Related Articles Halo femoral traction for one week between staged anterior and posterior fusion surgeries for severe adolescent scoliosis is effective and safe. World Neurosurg. 2020 Jun 22;: Authors: Wright DN, Kieser DC, Cunningham G, Liantis P, Hunt R, Ember TM, Kumar MM, Pereira EA, Lucas JD Abstract OBJECTIVE: To report the outcomes of Halo Femoral Traction (HFT) used for one week between anterior release and definitive posterior fusion...
Fri Jun 26, 2020 14:36
Awake Craniotomy with Cortical and Subcortical Speech Mapping for Supramarginal Cavernoma Resection.
Related Articles Awake Craniotomy with Cortical and Subcortical Speech Mapping for Supramarginal Cavernoma Resection. World Neurosurg. 2020 Jun 22;: Authors: Domingo R, Vivas-Buitrago T, Sabsevitz DS, Middlebrooks EH, Quinones-Hinojosa A Abstract Awake craniotomy allows mapping of eloquent brain regions and monitoring neurocognitive functioning intraoperatively to maximize extent of resection and minimize cognitive morbidity.1,2 During resection...
Fri Jun 26, 2020 14:36
Related Articles Posterior cranial fossa maldevelopment in infants with repaired open myelomeningoceles. Double trouble or a dynamic process of posterior cranial fossa abnormalities? World Neurosurg. 2020 Jun 22;: Authors: Calandrelli R, Pilato F, Massimi L, Panfili M, Di Rocco C, Colosimo C Abstract OBJECTIVE: Two degrees of posterior cranial fossa (PCF) maldevelopment can be hypothesized in children with myelomeningocele (MMC). This paper...
Fri Jun 26, 2020 14:36
Related Articles Telehealth and Telemedicine in the COVID-19 era: A World of Opportunities for the Neurosurgeons. World Neurosurg. 2020 Jun 22;: Authors: Rahman MM, Azam MG, Bohorquez-Rivero J, Garcia-Ballestas E, Agrawal A, Moscote-Salazar LR PMID: 32585376 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 14:36
Related Articles Factors Impacting Outcomes and HealthCare Utilization in Osteoporotic Patients Undergoing Lumbar Spine Fusions: A MarketScan Database Analysis. World Neurosurg. 2020 Jun 22;: Authors: Sharma M, John K, Dietz N, Aljuboori Z, Madrigal FC, Adams S, Wang D, Ugiliweneza B, Drazin D, Boakye M Abstract OBJECTIVE: Identify factors impacting long-term complications, reoperations/readmission rates and healthcare utilization in OP patients...
Fri Jun 26, 2020 14:36
Related Articles Surgical Strategies for Cerebral Revascularization When There are Limited Bypass Conduit Options and Unexpected Intraoperative Difficulties. World Neurosurg. 2020 Jun 22;: Authors: Sayyahmelli S, Ozaydin B, Sahin B, Erginoglu U, Cikla U, Baskaya MK Abstract BACKGROUND: Cerebral bypass procedures are complex, require substantial experience and skills, and thorough preoperative planning. Cerebrovascular surgeons face increasingly...
Fri Jun 26, 2020 14:36
Related Articles Corrigendum to: Assessment of Cognitive, Emotional, and Motor Domains in Patients with Diffuse Gliomas Utilizing the NIH Toolbox Battery [World Neurosurgery 99 (2017) 448-456]. World Neurosurg. 2020 May 31;: Authors: Lang S, Cadieux M, Opoku-Darko M, Gaxiola-Valdez I, Partlo LA, Goodyear BG, Federico P, Kelly J PMID: 32576506 [PubMed - as supplied by publisher]
Thu Jun 25, 2020 14:05
Related Articles Patterns of motor recovery and structural neuroplasticity after striatal infarcts. Neurology. 2020 Jun 25;: Authors: Liu H, Peng X, Dahmani L, Wang H, Zhang M, Shan Y, Rong D, Guo Y, Li J, Li N, Wang L, Lin Y, Pan R, Lu J, Wang D Abstract OBJECTIVE: To elucidate the timeframe and spatial patterns of cortical reorganization after different stroke-induced basal ganglia lesions, we measured cortical thickness at five timepoints...
Sat Jun 27, 2020 16:41
Related Articles Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer. Redox Biol. 2020 May 23;36:101510 Authors: Rodríguez-Hernández MA, Cruz-Ojeda P, López-Grueso MJ, Navarro-Villarán E, Requejo-Aguilar R, Castejón-Vega B, Negrete M, Gallego P, Vega-Ochoa Á, Victor VM, Cordero MD, Del Campo JA, Bárcena JA, Padilla CA, Muntané J Abstract Cancer cells...
Sun Jun 28, 2020 15:09
Related Articles Mitomycin C-induced cell cycle arrest enhances 5-aminolevulinic acid-based photodynamic therapy for bladder cancer. Photodiagnosis Photodyn Ther. 2020 Jun 24;:101893 Authors: Nakayama T, Nozawa N, Kawada C, Yamamoto S, Ishii T, Ishizuka M, Namikawa T, Ogura SI, Hanazaki K, Inoue K, Karashima T Abstract BACKGROUND: Photodynamic therapy (PDT) and diagnosis using 5-aminolevulinic acid (ALA) to control the production of the intracellular...
