Tomato brown rugose fruit virus (ToBRFV) is a Tobamovirus that was first observed in 2014 and 2015 on tomato plants in Israel and Jordan causing discolorations and deformation of leaves and fruits. Apart from tomato, damage in pepper fruits has been reported. Since the first description, the virus has been found on all continents except Oceania and Antarctica. In October 2019, the Dutch National Plant Protection Organization received a tomato sample suspected to be infected with ToBRFV as part of...
Tue Jun 02, 2020 03:00
Background: The circadian clock is a biological timing system that improves the ability of organisms to deal with environmental fluctuations. At the molecular level it consists of a network of transcription-translation feedback loops, involving genes that activate (bmal and clock - positive loop) and repress expression (cryptochrome (cry) and period (per) - negative loop). This is regulated by daily alternations of light but can also be affected by temperature. Fish, as ectothermic, depend on the...
Tue Jun 02, 2020 03:00
Background: Grade I meningiomas are generally benign and non-invasive whereas Grade II (atypical) and Grade III (malignant) meningiomas tend to be invasive with a high risk of recurrence. SPARC, secreted protein, acidic and rich in cysteine, is a multifunctional glycoprotein which has been proposed to be a potential diagnostic marker of invasive meningiomas. There has been increased reporting of atypical meningiomas since the current World Health Organization (WHO) included brain invasion as a grading...
Tue Jun 02, 2020 20:04
Aim: To assess the prognostic significance of nucleolar morphological parameters in a large cohort of patients with uveal melanoma. Patients and Methods: The presence, size and number of nucleoli of cancer cells were assessed in haematoxylin and eosin (HE)-stained slides of 164 formalin-fixed paraffin-embedded primary uveal melanoma tissue specimens. The results were correlated with clinicopathological features and patient survival. Results: The presence of macronucleoli and multiple nucleoli significantly...
Tue Jun 02, 2020 20:04
Background/Aim: C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway. We examined whether this signaling pathway...
Tue Jun 02, 2020 20:04
Background/Aim: Exosomes are produced by normal and cancer cells. Exosomes are found in the serum of cancer patients and have been used for diagnosis and prognosis. Recently tears from non-cancer patients have been found to contain exosomes. In the present report we describe tears from advanced breast-cancer patients. Materials and Methods: We found oncogenic miRNAs in the exosomes isolated from tear fluids obtained from five patients with metastatic breast cancer and compared them with tear exosomes...
Tue Jun 02, 2020 20:04
The idea of utilizing poly-ADP-ribose polymerase inhibitors (PARPi) as therapeutics for cancer has grown in popularity since its original approval for clinical usage in treatment of BRCA DNA repair-associated-mutated ovarian cancer. In this study, we evaluated experimental data regarding in vitro studies utilizing PARPi as a treatment for tyrosine kinase (TK)-dependent leukemia. Studies from 2015 to 2019 were compiled and the ones with most relevant TK pathways and PARP inhibition were analyzed....
Tue Jun 02, 2020 20:04
Background/Aim: Head and neck squamous cell carcinoma affects nearly 500,000 people annually. Augmenting PPAR functional activation is linked with multiple anti-carcinogenic processes in aerodigestive cell lines and animal models. PPAR/RXRα heterodimers may be key partners in this activation. Materials and Methods: CA 9-22 and NA cell lines were treated with the PPAR agonist ciglitazone and/or the RXRα agonist 9-cis-retinoic acid. PPAR functional activation, cellular proliferation, apoptosis activity,...
Tue Jun 02, 2020 20:04
Endometrial cancer is the most common gynecologic malignancy. The mainstay of treatment for endometrial cancer is total hysterectomy with bilateral salpingo-oophorectomy. Radiation and chemotherapy accompanied with progestins can also play a significant role in treatment. Lower urinary tract symptoms (LUTS) following therapy for endometrial cancer are an extremely difficult and challenging condition that deteriorates patients' quality of life. Current literature remains rather scarce regarding LUTS...
Tue Jun 02, 2020 20:04
Perineural invasion (PNI) is detected in 7.0-35.1% of cervical carcinomas. This histological finding correlates with cervical invasion, lymph-vascular space invasion (LVSI), tumor size, positive resection margins, parametrial invasion, node metastases and advanced stage. Some authors have reported that PNI has no prognostic relevance, others have found that PNI is related to disease-free survival or overall survival (OS) at univariate analysis, and others have observed that it is an independent poor...
