Cancers, Vol. 12, Pages 1709: Lifestyle Intervention on Body Weight and Physical Activity in Patients with Breast Cancer can reduce the Risk of Death in Obese Women: The EMILI Study Cancers doi: 10.3390/cancers12071709 Authors: Cortesi Sebastiani Iannone Marcheselli Venturelli Piombino Toss Federico : Background obesity and sedentary lifestyle have been shown to negatively affect survival in breast cancer (BC). The purpose of this study was to test the efficacy...
Sat Jun 27, 2020 03:00
Cancers, Vol. 12, Pages 1704: CRISPR-Mediated Non-Viral Site-Specific Gene Integration and Expression in T Cells: Protocol and Application for T-Cell Therapy Cancers doi: 10.3390/cancers12061704 Authors: Odé Condori Peterson Zhou Krenciute T cells engineered with chimeric antigen receptors (CARs) show great promise in the treatment of some cancers. Modifying T cells to express CARs generally relies on T-cell transduction using viral vectors carrying a transgene, resulting...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1703: Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965 Cancers doi: 10.3390/cancers12061703 Authors: Marta Braga Maciej Kaliszczak Laurence Carroll Zachary T. Schug Kathrin Heinzmann Nicoleta Baxan Adrian Benito Gabriel N. Valbuena Stephen Stribbling Alice Beckley Gillian Mackay Francesco Mauri John Latigo Chris Barnes Hector Keun Eyal Gottlieb Eric O. Aboagye The monocarboxylate...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1702: TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells Cancers doi: 10.3390/cancers12061702 Authors: Yi-Yue Wang Kyung-Tae Lee Myong Cheol Lim Jung-Hye Choi In addition to their analgesic activity, transient receptor potential vanilloid 1 (TRPV1) agonists and antagonists demonstrate profound anti-cancer activities in various human cancers. In the present study, we investigated...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1705: Potential of Tyrosine Kinase Receptor TIE-1 as Novel Therapeutic Target in High-PI3K-Expressing Ovarian Cancer Cancers doi: 10.3390/cancers12061705 Authors: Xuewei Zhang Masumi Ishibashi Kazuyuki Kitatani Shogo Shigeta Hideki Tokunaga Masafumi Toyoshima Muneaki Shimada Nobuo Yaegashi Tyrosine kinase receptor TIE-1 plays a critical role in angiogenesis and blood-vessel stability. In recent years, increased TIE-1 expression has been observed...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1698: The Value of Laboratory Parameters for Anemia, Renal Function, Systemic Inflammation and Nutritional Status as Predictors for Outcome in Elderly Patients with Head-and-Neck Cancers Cancers doi: 10.3390/cancers12061698 Authors: Alexander Rühle Erik Haehl Hélène David Tobias Kalckreuth Tanja Sprave Raluca Stoian Constantinos Zamboglou Eleni Gkika Andreas Knopf Anca-Ligia Grosu Nils Henrik Nicolay The purpose of this study was...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1700: Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? Cancers doi: 10.3390/cancers12061700 Authors: Xianwen Shang Allison M. Hodge Wei Peng Mingguang He Lei Zhang Data on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45–64 years from the 45 and Up Study...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1699: Optimizing Oncolytic Viral Design to Enhance Antitumor Efficacy: Progress and Challenges Cancers doi: 10.3390/cancers12061699 Authors: Shyambabu Chaurasiya Yuman Fong Susanne G. Warner The field of oncolytic virotherapy has seen remarkable advancements in last two decades, leading to approval of the first oncolytic immuno-virotherapy, Talimogene Laherparepvec, for the treatment of melanoma. A plethora of preclinical and clinical studies have demonstrated...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1701: Mixed Type Histology as a Predictive Factor for Esophagojejunostomy Leak in Advanced Gastric Cancer Cancers doi: 10.3390/cancers12061701 Authors: Karol Rawicz-Pruszyński Katarzyna Sędłak Radosław Mlak Jerzy Mielko Wojciech Polkowski Since esophagojejunostomy leak (EJL) after gastrectomy is a potentially fatal complication and may impact the survival of patients with advanced gastric cancer (GC), it is important to establish risk factors for the...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1697: Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination Cancers doi: 10.3390/cancers12061697 Authors: Angelica Avagliano Giuseppe Fiume Maria Rosaria Ruocco Nunzia Martucci Eleonora Vecchio Luigi Insabato Daniela Russo Antonello Accurso Stefania Masone Stefania Montagnani Alessandro Arcucci The stromal microenvironment regulates mammary gland development...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1696: Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs Cancers doi: 10.3390/cancers12061696 Authors: Michael Seifert Gabriele Schackert Achim Temme Evelin Schröck Andreas Deutsch Barbara Klink Astrocytomas are primary human brain tumors including diffuse or anaplastic astrocytomas that develop towards secondary glioblastomas over time. However, only little is known about...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1695: Association of Allostatic Load with All-Cause and Cancer Mortality by Race and Body Mass Index in the REGARDS Cohort Cancers doi: 10.3390/cancers12061695 Authors: Akinyemiju Wilson Deveaux Aslibekyan Cushman Gilchrist Safford Judd Howard Among 29,701 Black and White participants aged 45 years and older in the Reasons forGeographic and Racial Difference in Stroke (REGARDS) study, allostatic load (AL) was defined asthe...