Sun Jun 28, 2020 15:09
Related Articles Encapsulation of Cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. Int J Pharm. 2020 Jun 24;:119565 Authors: Bakar-Ates F, Ozkan E, Tuba Sengel-Turk C Abstract In the present study, we developed the lipid polymer hybrid nanoparticles of cucurbitacin B (CuB) and evaluated its effects on triple negative breast cancer cells. The 32 factorial design was utilized to understand...
Sun Jun 28, 2020 15:09
Related Articles HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line. Pathol Oncol Res. 2020 Jun 26;: Authors: Hegedűs L, Rittler D, Garay T, Stockhammer P, Kovács I, Döme B, Theurer S, Hager T, Herold T, Kalbourtzis S, Bankfalvi A, Schmid KW, Führer D, Aigner C, Hegedűs B Abstract While papillary thyroid cancer (PTC) has largely favorable prognosis, anaplastic thyroid cancer (ATC) is a rare but extremely...
Sun Jun 28, 2020 13:11
Related Articles Nuclear ErbB2 expression in hepatocytes in liver disease. Virchows Arch. 2020 Jun 26;: Authors: Döring P, Calvisi DF, Dombrowski F Abstract ErbB2 is a prominent representative of the epidermal growth factor receptors that mainly attract attention as oncogenic drivers and therapeutic targets in cancer. Besides transmembrane signaling, ErbB2 may also translocate into the nucleus and mediate distinct nuclear signaling effects including...
Sun Jun 28, 2020 13:11
Related Articles Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma. Leukemia. 2020 Jun 26;: Authors: Lantermans HC, Minderman M, Kuil A, Kersten MJ, Pals ST, Spaargaren M Abstract Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma subtype arising from naïve B cells. Although novel therapeutics have improved patient prognosis, drug resistance remains a key problem. Here, we show...
Sun Jun 28, 2020 13:11
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation.
Related Articles NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nat Commun. 2020 Jun 26;11(1):3256 Authors: Miao K, Lei JH, Valecha MV, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su SM, Shao F, Rajendran BK, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong KH, Xu X, Deng CX Abstract BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC),...
Sun Jun 28, 2020 13:11
Related Articles Expression of Concern: Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. J Biol Chem. 2020 Jun 26;295(26):8882 Authors: PMID: 32591458 [PubMed - as supplied by publisher]
Sun Jun 28, 2020 13:11
Related Articles Expression of Concern: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J Biol Chem. 2020 Jun 26;295(26):8878 Authors: PMID: 32591454 [PubMed - as supplied by publisher]
Sun Jun 28, 2020 13:11
Related Articles Expression of Concern: Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. J Biol Chem. 2020 Jun 26;295(26):8876 Authors: PMID: 32591452 [PubMed - as supplied by publisher]
Sun Jun 28, 2020 13:11
Related Articles Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line. J Toxicol Environ Health A. 2020 Jun 26;:1-12 Authors: Nunes HL, Tuttis K, Serpeloni JM, Nascimento JRD, da Rocha CQ, Silva VAO, Lengert AVH, Reis RM, de Syllos Cólus IM Abstract Brachydins (Br) A, B, and C are flavonoids extracted from Fridericia platyphylla (Cham.) L.G. Lohmann roots (synonym...
Sun Jun 28, 2020 13:11
Related Articles Moringa oleifera methanolic leaves extract induces apoptosis and G0/G1 cell cycle arrest via downregulation of Hedgehog Signaling Pathway in human prostate PC-3 cancer cells. J Food Biochem. 2020 Jun 25;:e13338 Authors: Khan F, Pandey P, Ahmad V, Upadhyay TK Abstract The inadequacy of effective treatment approaches for prostate cancer enlightens the crucial necessity for the search and emergence of novel and multitasking...
Sat Jun 27, 2020 13:30
Related Articles Vitamin C Promotes Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma. Front Oncol. 2020;10:976 Authors: Zhou J, Chen C, Chen X, Fei Y, Jiang L, Wang G Abstract Oral squamous cell carcinoma (OSCC) is currently ranked as the eighth most prevalent type of cancer. Despite recent advances in cancer research, the 8-year survival rate for oral squamous cell carcinoma remains only 50-60%. Therefore, markers for early...
Sat Jun 27, 2020 13:30
Related Articles AATF/Che-1-An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis. Front Oncol. 2020;10:919 Authors: Kaiser RWJ, Erber J, Höpker K, Fabretti F, Müller RU Abstract The DNA damage response (DDR) is a complex signaling network that is activated upon genotoxic stress. It determines cellular fate by either activating cell cycle arrest or initiating apoptosis and thereby ensures genomic stability....
Sat Jun 27, 2020 13:30
Related Articles Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT-CRP Induces Selective ROS-Dependent Apoptosis in T-Acute Lymphoblastic Leukemia Cell Lines. J Oncol. 2020;2020:1598503 Authors: Lorenzo-Anota HY, Martínez-Torres AC, Scott-Algara D, Tamez-Guerra RS, Rodríguez-Padilla C Abstract Immunotherapies strengthen the immune system to fight multiple diseases such as infections, immunodeficiencies, and autoimmune diseases, and recently,...
