IJMS, Vol. 21, Pages 4601: Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3 International Journal of Molecular Sciences doi: 10.3390/ijms21134601 Authors: Ryley T. Yost J. Wesley Robinson Carling M. Baxter Andrew M. Scott Liam P. Brown M. Sol Aletta Ramtin Hakimjavadi Asad Lone Robert C. Cumming Reuven Dukas Brian Mozer Anne F. Simon Social interactions are typically impaired in neuropsychiatric disorders such...
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IJMS, Vol. 21, Pages 4599: Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia International Journal of Molecular Sciences doi: 10.3390/ijms21134599 Authors: Pluta Ułamek-Kozioł Januszewski Czuczwar Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4600: Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients International Journal of Molecular Sciences doi: 10.3390/ijms21134600 Authors: Plana Gálvez Medina Navarro Fornés-Ferrer Panadero Miralles microRNAs (miRNAs) are small RNAs that regulate different biological processes. Our objective was to identify miRNAs dysregulated in plasma and tissue of patients with abdominal aortic...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4598: Sex Chromosomes Are Severely Disrupted in Gastric Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21134598 Authors: Oh Min Kim Lee Sex has not received enough attention as an important biological variable in basic research, even though the sex of cells often affects cell proliferation, differentiation, apoptosis, and response to stimulation. Knowing and considering the sex of cells used in basic research is essential...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4597: Trace Element Bioaccumulation in Stone Curlew (Burhinus oedicnemus, Linnaeus, 1758): A Case Study from Sicily (Italy) International Journal of Molecular Sciences doi: 10.3390/ijms21134597 Authors: Copat Ferrante Hernout Giunta Grasso Messina Grasso Spena : The study aimed to highlight the degree of trace element contamination along three sites of Sicily: the Magnisi peninsula (MP), located in proximity to the Augusta–Priolo–Melilli...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4596: Anti-Inflammatory and General Glucocorticoid Physiology in Skeletal Muscles Affected by Duchenne Muscular Dystrophy: Exploration of Steroid-Sparing Agents International Journal of Molecular Sciences doi: 10.3390/ijms21134596 Authors: Herbelet Rodenbach Paepe De Bleecker In Duchenne muscular dystrophy (DMD), the activation of proinflammatory and metabolic cellular pathways in skeletal muscle cells is an inherent characteristic. Synthetic glucocorticoid...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4594: Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis International Journal of Molecular Sciences doi: 10.3390/ijms21134594 Authors: Baran Nowowiejska Krahel Kaminski Maciaszek Flisiak Selenoprotein P (SeP), a member of hepatokines, is involved in the development of various metabolic diseases closely related to psoriasis, but it has not been explored in that dermatosis so far. The study aimed to...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4593: Crosstalk between Hydrogen Sulfide and Other Signal Molecules Regulates Plant Growth and Development International Journal of Molecular Sciences doi: 10.3390/ijms21134593 Authors: Xuan Li Wang Wang Hydrogen sulfide (H2S), once recognized only as a poisonous gas, is now considered the third endogenous gaseous transmitter, along with nitric oxide (NO) and carbon monoxide (CO). Multiple lines of emerging evidence suggest that H2S plays positive roles...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4595: Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21134595 Authors: Sarne Huter Braunmueller Rakob Jacobi Kitzwögerer Wiesner Obrist Seeboeck Specific gene promoter DNA methylation is becoming a powerful epigenetic biomarker in cancer diagnostics. Five genes (CDH1, CDKN2Ap16, RASSF1A, TERT, and WT1) were selected based on...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4592: PchE Regulation of Escherichia coli O157:H7 Flagella, Controlling the Transition to Host Cell Attachment International Journal of Molecular Sciences doi: 10.3390/ijms21134592 Authors: Andreozzi Uhlich Shiga toxins and intimate adhesion controlled by the locus of enterocyte effacement are major enterohemorrhagic Escherichia coli (EHEC) virulence factors. Curli fimbriae also contribute to cell adhesion and are essential biofilm components. The transcriptional...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4590: Danger-Associated Peptide Regulates Root Immune Responses and Root Growth by Affecting ROS Formation in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21134590 Authors: Jing Shen Zheng Fu Zhao Lan Luan Plant elicitor peptides (Peps) are damage/danger-associated molecular patterns (DAMPs) that are perceived by a pair of receptor-like kinases, PEPR1 and PEPR2, to enhance innate immunity and induce the growth...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4591: Early Elevation of Systemic Plasma Clusterin after Reperfused Acute Myocardial Infarction in a Preclinical Porcine Model of Ischemic Heart Disease International Journal of Molecular Sciences doi: 10.3390/ijms21134591 Authors: Traxler Spannbauer Einzinger Mester-Tonczar Lukovic Winkler Zlabinger Gugerell Mandic Gyöngyösi Pavo Clusterin exerts anti-inflammatory, cytoprotective and anti-apoptotic effects. Both an increase...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4588: Influence of Intermittent Cold Stimulations on CREB and Its Targeting Genes in Muscle: Investigations into Molecular Mechanisms of Local Cryotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21134588 Authors: Sugasawa Tome Takeuchi Yoshida Yahagi Sharma Aita Ueda Maruyama Takeuchi Morita Kawamai Takekoshi Local cryotherapy is widely used as a treatment for sports-related skeletal muscle injuries....
