Antibiotics, Vol. 9, Pages 363: Derivates of the Antifungal Peptide Cm-p5 Inhibit Development of Candida auris Biofilms In Vitro Antibiotics doi: 10.3390/antibiotics9070363 Authors: Dennis Kubiczek Heinz Raber Melaine Gonzalez-García Fidel Morales-Vicente Ludger Staendker Anselmo J. Otero-Gonzalez Frank Rosenau Growth in biofilms as a fascinating and complex microbial lifestyle has become widely accepted as one of the key features of pathogenic microbes, to successfully...
Sat Jun 27, 2020 03:00
Antibiotics, Vol. 9, Pages 362: N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus Antibiotics doi: 10.3390/antibiotics9060362 Authors: Eliana De Gregorio Anna Esposito Adriana Vollaro Maria De Fenza Daniele D’Alonzo Antonella Migliaccio Vita Dora Iula Raffaele Zarrilli Annalisa Guaragna Staphylococcus aureus is one of the major causes of hospital- and community-associated bacterial...
Fri Jun 26, 2020 03:00
Antibiotics, Vol. 9, Pages 361: In Vitro Azole and Amphotericin B Susceptibilities of Malassezia furfur from Bloodstream Infections Using E-Test and CLSI Broth Microdilution Methods Antibiotics doi: 10.3390/antibiotics9060361 Authors: Wafa Rhimi Chioma Inyang Aneke Adriana Mosca Domenico Otranto Claudia Cafarchia The number of reports of Malassezia furfur bloodstream infections is constantly increasing and there is a need for more simple antifungal susceptibility methods...
Fri Jun 26, 2020 03:00
Antibiotics, Vol. 9, Pages 360: Development of a Tailored, Complex Intervention for Clinical Reflection and Communication about Suspected Urinary Tract Infections in Nursing Home Residents Antibiotics doi: 10.3390/antibiotics9060360 Authors: Sif H. Arnold Julie A. Olesen Jette N. Jensen Lars Bjerrum Anne Holm Marius B. Kousgaard Background: Inappropriate antibiotic treatments for urinary tract infections (UTIs) in nursing homes cause the development of resistant bacteria....
Thu Jun 25, 2020 03:00
Antibiotics, Vol. 9, Pages 359: Determination of Delafloxacin in Pharmaceutical Formulations Using a Green RP-HPTLC and NP-HPTLC Methods: A Comparative Study Antibiotics doi: 10.3390/antibiotics9060359 Authors: Prawez Alam Essam Ezzeldin Muzaffar Iqbal Gamal A.E. Mostafa Md. Khalid Anwer Mohammed H. Alqarni Ahmed I. Foudah Faiyaz Shakeel In this work; delafloxacin (DLFX) was determined using a validated green RP-HPTLC and NP-HPTLC methods in commercial tablets and...
Thu Jun 25, 2020 03:00
Antibiotics, Vol. 9, Pages 358: Anti-Bacterial Effects of Essential Oils Against Uropathogenic Bacteria Antibiotics doi: 10.3390/antibiotics9060358 Authors: Loose Pilger Wagenlehner Given the increasing antimicrobial resistance in urinary tract infections (UTI), alternative strategies need to be investigated. Determination of minimal inhibitory and bactericidal concentrations of essential oils from cajeput, lemongrass, tea tree, and thyme in artificial urine, revealed bactericidal...
Thu Jun 25, 2020 03:00
Antibiotics, Vol. 9, Pages 357: Perioperative Antibiotic Prophylaxis: Knowledge and Attitudes among Resident Physicians in Italy Antibiotics doi: 10.3390/antibiotics9060357 Authors: Concetta Paola Pelullo Angela Pepe Francesco Napolitano Nicola Coppola Gabriella Di Giuseppe The aim of this study is to evaluate knowledge and attitudes on the perioperative antibiotic prophylaxis (PAP) among surgery and anesthesiology resident physicians in Italy. A Web-based national survey...
Thu Jun 25, 2020 03:00
Antibodies, Vol. 9, Pages 27: Expression of DOCK9 and DOCK11 Analyzed with Commercial Antibodies: Focus on Regulation of Mutually Exclusive First Exon Isoforms Antibodies doi: 10.3390/antib9030027 Authors: Antonio Parrado Dedicators of cytokinesis 9 and 11 (DOCK9 and DOCK11) are members of the dedicator of cytokinesis protein family encoding the guanosine nucleotide exchange factors for Rho GTPases. Together with DOCK10, they constitute the DOCK-D or Zizimin subfamily. Two alternative...
Sat Jun 27, 2020 03:00
Antibodies, Vol. 9, Pages 28: Ribosome Display Technology: Applications in Disease Diagnosis and Control Antibodies doi: 10.3390/antib9030028 Authors: Adinarayana Kunamneni Christian Ogaugwu Steven Bradfute Ravi Durvasula Antibody ribosome display remains one of the most successful in vitro selection technologies for antibodies fifteen years after it was developed. The unique possibility of direct generation of whole proteins, particularly single-chain antibody fragments (scFvs),...
Sat Jun 27, 2020 03:00
Antioxidants, Vol. 9, Pages 565: Qualitative Aspects of Some of Some Traditional Landraces of the Tomato “Piennolo” (Solanum lycopersicum L.) of the Campania Region, Southern Italy Antioxidants doi: 10.3390/antiox9070565 Authors: Florinda Fratianni Autilia Cozzolino Antonio d’Acierno Filomena Nazzaro Riccardo Riccardi Patrizia Spigno Our study aimed to analyze some qualitative aspects of five landraces of the tomato “Piennolo,” typical of the Vesuvian...
Sun Jun 28, 2020 03:00
Antioxidants, Vol. 9, Pages 564: Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace - Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial Antioxidants doi: 10.3390/antiox9070564 Authors: Choi Lee Cho Lee Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant...