Sat Jun 27, 2020 13:30
Related Articles Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells. Stem Cell Res Ther. 2020 Jun 26;11(1):258 Authors: Wang L, Zi H, Luo Y, Liu T, Zheng H, Xie C, Wang X, Huang X Abstract BACKGROUND: Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance...
Sat Jun 27, 2020 13:30
Related Articles Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. BMC Cancer. 2020 Jun 26;20(1):595 Authors: Sizemore G, McLaughlin S, Newman M, Brundage K, Ammer A, Martin K, Pugacheva E, Coad J, Mattes MD, Yu HG Abstract BACKGROUND: Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective...
Sat Jun 27, 2020 13:30
Related Articles Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling Pathways. Cancers (Basel). 2020 Jun 23;12(6): Authors: Podralska M, Ciesielska S, Kluiver J, van den Berg A, Dzikiewicz-Krawczyk A, Slezak-Prochazka I Abstract Radiotherapy is a cancer treatment that applies high doses of ionizing radiation to induce cell death, mainly by triggering DNA double-strand breaks. The...
Sat Jun 27, 2020 13:30
Related Articles WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis. Development. 2019 10 21;146(20): Authors: Qin Y, Zhou Y, Shen Z, Xu B, Chen M, Li Y, Chen M, Behrens A, Zhou J, Qi X, Meng W, Wang Y, Gao F Abstract WDR62 is the second most common genetic alteration associated with microcephaly. It has been shown that Wdr62 is required for germ cell meiosis initiation in mice, and the majority of male germ...
Sat Jun 27, 2020 13:30
Related Articles Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug. iScience. 2020 Jun 12;23(7):101262 Authors: Miller M, Mellul A, Braun M, Sherill-Rofe D, Cohen E, Shpilt Z, Unterman I, Braitbard O, Hochman J, Tshuva EY, Tabach Y Abstract PhenolaTi is an advanced non-toxic anticancer chemotherapy; this inert bis(phenolato)bis(alkoxo) Ti(IV) complex demonstrates the intriguing combination...
Fri Jun 26, 2020 14:47
Related Articles Differences in Stability, Cytotoxicity, and Mechanism of Action of Ru(II) and Pt(II) Complexes of a Bidentate N,O Donor Ligand. Inorg Chem. 2020 Jun 25;: Authors: Maji M, Acharya S, Maji S, Purkait K, Gupta A, Mukherjee A Abstract We report [RuII(L)(η6-p-cym)Cl] (1 and 2) and [PtII(L)(DMSO)Cl] (3 and 4) complexes, where L is a chelate imine ligand derived from chloroethylamine and salicylaldehyde (HL1) or o-vanillin (HL2)....
Fri Jun 26, 2020 14:47
Related Articles Serial Measurement of Cell-cycle Arrest Biomarkers [TIMP-2]•[IGFBP7] and Risk for Progression to Death, Dialysis or Severe Acute Kidney Injury in Patients with Septic Shock. Am J Respir Crit Care Med. 2020 Jun 25;: Authors: Fiorentino M, Xu Z, Smith A, Singbartl K, Palevsky PM, Chawla LS, Huang DT, Yealy DM, Angus DC, Kellum JA, ProCESS and ProGReSS-AKI Investigators Abstract RATIONALE: Urinary tissue inhibitor of metalloproteinases-2...
Fri Jun 26, 2020 14:47
Related Articles Restoration of miR-330 expression suppresses lung cancer cell viability, proliferation, and migration. J Cell Physiol. 2020 Jun 24;: Authors: Mohammadi A, Mansoori B, Duijf PHG, Safarzadeh E, Tebbi L, Najafi S, Shokouhi B, Sorensen GL, Holmskov U, Baradaran B Abstract Lung cancer is one of the most common cancers and its incidence is rising around the world. Various studies suggest that miR-330 acts as a tumor-suppressor...
Fri Jun 26, 2020 13:47
Related Articles Melatonin: an endogenous miraculous indolamine, fights against cancer progression. J Cancer Res Clin Oncol. 2020 Jun 24;: Authors: Samanta S Abstract PURPOSE: Melatonin is an amphipathic indolamine molecule ubiquitously present in all organisms ranging from cyanobacteria to humans. The pineal gland is the site of melatonin synthesis and secretion under the influence of the retinohypothalamic tract. Some extrapineal tissues...
Fri Jun 26, 2020 13:47
Related Articles Holliday junction‑recognition protein modulates apoptosis, cell cycle arrest and reactive oxygen species stress in human renal cell carcinoma. Oncol Rep. 2020 Jun 22;: Authors: Yuan JS, Chen ZS, Wang K, Zhang ZL Abstract Holliday junction recognition protein (HJURP) is involved in the regulation of mortality in various cell types, including renal cell carcinoma (RCC) cells. The specific mechanisms by which HJURP regulates...
Fri Jun 26, 2020 13:47
Related Articles Liriopesides B from Liriope spicata var. prolifera inhibits metastasis and induces apoptosis in A2780 human ovarian cancer cells. Mol Med Rep. 2020 Jun 18;: Authors: Yu H, Wang H, Yin Y, Wang Z Abstract Ovarian cancer is the most frequent cause of death among gynecological cancers. In the present study, the anti‑cancer effect of liriopesides B, a steroidal saponin from Liriope spicata var. prolifera, against A2780 cells...