Fri Jun 26, 2020 03:00
Cancers, Vol. 12, Pages 1693: Tumor-Suppressive miR-192-5p Has Prognostic Value in Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12061693 Authors: Isabelle Flammang Moritz Reese Zixuan Yang Johannes A. Eble Sameer A. Dhayat Pancreatic ductal adenocarcinoma (PDAC) is characterized by fast tumor progression and diagnosis at advanced, inoperable stages. Previous studies could demonstrate an involvement of miR-192-5p in epigenetic regulation of visceral carcinomas....
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1692: Integrated Assessment of Circulating Cell-Free MicroRNA Signatures in Plasma of Patients with Melanoma Brain Metastasis Cancers doi: 10.3390/cancers12061692 Authors: Matias A. Bustos Kevin D. Tran Negin Rahimzadeh Rebecca Gross Selena Y. Lin Yoshiaki Shoji Tomohiro Murakami Christine L. Boley Linh T. Tran Hunter Cole Daniel F. Kelly Steven O’Day Dave S.B. Hoon Primary cutaneous melanoma frequently metastasizes to distant...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1694: Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-mediated Apoptosis Cancers doi: 10.3390/cancers12061694 Authors: Aleksandr Ianevski Evgeny Kulesskiy Klara Krpina Guofeng Lou Yahyah Aman Andrii Bugai Koit Aasumets Yevhen Akimov Daria Bulanova Kiira Gildemann Albert F. Arutyunyan Olga Yu. Susova Alexei L. Zhuze Ping Ji Wei Wang Toril Holien Marit Bugge Eva Zusinaite Valentyn Oksenych...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1689: Impact of Tumor Localization and Molecular Subtypes on the Prognostic and Predictive Significance of p53 Expression in Gastric Cancer Cancers doi: 10.3390/cancers12061689 Authors: Bianca Grosser Meike Kohlruss Julia Slotta-Huspenina Moritz Jesinghaus Nicole Pfarr Katja Steiger Alexander Novotny Matthias M. Gaida Thomas Schmidt Alexander Hapfelmeier Katja Ott Wilko Weichert Gisela Keller We investigated the prognostic and...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1687: Telomerase and CD4 T Cell Immunity in Cancer Cancers doi: 10.3390/cancers12061687 Authors: Magalie Dosset Andrea Castro Hannah Carter Maurizio Zanetti Telomerase reverse transcriptase (TERT) is a conserved self-tumor antigen which is overexpressed in most tumors and plays a critical role in tumor formation and progression. As such, TERT is an antigen of great relevance to develop widely applicable immunotherapies. CD4 T cells play a major role in...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1690: Optimal Androgen Deprivation Therapy Combined with Proton Beam Therapy for Prostate Cancer: Results from a Multi-Institutional Study of the Japanese Radiation Oncology Study Group Cancers doi: 10.3390/cancers12061690 Authors: Motohiro Murakami Hitoshi Ishikawa Shosei Shimizu Hiromitsu Iwata Tomoaki Okimoto Masaru Takagi Shigeyuki Murayama Tetsuo Akimoto Hitoshi Wada Takeshi Arimura Yoshitaka Sato Masahiko Gosho Katsumasa Nakamura...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1688: Immunoglobulin M Paraproteinaemias Cancers doi: 10.3390/cancers12061688 Authors: Louis-Pierre Girard Cinnie Yentia Soekojo Melissa Ooi Li Mei Poon Wee-Joo Chng Sanjay de Mel Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation. Immunoglobulin M (IgM)...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1686: Obesity and Breast Cancer: A Case of Inflamed Adipose Tissue Cancers doi: 10.3390/cancers12061686 Authors: Ryan Kolb Weizhou Zhang Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in postmenopausal women and a worse prognosis for all major breast cancer subtypes regardless of menopausal status. While the link between obesity and the pathogenesis of breast cancer is clear, the molecular mechanism of this association...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1691: Effectiveness and Healthcare Cost of Adding Trastuzumab to Standard Chemotherapy for First-Line Treatment of Metastatic Gastric Cancer: A Population-Based Cohort Study Cancers doi: 10.3390/cancers12061691 Authors: Matteo Franchi Roberta Tritto Lorena Torroni Chiara Reno Carlo La Vecchia Giovanni Corrao A randomized clinical trial showed that trastuzumab, added to traditional chemotherapy, significantly improved overall survival in human epidermal...