Sat Jun 27, 2020 03:00
Antioxidants, Vol. 9, Pages 562: Carotenoids, Fatty Acids, and Volatile Compounds in Apricot Cultivars from Romania—A Chemometric Approach Antioxidants doi: 10.3390/antiox9070562 Authors: Pintea Dulf Bunea Socaci Pop Opriță Giuffrida Cacciola Bartolomeo Mondello Lipophilic constituents are important for the color and aroma of apricots, but also for their health benefits. In the present study, carotenoids, fatty acids, and volatiles were analyzed in...
Sat Jun 27, 2020 03:00
Antioxidants, Vol. 9, Pages 563: Lindera obtusiloba Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Ovalbumin-Challenged Asthma Antioxidants doi: 10.3390/antiox9070563 Authors: Lee Ha Shin Jeong Kim Lee Park Kwon Jung Lee Ryu Jeong Lee Lindera obtusiloba is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory...
Sat Jun 27, 2020 03:00
Antioxidants, Vol. 9, Pages 559: Vitamin D3 Supplementation in Drinking Water Prior to Slaughter Improves Oxidative Status, Physiological Stress, and Quality of Pork Antioxidants doi: 10.3390/antiox9060559 Authors: Rey Segura Castejón Fernández-Valle Cambero Calvo The aims of this study were to investigate the effect of vitamin D3 administration in drinking water during lairage time prior to slaughter on physiological stress, oxidative status, and pork quality characteristics....
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 558: Effects of Darkness and Light Spectra on Nutrients and Pigments in Radish, Soybean, Mung Bean and Pumpkin Sprouts Antioxidants doi: 10.3390/antiox9060558 Authors: Linda Mastropasqua Nunzio Dipierro Costantino Paciolla Fresh sprouts are an important source of antioxidant compounds and contain useful phytonutrients in the human diet. Many factors, such as the time of germination and types of light, influence the physiological processes and biosynthetic...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 561: Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials Antioxidants doi: 10.3390/antiox9060561 Authors: Garcia-Medina Rubio-Velazquez Foulquie-Moreno Casaroli-Marano Pinazo-Duran Zanon-Moreno del-Rio-Vellosillo Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 560: Platelet-Rich Fibrin Can Neutralize Hydrogen Peroxide-Induced Cell Death in Gingival Fibroblasts Antioxidants doi: 10.3390/antiox9060560 Authors: Kargarpoor Nasirzade Di Summa Panahipour Miron Gruber Hydrogen peroxide is a damage signal at sites of chronic inflammation. The question arises whether platelet-rich fibrin (PRF), platelet-poor plasma (PPP), and the buffy coat can neutralize hydrogen peroxide toxicity and thereby counteract...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 556: Biochemical Characterization of Traditional Varieties of Sweet Pepper (Capsicum annuum L.) of the Campania Region, Southern Italy Antioxidants doi: 10.3390/antiox9060556 Authors: Fratianni d’Acierno Cozzolino Spigno Riccardi Raimo Pane Zaccardelli Tranchida Lombardo Tucci Grillo Coppola Nazzaro Bioactive compounds of different Campania native sweet pepper varieties were evaluated. Polyphenols ranged between...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 555: The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond Antioxidants doi: 10.3390/antiox9060555 Authors: Filice Mazza Leo Gattuso Cerra Imbrogno The extraordinary capacity of the goldfish (Carassius auratus) to increase its cardiac performance under acute hypoxia is crucial in ensuring adequate oxygen supply to tissues and organs. However, the underlying physiological mechanisms are not yet completely...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 557: Antioxidant, Physicochemical, and Cellular Secretion of Glucagon-Like Peptide-1 Properties of Oat Bran Protein Hydrolysates Antioxidants doi: 10.3390/antiox9060557 Authors: Mallory E. Walters William G. Willmore Apollinaire Tsopmo The aim of this work was to determine the physicochemical and biological activities of hydrolyzed proteins from sonicated oat brans. In addition to the control bran sample, two types of pre-treatment procedures—namely,...
Fri Jun 26, 2020 03:00
Antioxidants, Vol. 9, Pages 552: Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria Antioxidants doi: 10.3390/antiox9060552 Authors: Kavindra Kumar Kesari Anupam Dhasmana Shruti Shandilya Neeraj Prabhakar Ahmed Shaukat Jinze Dou Jessica M. Rosenholm Tapani Vuorinen Janne Ruokolainen Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s...
Thu Jun 25, 2020 03:00
Antioxidants, Vol. 9, Pages 553: ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function Antioxidants doi: 10.3390/antiox9060553 Authors: Kiran Chaudhari Jessica M. Wong Philip H. Vann Tori Como Sid E. O’Bryant Nathalie Sumien This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer’s disease risk. Starting at 12 months...
Thu Jun 25, 2020 03:00
Antioxidants, Vol. 9, Pages 551: Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells Antioxidants doi: 10.3390/antiox9060551 Authors: Letizia Pruccoli Fabiana Morroni Giulia Sita Patrizia Hrelia Andrea Tarozzi Oxidative stress (OS) appears to be an important determinant during the different stages of progression of Alzheimer’s Disease (AD). In particular, impaired antioxidant...
Thu Jun 25, 2020 03:00
Antioxidants, Vol. 9, Pages 554: In Vitro Antioxidant, Anti-Inflammatory, Anti-Metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [Levisticum officinale Koch] Elicited with Jasmonic Acid and Yeast Extract Antioxidants doi: 10.3390/antiox9060554 Authors: Jakubczyk Złotek Szymanowska Rybczyńska-Tkaczyk Jęderka Lewicki Lovage seedlings were elicited with jasmonic acid (JA) and yeast extract (YE) to induce the...
Thu Jun 25, 2020 03:00
Atmosphere, Vol. 11, Pages 682: The R Language as a Tool for Biometeorological Research Atmosphere doi: 10.3390/atmos11070682 Authors: Charalampopoulos R is an open-source programming language which gained a central place in the geosciences over the last two decades as the primary tool for research. Now, biometeorological research is driven by the diverse datasets related to the atmosphere and other biological agents (e.g., plants, animals and human beings) and the wide variety of software...