Fri Jun 26, 2020 13:47
Related Articles Alisol A is potentially therapeutic in human breast cancer cells. Oncol Rep. 2020 Jun 22;: Authors: Shi Y, Wang M, Wang P, Zhang T, Yu J, Shi L, Li M, Wang H, Zhang Q, Zhao H Abstract Recent developments in breast cancer therapy have significantly improved patient survival rate; however, recurrence remains a major problem. Systemic treatment of breast cancer with available therapies is not curative. Natural products can...
Fri Jun 26, 2020 13:47
Related Articles CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma. Front Cell Dev Biol. 2020;8:417 Authors: Suwannakul N, Ma N, Midorikawa K, Oikawa S, Kobayashi H, He F, Kawanishi S, Murata M Abstract Background: Our previous study demonstrated an overexpression of CD44 variant 9 (CD44v9) in human cholangiocarcinoma (CCA) tissues that was associated with inflammation-related tumor development. However, the participation...
Fri Jun 26, 2020 13:47
Related Articles Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction. Front Pharmacol. 2020;11:861 Authors: Wang F, Mayca Pozo F, Tian D, Geng X, Yao X, Zhang Y, Tang J Abstract Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer...
Fri Jun 26, 2020 13:47
Related Articles Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer. Int J Mol Sci. 2020 Jun 22;21(12): Authors: Mbemi AT, Sims JN, Yedjou CG, Noubissi FK, Gomez CR, Tchounwou PB Abstract The treatment for ovarian cancers includes chemotherapies which use drugs such as cisplatin, paclitaxel, carboplatin, platinum, taxanes, or their combination, and other molecular target therapies. However, these current therapies are...
Fri Jun 26, 2020 13:47
Related Articles Extracellular Adenine Nucleotides and Adenosine Modulate the Growth and Survival of THP-1 Leukemia Cells. Int J Mol Sci. 2020 Jun 22;21(12): Authors: Puchałowicz K, Tarnowski M, Tkacz M, Chlubek D, Kłos P, Dziedziejko V Abstract A new approach to improve the effectiveness of acute myeloid leukemia (AML) treatment is to use the properties of purinergic signaling molecules secreted into the bone marrow milieu in response...
Fri Jun 26, 2020 13:47
Related Articles Active Compound of Pharbitis Semen (Pharbitis nil Seeds) Suppressed KRAS-Driven Colorectal Cancer and Restored Muscle Cell Function during Cancer Progression. Molecules. 2020 Jun 22;25(12): Authors: Song J, Seo H, Kim MR, Lee SJ, Ahn S, Song M Abstract Kirsten rat sarcoma viral oncogene homolog (KRAS)-driven colorectal cancer (CRC) is notorious to target with drugs and has shown ineffective treatment response. The seeds...
Fri Jun 26, 2020 13:47
Related Articles Iguratimod encapsulated PLGA-NPs improves therapeutic outcome in glioma, glioma stem-like cells and temozolomide resistant glioma cells. Nanomedicine. 2019 11;22:102101 Authors: Younis M, Faming W, Hongyan Z, Mengmeng T, Hang S, Liudi Y Abstract Glioma is the most common neoplasm of the central nervous system, with the highest mortality rate. The present study was designed to examine the therapeutic effect of Iguratimod (IGU)...
Fri Jun 26, 2020 13:47
Related Articles The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells. Stem Cell Res Ther. 2019 07 29;10(1):228 Authors: Shahbazi M, Cundiff P, Zhou W, Lee P, Patel A, D'Souza SL, Abbasi F, Quertermous T, Knowles JW Abstract BACKGROUND: Human-induced pluripotent stem cells (hiPSCs) show a great promise as a renewable source of cells with broad biomedical applications. Since...
Fri Jun 26, 2020 13:47
Related Articles iRoot BP Plus promotes osteo/odontogenic differentiation of bone marrow mesenchymal stem cells via MAPK pathways and autophagy. Stem Cell Res Ther. 2019 07 29;10(1):222 Authors: Lu J, Li Z, Wu X, Chen Y, Yan M, Ge X, Yu J Abstract BACKGROUND: iRoot BP Plus is a novel bioceramic endodontic material. Recently, it has been considered as an alternative to MTA which is the most popular scaffold cover during regenerative endodontic...
Fri Jun 26, 2020 13:47
Related Articles Paclitaxel-Loaded Folate-Coated pH-Sensitive Liposomes Enhance Cellular Uptake and Antitumor Activity. Mol Pharm. 2019 08 05;16(8):3477-3488 Authors: Monteiro LOF, Fernandes RS, Castro L, Reis D, Cassali GD, Evangelista F, Loures C, Sabino AP, Cardoso V, Oliveira MC, Branco de Barros A, Leite EA Abstract Paclitaxel (PTX) is a microtubule-stabilizing agent widely used to treat breast cancer. Nevertheless, the low solubility...
Fri Jun 26, 2020 13:47
Related Articles Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis. Cell Death Dis. 2019 05 29;10(6):421 Authors: Folkerts H, Wierenga AT, van den Heuvel FA, Woldhuis RR, Kluit DS, Jaques J, Schuringa JJ, Vellenga E Abstract Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy....
