Antibiotics, Vol. 9, Pages 298: Anti-Infectious Plants of The Thai Karen: A Meta-Analysis Antibiotics doi: 10.3390/antibiotics9060298 Authors: Methee Phumthum Henrik Balslev Pharmacology has developed many drugs to treat infections, but many people, especially in developing countries, cannot afford to purchase them, and still depend on traditional knowledge and local medicinal plants to fight off infections. In addition, numerous microbes have developed resistance to the pharmaceutical...
Tue Jun 02, 2020 03:00
Antibiotics, Vol. 9, Pages 297: Cannabinoids‐Promising Antimicrobial Drugs or Intoxicants with Benefits? Antibiotics doi: 10.3390/antibiotics9060297 Authors: Klahn Novel antimicrobial drugs are urgently needed to counteract the increasing occurrence ofbacterial resistance. Extracts of Cannabis sativa have been used for the treatment of several diseasessince ancient times. However, its phytocannabinoid constituents are predominantly associated withpsychotropic effects and medical applications...
Tue Jun 02, 2020 03:00
Antibiotics, Vol. 9, Pages 296: Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration Antibiotics doi: 10.3390/antibiotics9060296 Authors: Pilvi Ruotsalainen Cindy Given Reetta Penttinen Matti Jalasvuori Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being...
Tue Jun 02, 2020 03:00
Antibiotics, Vol. 9, Pages 295: No Prescription, No Problem! A Mixed-Methods Study of Antimicrobial Stewardship Relating to Working Equines in Drug Retail Outlets of Northern India Antibiotics doi: 10.3390/antibiotics9060295 Authors: Caroline Nye Tamlin Watson Laura Kubasiewicz Zoe Raw Faith Burden Multidrug resistance (MDR) is already occurring among some equids in India. Donkeys and mules are a mobile species moving between regions and international borders, often populating...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 479: Determination of Polyphenols Using Liquid Chromatography–Tandem Mass Spectrometry Technique (LC–MS/MS): A Review Antioxidants doi: 10.3390/antiox9060479 Authors: Olalla López-Fernández Rubén Domínguez Mirian Pateiro Paulo E.S. Munekata Gabriele Rocchetti José M. Lorenzo In recent years, the consumption of polyphenols has been increasing, largely due to its beneficial effects on health. They are present in a wide variety of foods, but their...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 478: Anthocyanins in Blueberries Grown in Hot Climate Exert Strong Antioxidant Activity and May Be Effective against Urinary Tract Bacteria Antioxidants doi: 10.3390/antiox9060478 Authors: Ana B. Cerezo Giorgiana M. Cătunescu Mercedes Martínez-Pais González Ruth Hornedo-Ortega Carmen R. Pop Crina Claudia Rusu Flore Chirilă Ancuța M. Rotar M. Carmen Garcia-Parrilla Ana M. Troncoso Anthocyanins are extensively studied for their health-related...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 480: Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur Antioxidants doi: 10.3390/antiox9060480 Authors: Andrei Mocan Mihai Babota Anca Pop Ionel Fizeșan Alina Diuzheva Marcello Locatelli Simone Carradori Cristina Campestre Luigi Menghini Cristian R. Sisea Marina Soković Gokhan Zengin Ramona Păltinean...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 475: NRF2 and Primary Cilia: An Emerging Partnership Antioxidants doi: 10.3390/antiox9060475 Authors: Ana Martin-Hurtado Isabel Lastres-Becker Antonio Cuadrado Francesc R. Garcia-Gonzalo When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane. Primary cilia play important...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 476: Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study Antioxidants doi: 10.3390/antiox9060476 Authors: Bernardo U. Peres AJ Hirsch Allen Aditi Shah Nurit Fox Ismail Laher Fernanda Almeida Rachel Jen Najib Ayas Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 477: Use of Melatonin in Oxidative Stress Related Neonatal Diseases Antioxidants doi: 10.3390/antiox9060477 Authors: Gabriella D’Angelo Roberto Chimenz Russel J. Reiter Eloisa Gitto Reactive oxygen species have a crucial role in the pathogenesis of perinatal diseases. Exposure to inflammation, infections, or high oxygen concentrations is frequent in preterm infants, who have high free iron levels that enhance toxic radical generation and diminish...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 474: (−)-Loliolide Isolated from Sargassum horneri Protects against Fine Dust-Induced Oxidative Stress in Human Keratinocytes Antioxidants doi: 10.3390/antiox9060474 Authors: Mawalle Kankanamge Hasitha Madhawa Dias Dissanayaka Mudiyanselage Dinesh Madusanka Eui Jeong Han Min Ju Kim You-Jin Jeon Hyun-Soo Kim Ilekuttige Priyan Shanura Fernando Ginnae Ahn The emergence of fine dust (FD) among air pollutants has taken a toll during the past...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 472: An Update on Mitochondrial Reactive Oxygen Species Production Antioxidants doi: 10.3390/antiox9060472 Authors: Mailloux Mitochondria are quantifiably the most important sources of superoxide (O2●−) and hydrogen peroxide (H2O2) in mammalian cells. The overproduction of these molecules has been studied mostly in the contexts of the pathogenesis of human diseases and aging. However, controlled bursts in mitochondrial ROS production, most notably...