Sun Jun 28, 2020 03:00
Atmosphere, Vol. 11, Pages 683: Physics-Based Simulations of Flow and Fire Development Downstream of a Canopy Atmosphere doi: 10.3390/atmos11070683 Authors: Gilbert Accary Duncan Sutherland Nicolas Frangieh Khalid Moinuddin Ibrahim Shamseddine Sofiane Meradji Dominique Morvan The behavior of a grassland fire propagating downstream of a forest canopy has been simulated numerically using the fully physics-based wildfire model FIRESTAR3D. This configuration reproduces...
Sun Jun 28, 2020 03:00
Atmosphere, Vol. 11, Pages 680: Mapping Climate Change, Natural Hazards and Tokyo’s Built Heritage Atmosphere doi: 10.3390/atmos11070680 Authors: Brimblecombe Hayashi Futagami Although climate change is well recognised as an important issue in Japan, there has been little interest from scientists or the public on the potential threat it poses to heritage. The present study maps the impact of emerging pressures on museums and historic buildings in the Tokyo Area. We examine a...
Sun Jun 28, 2020 03:00
Atmosphere, Vol. 11, Pages 681: Simulation of Climate Change Impacts on Phenology and Production of Winter Wheat in Northwestern China Using CERES-Wheat Model Atmosphere doi: 10.3390/atmos11070681 Authors: Zheng Cai Wang Wang Wheat plays a very important role in China’s agriculture. The wheat grain yields are affected by the growing period that is determined by temperature, precipitation, and field management, such as planting date and cultivar species. Here, we...
Sun Jun 28, 2020 03:00
Atmosphere, Vol. 11, Pages 679: Tornadoes in Portugal: An Overview Atmosphere doi: 10.3390/atmos11070679 Authors: Paula Leitão Paulo Pinto From 2000 onwards, a systematic documentation of tornado reports was maintained at the Portuguese Meteorological Service (IPMA). The characteristics of 195 tornado events over land and at sea off the coast of mainland Portugal, Azores, and Madeira Islands, reported until 2020, were compiled into a new tornado database for Portugal. Each event was...
Sun Jun 28, 2020 03:00
Atmosphere, Vol. 11, Pages 678: Are Empirical Equations an Appropriate Tool to Assess Separation Distances to Avoid Odour Annoyance? Atmosphere doi: 10.3390/atmos11070678 Authors: Brancher Piringer Knauder Wu Griffiths Schauberger Annoyance due to environmental odour exposure is in many jurisdictions evaluated by a yes/no decision. Such a binary decision has been typically achieved via odour impact criteria (OIC) and, when applicable, the resultant separation distances...
Sat Jun 27, 2020 03:00
Atmosphere, Vol. 11, Pages 677: Spatial–Temporal Variation of Cropping Patterns in Relation to Climate Change in Neolithic China Atmosphere doi: 10.3390/atmos11070677 Authors: Ruo Li Feiya Lv Liu Yang Fengwen Liu Ruiliang Liu Guanghui Dong The Neolithic period witnessed the start and spread of agriculture across Eurasia, as well as the beginning of important climate changes which would take place over millennia. Nevertheless, it remains rather unclear in what ways local...
Sat Jun 27, 2020 03:00
Atmosphere, Vol. 11, Pages 676: Machine Learning in Tropical Cyclone Forecast Modeling: A Review Atmosphere doi: 10.3390/atmos11070676 Authors: Rui Chen Weimin Zhang Xiang Wang Tropical cyclones have always been a concern of meteorologists, and there are many studies regarding the axisymmetric structures, dynamic mechanisms, and forecasting techniques from the past 100 years. This research demonstrates the ongoing progress as well as the many remaining problems. Machine learning,...
Sat Jun 27, 2020 03:00
Atmosphere, Vol. 11, Pages 675: Large Variations in N2O Fluxes from Bioenergy Crops According to Management Practices and Crop Type Atmosphere doi: 10.3390/atmos11060675 Authors: Fabien Ferchaud Céline Peyrard Joël Léonard Eric Gréhan Bruno Mary Field N2O emissions are a key point in the evaluation of the greenhouse gas benefits of bioenergy crops. The aim of this study was to investigate N2O fluxes from perennial (miscanthus and switchgrass), semi-perennial (fescue and alfalfa)...
Fri Jun 26, 2020 03:00
Atmosphere, Vol. 11, Pages 674: Policy Framework for Energy Retrofitting of Built Heritage: A Critical Comparison of UK and Turkey Atmosphere doi: 10.3390/atmos11060674 Authors: Jahed Aktaş Rickaby Bilgin Altınöz Energy efficiency is one of the most prominent global challenges of our era. Heritage buildings usually have a poor energy performance, not necessarily because of their intrinsic constructive features but due to their mostly dilapidated condition owed to age and...
Fri Jun 26, 2020 03:00
Atmosphere, Vol. 11, Pages 673: Strategies for Assimilating High-Density Atmospheric Motion Vectors into a Regional Tropical Cyclone Forecast Model (HWRF) Atmosphere doi: 10.3390/atmos11060673 Authors: Lewis Velden Stettner In recent years, atmospheric numerical modeling frameworks and satellite observing systems have both undergone significant advances. While these developments offer considerable potential for improving forecasts of high-impact weather events such as tropical...
Fri Jun 26, 2020 03:00
Atmosphere, Vol. 11, Pages 672: Role of Horizontal Eddy Diffusivity within the Canopy on Fire Spread
Atmosphere, Vol. 11, Pages 672: Role of Horizontal Eddy Diffusivity within the Canopy on Fire Spread Atmosphere doi: 10.3390/atmos11060672 Authors: Yana Bebieva Julia Oliveto Bryan Quaife Nicholas S. Skowronski Warren E. Heilman Kevin Speer Wind profile observations are used to estimate turbulent mixing in the atmospheric boundary layer from 1 m up to 300 m height in two locations of pine forests characteristic of the southeast US region, and to 30 m height at one location...
Fri Jun 26, 2020 03:00
Atmosphere, Vol. 11, Pages 670: Characteristics of DSD Bulk Parameters: Implication for Radar Rain Retrieval Atmosphere doi: 10.3390/atmos11060670 Authors: Liao Meneghini Iguchi Tokay With the use of 213,456 one-minute measured data of droplet-size distribution (DSD) of rain collected during several National Aeronautics and Space Administration (NASA)-sponsored field campaigns, the relationships between rainfall rate R, mass-weighted diameter Dm and normalized intercept...
