Traditional superficial musculoaponeurotic system (SMAS) facelifting surgery uses a laminar surgical dissection. This approach does not treat areas of facial volume loss, and requires additional volume supplementation with fat grafting or fillers. The novel volumizing extended deep-plane facelift uses a composite approach to the facelift flap. By incorporating a platysma myotomy in the extended deep-plane flap, a novel composite transposition flap can be created that revolumizes the posterior jawline,...
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Face-lift procedures have always exemplified the improvements that can be provided to patients through facial plastic surgery to surgeons as well as to the public in general. Variations in techniques have evolved through the years with some aspects of the surgery being emphasized and encouraged for periods of time and then to be overshadowed by alternative procedures by other surgeons over various time periods. At this point in time, 2 basic face-lift approaches, coupled with described variations,...
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In this trial of PD-1 blockade with toripalimab in previously-treated Chinese patients with melanoma, unique histologic and molecular features may explain why the objective response rate is lower than those defined in Western populations. This work suggests future avenues for investigating mechanisms of melanoma formation and resistance to PD-1 blockade.
Tue Jun 02, 2020 16:19
Abstract The purpose of this study is to find out if the biological behavior and the capacity of the odontogenic keratocyst (OKC) in maintaining pathologic cells alive are more similar to the dentigerous cyst or to the ameloblastoma by assessing bcl-2. We searched MEDLINE, Web of Science, and Scopus for immunohistochemical studies reporting OKCs, dentigerous cysts, and ameloblastomas. Risk difference between the lesions expressing bcl-2 was the effect measure and a P value <...
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c01017
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01204
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00475
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00420
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01311
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00661
Tue Jun 02, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05778
Tue Jun 02, 2020 07:00
Abstract Glioblastoma multiforme (GBM) is a very aggressive and infiltrative brain tumor with a high mortality rate. There are radiomic models with handcrafted features to estimate glioblastoma prognosis. In this work, we evaluate to what extent of combining genomic with radiomic features makes an impact on the prognosis of overall survival (OS) in patients with GBM. We apply a hypercolumn-based convolutional network to segment tumor regions from magnetic resonance images (MRI),...
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British Journal of Cancer, Published online: 03 June 2020; doi:10.1038/s41416-020-0873-zHuman Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
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British Journal of Cancer, Published online: 03 June 2020; doi:10.1038/s41416-020-0909-4Phase 2 study of cabazitaxel as second-line treatment in patients with HER2-negative metastatic breast cancer previously treated with taxanes—a Hellenic Cooperative Oncology Group (HeCOG) Trial
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British Journal of Cancer, Published online: 03 June 2020; doi:10.1038/s41416-020-0924-5The relationships between systemic cytokine profiles and inflammatory markers in colorectal cancer and the prognostic significance of these parameters
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Abstract Precise knowledge of a species’ habitat requirements is essential for its conservation. Very little information exists on the habitat requirements of the Malabar slender loris (Loris lydekkerianus malabaricus), a nocturnal primate, making it difficult to formulate conservation action plans. The goal of this study was to evaluate the ecological determinants of t he Malabar slender loris at the Aralam Wildlife Sanctuary, Kerala, India. We conducted surveys in a 1-km2 area...
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Horm Metab ResDOI: 10.1055/a-1159-4506BMIz-score (BMIz) is commonly used to assess childhood obesity. Whether change in BMIz score predicts change in visceral fat remains unclear. The objective of the work was to study changes in visceral fat, cardiovascular fitness (CVF), and metabolic health over 6 months in children with stable/decreased-BMIz vs. increased-BMIz. Ninety children with obesity, referred for lifestyle intervention were studied (mean age 11±3.1 years, 50% girls, 22% Hispanic). Assessment...