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1576: Notch-Inflammation Networks in Regulation of Breast Cancer Progression Cells doi: 10.3390/cells9071576 Authors: Liubomirski Ben-Baruch Members of the Notch family and chronic inflammation were each separately demonstrated to have prominent malignancy-supporting roles in breast cancer. Recent investigations indicate that bi-directional interactions that exist between these two pathways promote the malignancy phenotype of breast tumor cells and of their...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1573: Cetuximab and IL-15 Promote NK and Dendritic Cell Activation In Vitro in Triple Negative Breast Cancer Cells doi: 10.3390/cells9071573 Authors: Juliá Mordoh Levy Triple Negative Breast Cancer (TNBC) treatment is still challenging, and immunotherapy is a potential approach in this tumor subtype. Cetuximab is an IgG1 monoclonal antibody (mAb) directed against Epidermic Growth Factor Receptor (EGFR), a protein overexpressed in a subgroup of TNBC patients...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1574: Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story Cells doi: 10.3390/cells9071574 Authors: Ugo Ala MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1575: NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy Cells doi: 10.3390/cells9071575 Authors: Marmolejo-Martínez-Artesero Romeo-Guitart Mañas-García Barreiro Casas Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1572: Progressively De-Differentiated Pancreatic Cancer Cells Shift from Glycolysis to Oxidative Metabolism and Gain a Quiescent Stem State Cells doi: 10.3390/cells9071572 Authors: Ambrosini Dalla Pozza Fanelli Di Carlo Vettori Cannino Cavallini Carmona-Carmona Brandi Rinalducci Scupoli Rasola Cecconi Palmieri Dando Pancreatic ductal adenocarcinoma (PDAC) is typically characterized by high chemoresistance and...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1571: Boosting the Intra-Articular Efficacy of Low Dose Corticosteroid through a Biopolymeric Matrix: An In Vivo Model of Osteoarthritis Cells doi: 10.3390/cells9071571 Authors: Tschon Salamanna Martini Giavaresi Lorenzini Calzà Fini The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL...
Sun Jun 28, 2020 03:00
Cells, Vol. 9, Pages 1570: The Molecular Landscape of Hürthle Cell Thyroid Cancer Is Associated with Altered Mitochondrial Function—A Comprehensive Review Cells doi: 10.3390/cells9071570 Authors: Sonam Kumari Ruth Adewale Joanna Klubo-Gwiezdzinska Hürthle cell thyroid carcinoma (HTC) accounts for 3–5% of all thyroid malignancies. Widely invasive HTC is characterized by poor prognosis and limited responsiveness to standard therapy with radioiodine. The molecular...
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1569: The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network Cells doi: 10.3390/cells9071569 Authors: Davies Chadwick Hewson Fontana Mankouri Barr : The family Hantaviridae within the Bunyavirales order comprises tri-segmented negative sense RNA viruses, many of which are rodent-borne emerging pathogens associated with fatal human disease. In contrast, hantavirus infection of corresponding rodent hosts results...
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1566: miR-615 Fine-Tunes Growth and Development and Has a Role in Cancer and in Neural Repair Cells doi: 10.3390/cells9071566 Authors: Godínez-Rubí Ortuño-Sahagún MicroRNAs (miRNAs) are small noncoding RNAs that function as epigenetic modulators regulating almost any gene expression. Similarly, other noncoding RNAs, as well as epigenetic modifications, can regulate miRNAs. This reciprocal interaction forms a miRNA-epigenetic feedback loop, the deregulation of...
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1567: mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation Cells doi: 10.3390/cells9071567 Authors: Po-Chien Chou Swati Rajput Xiaoyun Zhao Chadni Patel Danielle Albaciete Won Jun Oh Heineken Queen Daguplo Nikhil Patel Bing Su Guy Werlen Estela Jacinto Cells adjust to nutrient fluctuations to restore metabolic homeostasis. The mechanistic target of rapamycin (mTOR) complex 2 responds to nutrient...