Thu Jun 25, 2020 03:00
Atmosphere, Vol. 11, Pages 671: Robust Decadal Hydroclimate Predictions for Northern Italy based on a Twofold Statistical Approach Atmosphere doi: 10.3390/atmos11060671 Authors: Rubinetti Taricco Alessio Rubino Bizzarri Zanchettin The Mediterranean area belongs to the regions most exposed to hydroclimatic changes, with a likely increase in frequency and duration of droughts in the last decades. However, many climate records like, e.g., North Italian precipitation...
Thu Jun 25, 2020 03:00
Atmosphere, Vol. 11, Pages 669: Time-Dependent Downscaling of PM2.5 Predictions from CAMS Air Quality Models to Urban Monitoring Sites in Budapest Atmosphere doi: 10.3390/atmos11060669 Authors: Adrienn Varga-Balogh Ádám Leelőssy István Lagzi Róbert Mészáros Budapest, the capital of Hungary, has been facing serious air pollution episodes in the heating season similar to other metropolises. In the city a dense urban air quality monitoring network is available; however, air quality...
Thu Jun 25, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 106: She Thinks in English, But She Wants in Mandarin: Differences in Singaporean Bilingual English–Mandarin Maternal Mental-State-Talk Behavioral Sciences doi: 10.3390/bs10070106 Authors: Michelle Cheng Peipei Setoh Marc H. Bornstein Gianluca Esposito Chinese-speaking parents are believed to use less cognitive mental-state-talk than their English-speaking counterparts on account of their cultural goals in socializing their children to follow...
Sat Jun 27, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 105: A Comparative Study of Problem-Based Learning and Traditional Approaches in College English Classrooms: Analyzing Pedagogical Behaviors Via Classroom Observation Behavioral Sciences doi: 10.3390/bs10060105 Authors: Shifang Tang Manli Long Fuhui Tong Zhuoying Wang Henan Zhang Kara L. Sutton-Jones In this study, we described and compared an English as a foreign language (EFL) teacher’s pedagogical behaviors in traditional...
Fri Jun 26, 2020 03:00
Bioengineering, Vol. 7, Pages 63: Performances of Conventional and Hybrid Fixed Bed Anaerobic Reactors for the Treatment of Aquaculture Sludge Bioengineering doi: 10.3390/bioengineering7030063 Authors: Chiumenti Fait Limina da Borso Aquaculture fish production is experiencing an increasing trend worldwide and determines environmental concerns mainly related to the emission of pollutants. The present work is focused on the improvement of the sustainability of this sector...
Sat Jun 27, 2020 03:00
Bioengineering, Vol. 7, Pages 62: An Uncertainty Modeling Framework for Intracardiac Electrogram Analysis Bioengineering doi: 10.3390/bioengineering7020062 Authors: Amirhossein Koneshloo Dongping Du Yuncheng Du Intracardiac electrograms (EGMs) are electrical signals measured within the chambers of the heart, which can be used to locate abnormal cardiac tissue and guide catheter ablations to treat cardiac arrhythmias. EGMs may contain large amounts of uncertainty and irregular variations,...
Fri Jun 26, 2020 03:00
Biology, Vol. 9, Pages 144: Potassium and Magnesium Mediate the Light and CO2 Photosynthetic Responses of Grapevines Biology doi: 10.3390/biology9070144 Authors: Rogiers Greer Moroni Baby Potassium (K) and magnesium (Mg) deficiency are common stresses that can impact on grape yield and quality, but their effects on photosynthesis have received little attention. Understanding the diffusional and biochemical limitations to photosynthetic constraints will help to guide improvements...
Sun Jun 28, 2020 03:00
Biology, Vol. 9, Pages 143: A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK Biology doi: 10.3390/biology9070143 Authors: Ji-Hoon Jeong Hyunhee Kim Seung-Ho Park Hayeon Park Minseok Jeong Sungmin Kwak Gi-Jun Sung Ji-Hye Song Younghwa Na Kyung-Chul Choi Transforming growth factor-β1 (TGF-β1) is highly expressed in the tumor microenvironment and known to play...
Sun Jun 28, 2020 03:00
Biology, Vol. 9, Pages 142: Inhibition on JNK Mimics Silencing of Wnt-11 Mediated Cellular Response in Androgen-Independent Prostate Cancer Cells Biology doi: 10.3390/biology9070142 Authors: Elif Arisan Ozge Rencuzogullari Buse Keskin Guy Grant Pinar Uysal-Onganer Prostate cancer (PCa) is one of the most common cancers among men, and one of the leading causes of cancer death for men. The c-Jun N-terminal kinase (JNK) pathway is required for several cellular functions, such...
Sat Jun 27, 2020 03:00
Biology, Vol. 9, Pages 140: Mass Spectrometry to Study Chromatin Compaction Biology doi: 10.3390/biology9060140 Authors: Stephanie Stransky Jennifer Aguilan Jake Lachowicz Carlos Madrid-Aliste Edward Nieves Simone Sidoli Chromatin accessibility is a major regulator of gene expression. Histone writers/erasers have a critical role in chromatin compaction, as they “flag” chromatin regions by catalyzing/removing covalent post-translational modifications...
Fri Jun 26, 2020 03:00
Biology, Vol. 9, Pages 141: Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future
Biology, Vol. 9, Pages 141: Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future Biology doi: 10.3390/biology9060141 Authors: Pandey Yadav Pandey Tripathi Khawary Kant Tripathi The COVID-19 pandemic is rising at an unprecedented rate. The surging number of deaths every day, global lockdown and travel restrictions have resulted in huge losses to society. The impact is massive and will leave a historical footprint. The Spanish Flu of 1918, which...