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4589: Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-Phenyl-Benzeneacetamide that Reduces Melanin Synthesis by Inhibiting Tyrosinase Activity Independently of Epigenetic Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21134589 Authors: Song Hwang Ha Boo The aim of this study was to identify novel antimelanogenic drugs from an epigenetic screening library containing various modulators...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4587: Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition International Journal of Molecular Sciences doi: 10.3390/ijms21134587 Authors: Barwiolek Kaczmarek-Kędziera Muziol Jankowska Jezierska Bieńko Two Cu(II) complexes, 1 and 2, with tridentate Schiff bases derived from 2-hydroxy-5-methylisophthalaldehyde...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4586: An AP2/ERF Gene, HuERF1, from Pitaya (Hylocereus undatus) Positively Regulates Salt Tolerance International Journal of Molecular Sciences doi: 10.3390/ijms21134586 Authors: Qu Nong Jian Lu Zhang Xia Pitaya (Hylocereus undatus) is a high salt-tolerant fruit, and ethylene response factors (ERFs) play important roles in transcription-regulating abiotic tolerance. To clarify the function of HuERF1 in the salt tolerance of pitaya, HuERF1 was...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4585: Brachytherapy in a Single Dose of 10Gy as an “in situ” Vaccination International Journal of Molecular Sciences doi: 10.3390/ijms21134585 Authors: Jarosz-Biej Smolarczyk Cichoń Drzyzga Czapla Urbaś Pilny Matuszczak Wojcieszek Radiotherapy (RT) is one of the major methods of cancer treatment. RT destroys cancer cells, but also affects the tumor microenvironment (TME). The delicate balance between immunomodulation processes in...
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4584: RIP1 Is a Novel Component of γ-ionizing Radiation-Induced Invasion of Non-Small Cell Lung Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21134584 Authors: Kang Cho Lee Song Hwang Lee Um Park Abstract: Previously, we demonstrated that γ-ionizing radiation (IR) triggers the invasion/migration of A549 cells via activation of an EGFR–p38/ERK–STAT3/CREB-1–EMT pathway....
Sun Jun 28, 2020 03:00
IJMS, Vol. 21, Pages 4583: Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes International Journal of Molecular Sciences doi: 10.3390/ijms21134583 Authors: Marianna Martella Caterina Catalanotto Claudio Talora Anna La Teana Paola Londei Dario Benelli The eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for the viability of the cells whose...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4582: Gene Expression and Functional Analyses of Odorant Receptors in Small Hive Beetles (Aethina tumida) International Journal of Molecular Sciences doi: 10.3390/ijms21134582 Authors: Yuanzhen Liu Alexis Beaurepaire Curtis W. Rogers Dawn Lopez Jay D. Evans Lars Straub Peter Neumann Steven C. Cook Qiang Huang Olfaction is key to many insects. Odorant receptors (ORs) stand among the key chemosensory receptors mediating the detection of pheromones...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4581: Cell-Fate Determination from Embryo to Cancer Development: Genomic Mechanism Elucidated International Journal of Molecular Sciences doi: 10.3390/ijms21134581 Authors: Masa Tsuchiya Alessandro Giuliani Kenichi Yoshikawa Elucidation of the genomic mechanism that guides the cell-fate change is one of the fundamental issues of biology. We previously demonstrated that whole genome expression is coordinated by the emergence of a critical point at both the cell-population...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4580: Rounding up the Usual Suspects: Assessing Yorkie, AP-1, and Stat Coactivation in Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21134580 Authors: Fisun Hamaratoglu Mardelle Atkins Can hyperactivation of a few key signaling effectors be the underlying reason for the majority of epithelial cancers despite different driver mutations? Here, to address this question, we use the Drosophila model, which allows analysis of gene expression...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4578: Antimicrobial Peptides Display Strong Synergy with Vancomycin Against Vancomycin-Resistant E. faecium, S. aureus, and Wild-Type E. coli International Journal of Molecular Sciences doi: 10.3390/ijms21134578 Authors: Wu Hsueh Yip Chih Peng Cheng There is an urgent and imminent need to develop new antimicrobials to fight against antibiotic-resistant bacterial and fungal strains. In this study, a checkerboard method was used to evaluate the...