Fri Jun 26, 2020 13:47
Related Articles Kinesin-14 motor protein KIFC1 participates in DNA synthesis and chromatin maintenance. Cell Death Dis. 2019 05 24;10(6):402 Authors: Wei YL, Yang WX Abstract The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence...
Fri Jun 26, 2020 13:47
Related Articles Opposing roles of TCF7/LEF1 and TCF7L2 in cyclin D2 and Bmp4 expression and cardiomyocyte cell cycle control during late heart development. Lab Invest. 2019 06;99(6):807-818 Authors: Ye B, Li L, Xu H, Chen Y, Li F Abstract Bone morphogenetic protein (BMP) and Wnt pathways regulate cell proliferation and differentiation, but how these two pathways interact and mediate their nuclear actions in the heart, especially during late...
Fri Jun 26, 2020 13:47
Related Articles Survival Association and Cell Cycle Effects of B7H3 in Neuroblastoma. J Korean Neurosurg Soc. 2020 Jun 24;: Authors: Zhang H, Zhang J, Li C, Xu H, Dong R, Chen CC, Hua W Abstract Objective: The function of B7H3, a member of the B7 family of proteins, in neuroblastoma (NB) remains poorly characterized. Here we examine the expression pattern of B7H3 in clinical NB specimens and characterize the phenotype of B7H3 knock-down...
Thu Jun 25, 2020 15:00
Related Articles Role of bioactive sphingolipids in physiology and pathology. Essays Biochem. 2020 Jun 24;: Authors: Gomez-Larrauri A, Presa N, Dominguez-Herrera A, Ouro A, Trueba M, Gomez-Muñoz A Abstract Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases, namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential constituents of eukaryotic cells. They were first described as major...
Thu Jun 25, 2020 15:00
Related Articles A synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at G0/G1 stage, induces apoptosis, and inhibits metastasis via ROS-mediated p53 and AKT signaling pathways in A549 cells. J Biochem Mol Toxicol. 2020 Jun 24;:e22553 Authors: Umar S, Soni R, Durgapal SD, Soman S, Balakrishnan S Abstract New chemotherapeutic agents with minimum side effects are indispensable to treat non-small-cell...
Thu Jun 25, 2020 15:00
Related Articles Emerging use of senolytics and senomorphics against aging and chronic diseases. Med Res Rev. 2020 Jun 24;: Authors: Martel J, Ojcius DM, Wu CY, Peng HH, Voisin L, Perfettini JL, Ko YF, Young JD Abstract Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related...
Thu Jun 25, 2020 15:00
Related Articles Roles of Chk2/CHEK2 in guarding against environmentally-induced DNA damage and replication-stress. Environ Mol Mutagen. 2020 Jun 24;: Authors: Mustofa MK, Tanoue Y, Tateishi C, Vaziri C, Tateishi S Abstract Checkpoint kinase 2 (human CHEK2; murine Chk2) is a critical mediator of the DNA damage response and has established roles in DNA Double Strand Break (DSB)-induced apoptosis and cell cycle arrest. DSBs may be invoked...
Thu Jun 25, 2020 15:00
Related Articles A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420917444 Authors: Collard M, Gallagher PE, Tallant EA Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that tends to affect young women and has a high propensity to metastasize. No targeted treatments are available for this type of breast cancer...
Thu Jun 25, 2020 15:00
Related Articles A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells. Nutr Cancer. 2020 Jun 24;:1-12 Authors: Abdel-Wahab AA, Effat H, Mahrous EA, Ali MA, Al-Shafie TA Abstract Targeting altered metabolism in cancer provides a promising preventive and therapeutic approach. Natural products interplay between gene expression and metabolism either by targeting...
Thu Jun 25, 2020 15:00
Related Articles MiR-96 promotes apoptosis of nucleus pulpous cells by targeting FRS2. Hum Cell. 2020 Jun 23;: Authors: Yang X, Liu H, Zhang Q, Liu K, Yu D, Zhang Y, Shi Z Abstract This study aimed to investigate the molecular mechanism by which microRNA (miR)-96 regulates the progression of intervertebral disc degeneration (IDD). The expression of miR-96 in normal intervertebral discs and in IDD was detected by performing reverse transcription-quantitative...
Thu Jun 25, 2020 13:02
Related Articles Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling. Mol Cell Biochem. 2020 Jun 23;: Authors: Tang H, Yang P, Yang X, Peng S, Hu X, Bao G Abstract It is of great significance to explore the molecular mechanism of thyroid cancer (TC) pathogenesis for its improvement and therapy. Growth factor receptor bound protein-7 (GRB7)...
Thu Jun 25, 2020 13:02
Related Articles Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly. Heliyon. 2020 Jun;6(6):e04165 Authors: Bennett CL, Sopher BL, La Spada AR Abstract The Senataxin (SETX) protein exhibits strong sequence conservation with the helicase domain of the yeast protein Sen1p, and recessive SETX mutations cause a severe ataxia, known as Ataxia with...