Fri Jun 26, 2020 03:00
Biology, Vol. 9, Pages 139: Spectral Distribution of Ultra-Weak Photon Emission as A Response to Wounding in Plants: An In Vivo Study Biology doi: 10.3390/biology9060139 Authors: Ankush Prasad Prabhakar Gouripeddi Hanumanth Rao Naidu Devireddy Alina Ovsii Dattatreya Prabhu Rachakonda Roeland Van Wijk Pavel Pospíšil It is well established that every living organism spontaneously emits photons referred to as ultra-weak photon emission (synonym biophotons or low-level...
Fri Jun 26, 2020 03:00
Biology, Vol. 9, Pages 138: Kinematic Sub-Populations in Bull Spermatozoa: A Comparison of Classical and Bayesian Approaches Biology doi: 10.3390/biology9060138 Authors: Luis Víquez Vinicio Barquero Carles Soler Eduardo R.S. Roldan Anthony Valverde The ejaculate is heterogenous and sperm sub-populations with different kinematic patterns can be identified in various species. Nevertheless, although these sub-populations are statistically well defined, the statistical differences...
Fri Jun 26, 2020 03:00
Biology, Vol. 9, Pages 137: The Role of Mitochondria in Cardiovascular Diseases Biology doi: 10.3390/biology9060137 Authors: Anastasia V. Poznyak Ekaterina A. Ivanova Igor A. Sobenin Shaw-Fang Yet Alexander N. Orekhov The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a central player in the regulation of cellular metabolism and a powerful controller of cellular fate, mitochondria appear to comprise an interesting potential therapeutic...
Thu Jun 25, 2020 03:00
Biology, Vol. 9, Pages 136: Termite Societies Promote the Taxonomic and Functional Diversity of Archaeal Communities in Mound Soils Biology doi: 10.3390/biology9060136 Authors: Monde Wakung’oli Adenike Eunice Amoo Ben Jesuorsemwen Enagbonma Olubukola Oluranti Babalola Recent studies involving microbial communities in termite mounds have been more focused on bacteria and fungi with little attention given to archaea, which play significant roles in nutrient cycling. Thus, we aimed...
Thu Jun 25, 2020 03:00
Biomedicines, Vol. 8, Pages 181: Identification of Differentially Methylated CpG Sites in Fibroblasts from Keloid Scars Biomedicines doi: 10.3390/biomedicines8070181 Authors: Alghamdi Wallace Melton Moses Stevenson AL-Eitan Rea Duke Danielsen Prêle Wood Fear As a part of an abnormal healing process of dermal injuries and irritation, keloid scars arise on the skin as benign fibroproliferative tumors. Although the etiology of keloid scarring...
Sun Jun 28, 2020 03:00
Biomedicines, Vol. 8, Pages 180: A Mechanism by which Ergosterol Inhibits the Promotion of Bladder Carcinogenesis in Rats Biomedicines doi: 10.3390/biomedicines8070180 Authors: Nobutomo Ikarashi Motohiro Hoshino Tetsuya Ono Takahiro Toda Yasuharu Yazawa Kiyoshi Sugiyama We previously showed that ergosterol has an inhibitory effect on bladder carcinogenesis. In this study, we aimed to elucidate the molecular mechanism by which ergosterol inhibits bladder carcinogenesis...
Sat Jun 27, 2020 03:00
Biomedicines, Vol. 8, Pages 179: Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation Biomedicines doi: 10.3390/biomedicines8070179 Authors: Ghila Bjørlykke Legøy Vethe Furuyama Chera Ræder Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction....
Sat Jun 27, 2020 03:00
Biomedicines, Vol. 8, Pages 178: Defining Parallels between the Salivary Glands and Pancreas to Better Understand Pancreatic Carcinogenesis Biomedicines doi: 10.3390/biomedicines8060178 Authors: Céline Tiffon Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a dismal prognosis, largely due to its late presentation. Methods for early detection, the development of reliable screening tools, and the identification of sensitive and specific biomarkers have remained...
Fri Jun 26, 2020 03:00
Biomedicines, Vol. 8, Pages 176: Hyperthermia Disturbs and Delays Spontaneous Differentiation of Human Embryoid Bodies Biomedicines doi: 10.3390/biomedicines8060176 Authors: Ji Hyun Kwon Hyun Kyu Kim Tae Won Ha Jeong Suk Im Byung Hoo Song Ki Sung Hong Jae Sang Oh Jaeseok Han Man Ryul Lee Various types of stress stimuli have been shown to threaten the normal development of embryos during embryogenesis. Prolonged heat exposure is the most common stressor that poses...
Fri Jun 26, 2020 03:00
Biomedicines, Vol. 8, Pages 177: Carnosine Activates Cellular Stress Response in Podocytes and Reduces Glycative and Lipoperoxidative Stress Biomedicines doi: 10.3390/biomedicines8060177 Authors: Maria Scuto Angela Trovato Salinaro Sergio Modafferi Alessandra Polimeni Tilman Pfeffer Tim Weigand Vittorio Calabrese Claus Peter Schmitt Verena Peters Carnosine improves diabetic complications, including diabetic nephropathy, in in vivo models. To further understand...
Fri Jun 26, 2020 03:00
Biomedicines, Vol. 8, Pages 175: Risk Factors Contributing to the Occurrence and Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus Patients Treated with Direct-Acting Antivirals Biomedicines doi: 10.3390/biomedicines8060175 Authors: Sara Kishta Ashraf Tabll Tea Omanovic Kolaric Robert Smolic Martina Smolic Although hepatitis C virus (HCV) RNA may be eliminated from blood circulation by direct-acting antivirals (DAA) therapy as assessed by real-time polymerase chain...
Thu Jun 25, 2020 03:00
Biomedicines, Vol. 8, Pages 174: Evaluation of Ethnic Variations in Visceral, Subcutaneous, Intra-Pancreatic, and Intra-Hepatic Fat Depositions by Magnetic Resonance Imaging among New Zealanders Biomedicines doi: 10.3390/biomedicines8060174 Authors: John Zhiyong Yang Dech Dokpuang Reza Nemati Kevin Haokun He Andy Baige Zheng Maxim S. Petrov Jun Lu Anthropometric indices, such as body mass index (BMI), waist circumference (WC), and waist to height ratio (WHtR), have...