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4579: Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21134579 Authors: Cocco Piezzo Calabrese Cianniello Caputo Lauro Fusco Gioia Licenziato Laurentiis Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by aggressive behavior, high risk of distant recurrence, and poor survival. Chemotherapy is...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4577: Treatment Efficiency in Gaucher Patients Can Reliably Be Monitored by Quantification of Lyso-Gb1 Concentrations in Dried Blood Spots International Journal of Molecular Sciences doi: 10.3390/ijms21134577 Authors: Claudia Cozma Paskal Cullufi Guido Kramp Marina Hovakimyan Virtut Velmishi Agim Gjikopulli Sonila Tomori Steffen Fischer Sebastian Oppermann Ulrike Grittner Peter Bauer Christian Beetz Arndt Rolfs Gaucher disease...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4576: Targeted Therapy in Melanoma and Mechanisms of Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21134576 Authors: Czarnecka Bartnik Fiedorowicz Rutkowski The common mutation BRAFV600 in primary melanomas activates the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the introduction of proto-oncogene B-Raf (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors (BRAFi...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4574: Biosensors for D-Amino Acids: Detection Methods and Applications International Journal of Molecular Sciences doi: 10.3390/ijms21134574 Authors: Rosini D’Antona Pollegioni D-enantiomers of amino acids (D-AAs) are only present in low amounts in nature, frequently at trace levels, and for this reason, their biological function was undervalued for a long time. In the past 25 years, the improvements in analytical methods, such as gas chromatography, HPLC,...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4575: Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle International Journal of Molecular Sciences doi: 10.3390/ijms21134575 Authors: Rahman Angus Stokes Karpowicz Krause Regenerative capacity of skeletal muscle declines with age, the cause of which remains largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators during early regeneration timepoints...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4573: Host Epigenetics in Intracellular Pathogen Infections International Journal of Molecular Sciences doi: 10.3390/ijms21134573 Authors: Marek Fol Marcin Włodarczyk Magdalena Druszczyńska Some intracellular pathogens are able to avoid the defense mechanisms contributing to host epigenetic modifications. These changes trigger alterations tothe chromatin structure and on the transcriptional level of genes involved in the pathogenesis of many bacterial diseases....
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4570: Quantitative Ultrastructural Morphometry and Gene Expression of mTOR-Related Mitochondriogenesis within Glioblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21134570 Authors: Ferese Lenzi Fulceri Biagioni Fabrizi Gambardella Familiari Frati Limanaqi Fornai In glioblastoma (GBM) cells, an impairment of mitochondrial activity along with autophagy suppression occurs. Autophagy suppression in GBM promotes...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4571: The Potential Contribution of Dysfunctional RNA-Binding Proteins to the Pathogenesis of Neurodegeneration in Multiple Sclerosis and Relevant Models International Journal of Molecular Sciences doi: 10.3390/ijms21134571 Authors: Libner Salapa Levin Neurodegeneration in multiple sclerosis (MS) is believed to underlie disease progression and permanent disability. Many mechanisms of neurodegeneration in MS have been proposed, such as mitochondrial dysfunction,...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4572: Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals International Journal of Molecular Sciences doi: 10.3390/ijms21134572 Authors: Domińska In addition to the classic, endocrine renin-angiotensin system, local renin-angiotensin system (RAS) has been documented in many tissues and organs, including the ovaries. The localization and functional activity of the two opposing axes of the system, viz. ACE1/Ang II/AT1 and ACE2/Ang-(1-7)/MAS1,...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4569: Genetic Markers in Lung Cancer Diagnosis: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21134569 Authors: Wadowska Bil-Lula Trembecki Śliwińska-Mossoń Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are diagnosed at its advanced stage. The currently used diagnostic tools are not sensitive enough and...