Thu Jun 25, 2020 13:02
Related Articles Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer. J Exp Clin Cancer Res. 2020 Jun 23;39(1):119 Authors: Cao Y, Wang J, Tian H, Fu GH Abstract BACKGROUND: Gastric cancer (GC) is a common form of malignant cancer in worldwide which has a poor prognosis. Despite recent improvements in the treatment of GC, the prognosis is not yet...
Thu Jun 25, 2020 13:02
Related Articles Validation of Enhancing Effects of Curcumin on Radiotherapy with F98/FGT Glioblastoma-Bearing Rat Model. Int J Mol Sci. 2020 Jun 19;21(12): Authors: Wang WH, Shen CY, Chien YC, Chang WS, Tsai CW, Lin YH, Hwang JJ Abstract Glioblastoma, the most common and aggressive brain tumor with low survival rate, is difficult to be cured by neurosurgery or radiotherapy. Mounting evidence has reported the anti-inflammatory and anticancer...
Thu Jun 25, 2020 13:02
Related Articles Cell Death Response to DNA Damage. Yale J Biol Med. 2019 12;92(4):771-779 Authors: Wang JYJ Abstract The cell death response to DNA damage is discussed in this Perspectives piece with cancer as the backdrop because DNA damaging agents (DDA) are widely used to treat cancer. From decades of clinical results, we learn that DDA have cured some cancers but their toxicity is temporary in most cancers due to emergence of DDA-resistant...
Thu Jun 25, 2020 13:02
Related Articles Chemical Regeneration of Wound Defects: Relevance to the Canine Palatal Mucosa and Cell Cycle Up-Regulation in Human Gingival Fibroblasts. Tissue Eng Regen Med. 2019 12;16(6):675-684 Authors: Lee K, Ben Amara H, Lee SC, Leesungbok R, Chung MA, Koo KT, Lee SW Abstract Background: Trichloroacetic acid (TCA) is an agent widely applied in dermatology for skin regeneration. To test whether TCA can offer an advantage for the...
Thu Jun 25, 2020 13:02
Related Articles Fine-tuning of the replisome: Mcm10 regulates fork progression and regression. Cell Cycle. 2019 05;18(10):1047-1055 Authors: Brosh RM, Trakselis MA Abstract Several decades of research have identified Mcm10 hanging around the replisome making several critical contacts with a number of proteins but with no real disclosed function. Recently, the O'Donnell laboratory has been better able to map the interactions of Mcm10 with...
Thu Jun 25, 2020 13:02
Related Articles Epilepsy care cascade, treatment gap and its determinants in rural South Africa. Seizure. 2020 Jun 09;80:175-180 Authors: Wagner RG, Kabudula CW, Forsgren L, Ibinda F, Lindholm L, Kahn K, Tollman S, Newton CR Abstract PURPOSE: The percentage of people who are diagnosed with epilepsy (diagnostic gap), access, receive and adhere (treatment gap) to anti-seizure medication (ASM) in low- and middle- income countries remains low....
Sun Jun 28, 2020 15:09
Related Articles Psychometric properties of the Persian version of the Patient-Weighted Quality of Life in Epilepsy Inventory-10-P. Epilepsy Behav. 2020 Jun 24;111:107243 Authors: Barakchianc SN, Shati M, Mortazavi SS, Nikanfar M, Charsouei S Abstract BACKGROUND: The purpose of the study was to evaluate psychometric properties of the Persian version of the Patient-Weighted Quality of Life in Epilepsy Inventory-10-P (PV QOLIE-10-P). ...
Sun Jun 28, 2020 15:09
Related Articles Cannabidiol efficacy independent of clobazam: meta-analysis of four randomized-controlled trials. Acta Neurol Scand. 2020 Jun 26;: Authors: Devinsky O, Thiele EA, Wright S, Checketts D, Morrison G, Dunayevich E, Knappertz V Abstract OBJECTIVE: The efficacy of cannabidiol (CBD) with and without concomitant clobazam (CLB) was evaluated in stratified analyses of four large randomized controlled trials, two in Lennox-Gastaut syndrome...
Sun Jun 28, 2020 15:09
Related Articles Sulthiame add-on treatment in children with epileptic encephalopathy with status epilepticus: an efficacy analysis in etiologic subgroups. Neurol Sci. 2020 Jun 26;: Authors: Kanmaz S, Simsek E, Serin HM, Yilmaz S, Aktan G, Tekgul H, Gokben S Abstract PURPOSE: Sulthiame (STM) has been recommended as an effective antiepileptic drug (AED) in children with epileptic encephalopathy with status epilepticus in sleep (ESES). The aim...
Sun Jun 28, 2020 15:09
Related Articles Glucose transporter type 1 deficiency syndrome associated with autoantibodies to glutamate receptors. Brain Dev. 2020 Jun 23;: Authors: Hoshino H, Takayama K, Ishii A, Takahashi Y, Kanemura H Abstract BACKGROUND: The clinical spectrum of glucose transporter type 1 deficiency syndrome (GLUT1DS) has broadened, with increasing recognition of a milder phenotype. Antibodies targeting the subunits of glutamate receptors (GluRs), including...