Tue Jun 02, 2020 02:00
Abstract Although the prognostic significance of grade in endometrial cancer is well known, grade 2 cases have not been evaluated separately in most of the previous studies. In this study, we aim to investigate whether the oncologic outcomes of grade 2 endometrioid endometrial carcinomas trend towards grade 1 or 3 tumors. Patients’ records and pathological reports were reviewed retrospectively and eligible patients with endometrioid endometrial carcinoma were determined and distributed...
Tue Jun 02, 2020 03:00
Expression, Epigenetic, and Genetic Changes of HNF1B in Colorectal Lesions: an Analysis of 145 Cases
Abstract Hepatocyte nuclear factor 1 beta (HNF1B) is transcription factor which plays a crucial role in the regulation of the development of several organs, but also seems to be implicated in the development of certain tumours, especially the subset of clear cell carcinomas of the ovary and kidney. Depending on the type of the tumour, HNF1B may act as either a tumour suppressor or an oncogene, although the exact mechanism by which HNF1B participates in the process of cancerogenesis...
Mon Jun 01, 2020 03:00
Related ArticlesCandida auris infection in the central catheter of a patient without sepsis symptoms. Colomb Med (Cali). 2019 Dec 30;50(4):293-298 Authors: Castro LÁ, Álvarez MI, Rojas F, Giusiano G, Martínez E Abstract Background: Candida auris is an emerging yeast frequently reported as resistant to multiple antifungal drugs commonly used to treat Candida infections. This specie can colonize the patient's skin and has great ability for producing outbreaks...
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Related ArticlesExtreme Maternal Morbidity: a tracer event to improve the quality of obstetric care in Latin America. Colomb Med (Cali). 2019 Dec 30;50(4):286-292 Authors: Ortiz EI, Herrera E, De La Torre A Abstract This article reviews critical aspects that have had an impact on the implementation of epidemiological surveillance of extreme maternal morbidity, as a tracer event of quality maternal care at population and institutional level; taking into...
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Related ArticlesAn assessment of infant mortality rates in Colombia, 1980-2009. Colomb Med (Cali). 2019 Dec 30;50(4):275-285 Authors: Jaramillo MC, Chernichovsky D, Jiménez Moleón JJ Abstract Purpose: The infant mortality rate is a key indicator of human welfare and development. However, in Colombia, the Departamento Administrativo Nacional de Estadística has set the registered rate for 2009 as 13.69 per 1,000 live births, while the estimated rate is...
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Related ArticlesRisk of infection and disease progression in children exposed to tuberculosis at home, Colombia. Colomb Med (Cali). 2019 Dec 30;50(4):261-274 Authors: Benjumea-Bedoya D, Marín DM, Robledo J, Barrera LF, López L, Del Corral H, Ferro BE, Villegas SL, Díaz ML, Rojas CA, García LF, Arbeláez MP Abstract Aim: To assess the risk of tuberculosis (infection and disease) in children less than 15 years' old who are household contacts of pulmonary...
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Related ArticlesTpeak-Tend, Tpeak-Tend dispersion and Tpeak-Tend/QT in children and its relationship with clinical variables. Colomb Med (Cali). 2019 Dec 30;50(4):252-260 Authors: Castro-Torres Y, Carmona-Puerta R, Chávez-González E, González-Rodríguez EF Abstract Aim: To characterize the Tpeak-Tend, the Tpeak-Tend dispersion and Tpeak-Tend/QT in children and its relationship with clinical variables. Methods: Cross-sectional study in 126 children...
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Related ArticlesAssociation between metabolic syndrome and euthyroid nodular goiter: a case-control study. Colomb Med (Cali). 2019 Dec 30;50(4):239-251 Authors: Mayers RA, Soria Montoya A, Piscoya Rivera A, Silva Caso WG Abstract Background: Metabolic syndrome is a cluster of metabolic abnormalities and abdominal obesity; its pathophysiologic basis, insulin resistance, has been shown to act as agent in thyroid cell proliferation. Few studies analyze...