Sat Jun 27, 2020 03:00
IJMS, Vol. 21, Pages 4557: Naringenin-Functionalized Multi-Walled Carbon Nanotubes: A Potential Approach for Site-Specific Remote-Controlled Anticancer Delivery for the Treatment of Lung Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124557 Authors: Renata P. Morais Gabrielle B. Novais Leandro S. Sangenito André L. S. Santos Ronny Priefer Margreet Morsink Marcelo C. Mendonça Eliana B. Souto Patrícia Severino Juliana C. Cardoso Multi-walled...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4555: Metabolomic and Gene Expression Studies Reveal the Diversity, Distribution and Spatial Regulation of the Specialized Metabolism of Yacón (Smallanthus sonchifolius, Asteraceae) International Journal of Molecular Sciences doi: 10.3390/ijms21124555 Authors: Guillermo F. Padilla-González Evelyn Amrehn Maximilian Frey Javier Gómez-Zeledón Alevtina Kaa Fernando B. Da Da Costa Otmar Spring Smallanthus sonchifolius, also known as yacón,...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4554: A Review on the Environmental Fate Models for Predicting the Distribution of Engineered Nanomaterials in Surface Waters International Journal of Molecular Sciences doi: 10.3390/ijms21124554 Authors: Edward Suhendra Chih-Hua Chang Wen-Che Hou Yi-Chin Hsieh Exposure assessment is a key component in the risk assessment of engineered nanomaterials (ENMs). While direct and quantitative measurements of ENMs in complex environmental matrices remain challenging,...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4568: Validation of Breast Cancer Margins by Tissue Spray Mass Spectrometry International Journal of Molecular Sciences doi: 10.3390/ijms21124568 Authors: Vitaliy V. Chagovets Natalia L. Starodubtseva Alisa O. Tokareva Vladimir E. Frankevich Valerii V. Rodionov Vlada V. Kometova Konstantin Chingin Eugene N. Kukaev Huanwen Chen Gennady T. Sukhikh Current methods for the intraoperative determination of breast cancer margins commonly suffer...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4566: Diverse Physiological Functions of Cation Proton Antiporters across Bacteria and Plant Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124566 Authors: Tsujii Tanudjaja Uozumi Membrane intrinsic transport systems play an important role in maintaining ion and pH homeostasis and forming the proton motive force in the cytoplasm and cell organelles. In most organisms, cation/proton antiporters (CPAs) mediate the exchange of K+, Na+...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4564: Neuropathophysiology, Genetic Profile, and Clinical Manifestation of Mucolipidosis IV—A Review and Case Series International Journal of Molecular Sciences doi: 10.3390/ijms21124564 Authors: Aleksandra Jezela-Stanek Elżbieta Ciara Karolina M. Stepien Mucolipidosis type IV (MLIV) is an ultra-rare lysosomal storage disorder caused by biallelic mutations in MCOLN1 gene encoding the transient receptor potential channel mucolipin-1. So far, 35 pathogenic or...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4565: Newly Identified Regulators of Ovarian Folliculogenesis and Ovulation International Journal of Molecular Sciences doi: 10.3390/ijms21124565 Authors: Eran Gershon Nava Dekel Each follicle represents the basic functional unit of the ovary. From its very initial stage of development, the follicle consists of an oocyte surrounded by somatic cells. The oocyte grows and matures to become fertilizable and the somatic cells proliferate and differentiate into the...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4563: Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21124563 Authors: Sanchez-Bezanilla Åberg Crock Walker Nilsson Isgaard Ong Cognitive impairment is common after stroke, and disturbances in hippocampal function are often involved, even in remote non-hippocampal injuries. In terms of hippocampal function, growth hormone (GH)...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4562: Characterization of FLOWERING LOCUS C Homologs in Apple as a Model for Fruit Trees International Journal of Molecular Sciences doi: 10.3390/ijms21124562 Authors: Hidenao Kagaya Naoko Ito Tomoki Shibuya Sadao Komori Kazuhisa Kato Yoshinori Kanayama To elucidate the molecular mechanism of juvenility and annual flowering of fruit trees, FLOWERING LOCUS C (FLC), an integrator of flowering signals, was investigated in apple as a model. We performed...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4560: Correction: Elbadawy, M., et al. Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. Int. J. Mol. Sci. 2018, 19, 3031 International Journal of Molecular Sciences doi: 10.3390/ijms21124560 Authors: Mohamed Elbadawy Tatsuya Usui Hideyuki Yamawaki Kazuaki Sasaki The authors wish to make the following corrections to this paper [...]