Sun Jun 28, 2020 15:09
Related Articles Magnetic resonance-guided laser interstitial thermal therapy versus stereoelectroencephalography-guided radiofrequency thermocoagulation for drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsy Res. 2020 Jun 15;166:106397 Authors: Wang Y, Xu J, Liu T, Chen F, Chen S, Xie Z, Fang T, Liang S Abstract BACKGROUND: Magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) is a minimally invasive treatment...
Sat Jun 27, 2020 14:41
Related Articles Neuropolybin: a new antiseizure peptide obtained from wasp venom. Biochem Pharmacol. 2020 Jun 23;:114119 Authors: Castro E Silva J, Lopes do Couto L, de Oliveira Amaral H, Maria Medeiros Gomes F, Avohay Alves Campos G, Paulino Silva L, Renata Mortari M Abstract Epilepsy accounts for one of the most serious neurological disorders, and its treatment remains a challenge, due to high cost and harmful side effects. Bioactive molecules...
Sat Jun 27, 2020 14:41
Related Articles Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study. Cephalalgia. 2020 Jun 26;:333102420937742 Authors: Rustichelli C, Bellei E, Bergamini S, Monari E, Baraldi C, Castro FL, Tomasi A, Ferrari A Abstract BACKGROUND: Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as...
Sat Jun 27, 2020 14:41
Related Articles Prevalence and management of chronic insomnia in Swiss primary care: Cross-sectional data from the "Sentinella" practice-based research network. J Sleep Res. 2020 Jun 25;:e13121 Authors: Maire M, Linder S, Dvořák C, Merlo C, Essig S, Tal K, Del Giovane C, Syrogiannouli L, Duss SB, Heinzer R, Nissen C, Bassetti CLA, Auer R Abstract We investigated the prevalence and treatment of patients with chronic insomnia presenting to Swiss...
Sat Jun 27, 2020 14:41
Related Articles Do You See What I See? A Case of Alice in Wonderland Syndrome With EEG Correlate. Child Neurol Open. 2020 Jan-Dec;7:2329048X20932714 Authors: Shah A, Magaña SM, E Youssef P Abstract Alice in Wonderland syndrome is a disorienting perceptual disorder characterized by discrete episodes of bizarre visual illusions and spatial distortions which has been associated with numerous neurologic and psychiatric conditions. Little is known...
Sat Jun 27, 2020 14:41
Related Articles Investigating the efficacy of medical management for canine structural epilepsy. Vet Rec. 2020 Jun 25;: Authors: Norona FE, Volk HA Abstract BACKGROUND: Structural epilepsy in dogs is often treated medically with a combination of antiseizure drugs (ASDs) and other concurrent therapies for the primary condition. Unlike idiopathic epilepsy, there have been few studies on the efficacy of medical management in structural epilepsy....
Sat Jun 27, 2020 14:41
Related Articles A neuropsychological approach in a paediatric acquired brain injury unit under the public health system. Neurologia. 2020 Jun 22;: Authors: Cámara Barrio S, Esteso Orduña B, Vara Arias MT, Rodríguez Palero S, Fournier Del Castillo MC Abstract INTRODUCTION: Paediatric acquired brain injury (ABI) causes cognitive and behavioural difficulties and alters the course of child development. The ABI unit at Hospital Infantil Universitario...
Sat Jun 27, 2020 14:41
Related Articles Seizures in meningioma. Handb Clin Neurol. 2020;170:187-200 Authors: Harward SC, Rolston JD, Englot DJ Abstract More than one-third of patients with meningiomas will experience seizures at some point in their disease. Despite this, meningioma-associated epilepsy remains significantly understudied, as most investigations focus on tumor progression, extent of resection, and survival. Due to the impact of epilepsy on the patient's...
Sat Jun 27, 2020 14:41
Related Articles How effective are self-management interventions for children with epilepsy? A Cochrane Review summary with commentary. Dev Med Child Neurol. 2020 05;62(5):551-553 Authors: Oral A PMID: 32249941 [PubMed - indexed for MEDLINE]
Sat Jun 27, 2020 14:41
Related Articles CHD2 epilepsy: epigenetics and the quest for precision medicine. Dev Med Child Neurol. 2020 05;62(5):549-550 Authors: Symonds JD PMID: 31713838 [PubMed - indexed for MEDLINE]
Sat Jun 27, 2020 14:41
Related Articles Chronic post-encephalitic epilepsy following Japanese encephalitis: Clinical features, neuroimaging data, and outcomes. Seizure. 2019 Nov;72:49-53 Authors: Xiong W, Lu L, Chen J, Xiao Y, Zhou D Abstract PURPOSE: Japanese encephalitis (JE), the main cause of viral encephalitis in Asia, usually presents with acute symptomatic seizures; however, there have been very few systematic reports regarding late unprovoked seizures and...
Sat Jun 27, 2020 14:41
Related Articles Analysis of the reasons and costs of hospitalization for epilepsy patients in East China. Seizure. 2019 Nov;72:40-45 Authors: Yu N, Lin XJ, Zhang SG, Di Q Abstract PURPOSE: This study aimed to assess the cause and cause-specific risks of hospitalization for epilepsy patients in East China. Further analysis was performed for inpatient hospitalization days, hospital mortality and costs. METHOD: This study was performed...