Thu Jun 25, 2020 03:00
Biomedicines, Vol. 8, Pages 173: The Percentage of Free PSA and Urinary Markers Distinguish Prostate Cancer from Benign Hyperplasia and Contribute to a More Accurate Indication for Prostate Biopsy Biomedicines doi: 10.3390/biomedicines8060173 Authors: Zlata Huskova Jana Knillova Zdenek Kolar Jana Vrbkova Milan Kral Jan Bouchal The main advantage of urinary biomarkers is their noninvasive character and the ability to detect multifocal prostate cancer (CaP). We have previously...
Thu Jun 25, 2020 03:00
Biomimetics, Vol. 5, Pages 30: Fibrillar Collagen Type I Participates in the Survival and Aggregation of Primary Hepatocytes Cultured on Soft Hydrogels Biomimetics doi: 10.3390/biomimetics5020030 Authors: Nathalia Serna-Márquez Adriana Rodríguez-Hernández Marisol Ayala-Reyes Lorena Omega Martínez-Hernández Miguel Ángel Peña-Rico Jorge Carretero-Ortega Mathieu Hautefeuille Genaro Vázquez-Victorio Liver is an essential organ that carries out multiple functions such...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 972: Evaluation of Resin-Based Material Containing Copaiba Oleoresin (Copaifera Reticulata Ducke): Biological Effects on the Human Dental Pulp Stem Cells Biomolecules doi: 10.3390/biom10070972 Authors: Couto Rodrigues Ferreira Diniz Silva Lopez Lima Marques The purpose of this study was to analyze in vitro the biological effects on human dental pulp stem cells triggered in response to substances leached or dissolved from two experimental...
Sun Jun 28, 2020 03:00
Biomolecules, Vol. 10, Pages 971: Validation of a Novel Zebrafish Model of Dengue Virus (DENV-3) Pathology Using the Pentaherbal Medicine Denguenil Vati Biomolecules doi: 10.3390/biom10070971 Authors: Balkrishna Solleti Verma Varshney Dengue is a devastating viral fever of humans, caused by dengue virus. Using a novel zebrafish model of dengue pathology, we validated the potential anti-dengue therapeutic properties of pentaherbal medicine, Denguenil Vati. At two different...
Sun Jun 28, 2020 03:00
Biomolecules, Vol. 10, Pages 970: Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs Biomolecules doi: 10.3390/biom10070970 Authors: Lai Chiang Hsu Cheng Chen Fucoidan, a natural sulfated polysaccharide, which can activate the immune response and lessen adverse effects, is expected to be an adjuvant agent in combination with chemotherapy. Using...
Sun Jun 28, 2020 03:00
Biomolecules, Vol. 10, Pages 973: Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors Biomolecules doi: 10.3390/biom10070973 Authors: Hagerty Pegna Xu Tai Alewine Mesothelin (MSLN) is a cell surface glycoprotein normally expressed only on serosal surfaces, and not found in the parenchyma of vital organs. Many solid tumors also express MSLN, including mesothelioma and pancreatic adenocarcinoma. Due to this favorable expression profile, MSLN represents a viable...
Sun Jun 28, 2020 03:00
Biomolecules, Vol. 10, Pages 969: TOP mRNPs: Molecular Mechanisms and Principles of Regulation Biomolecules doi: 10.3390/biom10070969 Authors: Cockman Anderson Ivanov The cellular response to changes in the surrounding environment and to stress requires the coregulation of gene networks aiming to conserve energy and resources. This is often achieved by downregulating protein synthesis. The 5' Terminal OligoPyrimidine (5' TOP) motif-containing mRNAs, which encode proteins that...
Sat Jun 27, 2020 03:00
Biomolecules, Vol. 10, Pages 968: Co-Delivery of Imiquimod and Curcumin by Nanoemugel for Improved Topical Delivery and Reduced Psoriasis-Like Skin Lesions Biomolecules doi: 10.3390/biom10070968 Authors: Algahtani Ahmad Nourein Ahmad The current investigation aimed to improve the topical efficacy of imiquimod in combination with curcumin using the nanoemulsion-based delivery system through a combinatorial approach. Co-delivery of curcumin acts as an adjuvant therapeutic...
Sat Jun 27, 2020 03:00
Biomolecules, Vol. 10, Pages 967: Transcriptome Analysis Reveals Potential Roles of Abscisic Acid and Polyphenols in Adaptation of Onobrychis viciifolia to Extreme Environmental Conditions in the Qinghai-Tibetan Plateau Biomolecules doi: 10.3390/biom10060967 Authors: Hengxia Yin Huakun Zhou Wenying Wang Lam-Son Phan Tran Benyin Zhang A detailed understanding of the molecular mechanisms of plant stress resistance in the face of ever-changing environmental stimuli will be helpful...
Fri Jun 26, 2020 03:00
Biomolecules, Vol. 10, Pages 965: Vibrational Spectroscopy of Peritoneal Dialysis Effluent for Rapid Assessment of Patient Characteristics Biomolecules doi: 10.3390/biom10060965 Authors: Tom Grunert Rebecca Herzog Florian M. Wiesenhofer Andreas Vychytil Monika Ehling-Schulz Klaus Kratochwill Peritoneal dialysis (PD) offers specific advantages over hemodialysis, enabling increased autonomy of patients with end-stage renal disease, but PD-related complications need to be...
Fri Jun 26, 2020 03:00
Biomolecules, Vol. 10, Pages 966: Encapsulins—Bacterial Protein Nanocompartments: Structure, Properties, and Application Biomolecules doi: 10.3390/biom10060966 Authors: Anna N. Gabashvili Nelly S. Chmelyuk Maria V. Efremova Julia A. Malinovskaya Alevtina S. Semkina Maxim A. Abakumov Recently, a new class of prokaryotic compartments, collectively called encapsulins or protein nanocompartments, has been discovered. The shell proteins of these structures self-organize to...
Fri Jun 26, 2020 03:00
Biomolecules, Vol. 10, Pages 964: Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation Biomolecules doi: 10.3390/biom10060964 Authors: Yves Jossin During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway...