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4567: Binding of CML-Modified as Well as Heat-Glycated β-lactoglobulin to Receptors for AGEs is Determined by Charge and Hydrophobicity International Journal of Molecular Sciences doi: 10.3390/ijms21124567 Authors: Hannah E. Zenker Malgorzata Teodorowicz Arifa Ewaz R. J. Joost van Neerven Huub F. J. Savelkoul Nicolette W. De Jong Harry J. Wichers Kasper A. Hettinga Intake of dietary advanced glycation end products (AGEs) is associated with inflammation-related...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4561: Chitosan-Based Coacervate Polymers for Propolis Encapsulation: Release and Cytotoxicity Studies International Journal of Molecular Sciences doi: 10.3390/ijms21124561 Authors: Tabata Sato Daphne Mello Luana Vasconcelos Artur Valente Alexandre Borges Chitosan-DNA (CS-DNA) and Chitosan-Pectin (CS-P) hydrogels were formulated as a sustained drug delivery carrier for drug delivery. For this, hydrogels were prepared by emulsion technique: mixing aqueous...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4559: Familial Infertility (Azoospermia and Cryptozoospermia) in Two Brothers—Carriers of t(1;7) Complex Chromosomal Rearrangement (CCR): Molecular Cytogenetic Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21124559 Authors: Marta Olszewska Tomasz Stokowy Nijole Pollock Nataliya Huleyuk Andrew Georgiadis Svetlana Yatsenko Danuta Zastavna Alexander N. Yatsenko Maciej Kurpisz Structural aberrations involving more than...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4558: Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS) International Journal of Molecular Sciences doi: 10.3390/ijms21124558 Authors: Mirre De Bondt Niels Hellings Ghislain Opdenakker Sofie Struyf Neutrophils are the most abundant circulating and first-responding innate myeloid cells and have so far been underestimated in the context of multiple sclerosis (MS). MS is the most frequent, immune-mediated, inflammatory disease...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4556: Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21124556 Authors: Jaehak Lee Hyunjin Moon Bonghye Ku Keunho Lee Cheol-Yong Hwang Seung Joon Baek Osteosarcoma is known to be one of the frequently occurring cancers in dogs. Its prognosis is usually very poor, with a high incidence of lung metastasis. Although radiation therapy has become a major therapeutic...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4552: Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21124552 Authors: Chien-Ning Hsu I-Chun Lin Hong-Ren Yu Li-Tung Huang Mao-Meng Tiao You-Lin Tain Hypertension and chronic kidney disease (CKD) can originate during early-life....
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4553: HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition International Journal of Molecular Sciences doi: 10.3390/ijms21124553 Authors: Sung Min Kim Jung-Il Kang Hoon-Seok Yoon Youn Kyung Choi Ji Soo Go Sun Kyung Oh Meejung Ahn Jeongtae Kim Young Sang Koh Jin Won Hyun Eun-Sook Yoo Hee-Kyoung Kang The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4550: Peptides Derived from (RRWQWRMKKLG)2-K-Ahx Induce Selective Cellular Death in Breast Cancer Cell Lines through Apoptotic Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21124550 Authors: Diego Sebastián Insuasty-Cepeda Andrea Carolina Barragán-Cárdenas Alejandra Ochoa-Zarzosa Joel E. López-Meza Ricardo Fierro-Medina Javier Eduardo García-Castañeda Zuly Jenny Rivera-Monroy The effect on the cytotoxicity against breast cancer...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4551: On the Catalytic Activity of the Engineered Coiled-Coil Heptamer Mimicking the Hydrolase Enzymes: Insights from a Computational Study International Journal of Molecular Sciences doi: 10.3390/ijms21124551 Authors: Mario Prejanò Isabella Romeo Nino Russo Tiziana Marino Recently major advances were gained on the designed proteins aimed to generate biomolecular mimics of proteases. Although such enzyme-like catalysts must still suffer refinements for improving...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4546: Betacoronavirus Genomes: How Genomic Information has been Used to Deal with Past Outbreaks and the COVID-19 Pandemic International Journal of Molecular Sciences doi: 10.3390/ijms21124546 Authors: Alejandro Llanes Carlos M. Restrepo Zuleima Caballero Sreekumari Rajeev Melissa A. Kennedy Ricardo Lleonart In the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4549: SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host Interaction International Journal of Molecular Sciences doi: 10.3390/ijms21124549 Authors: Cheorl-Ho Kim The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into hosts upon zoonotic disease outbreak, although the CoV epidemy...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4548: Roles of Organellar RNA-Binding Proteins in Plant Growth, Development, and Abiotic Stress Responses International Journal of Molecular Sciences doi: 10.3390/ijms21124548 Authors: Kwanuk Lee Hunseung Kang Organellar gene expression (OGE) in chloroplasts and mitochondria is primarily modulated at post-transcriptional levels, including RNA processing, intron splicing, RNA stability, editing, and translational control. Nucleus-encoded Chloroplast or Mitochondrial...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4547: Functional Expression of Adenosine A3 Receptor in Yeast Utilizing a Chimera with the A2AR C-Terminus International Journal of Molecular Sciences doi: 10.3390/ijms21124547 Authors: Abhinav R. Jain Anne S. Robinson The adenosine A3 receptor (A3R) is the only adenosine receptor subtype to be overexpressed in inflammatory and cancer cells and therefore is considered a novel and promising therapeutic target for inflammatory diseases and cancer. Heterologous expression...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4545: Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury International Journal of Molecular Sciences doi: 10.3390/ijms21124545 Authors: Hiromasa Miyake Katsuyuki Tanabe Satoshi Tanimura Yuri Nakashima Tomoyo Morioka Kana Masuda Hitoshi Sugiyama Yasufumi Sato Jun Wada Acute kidney injury (AKI) has been increasingly recognized as a risk factor for transition to chronic kidney disease. Recent evidence...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4544: MicroRNAs as Key Players in Melanoma Cell Resistance to MAPK and Immune Checkpoint Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21124544 Authors: Maria Letizia Motti Michele Minopoli Gioconda Di Carluccio Paolo Antonio Ascierto Maria Vincenza Carriero Advances in the use of targeted and immune therapies have revolutionized the clinical management of melanoma patients, prolonging significantly their overall and progression-free...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4543: The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus International Journal of Molecular Sciences doi: 10.3390/ijms21124543 Authors: Liliana Rytel Slawomir Gonkowski Bisphenol A (BPA) is one of the most common environmental pollutants among endocrine disruptors. Due to its similarity to estrogen, BPA may affect estrogen receptors and show adverse effects on many internal organs. The reproductive system is particularly...