Sat Jun 27, 2020 14:41
Related Articles A case of DRESS (drug reaction with eosinophilia and systemic symptoms) under treatment with eslicarbazepine. Seizure. 2019 Nov;72:11-12 Authors: Willikens S, Wolking S PMID: 31541846 [PubMed - indexed for MEDLINE]
Sat Jun 27, 2020 14:41
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/06/26PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Jun 26, 2020 14:23
Related Articles Biopsychosocial factors associated with a current depressive episode in diabetes: the ELSA-Brasil study. Diabet Med. 2020 Jun 24;: Authors: van Duinkerken E, Moreno AB, Eto FN, Lotufo P, Barreto SM, Giatti L, Viana MC, Nunes MA, Chor D, Griep RH Abstract AIM: Depression is more prevalent in people with diabetes, and is associated with worse diabetes outcomes. Depression in diabetes is more treatment resistant, and as underlying...
Thu Jun 25, 2020 17:34
Related Articles Use of cannabis and its products among patients in a tertiary epilepsy center: A cross-sectional survey. Epilepsy Behav. 2020 Jun 21;111:107214 Authors: Puteikis K, Mameniškienė R Abstract PURPOSE: The purpose of this study was to evaluate whether the topic of using cannabis as a treatment option for epilepsy is relevant among adult patients with the disorder and assess the possible determinant attitudes for having a history...
Thu Jun 25, 2020 17:34
Related Articles Chronic cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus: epigenetic implications for psychiatric disease. Environ Mol Mutagen. 2020 Jun 24;: Authors: Wanner NM, Colwell M, Drown C, Faulk C Abstract Cannabidiol (CBD) is the primary non-psychoactive compound found in cannabis (Cannabis sativa) and an increasingly popular dietary supplement as a result of widespread availability of CBD-containing products....
Thu Jun 25, 2020 17:34
Related Articles Prenatal Exposure to Antibiotics and Development of Epilepsy in Children. J Clin Pharmacol. 2020 Jun 23;: Authors: Sassonker-Joseph N, Gorodischer R, Atar-Vardi M, Noyman I, Novack L Abstract We aimed to confirm or reject previous reports on the association of prenatal antibiotic exposure and development of epilepsy in offspring by accounting for known and unidentified confounding factors. In a retrospective cohort investigation,...
Thu Jun 25, 2020 14:05
Related Articles Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Precursors and Neurons. Adv Neurobiol. 2020;25:1-31 Authors: Sundberg M, Sahin M Abstract Tuberous sclerosis complex (TSC) is a rare genetic disorder that is caused by mutations in TSC1 or TSC2. TSC is a multi-organ disorder characterized by development of non-malignant cellular overgrowths, called hamartomas, in different organs...
Thu Jun 25, 2020 14:05
Related Articles Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice. Brain. 2020 Jun 24;: Authors: Amador A, Bostick CD, Olson H, Peters J, Camp CR, Krizay D, Chen W, Han W, Tang W, Kanber A, Kim S, Teoh J, Sah M, Petri S, Paek H, Kim A, Lutz CM, Yang M, Myers SJ, Bhattacharya S, Yuan H, Goldstein DB, Poduri A, Boland MJ, Traynelis SF, Frankel WN Abstract NMDA receptors play crucial roles in excitatory synaptic...
Thu Jun 25, 2020 14:05
Related Articles Children with congenital Zika syndrome: symptoms, comorbidities and gross motor development at 24 months of age. Heliyon. 2020 Jun;6(6):e04130 Authors: Frota LMDCP, Sampaio RF, Miranda JL, Brasil RMC, Gontijo APB, Mambrini JVM, Brandão MB, Mancini MC Abstract Background: Children with congenital Zika syndrome (CZS) maintain severe motor impairments at the end of the first year of life. Presence of certain symptoms and comorbidities...
Thu Jun 25, 2020 14:05
Related Articles Antioxidant and hepatoprotective potentials of active fractions of Lannea barteri Oliv. (Anarcadiaceae) in rats. Heliyon. 2020 Jun;6(6):e04099 Authors: Mbaoji FN, Nweze JA Abstract Introduction: Lannea barteri is used in the folkloric treatment of many disease states ranging from epilepsy, diarrhoea, oedema and ulcers, etc. This study investigated the antioxidant and hepatoprotective potentials of methanol (MFLB), n-hexane (nHFLB)...
Thu Jun 25, 2020 14:05
Related Articles Epileptic seizures. Discoveries (Craiova). 2020 Jun 12;8(2):e110 Authors: Anwar H, Khan QU, Nadeem N, Pervaiz I, Ali M, Cheema FF Abstract Epilepsy is a condition marked by abnormal neuronal discharges or hyperexcitability of neurons with synchronicity and is recognized as a major public health concern. The pathology is categorized into three subgroups: acquired, idiopathic, and epilepsy of genetic or developmental origin. There...
Thu Jun 25, 2020 14:05
Related Articles Characterization and Outcomes of Epileptic Seizures in Mexican Pediatric Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Cureus. 2020 May 20;12(5):e8211 Authors: Chavez-Castillo M, Ruiz-Garcia M, Herrera-Mora P Abstract Introduction Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is one of the most common autoimmune encephalitides. The frequency of anti-NMDAR encephalitis is known to exceed the frequency...
Thu Jun 25, 2020 14:05
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