Fri Jun 26, 2020 03:00
Biomolecules, Vol. 10, Pages 963: Concise Polygenic Models for Cancer-Specific Identification of Drug-Sensitive Tumors from Their Multi-Omics Profiles Biomolecules doi: 10.3390/biom10060963 Authors: Naulaerts Menden Ballester Abstract: In silico models to predict which tumors will respond to a given drug are necessary for Precision Oncology. However, predictive models are only available for a handful of cases (each case being a given drug acting on tumors of a specific cancer...
Fri Jun 26, 2020 03:00
Biomolecules, Vol. 10, Pages 961: The English (H6R) Mutation of the Alzheimer’s Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation Biomolecules doi: 10.3390/biom10060961 Authors: Sergey P. Radko Svetlana A. Khmeleva Dmitry N. Kaluzhny Olga I. Kechko Yana Y. Kiseleva Sergey A. Kozin Vladimir A. Mitkevich Alexander A. Makarov The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 957: Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation Biomolecules doi: 10.3390/biom10060957 Authors: Cristina Mas-Bargues Jorge Sanz-Ros Aurora Román-Domínguez Lucia Gimeno-Mallench Marta Inglés José Viña Consuelo Borrás Aging is accompanied by the accumulation of senescent cells that alter intercellular communication, thereby impairing tissue...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 962: Prolyl Endopeptidase-Like Facilitates the α-Synuclein Aggregation Seeding, and This Effect Is Reverted by Serine Peptidase Inhibitor PMSF Biomolecules doi: 10.3390/biom10060962 Authors: Gabriel S. Santos William Y. Oyadomari Elizangela A. Carvalho Ricardo S. Torquato Vitor Oliveira The aggregation of α-synuclein (α-Syn) is a characteristic of Parkinson’s disease (PD). α-Syn oligomerization/aggregation...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 959: Ethylene: A Master Regulator of Salinity Stress Tolerance in Plants Biomolecules doi: 10.3390/biom10060959 Authors: Riyazuddin Riyazuddin Radhika Verma Kalpita Singh Nisha Nisha Monika Keisham Kaushal Kumar Bhati Sun Tae Kim Ravi Gupta Salinity stress is one of the major threats to agricultural productivity across the globe. Research in the past three decades, therefore, has focused on analyzing the effects of salinity stress on...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 960: The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases Biomolecules doi: 10.3390/biom10060960 Authors: Zhao Liu Roderick J. Tan Youhua Liu Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but upregulated...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 958: The Hyperoxic-Hypoxic Paradox Biomolecules doi: 10.3390/biom10060958 Authors: Amir Hadanny Shai Efrati Effective metabolism is highly dependent on a narrow therapeutic range of oxygen. Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene expression, metabolic changes, and regenerative processes, including angiogenesis and stimulation of stem cell proliferation, migration, and differentiation. The sensing of...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 956: Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors Biomolecules doi: 10.3390/biom10060956 Authors: Felix Oh Jaime F. Modiano Veronika Bachanova Daniel A. Vallera Ligand-targeted toxins (LTTs) are bioengineered molecules which are composed of a targeting component linked to a toxin that induces cell death once the LTT binds its target. Bispecific targeting allows for the simultaneous targeting...
Thu Jun 25, 2020 03:00
Biomolecules, Vol. 10, Pages 955: Rapid Evaluation of Antibody Fragment Endocytosis for Antibody Fragment–Drug Conjugates Biomolecules doi: 10.3390/biom10060955 Authors: Eunhee G. Kim Jieun Jeong Junghyeon Lee Hyeryeon Jung Minho Kim Yi Zhao Eugene C. Yi Kristine M. Kim Antibody–drug conjugates (ADCs) have emerged as the most promising strategy in targeted cancer treatment. Recent strategies for the optimization ADCs include the development of antibody...
Thu Jun 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 407: Optimized Protocol to Generate Spinal Motor Neuron Cells from Induced Pluripotent Stem Cells from Charcot Marie Tooth Patients Brain Sciences doi: 10.3390/brainsci10070407 Authors: Pierre-Antoine Faye Nicolas Vedrenne Federica Miressi Marion Rassat Sergii Romanenko Laurence Richard Sylvie Bourthoumieu Benoît Funalot Franck Sturtz Frederic Favreau Anne-Sophie Lia Modelling rare neurogenetic diseases to develop new therapeutic...
Sat Jun 27, 2020 03:00
Brain Sciences, Vol. 10, Pages 406: Evaluating the Impact of Age, Acoustic Exposure, and Electrical Stimulation on Binaural Sensitivity in Adult Bilateral Cochlear Implant Patients Brain Sciences doi: 10.3390/brainsci10060406 Authors: Tanvi Thakkar Sean R. Anderson Alan Kan Ruth Y. Litovsky Deafness in both ears is highly disruptive to communication in everyday listening situations. Many individuals with profound deafness receive bilateral cochlear implants (CIs) to gain access...
Fri Jun 26, 2020 03:00
Brain Sciences, Vol. 10, Pages 405: Incubation of Negative Affect during Protracted Alcohol Withdrawal Is Age-, but Not Sex-Selective Brain Sciences doi: 10.3390/brainsci10060405 Authors: C. Leonardo Jimenez Chavez Michal A. Coelho Lindsey W. Brewin Isaiah Swauncy Tori Tran Taylor Albanese Angie Laguna Ivette Gabriela Karen K. Szumlinski A prior history of excessive drinking induces a negative affective state in both humans and laboratory rodents, the manifestation...
Fri Jun 26, 2020 03:00
Brain Sciences, Vol. 10, Pages 403: Neurodynamics of Patients during a Dolphin-Assisted Therapy by Means of a Fractal Intraneural Analysis Brain Sciences doi: 10.3390/brainsci10060403 Authors: Oswaldo Morales Matamoros Jesús Jaime Moreno Escobar Tejeida Padilla Lina Reyes The recent proliferation of sensor technology applications in therapies to children disabilities to promote positive behavior among such children has produced optimistic results in developing a variety of...
Thu Jun 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 404: The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task Brain Sciences doi: 10.3390/brainsci10060404 Authors: Claire V. Warren María J. Maraver Alberto de Luca Bruno Kopp Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to...