Fri Jun 26, 2020 03:00
IJMS, Vol. 21, Pages 4542: Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers International Journal of Molecular Sciences doi: 10.3390/ijms21124542 Authors: Ryan Limbocker Benedetta Mannini Rodrigo Cataldi Shianne Chhangur Aidan K. Wright Ryan P. Kreiser J. Alex Albright Sean Chia Johnny Habchi Pietro Sormanni Janet R. Kumita Francesco S. Ruggeri Christopher M. Dobson Fabrizio Chiti Francesco...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4540: Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility International Journal of Molecular Sciences doi: 10.3390/ijms21124540 Authors: Daphne Foong Jerry Zhou Ali Zarrouk Vincent Ho Michael D. O’Connor Millions of patients worldwide suffer from gastrointestinal (GI) motility disorders such as gastroparesis. These disorders typically include debilitating symptoms, such as chronic nausea and vomiting. As no cures...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4539: HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery International Journal of Molecular Sciences doi: 10.3390/ijms21124539 Authors: Hendrix Sanchez Ventriglia Lemmens Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4537: An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs International Journal of Molecular Sciences doi: 10.3390/ijms21124537 Authors: Svenja Koslowski Camille Latapy Pierrïck Auvray Marc Blondel Laurent Meijer Autosomal dominant polycystic kidney disease (ADPKD) is the most common inheritable cause of end stage renal disease and, as of today, only a single moderately effective...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4538: X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models International Journal of Molecular Sciences doi: 10.3390/ijms21124538 Authors: Samantha J. Borland Julia Behnsen Nick Ashton Sheila E. Francis Keith Brennan Michael J. Sherratt Philip J. Withers Ann E. Canfield Vascular calcification describes the formation of mineralized tissue within the blood vessel wall, and it is highly associated...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4536: Powdery Mildew-Induced Hormonal and Photosynthetic Changes in Barley Near Isogenic Lines Carrying Various Resistant Genes International Journal of Molecular Sciences doi: 10.3390/ijms21124536 Authors: Diana Saja Anna Janeczko Balázs Barna Andrzej Skoczowski Michał Dziurka Andrzej Kornaś Gábor Gullner The present work focused on the characterization of some physiological mechanisms activated upon powdery mildew inoculation of the susceptible...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4531: Terpinen-4-ol as an Antibacterial and Antibiofilm Agent against Staphylococcus aureus International Journal of Molecular Sciences doi: 10.3390/ijms21124531 Authors: Laísa Cordeiro Pedro Figueiredo Helivaldo Souza Aleson Sousa Francisco Andrade-Júnior Daianne Medeiros Jefferson Nóbrega Daniele Silva Evandro Martins José Barbosa-Filho Edeltrudes Lima Staphylococcus aureus is able to rapidly develop mechanisms of resistance to various...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4535: Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm International Journal of Molecular Sciences doi: 10.3390/ijms21124535 Authors: Werner Hoffmann Trefoil factor family peptides (TFF1, TFF2, TFF3) are typically co-secreted together with mucins. Tff1 represents a gastric tumor suppressor gene in mice. TFFs are also synthesized in minute amounts in the immune and central nervous...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4532: Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21124532 Authors: Sujin Kim Hyunju Chung Han Ngoc Mai Yunkwon Nam Soo Jung Shin Yong Ho Park Mi Joo Chung Jong Kil Lee Hak Young Rhee Geon-Ho Jahng Youngkyong Kim Yu Jin Lim Moonkyoo Kong Minho Moon Weon Kuu Chung Alzheimer’s disease (AD) is the most...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4541: Platelets in Healthy and Disease States: From Biomarkers Discovery to Drug Targets Identification by Proteomics International Journal of Molecular Sciences doi: 10.3390/ijms21124541 Authors: Erica Gianazza Maura Brioschi Roberta Baetta Alice Mallia Cristina Banfi Elena Tremoli Platelets are a heterogeneous small anucleate blood cell population with a central role both in physiological haemostasis and in pathological states, spanning from thrombosis...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4533: Tocotrienols Influence Body Weight Gain and Brain Protein Expression in Long-Term High-Fat Diet-Treated Mice International Journal of Molecular Sciences doi: 10.3390/ijms21124533 Authors: Yugo Kato Yoshinori Aoki Koji Fukui Obesity induces serious diseases such as diabetes and cardiovascular disease. It has been reported that obesity increases the risk of cognitive dysfunction. Cognitive dysfunction is a characteristic symptom of Alzheimer’s...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4534: SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21124534 Authors: Da Eun Kim Bo Yoon Chang Byeong Min Jeon Jong In Baek Sun Chang Kim Sung Yeon Kim A ginsenoside F2-enhanced mixture (SGL 121) increases the content of ginsenoside F2 by biotransformation. In the present study, we investigated the effect of SGL 121 on...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4527: The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21124527 Authors: Yoshiko Hada Haruhito A. Uchida Nozomu Otaka Yasuhiro Onishi Shugo Okamoto Mariko Nishiwaki Rika Takemoto Hidemi Takeuchi Jun Wada The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence....