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1568: Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase Cells doi: 10.3390/cells9071568 Authors: Jaroslav Kalous Denisa Jansová Andrej Šušor Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival....
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1565: Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids Cells doi: 10.3390/cells9071565 Authors: Keshavarz-Bahaghighat Darwesh Sosnowski Seubert Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. Indeed, age is considered a risk factor for heart failure and serves...
Sat Jun 27, 2020 03:00
Cells, Vol. 9, Pages 1564: Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives Cells doi: 10.3390/cells9061564 Authors: Tamás Biernacki Dániel Sandi Krisztina Bencsik László Vécsei Over the past years, an increasing amount of evidence has emerged in support of the kynurenine pathway’s (KP) pivotal role in the pathogenesis of several neurodegenerative, psychiatric, vascular and autoimmune diseases. Different neuroactive metabolites of the...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1559: Immunotherapy in Myeloproliferative Diseases Cells doi: 10.3390/cells9061559 Authors: Lukas M. Braun Robert Zeiser Myeloproliferative diseases, including myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS), are driven by genetic abnormalities and increased inflammatory signaling and are at high risk to transform into acute myeloid leukemia (AML). Myeloid-derived suppressor cells were reported to enhance leukemia immune escape by suppressing...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1562: Characterization of Hspb8 in Zebrafish Cells doi: 10.3390/cells9061562 Authors: Magda Dubińska-Magiera Joanna Niedbalska-Tarnowska Marta Migocka-Patrzałek Ewelina Posyniak Małgorzata Daczewska Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1561: Cathelicidin-Related Antimicrobial Peptide Regulates CD73 Expression in Mouse Th17 Cells via p38 Cells doi: 10.3390/cells9061561 Authors: Jeonghyun Lee Kyong-Oh Shin Yesol Kim Jaewon Cho Hyung W. Lim Sung-Il Yoon Geun-Shik Lee Hyun-Jeong Ko Pyeung-Hyeun Kim Yoshikazu Uchida Kyungho Park Seung Goo Kang The effector function of tumor-infiltrated CD4+ T cells is readily suppressed by many types of immune regulators in the tumor...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1558: Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease
Cells, Vol. 9, Pages 1558: Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease Cells doi: 10.3390/cells9061558 Authors: Eleonora Cianflone Michele Torella Flavia Biamonte Antonella De Angelis Konrad Urbanek Francesco S. Costanzo Marcello Rota Georgina M. Ellison-Hughes Daniele Torella Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all cell types of...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1560: Mistletoe-Extract Drugs Stimulate Anti-Cancer Vγ9Vδ2 T Cells Cells doi: 10.3390/cells9061560 Authors: Ling Ma Swati Phalke Caroline Stévigny Florence Souard David Vermijlen Human phosphoantigen-reactive Vγ9Vδ2 T cells possess several characteristics, including MHC-independent recognition of tumor cells and potent killing potential, that make them attractive candidates for cancer immunotherapeutic approaches. Injectable preparations...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1563: Polysaccharide Multilayer Films in Sensors for Detecting Prostate Tumor Cells Based on Hyaluronan-CD44 Interactions Cells doi: 10.3390/cells9061563 Authors: João Batista Maia Rocha Neto Andrey Coatrini Soares Rogério Aparecido Bataglioli Olívia Carr Carlos Alberto Rodrigues Costa Osvaldo N. Oliveira Marisa Masumi Beppu Hernandes F. Carvalho The increasing need for point-of-care diagnosis has sparked the development of label-free sensing...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1555: Redox Regulation of NOX Isoforms on FAK(Y397)/SRC(Y416) Phosphorylation Driven Epithelial-to-Mesenchymal Transition in Malignant Cervical Epithelial Cells Cells doi: 10.3390/cells9061555 Authors: Young Mee Kim Karthika Muthuramalingam Moonjae Cho Epithelial-to-mesenchymal transition (EMT) promulgates epithelial cell associated disease-defining characteristics in tumorigenesis and organ fibrosis. Growth factors such as epidermal growth factor and fibroblast...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1553: Amyloid Proteins and Peripheral Neuropathy Cells doi: 10.3390/cells9061553 Authors: Mohammed M. H. Asiri Sjoukje Engelsman Niels Eijkelkamp Jo W. M. Höppener Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1556: Circulating microRNA Signature Associated to Interstitial Lung Abnormalities in Respiratory Asymptomatic Subjects Cells doi: 10.3390/cells9061556 Authors: Blanca Ortiz-Quintero Ivette Buendía-Roldán Eric Gustavo Ramírez-Salazar Yalbi I Balderas-Martínez Sandra Lizbeth Ramírez-Rodríguez Karen Martínez-Espinosa Moisés Selman Interstitial lung abnormalities (ILA) are observed in around 9% of older respiratory asymptomatic subjects, mainly smokers....