Tue Jun 02, 2020 20:04
Background/Aim: Recent studies have demonstrated the inferior overall survival outcomes of patients with early-stage cervical cancer who undergo minimally invasive surgery (MIS). One possible explanation for these unexpected results is intraoperative tumor manipulation. Materials and Methods: Considering this hypothesis, we have reviewed the literature on the oncological outcomes of patients with villoglandular adenocarcinoma (VGA) of the cervix, an uncommon variant of cervical cancer that has an...
Tue Jun 02, 2020 20:04
Over the past few decades, longevity without disease has become an important topic worldwide. However, as life expectancy increases, the number of patients with cancer is also increasing. Tumor progression is related to interactions between tumor cells and mesenchymal stem cells (MSCs) in the tumor microenvironment. MSCs are multipotent stromal cells known to be present in a variety of locations in the body, including bones, cartilage, fat, muscles, and dental pulp. MSCs migrate toward inflamed areas...
Tue Jun 02, 2020 20:04
Background/Aim: To evaluate the improvement in the prognosis by adjuvant trastuzumab in clinical practice and the risk factors for distant recurrence, we retrospectively investigated the prognosis of HER2-positive early breast cancer in our department before and after the introduction of adjuvant trastuzumab. Patients and Methods: Cohorts A and B included 161 and 182 cases, respectively, who underwent surgery before (2000-2007) and after (2008-2015) the introduction of adjuvant trastuzumab. Results:...
Tue Jun 02, 2020 20:04
Biliary tract cancer (BTC) patients usually have poor prognosis. Whereas combination chemotherapy has been shown to improve survival in the frontline setting, second-line treatment is subject to a lot of debate in the scientific community. Recent data of the ABC-06 trial has provided slight evidence for the use of second-line chemotherapy after progression on cisplatin plus gemcitabine combination. In this study, mFOLFOX plus active symptom control (ASC) improved overall survival (OS) after progression...
Tue Jun 02, 2020 20:04
Background/Aim: A variety of self-tests addressing individual skin cancer risk are available online. These are generally based on self-estimated measures, such as self-rated skin sensitivity to sun exposure, affecting its reliability. The aim of this study was to investigate whether the addition of objective variables, by means of ultraviolet (UV) sensitivity phototesting and nevi count, could be of contributory value for the composition of a comprehensive risk score for skin cancer, and whether...
Tue Jun 02, 2020 20:04
Publication date: July 2020Source: Cortex, Volume 128Author(s):
Tue Jun 02, 2020 22:10
Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Atefeh Vejdani Noghreiyan, Armin Imanparast, Elham Shayesteh Ara, Samaneh Soudmand, Vajiheh Vejdani Noghreiyan, Ameneh Sazgarnia
Tue Jun 02, 2020 21:56
Publication date: Available online 1 June 2020Source: Pathology - Research and PracticeAuthor(s): Zhi-Yun Zhang, Meng Lu, Ze-Kun Liu, Hao Li, Yu-Le Yong, Ren-Yu Zhang, Zhi-Nan Chen, Huijie Bian
Tue Jun 02, 2020 21:50
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Xin Song, Tailin Xu, Yongchao Song, Xuecheng He, Dongdong Wang, Conghui Liu, Xueji Zhang
Tue Jun 02, 2020 21:27
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Ning Li, Shuzhen Dou, Lei Feng, Qunyan Zhu, Nan Lu
Tue Jun 02, 2020 21:27
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Chao Wang, Yequan Chen, Dmytro Snizhko, Fangxin Du, Xiangui Ma, Baohua Lou, Jianping Li, Guobao Xu
Tue Jun 02, 2020 21:27
Publication date: 1 October 2020Source: Talanta, Volume 218Author(s): Yaru Zhang, Ji Ma, Xing Na, Yunbin Shao, Jixin Liu, Xuefei Mao, Guoying Chen, Di Tian, Yongzhong Qian
Tue Jun 02, 2020 21:27
Abstract Objectives To assess the utility of MDCT tumor–vascular interface criteria for predicting vascular invasion and resectability in borderline pancreatic cancer (BRPC) patients after neoadjuvant therapy (NAT). Methods This prospective study included 90 patients with BRPC who finished NAT, showed no progression in preoperative CTs and underwent surgery....
Mon Jun 01, 2020 03:00
Abstract Purpose To evaluate the usefulness of the advanced monoenergetic imaging (AMI) reconstruction technique for dual-energy computed tomography to evaluate endoleaks after endovascular stent-graft placement. Materials and methods Ninety-five dual-phase (early and delayed phases) enhanced CT examinations were performed for 60 patients who underwent endovascular...