Tue Jun 02, 2020 03:00
Antioxidants, Vol. 9, Pages 473: Punicalagin Protects Human Retinal Pigment Epithelium Cells from Ultraviolet Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway and Reducing Apoptosis Antioxidants doi: 10.3390/antiox9060473 Authors: Clementi Sampaolese Sciandra Tringali The oxidative damage of the retinal pigment epithelium (RPE) is the early event that underlies the pathogenesis of maculopathies. Numerous studies have shown that punicalagin (PUN),...
Tue Jun 02, 2020 03:00
Atmosphere, Vol. 11, Pages 582: Real-World Exhaust Emissions of Diesel Locomotives and Motorized Railcars during Scheduled Passenger Train Runs on Czech Railroads Atmosphere doi: 10.3390/atmos11060582 Authors: Michal Vojtisek-Lom Jonáš Jirků Martin Pechout The paper summarizes exhaust emissions measurements on two diesel-electric locomotives and one diesel-hydraulic railcar, each tested for several days during scheduled passenger service. While real driving emissions of buses decrease...
Tue Jun 02, 2020 03:00
Atmosphere, Vol. 11, Pages 581: Quantitative Determination Procedures for Regional Extreme Drought Conditions: Application to Historical Drought Events in South Korea Atmosphere doi: 10.3390/atmos11060581 Authors: Chan Wook Lee Moo Jong Park Do Guen Yoo Recently, the signs of extreme droughts, which were thought of as exceptional and unlikely, are being detected worldwide. It is necessary to prepare countermeasures against extreme droughts; however, current definitions of extreme...
Tue Jun 02, 2020 03:00
Atmosphere, Vol. 11, Pages 580: Reconstructing Elemental Carbon Long-Term Trend in the Po Valley (Italy) from Fog Water Samples Atmosphere doi: 10.3390/atmos11060580 Authors: Stefania Gilardoni Leone Tarozzi Silvia Sandrini Pierina Ielpo Daniele Contini Jean-Philippe Putaud Fabrizia Cavalli Vanes Poluzzi Dimitri Bacco Cristina Leonardi Alessandra Genga Leonardo Langone Sandro Fuzzi Elemental carbon (EC), a ubiquitous component of fine atmospheric aerosol...
Tue Jun 02, 2020 03:00
Beverages, Vol. 6, Pages 37: Chemical Migration from Beverage Packaging Materials—A Review Beverages doi: 10.3390/beverages6020037 Authors: Petra Schmid Frank Welle The packaging of a beverage is an essential element for customer convenience and the preservation of beverage quality. On the other hand, chemical compounds present in the packaging materials, either intentionally added or non-intentionally, may be transferred to the food. With a huge variety of materials used in the production,...
Tue Jun 02, 2020 03:00
Biology, Vol. 9, Pages 116: Saline and Arid Soils: Impact on Bacteria, Plants, and their Interaction
Biology, Vol. 9, Pages 116: Saline and Arid Soils: Impact on Bacteria, Plants, and their Interaction Biology doi: 10.3390/biology9060116 Authors: Gamalero Bona Todeschini Lingua Salinity and drought are the most important abiotic stresses hampering crop growth and yield. It has been estimated that arid areas cover between 41% and 45% of the total Earth area worldwide. At the same time, the world’s population is going to soon reach 9 billion and the survival of...
Tue Jun 02, 2020 03:00
Biology, Vol. 9, Pages 115: Notch Inhibition via GSI Treatment Elevates Protein Synthesis in C2C12 Myotubes Biology doi: 10.3390/biology9060115 Authors: Joshua R. Huot Joseph S. Marino Michael J. Turner Susan T. Arthur The role of Notch signaling is widely studied in skeletal muscle regeneration but little is known about its influences on muscle protein synthesis (MPS). The purpose of this study was to investigate whether Notch signaling is involved in the regulation of MPS....