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1554: Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors Cells doi: 10.3390/cells9061554 Authors: Maria Patrizia Somma Evgeniya N. Andreyeva Gera A. Pavlova Claudia Pellacani Elisabetta Bucciarelli Julia V. Popova Silvia Bonaccorsi Alexey V. Pindyurin Maurizio Gatti Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1552: The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process Cells doi: 10.3390/cells9061552 Authors: Maria Sebastian-Valverde Giulio M. Pasinetti As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from a broad spectrum of diseases need to be better...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1557: Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk Cells doi: 10.3390/cells9061557 Authors: Ilona Hromadnikova Katerina Kotlabova Lenka Dvorakova Ladislav Krofta Jan Sirc Gestational diabetes mellitus (GDM), one of the major pregnancy-related...
Fri Jun 26, 2020 03:00
Cells, Vol. 9, Pages 1551: Synthesis and Evaluation of Dodecaboranethiol Containing Kojic Acid (KA-BSH) as a Novel Agent for Boron Neutron Capture Therapy Cells doi: 10.3390/cells9061551 Authors: Koji Takeuchi Yoshihide Hattori Shinji Kawabata Gen Futamura Ryo Hiramatsu Masahiko Wanibuchi Hiroki Tanaka Shin-ichiro Masunaga Koji Ono Shin-Ichi Miyatake Mitsunori Kirihata Boron neutron capture therapy (BNCT) is a form of tumor-cell selective particle irradiation...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1548: Molecular Basis for Ser/Thr Specificity in PKA Signaling Cells doi: 10.3390/cells9061548 Authors: Matthias J. Knape Maximilian Wallbott Nicole C.G. Burghardt Daniela Bertinetti Jan Hornung Sven H. Schmidt Robin Lorenz Friedrich W. Herberg cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates,...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1550: Nicotinamide Supplementation during the In Vitro Maturation of Oocytes Improves the Developmental Competence of Preimplantation Embryos: Potential Link to SIRT1/AKT Signaling Cells doi: 10.3390/cells9061550 Authors: Marwa El Sheikh Ahmed Atef Mesalam Muhammad Idrees Tabinda Sidrat Ayman Mesalam Kyeong-Lim Lee Il-Keun Kong Nicotinamide (NAM), the amide form of vitamin B3, plays pivotal roles in regulating various cellular processes including...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1545: A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease Cells doi: 10.3390/cells9061545 Authors: Narek Manukjan Zubair Ahmed Daniel Fulton W. Matthijs Blankesteijn Sébastien Foulquier Key pathological features of cerebral small vessel disease (cSVD) include impairment of the blood brain barrier (BBB) and the progression of white matter lesions (WMLs) amongst other...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1547: Insight into Salivary Gland Aquaporins Cells doi: 10.3390/cells9061547 Authors: Claudia D’Agostino Osama A. Elkashty Clara Chivasso Jason Perret Simon D. Tran Christine Delporte The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane channel proteins permeable to water to allow water transport across cell membranes according...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1549: A Review on Notch Signaling and Colorectal Cancer Cells doi: 10.3390/cells9061549 Authors: Ashish Tyagi Arun K. Sharma Chendil Damodaran Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway. The role of Notch receptors varies according to the difference in their structures;...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1546: Protein Kinase CK2 Regulates Nerve/Glial Antigen (NG)2-Mediated Angiogenic Activity of Human Pericytes Cells doi: 10.3390/cells9061546 Authors: Beate M. Schmitt Anne S. Boewe Vivien Becker Lisa Nalbach Yuan Gu Claudia Götz Michael D. Menger Matthias W. Laschke Emmanuel Ampofo Protein kinase CK2 is a crucial regulator of endothelial cell proliferation, migration and sprouting during angiogenesis. However, it is still unknown whether this...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1544: Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance Cells doi: 10.3390/cells9061544 Authors: Jesús Beltrán-García Rebeca Osca-Verdegal Elena Nacher-Sendra Federico V. Pallardó José Luis García-Giménez Sepsis is a life-threatening condition that occurs when the body responds to an infection that damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in patients, which can progress to septic...