Tue Jun 02, 2020 03:00
Publication date: Available online 1 June 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Wen Long, Xiaobao Gong, Yixin Yang, Kai Yang
Tue Jun 02, 2020 21:24
Publication date: Available online 1 June 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Salvatore Sembronio, Alessandro Tel, Giovanna Perrotti, Massimo Robiony
Tue Jun 02, 2020 21:24
Publication date: Available online 1 June 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Amerigo Giudice, Selene Barone, Federica Diodati, Alessandro Antonelli, Riccardo Nocini, Maria Giulia Cristofaro
Tue Jun 02, 2020 21:24
This protocol describes best practices for calibrating a vector network analyzer prior to use as an accurate instrument, intended to measure components of a radio frequency propagation measurement test system.
Tue Jun 02, 2020 21:00
This protocol is designed for the imaging and analysis of the dynamics of cell orientation and tissue growth in the Drosophila abdominal epithelia as the fruit fly undergoes metamorphosis. The methodology described here can be applied to the study of different developmental stages, tissues, and subcellular structures in Drosophila or other model organisms.
Tue Jun 02, 2020 20:13
The present report highlights chronological requirements for extracellular vesicle (EV) isolation from microglia or blood macrophages. Microglia-derived EVs were evaluated as regulators of the neurite outgrowth while blood macrophage-derived EVs were studied in the control of C6 glioma cell invasion in in vitro assays. The goal is to better understand these EV functions as immune mediators in specific microenvironments.
Tue Jun 02, 2020 20:00
Abstract Background Pericoronal radiolucent lesions are a common radiographic finding, but it is rare that they occur in multiple forms. Multiple calcifying hyperplastic dental follicles (MCHDF) are entities with few cases described to date; nevertheless, they appear to have a very particular phenotypic pattern. Cases presentation Case...
Mon Jun 01, 2020 03:00
Abstract Background As the strategies proposed for oral health improvement in developed countries are not adapted for developing ones, this study aimed to identify the challenges of oral health policy implementation in Iran as a low-income developing country. Methods This qualitative study was conducted in 2019 in Iran as a middle-eastern...
Mon Jun 01, 2020 03:00
Abstract Background Three-dimensional (3D) printing is widely used in the fabrication of dental prostheses; however, the influence of dental materials used for 3D printing on temporary restoration of fibroblasts in tissues is unclear. Thus, the influence of different dental materials on fibroblasts were investigated. Methods Digital light...
Mon Jun 01, 2020 03:00
Staphylococcus agnetis has been previously associated with subclinical or clinically mild cases of mastitis in dairy cattle and is one of several staphylococcal species that have been isolated from the bones and blood of lame broilers. We reported that S. agnetis could be obtained frequently from bacterial chondronecrosis with osteomyelitis (BCO) lesions of lame broilers (A. Al-Rubaye et al., PLoS One 10:e0143336, 2015 [https://doi.org/10.1371/journal.pone.0143336]). A particular isolate, S. agnetis...
Tue Jun 02, 2020 18:00
Abstract Better prognostication/stratification of pancreatic neuroendocrine tumors (PanNETs) is needed. In this detailed morpheomic study of 163 resected PanNETs, 11 unusual variants, some of which were not previously recognized, and others scarcely documented in the literature, were identified, and their pathologic characteristics were further analyzed. By behavior and clinicopathologic associations, these variants could be grouped into three prognostically different categories....
Mon Jun 01, 2020 03:00
Abstract Osteoarthritis (OA), in which inflammation plays a crucial role, is the most common joint disease characterized by cartilage degradation. Neferine (Nef), a dibenzyl isoquinoline alkaloid, has shown its anti-inflammatory effects on other inflammatory diseases. Therefore, we hypothesized that Nef might also have an anti-inflammatory effect on OA and explored its effect on IL-1β-treated rat chondrocytes. Sprague Dawley (SD) rat...
Tue Jun 02, 2020 03:00
Abstract To better understand the acute inflammatory mechanisms, the modulation, and to investigate the key node in predicting inflammatory diseases, high-sensitivity LC-MS/MS-based proteomics and phosphoproteomics approaches were used to identify differential proteins in RAW264.7 macrophages with lipopolysaccharide (LPS). Furthermore, differential proteins and their main biological process, as well as signaling pathways, were analyzed...
Tue Jun 02, 2020 03:00
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