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4529: MSX1—A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas International Journal of Molecular Sciences doi: 10.3390/ijms21124529 Authors: Simon Eppich Christina Kuhn Elisa Schmoeckel Doris Mayr Sven Mahner Udo Jeschke Julia Gallwas Helene Hildegard Heidegger Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4522: Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects International Journal of Molecular Sciences doi: 10.3390/ijms21124522 Authors: Jan P. Elskens Joke M. Elskens Annemieke Madder Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize analytes with extraordinary target selectivity and affinity. Despite their promising properties and diagnostic potential,...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4530: Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion International Journal of Molecular Sciences doi: 10.3390/ijms21124530 Authors: Carmen Siebenaller Benedikt Junglas Annika Lehmann Nadja Hellmann Dirk Schneider The inner membrane-associated protein of 30 kDa (IM30) is crucial for the development and maintenance of the thylakoid membrane system in chloroplasts and cyanobacteria. While its exact physiological function still...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4528: HLA-G: A New Immune Checkpoint in Cancer? International Journal of Molecular Sciences doi: 10.3390/ijms21124528 Authors: Daniëlle Krijgsman Jessica Roelands Wouter Hendrickx Davide Bedognetti Peter J. K. Kuppen Human leukocyte antigen G (HLA-G), known as a central protein in providing immune tolerance to the fetus in pregnant women, is also studied for a possible role in tumor development. Many studies have claimed HLA-G as a new immune checkpoint...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4525: Angiotensin II, Hypercholesterolemia, and Vascular Smooth Muscle Cells: A Perfect Trio for Vascular Pathology International Journal of Molecular Sciences doi: 10.3390/ijms21124525 Authors: Amanda St. Paul Cali B. Corbett Rachael Okune Michael V. Autieri Cardiovascular disease is the leading cause of morbidity and mortality in the Western and developing world, and the incidence of cardiovascular disease is increasing with the longer lifespan afforded...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4524: Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions International Journal of Molecular Sciences doi: 10.3390/ijms21124524 Authors: Inna Uliyakina Hugo M. Botelho Ana C. da Paula Sara Afonso Miguel J. Lobo Verónica Felício Carlos M. Farinha Margarida D. Amaral Cystic Fibrosis (CF) is caused by mutations in the CF Transmembrane conductance Regulator (CFTR), the only ATP-binding...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4523: What Is the Evolutionary Fingerprint in Neutrophil Granulocytes? International Journal of Molecular Sciences doi: 10.3390/ijms21124523 Authors: Leonie Fingerhut Gaby Dolz Nicole de Buhr Over the years of evolution, thousands of different animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of different species are obviously counteracting against the same...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4526: The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process International Journal of Molecular Sciences doi: 10.3390/ijms21124526 Authors: Giovanni Barillari In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4521: Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21124521 Authors: Ehab Kotb Elmahallawy Yasser Mohamed Walied Abdo Tokuma Yanai Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects....