Thu Jun 25, 2020 03:00
Cells, Vol. 9, Pages 1543: Genetic Control of Muscle Diversification and Homeostasis: Insights from Drosophila Cells doi: 10.3390/cells9061543 Authors: Preethi Poovathumkadavil Krzysztof Jagla In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for...
Thu Jun 25, 2020 03:00
Chemosensors, Vol. 8, Pages 45: Switchable Graphene-Based Bioelectronics Interfaces Chemosensors doi: 10.3390/chemosensors8020045 Authors: Choudhary Shukla Narang Kumar Govender Niv Hussain Wang Mangala Babu Integration of materials acts as a bridge between the electronic and biological worlds, which has revolutionized the development of bioelectronic devices. This review highlights the rapidly emerging field of switchable interface and its bioelectronics...
Fri Jun 26, 2020 03:00
Children, Vol. 7, Pages 67: Impact of Point-of-Care Decision Support Tool on Laboratory Screening for Comorbidities in Children with Obesity Children doi: 10.3390/children7070067 Authors: Tara K. Kaufman Natalie Gentile Seema Kumar Marian Halle Brian A. Lynch Valeria Cristiani Karen Fischer Rajeev Chaudhry Background: Childhood obesity is associated with dyslipidemia, fatty liver disease, and type 2 diabetes. Expert guidelines recommend screening for these conditions...
Sat Jun 27, 2020 03:00
Children, Vol. 7, Pages 66: Relationships between Dietary Patterns and Indices of Arterial Stiffness and Central Arterial Wave Reflection in 9–11-Year-Old Children Children doi: 10.3390/children7060066 Authors: Pouya Saeedi Jillian Haszard Lee Stoner Sheila Skeaff Katherine E. Black Brittany Davison Harriet Harrex Kim Meredith-Jones Robin Quigg Jyh Eiin Wong Paula M.L. Skidmore Arterial stiffness is an important marker of vascular damage and a strong predictor...
Thu Jun 25, 2020 03:00
Climate, Vol. 8, Pages 82: Willingness to Pay for Urban Heat Island Mitigation: A Case Study of Singapore Climate doi: 10.3390/cli8070082 Authors: Borzino Chng Mughal Schubert In many countries, urban heat island (UHI) effects come along with urbanization in metropolitan areas. They have relevant adverse effects on the health and wellbeing of citizens. Singapore is strongly affected by UHI. In this study, we assess Singaporeans’ willingness to pay (WTP) for UHI...
Sat Jun 27, 2020 03:00
Climate, Vol. 8, Pages 81: Canopy Urban Heat Island and Its Association with Climate Conditions in Dubai, UAE Climate doi: 10.3390/cli8060081 Authors: Afifa Mohammed Gloria Pignatta Evangelia Topriska Mattheos Santamouris The impact that climate change and urbanization are having on the thermal-energy balance of the built environment is a major environmental concern today. Urban heat island (UHI) is another phenomenon that can raise the temperature in cities. This study aims...
Fri Jun 26, 2020 03:00
Dentistry Journal, Vol. 8, Pages 61: Current Concepts of Laser–Oral Tissue Interaction Dentistry Journal doi: 10.3390/dj8030061 Authors: Parker Cronshaw Anagnostaki Mylona Lynch Grootveld Abstract: Fundamental to the adjunctive use of laser photonic energy for delivering therapy and tissue management, is the ability of the incident energy to be absorbed by target tissues. The aim of this review is to examine the differential performance of the separate components...
Sun Jun 28, 2020 03:00
Diagnostics, Vol. 10, Pages 439: Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis Diagnostics doi: 10.3390/diagnostics10070439 Authors: Chagan-Yasutan Hanan Niki Bai Ashino Egawa Telan Hattori : Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis,...
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Diagnostics, Vol. 10, Pages 438: Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance Diagnostics doi: 10.3390/diagnostics10070438 Authors: Alhaj-Qasem Al-Hatamleh Irekeola Khalid Mohamud Ismail Mustafa Paratyphoid fever is caused by the bacterium Salmonella enterica serovar Paratyphi (A, B and C), and contributes significantly to global disease burden. One of the major challenges in the diagnosis of paratyphoid fever is the lack...