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Related ArticlesTrends in cancer incidence in Uruguay: 2002 -2015. Colomb Med (Cali). 2019 Dec 30;50(4):224-238 Authors: Garau M, Musetti C, Alonso R, Barrios E Abstract Background: Uruguay is the south American country which has the highest cancer incidence and mortality rates. The National Cancer Registry collects data on cancer cases nationwide since 1989 and has reached high quality standards in the last decades. This is the first report on incidence...
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Related ArticlesEditorial progress of the Colombia Medica Journal. Colomb Med (Cali). 2019 Dec 30;50(4):222-223 Authors: Palacios M PMID: 32476688 [PubMed - in process]
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Abstract Purpose A skeleton named Iuzu has been unearthed from an exceptional middle Holocene burial in Toca dos Coqueiros site, in Serra da Capivara National Park (UNESCO World Heritage Site, Piauí State, Brazil). During a bioarchaeological analysis of its remains, we discovered that Iuzu was suffering from rare vertebral malformations. A double foramen transversaria, the agenesis of a foramen on the atlas and the hypoplasia of the...
Tue Jun 02, 2020 03:00
Phosphatidylserine flippase (P4-ATPase) transports PS from the outer to the inner leaflet of the lipid bilayer in the membrane to maintain PS asymmetry, which is important for biological activities of the cell. ATP11A is expressed in multiple tissues and plays a role in myotube formation. However, the detailed cellular function of ATP11A remains elusive. Mutation analysis revealed that I91, L308, and E897 residues in ATP8A2 are important for flippase activity. In order to investigate the roles of...
Tue Jun 02, 2020 18:20
The incidence of cystic fibrosis (CF) and the frequency of the variants reported for CFTR depend on the population; furthermore, CF symptomatology is characterized by obstructive lung disease and pancreatic insufficiency among other symptoms, which are reliant on the individual's genotype. The Ecuadorian population is a mixture of Native Americans, Europeans, and Africans. That population admixture could be the reason for the new mutations reported in a previous study by Ruiz et al. (2019). A panel...
Tue Jun 02, 2020 16:35
Therapeutic antibodies are one of the most important parts of the pharmaceutical industry. They are widely used in treating various diseases such as autoimmune diseases, cancer, inflammation, and infectious diseases. Their development process however is often brought to a standstill or takes a longer time and is then more expensive due to their hydrophobicity problems. Hydrophobic interactions can cause problems on half-life, drug administration, and immunogenicity at all stages of antibody drug...
Tue Jun 02, 2020 16:05
Background. The purpose of this study was to investigate the effects of upper extremity immobilization and consequent walking speed on spatiotemporal gait parameters in stroke patients with hemiparesis. Methods. The following variables were assessed or measured in 29 stroke patients: age, height, weight, disease duration, Korean version of the Mini-Mental State Examination (MMSE-K), Berg balance scale (BBS-K), functional gait assessment (FGA-K), cause of the disease (type of lesion), and hemiparetic...
Tue Jun 02, 2020 15:50
The Loopamp™ MTBC kit (TB-LAMP) is recommended by WHO for Mycobacterium tuberculosis complex detection in low-income countries with a still low drug-resistant tuberculosis (TB) rate. This study is aimed at testing its feasibility in Cambodia on sputa collected from presumptive tuberculosis patients. 499 samples were tested at a smear microscopy center and 200 at a central-level mycobacteriology laboratory. Using mycobacterial cultures as reference, TB-LAMP results were compared with those of LED...
Tue Jun 02, 2020 12:20
Dexmedetomidine refers to an α2-adrenergic receptor agonist causing potent sedative, analgesic, and minimal respiratory depression compared with alternative drugs. The present study was aimed at comparing the efficaciousness and safety of midazolam and dexmedetomidine as sedatives for dental implantation. We recruited 60 patients belonging to group I or II of the American Society of Anesthesiologists (ASA) and treated them with either midazolam or dexmedetomidine in a random manner. Patients’ duration...
Tue Jun 02, 2020 12:20
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