Thu Jun 25, 2020 03:00
Cancers, Vol. 12, Pages 1719: Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes Cancers doi: 10.3390/cancers12071719 Authors: Lavelle Alver Heintz Wernhoff Nygaard Nakken Øy Bøe Urbanucci Hovig The MC1R/cAMP/MITF pathway is a key determinant for growth, differentiation, and survival of melanocytes and melanoma. MITF-M is the melanocyte-specific isoform of Microphthalmia-associated Transcription Factor (MITF) in human melanoma....
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1718: Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial–Mesenchymal Transition Score in Prognosis Prediction Cancers doi: 10.3390/cancers12071718 Authors: Ko Lai Hsu Wang Su Chen Tsai Wu Hsiao Chang Wu Robinson Lin Lin In many solid tumors, tissue of the mesenchymal subtype is frequently associated with epithelial–mesenchymal transition (EMT), strong stromal infiltration, and poor...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1720: Design, Implementation, Evaluation and Application of a 32-Channel Radio Frequency Signal Generator for Thermal Magnetic Resonance Based Anti-Cancer Treatment Cancers doi: 10.3390/cancers12071720 Authors: Han Eigentler Wang Kretov Winter Hoffmann Grass Niendorf Thermal Magnetic Resonance (ThermalMR) leverages radio frequency (RF)-induced heating to examine the role of temperature in biological systems and disease. To advance...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1715: Efficacy of Panitumumab and Cetuximab in Patients with Colorectal Cancer Previously Treated with Bevacizumab; a Combined Analysis of Individual Patient Data from ASPECCT and WJOG6510G Cancers doi: 10.3390/cancers12071715 Authors: Taniguchi Yamanaka Sakai Muro Yamazaki Nakata Kimura Ruff Kim Peeters Price Background: Phase-III ASPECCT and randomised phase-II WJOG6510G trials demonstrated the noninferiority of panitumumab,...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1717: The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner Cancers doi: 10.3390/cancers12071717 Authors: Deville Vehlow Förster Dickreuter Borgmann Cordes The treatment resistance of cancer cells is a multifaceted process in which DNA repair emerged as a potential therapeutic target. DNA repair is predominantly conducted by nuclear events; yet, how extra-nuclear cues impact the DNA damage response...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1713: DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome Cancers doi: 10.3390/cancers12071713 Authors: Tomasova Cumova Seborova Horak Koucka Vodickova Vaclavikova Vodicka There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, highpenetrance germline mutations in DNA repair genes are important...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1714: Current and Future Treatments in the Fight Against Non-Alcoholic Fatty Liver Disease Cancers doi: 10.3390/cancers12071714 Authors: Smeuninx Boslem Febbraio Obesity is recognised as a risk factor for many types of cancers, in particular hepatocellular carcinoma (HCC). A critical factor in the development of HCC from non-alcoholic fatty liver disease (NAFLD) is the presence of non-alcoholic steatohepatitis (NASH). Therapies aimed at NASH to reduce...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1712: Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling Cancers doi: 10.3390/cancers12071712 Authors: Zupančič Korać-Prlić Kreft Franković Vilović Jeruc Romih Terzić Urinary bladder cancer is one of the leading malignancies worldwide, with the highest recurrence rates. A diet rich in vitamin A has proven to lower the risk of cancer, yet the molecular mechanisms underlying this effect...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1711: Single-Drug Approach with Edoxaban is Effective for Resolving Non-Acute Cancer-Associated Venous Thrombosis: A Single-Arm Retrospective Analysis Cancers doi: 10.3390/cancers12071711 Authors: Toshima Hisamatsu Kobayashi Ishida Shimada Recently, cancer-related venous thromboembolism (VTE) has been termed “cancer-associated thrombosis (CAT)” and is the focus of current research. We retrospectively investigated the efficacy...
Sun Jun 28, 2020 03:00
Cancers, Vol. 12, Pages 1710: Stratifying Brain Tumour Histological Sub-Types: The Application of ATR-FTIR Serum Spectroscopy in Secondary Care Cancers doi: 10.3390/cancers12071710 Authors: James M. Cameron Christopher Rinaldi Holly J. Butler Mark G Hegarty Paul M. Brennan Michael D. Jenkinson Khaja Syed Katherine M. Ashton Timothy P. Dawson David S. Palmer Matthew J. Baker Patients living with brain tumours have the highest average years of life lost of...
Sat Jun 27, 2020 03:00
Cancers, Vol. 12, Pages 1707: Multi-Habitat Radiomics Unravels Distinct Phenotypic Subtypes of Glioblastoma with Clinical and Genomic Significance Cancers doi: 10.3390/cancers12071707 Authors: Seung Won Choi Hwan-ho Cho Harim Koo Kyung Rae Cho Karl-Heinz Nenning Georg Langs Julia Furtner Bernhard Baumann Adelheid Woehrer Hee Jin Cho Jason K. Sa Doo-Sik Kong Ho Jun Seol Jung-il Lee Do-hyun Nam Hyunjin Park We aimed to evaluate the potential...
Sat Jun 27, 2020 03:00
Cancers, Vol. 12, Pages 1708: Protein Conformational Changes in Breast Cancer Sera Using Infrared Spectroscopic Analysis Cancers doi: 10.3390/cancers12071708 Authors: Hemendra Ghimire Chakravarthy Garlapati Emiel A. M. Janssen Uma Krishnamurti Gengsheng Qin Ritu Aneja A. G. Unil Perera Protein structural alterations, including misfolding and aggregation, are a hallmark of several diseases, including cancer. However, the possible clinical application of protein conformational...
Sat Jun 27, 2020 03:00
Cancers, Vol. 12, Pages 1706: Targeting the Redox Landscape in Cancer Therapy Cancers doi: 10.3390/cancers12071706 Authors: Narayanan Ma Özcelik Reactive oxygen species (ROS) are produced predominantly by the mitochondrial electron transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum. The antioxidative defense counters overproduction of ROS with detoxifying enzymes and molecular scavengers, for instance, superoxide dismutase and glutathione,...
Sat Jun 27, 2020 03:00
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