Tue Jun 02, 2020 03:00
Biomedicines, Vol. 8, Pages 150: Animal-Assisted and Pet-Robot Interventions for Ameliorating Behavioral and Psychological Symptoms of Dementia: A Systematic Review and Meta-Analysis Biomedicines doi: 10.3390/biomedicines8060150 Authors: Park Bak Kim Nam Kim Yoo Moon Patients with dementia suffer from psychological symptoms such as depression, agitation, and aggression. One purpose of dementia intervention is to manage patients’ inappropriate behaviors...
Tue Jun 02, 2020 03:00
Biomedicines, Vol. 8, Pages 149: CD40 Receptor Knockout Protects against Microcystin-LR (MC-LR) Prolongation and Exacerbation of Dextran Sulfate Sodium (DSS)-Induced Colitis Biomedicines doi: 10.3390/biomedicines8060149 Authors: Robin C. Su Emily A. Warner Joshua D. Breidenbach Apurva Lad Thomas M. Blomquist Andrew L. Kleinhenz Nikolai Modyanov Deepak Malhotra David J. Kennedy Steven T. Haller Inflammatory Bowel Disease (IBD) is one of the most common gastrointestinal...
Tue Jun 02, 2020 03:00
Biomedicines, Vol. 8, Pages 148: Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors Biomedicines doi: 10.3390/biomedicines8060148 Authors: Wilhelm Gossing Marcus Frohme Lars Radke Pituitary neuroendocrine tumors (PitNET) do not only belong to the most common intracranial neoplasms but seem to be generally more common than has been thought. Minimally invasive liquid biopsies have the potential to improve their early screening efficiency as well as monitor prognosis...
Tue Jun 02, 2020 03:00
Biomolecules, Vol. 10, Pages 847: Erratum: Touil, H.F.Z. et al. Optimum Inhibition of Amphotericin-B-Resistant Candida albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids. Biomolecules 2020, 10, 342. Biomolecules doi: 10.3390/biom10060847 Authors: Touil Boucherit Boucherit-Otmani Khoder Madkour Soliman The authors wish to make the following correction to this paper [1] [...]
Tue Jun 02, 2020 03:00
Biomolecules, Vol. 10, Pages 846: Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite Biomolecules doi: 10.3390/biom10060846 Authors: Sara Ceccacci Jana Deitersen Matteo Mozzicafreddo Elva Morretta Peter Proksch Sebastian Wesselborg Björn Stork Maria Chiara Monti Phomoxanthone A, a bioactive xanthone dimer isolated from the endophytic fungus Phomopsis sp., is a mitochondrial toxin weakening cellular respiration and electron...
Tue Jun 02, 2020 03:00
Biomolecules, Vol. 10, Pages 845: The Effect of the Photoperiod on the Fatty Acid Profile and Weight in Hatchery-Reared Underyearlings and Yearlings of Atlantic Salmon Salmo salar L Biomolecules doi: 10.3390/biom10060845 Authors: Nina N. Nemova Zinaida A. Nefedova Svetlana N. Pekkoeva Viktor P. Voronin Natalia S. Shulgina Maria V. Churova Svetlana A. Murzina The influence of two light regimes, 16:8 h light/dark (LD 16:8) and 24:0 h light/dark (LD 24:0), in comparison...
Tue Jun 02, 2020 03:00
Biosensors, Vol. 10, Pages 60: Smartphone and Paper-Based Fluorescence Reader: A Do It Yourself Approach Biosensors doi: 10.3390/bios10060060 Authors: Laura Alejandra Ireta-Muñoz Eden Morales-Narváez Given their photoluminescent character, portable quantum dot readers are often sophisticated and relatively expensive. In response, we engineered a “do it yourself” fluorescence reader employing paper materials and a mid-range smartphone camera. Black paperboard facilitated...
Tue Jun 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 338: Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System Brain Sciences doi: 10.3390/brainsci10060338 Authors: Maria Chountoulesi Costas Demetzos Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis. Although several drugs were designed for the treatment of MS, with some of them being...
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1447: Comparative Analysis of Age- and Gender-Associated Microbiome in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12061447 Authors: Lindsay M. Wong Neil Shende Wei Tse Li Grant Castaneda Lauren Apostol Eric Y. Chang Weg M. Ongkeko The intra-tumor microbiota has been increasingly implicated in cancer pathogenesis. In this study, we aimed to examine the microbiome in lung adenocarcinoma (LUAD) and lung squamous...