Sun Jun 28, 2020 03:00
Diagnostics, Vol. 10, Pages 437: Value of Serum NEUROG1 Methylation for the Detection of Advanced Adenomas and Colorectal Cancer Diagnostics doi: 10.3390/diagnostics10070437 Authors: Otero-Estévez Gallardo-Gomez Cadena Rodríguez-Berrocal Cubiella Ramirez García-Nimo Chiara Aberrant DNA methylation detected in liquid biopsies is a promising approach for colorectal cancer (CRC) detection, including premalignant advanced adenomas (AA). We evaluated the diagnostic...
Sun Jun 28, 2020 03:00
Diagnostics, Vol. 10, Pages 436: Overexpression of EIF5A2 Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma Diagnostics doi: 10.3390/diagnostics10070436 Authors: Lin Chen Chen Yeh Sung Oral squamous cell carcinoma (OSCC) is the most common epithelial malignancy affecting the oral cavity, and it is especially significant in Asian countries. Patients diagnosed with OSCC have an unfavorable prognosis and additional prognostic markers would help improve...
Sat Jun 27, 2020 03:00
Diagnostics, Vol. 10, Pages 435: A Recurrent Exertional Syncope and Sudden Cardiac Arrest in a Young Athlete with Known Pathogenic p.Arg420Gln Variant in the RYR2 Gene Diagnostics doi: 10.3390/diagnostics10070435 Authors: Małgorzata Stępień-Wojno Joanna Ponińska Elżbieta K. Biernacka Bogna Foss-Nieradko Tomasz Chwyczko Piotr Syska Rafał Płoski Zofia T. Bilińska Catecholaminergic polymorphic ventricular tachycardia (CPVT) is one of causes of sudden cardiac death in...
Sat Jun 27, 2020 03:00
Diagnostics, Vol. 10, Pages 434: Molecular and Serological Tests for COVID-19 a Comparative Review of SARS-CoV-2 Coronavirus Laboratory and Point-of-Care Diagnostics Diagnostics doi: 10.3390/diagnostics10060434 Authors: Robert Kubina Arkadiusz Dziedzic Validated and accurate laboratory testing for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a crucial part of the timely management of Coronavirus Disease 2019 (COVID-19) disease, supporting the clinical decision-making...
Fri Jun 26, 2020 03:00
Diagnostics, Vol. 10, Pages 432: Ultrasound-Guided Percutaneous Antegrade Varicocele Embolization with Cyanoacrylate Glue as an Alternative to the Standard Retrograde Approach Diagnostics doi: 10.3390/diagnostics10060432 Authors: Olivier Chevallier Julie Pellegrinelli Kevin Guillen Romaric Loffroy We report a case of a 29-year-old male referred to our hospital for endovascular treatment of a left-sided painful varicocele. Standard retrograde embolization via the left renal vein...
Thu Jun 25, 2020 03:00
Diagnostics, Vol. 10, Pages 433: Anthropometric Measurements and Frailty in Patients with Liver Diseases Diagnostics doi: 10.3390/diagnostics10060433 Authors: Hiroki Nishikawa Kazunori Yoh Hirayuki Enomoto Naoto Ikeda Nobuhiro Aizawa Takashi Koriyama Takashi Nishimura Shuhei Nishiguchi Hiroko Iijima There have been scarce data regarding the relationship between frailty and anthropometry measurements (AMs) in patients with chronic liver diseases (CLDs). We aimed...
Thu Jun 25, 2020 03:00
Diagnostics, Vol. 10, Pages 431: Accuracy of a Semi-Quantitative Ultrasound Method to Determine Liver Fat Infiltration in Early Adulthood Diagnostics doi: 10.3390/diagnostics10060431 Authors: Camila Ibacahe Paulina Correa-Burrows Raquel Burrows Gladys Barrera Elissa Kim Sandra Hirsch Boris Jofré Estela Blanco Sheila Gahagan Daniel Bunout An inexpensive and simple method to determine non-alcoholic fatty liver disease (NAFLD) is the abdominal ultrasound, but...
Thu Jun 25, 2020 03:00
Diversity, Vol. 12, Pages 260: High-Mountain Lakes, Indicators of Global Change: Ecological Characterization and Environmental Pressures Diversity doi: 10.3390/d12060260 Authors: Paolo Pastorino Marino Prearo Though mountain lakes are generally much less influenced by human activities than other habitats, global and local anthropogenic threats can alter their natural condition. The most alarming threats are climate change, water exploitation and abstraction, alien species introduction,...
