome (SOS) in colorectal cancer (CRC) patients receiving capecitabine plus oxaliplatin (CapeOX) therapy. Patients and Methods: In this retrospective study, we measured SV in 41 patients receiving adjuvant CapeOX for CRC at five different time points. We compared the clinical data of the 18 patients who experienced ≥30% increases in SV immediately after vs. before CapeOX (group A) with data for the remaining...
Tue Jun 02, 2020 20:04
Background/Aim: The aim of this study was to directly compare the anti-infectious and anti-cancer effects of five commercially available glucans. Materials and Methods: We used five different glucans isolated from algae, yeast, bacteria, oat, and mushroom. We compared their effects on the stimulation of phagocytosis of blood cells, on the secretion of IL-2, and on the inhibition of melanoma and breast and lung cancers. In addition, we evaluated the effects of glucan supplementation on two experimental...
Tue Jun 02, 2020 20:04
Background/Aim: Despite early detection by widespread use of abdominal imaging more than 40% of patients with conventional renal cell carcinoma (RCC) will die due to metastatic disease. Small kinase inhibitors for AXL receptor tyrosine kinase may delay the progression of metastatic cRCC. Patients and Methods: We analysed AXL expression by immunohistochemistry on tissue multi arrays of 691 conventional RCC without metastasis at the time of nephrectomy. Results: The Kaplan-Meier survival analysis indicated...
Tue Jun 02, 2020 20:04
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