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1449: Current Strategies and Novel Therapeutic Approaches for Metastatic Urothelial Carcinoma Cancers doi: 10.3390/cancers12061449 Authors: Veronica Mollica Alessandro Rizzo Rodolfo Montironi Liang Cheng Francesca Giunchi Riccardo Schiavina Matteo Santoni Michelangelo Fiorentino Antonio Lopez-Beltran Eugenio Brunocilla Giovanni Brandi Francesco Massari Urothelial carcinoma (UC) is a frequent cause of cancer-related deaths worldwide....
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1450: Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease Cancers doi: 10.3390/cancers12061450 Authors: Francisca Dias Ana Luísa Teixeira Inês Nogueira Mariana Morais Joana Maia Cristian Bodo Marta Ferreira Alexandra Silva Manuela Vilhena João Lobo José Pedro Sequeira Joaquina Maurício Jorge Oliveira Klaas Kok Bruno...
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1448: Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far Cancers doi: 10.3390/cancers12061448 Authors: Stefano Martellucci Letizia Clementi Samantha Sabetta Vincenzo Mattei Lorenzo Botta Adriano Angelucci Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor kinase class that controls multiple signaling pathways in animal cells. SFKs activation is necessary for the mitogenic...
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1446: Rlip Depletion Suppresses Growth of Breast Cancer Cancers doi: 10.3390/cancers12061446 Authors: Chhanda Bose Sushma Yadav Sharad S. Singhal Jyotsana Singhal Ashly Hindle Jihyun Lee Naga K. S. Cheedella Shabnam Rehman Rakhshanda Layeequr Rahman Catherine Jones Meenakshi Darden Philip T. Palade David Berz Sharda P. Singh Sanjay Awasthi RLIP76 (RAL-binding protein-1, Rlip) is a stress-protective mercapturic-acid-pathway...
Tue Jun 02, 2020 03:00
Cancers, Vol. 12, Pages 1445: The Long and Short of It: The Emerging Roles of Non-Coding RNA in Small Extracellular Vesicles Cancers doi: 10.3390/cancers12061445 Authors: Agata Abramowicz Michael D Story Small extracellular vesicles (EVs) play a significant role in intercellular communication through their non-coding RNA (ncRNA) cargo. While the initial examination of EV cargo identified both mRNA and miRNA, later studies revealed a wealth of other types of EV-related non-randomly...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1385: Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy Cells doi: 10.3390/cells9061385 Authors: Mankhong Kim Moon Kwak Park Kang Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional disability, falls, hospitalization, and mortality, and is becoming a major geriatric disorder owing to the...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1386: CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes Cells doi: 10.3390/cells9061386 Authors: Chiarini Armato Hu Dal Prà Available evidence shows that human cortical neurons’ and astrocytes’ calcium-sensing receptors (CaSRs) bind Amyloid-beta (Aβ) oligomers triggering the overproduction/oversecretion of several...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1381: BMP-2 Variants in Breast Epithelial to Mesenchymal Transition and Microcalcifications Origin Cells doi: 10.3390/cells9061381 Authors: Manuel Scimeca Raffaella Giocondo Manuela Montanaro Annarita Granaglia Rita Bonfiglio Virginia Tancredi Alessandro Mauriello Nicoletta Urbano Orazio Schillaci Elena Bonanno This study aims to investigate the possible different roles of the BMP-2 variants, cytoplasmic and nuclear variant, in both epithelial...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1383: Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 Cells doi: 10.3390/cells9061383 Authors: Bhawna Tomar Hans-Joachim Anders Jyaysi Desai Shrikant R. Mulay The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome,...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1379: Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration Cells doi: 10.3390/cells9061379 Authors: Carolina Duarte Juliet Akkaoui Chiaki Yamada Anny Ho Cungui Mao Alexandru Movila Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine...
Tue Jun 02, 2020 03:00
Cells, Vol. 9, Pages 1382: Anti-PSMA CAR-engineered NK-92 Cells: An Off-the-shelf Cell Therapy for Prostate Cancer Cells doi: 10.3390/cells9061382 Authors: Isabella Monia Montagner Alessandro Penna Giulio Fracasso Debora Carpanese Anna Dalla Pietà Vito Barbieri Gaia Zuccolotto Antonio Rosato Prostate cancer (PCa) has become the most common cancer among males in Europe and the USA. Adoptive immunotherapy appears a promising strategy to control the advanced stages...
Tue Jun 02, 2020 03:00
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