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4520: The Presence of Seminal Plasma during Liquid Storage of Pig Spermatozoa at 17 °C Modulates Their Ability to Elicit In Vitro Capacitation and Trigger Acrosomal Exocytosis International Journal of Molecular Sciences doi: 10.3390/ijms21124520 Authors: Ana Paula Pinoti Pavaneli Sandra Recuero Bruna Resende Chaves Estela Garcia-Bonavila Marc Llavanera Elisabeth Pinart Sergi Bonet André Furugen Cesar De Andrade Marc Yeste Although seminal...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4518: In Vivo Analysis of the Biocompatibility and Immune Response of Jellyfish Collagen Scaffolds and its Suitability for Bone Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21124518 Authors: Iris Flaig Milena Radenković Stevo Najman Annica Pröhl Ole Jung Mike Barbeck Jellyfish collagen, which can be defined as “collagen type 0” due to its homogeneity to the mammalian types I, II, III, V, and IX and its...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4517: Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C International Journal of Molecular Sciences doi: 10.3390/ijms21124517 Authors: Kazuya Takemura Etsuko Takizawa Akihiro Tamori Mika Nakamae Hiroshi Kubota Sawako Uchida-Kobayashi Masaru Enomoto Norifumi Kawada Masayuki Hino Patients with chronic hepatitis C...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4519: Innovative Three-Dimensional Microscopic Analysis of Uremic Growth Plate Discloses Alterations in the Process of Chondrocyte Hypertrophy: Effects of Growth Hormone Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21124519 Authors: Ángela Fernández-Iglesias Rocío Fuente Helena Gil-Peña Laura Alonso-Durán María García-Bengoa Fernando Santos José Manuel López Chronic kidney disease (CKD) alters the morphology and function...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4515: Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21124515 Authors: Zhuanzhuan Jiang Li Zhu Qiuyu Wang Xin Hou Chloroplasts are extraordinary organelles for photosynthesis and nutrient storage in plants. During leaf senescence or under stress conditions, damaged chloroplasts are degraded and provide nutrients for developing organs. Autophagy...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4514: Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1 International Journal of Molecular Sciences doi: 10.3390/ijms21124514 Authors: Keitaro Takahashi Mikihiro Fujiya Hiroaki Konishi Yuki Murakami Takuya Iwama Takahiro Sasaki Takehito Kunogi Aki Sakatani Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hiroki Tanabe Toshikatsu...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4516: IPSC-Derived Neuronal Cultures Carrying the Alzheimer’s Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network International Journal of Molecular Sciences doi: 10.3390/ijms21124516 Authors: Soraia Martins Andreas Müller-Schiffmann Lars Erichsen Martina Bohndorf Wasco Wruck Kristel Sleegers Christine Van Broeckhoven Carsten Korth James Adjaye Genes associated with immune response and inflammation...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4511: Single Exon Skipping Can Address a Multi-Exon Duplication in the Dystrophin Gene International Journal of Molecular Sciences doi: 10.3390/ijms21124511 Authors: Kane Greer Russell Johnsen Yoram Nevo Yakov Fellig Susan Fletcher Steve D. Wilton Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease typically caused by protein-truncating mutations that preclude synthesis of a functional dystrophin. Exonic deletions are the most common...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4512: Pulmonary Involvement in a Mouse Model of Sjögren’s Syndrome Induced by STING Activation International Journal of Molecular Sciences doi: 10.3390/ijms21124512 Authors: Joanna Papinska Harini Bagavant Grzegorz B. Gmyrek Umesh S. Deshmukh Sjögren’s Syndrome (SS), a chronic autoimmune disorder affecting multiple organ systems, is characterized by an elevated type I interferon (IFN) response. Activation of Stimulator of Interferon Genes...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4513: Linking the Peptidoglycan Synthesis Protein Complex with Asymmetric Cell Division during Bacillus subtilis Sporulation International Journal of Molecular Sciences doi: 10.3390/ijms21124513 Authors: Katarína Muchová Zuzana Chromiková Imrich Barák Peptidoglycan is generally considered one of the main determinants of cell shape in bacteria. In rod-shaped bacteria, cell elongation requires peptidoglycan synthesis to lengthen the cell wall. In addition, peptidoglycan...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4510: Sharing Marks: H3K4 Methylation and H2B Ubiquitination as Features of Meiotic Recombination and Transcription International Journal of Molecular Sciences doi: 10.3390/ijms21124510 Authors: Joan Serrano-Quílez Sergi Roig-Soucase Susana Rodríguez-Navarro Meiosis is a specialized cell division that gives raise to four haploid gametes from a single diploid cell. During meiosis, homologous recombination is crucial to ensure genetic diversity and guarantee...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4509: Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21124509 Authors: Iwona Bednarz-Misa Paulina Fortuna Dorota Diakowska Natalia Jamrozik Małgorzata Krzystek-Korpacka Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4508: A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21124508 Authors: Ilia Banakh Perdita Cheshire Mostafizur Rahman Irena Carmichael Premlatha Jagadeesan Neil R. Cameron Heather Cleland Shiva Akbarzadeh Engineered dermal templates have revolutionised the repair and reconstruction of skin defects. Their interaction with the wound microenvironment...
Thu Jun 25, 2020 03:00
IJMS, Vol. 21, Pages 4507: The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21124507 Authors: Boris Y. Shorning Manisha S. Dass Matthew J. Smalley Helen B. Pearson Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B (PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in prostate cancer that facilitates tumor formation,...
Thu Jun 25, 2020 03:00
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