Fri Jun 26, 2020 03:00
Diversity, Vol. 12, Pages 259: Landscape-Level Effects of Forest on Pollinators and Fruit Set of Guava (Psidium guajava L.) in Orchards across Southern Thailand Diversity doi: 10.3390/d12060259 Authors: Katrine Hansen Tuanjit Sritongchuay Sara Bumrungsri Benno I. Simmons Niels Strange Bo Dalsgaard Pollination by wild pollinators is a key ecosystem service threatened by anthropogenic-induced land-use change. The proximity to natural habitat has previously been shown to...
Thu Jun 25, 2020 03:00
Diversity, Vol. 12, Pages 258: A Mediterranean Monk Seal Pup on the Apulian Coast (Southern Italy): Sign of an Ongoing Recolonisation? Diversity doi: 10.3390/d12060258 Authors: Tatiana Fioravanti Andrea Splendiani Tommaso Righi Nicola Maio Sabrina Lo Brutto Antonio Petrella Vincenzo Caputo Barucchi The Mediterranean monk seal (Monachus monachus) is one of the most endangered marine mammals in the world. This species has been threatened since ancient times by human activities...
Thu Jun 25, 2020 03:00
Epigenomes, Vol. 4, Pages 10: Exploring DNA Methylation Diversity in the Honey Bee Brain by Ultra-Deep Amplicon Sequencing Epigenomes doi: 10.3390/epigenomes4020010 Authors: Robert Kucharski Ryszard Maleszka Understanding methylation dynamics in organs or tissues containing many different cell types is a challenging task that cannot be efficiently addressed by the low-depth bisulphite sequencing of DNA extracted from such sources. Here we explored the feasibility of ultra-deep bisulphite...
Thu Jun 25, 2020 03:00
Foods, Vol. 9, Pages 842: Characterisation of Biologically Active Hydrolysates and Peptide Fractions of Vacuum Packaging String Bean (Phaseolus vulgaris L.) Foods doi: 10.3390/foods9070842 Authors: Jakubczyk Karaś Stanikowski Rutkowska Dziedzic Zielińska Szychowski Binduga Rybczyńska-Tkaczyk Baraniak The aim of the study is to characterise biologically active hydolysates and peptide fractions obtained from vacuum-packed string beans (Phaseolus vulragis...
Sun Jun 28, 2020 03:00
Foods, Vol. 9, Pages 843: Exploitation of Agro-Industrial Waste as Potential Source of Bioactive Compounds for Aquaculture Foods doi: 10.3390/foods9070843 Authors: Leyva-López Lizárraga-Velázquez Hernández Sánchez-Gutiérrez The agroindustry generates a large amount of waste. In postharvest, food losses can reach up to 50%. This waste represents a source of contamination of soil, air, and bodies of water. This represents a problem for the environment as well as for public...
Sun Jun 28, 2020 03:00
Foods, Vol. 9, Pages 841: Target Quantification and Semi-Target Screening of Undesirable Substances in Pear Juices Using Ultra-High-Performance Liquid Chromatography-Quadrupole Orbitrap Mass Spectrometry Foods doi: 10.3390/foods9070841 Authors: Alfonso Narváez Yelko Rodríguez-Carrasco Luana Izzo Luigi Castaldo Alberto Ritieni Fruit juices are common products in modern diets due to the supply of vegetal nutrients combined with its tastiness. Nevertheless, potential contaminants,...
Sun Jun 28, 2020 03:00
Foods, Vol. 9, Pages 840: Comparative Analysis of the Nutritional Components and Antioxidant Activities of Different Brassica Juncea Cultivars Foods doi: 10.3390/foods9060840 Authors: Kwon Choi Park Choi Sim Yeo Cho Lee The purpose of this study was to compare the nutritional components and antioxidant activities of two different cultivars of Brassica juncea (Dolsan, Yeosu, Korea (BJD) and (Jeongseon, Gangwon, Korea (BJJ)). We investigated the proximate composition...
Fri Jun 26, 2020 03:00
Foods, Vol. 9, Pages 839: High-Intensity Ultrasound Treatment on Soy Protein after Selectively Proteolyzing Glycinin Component: Physical, Structural, and Aggregation Properties Foods doi: 10.3390/foods9060839 Authors: Wenjie Xia Siyi Pan Zhe Cheng Yan Tian Xingjian Huang In this study, a novel method called selective proteolysis was applied to the glycinin component of soy protein isolate (SPI), and a degraded glycinin hydrolysate (DGH) was obtained. The effects of high-intensity...
Fri Jun 26, 2020 03:00
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