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Sat Jun 27, 2020 13:54
Related Articles Shine Brightly as We Write Our Story:: The global coronavirus pandemic has overtaken our world and our lives in unfathomable ways, and we are all experiencing it in our own unique manner. J Acad Nutr Diet. 2020 Jul;120(7):1117 Authors: Farr LT PMID: 32586605 [PubMed - in process]
Sat Jun 27, 2020 13:54
Related Articles Resistance mechanisms to immune checkpoints blockade by monoclonal antibody drugs in cancer immunotherapy: Focus on myeloma. J Cell Physiol. 2020 Jun 27;: Authors: Isazadeh A, Hajazimian S, Garshasbi H, Shadman B, Baghbanzadeh A, Chavoshi R, Taefehshokr S, Farhoudi Sefidan Jadid M, Hajiasgharzadeh K, Baradaran B Abstract Multiple myeloma (MM) is a clonal B-cell malignancy characterized by the accumulation of neoplastic proliferation...
Sun Jun 28, 2020 15:34
Related Articles Absence of the MFG-E8 gene prevents hypoxia-induced pulmonary hypertension in mice. J Cell Physiol. 2020 Jun 27;: Authors: Wang J, Wu J, Zhu X, Chen J, Zhao J, Xu Y, Xie J Abstract Pulmonary hypertension (PH) is a chronic vascular disease characterized by elevated pulmonary arterial resistance and vascular remodeling, and chronic hypoxia plays an important role in PH. Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein...
Sun Jun 28, 2020 15:34
Related Articles Hsa_circ_001988 attenuates GC progression in vitro and in vivo via sponging miR-197-3p. J Cell Physiol. 2020 Jun 27;: Authors: Sun D, Wang G, Xiao C, Xin Y Abstract Hsa_circ_001988 has been identified as a tumor suppressor gene in several carcinomas. However, its expression pattern and role in gastric cancer (GC) have still remained elusive. This study aimed to explore the functions of hsa_circ_001988 in GC. Quantitative reverse...
Sun Jun 28, 2020 15:34
Related Articles LncRNA SNHG1 contributes to the regulation of acute myeloid leukemia cell growth by modulating miR-489-3p/SOX12/Wnt/β-catenin signaling. J Cell Physiol. 2020 Jun 27;: Authors: Li C, Gao Q, Wang M, Xin H Abstract The long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is a critical regulator for the development and progression of multiple tumors. Yet, the role of SNHG1 in acute myeloid leukemia (AML) is unknown....
Sun Jun 28, 2020 15:34
The secretome from embryonic stem cell cardiomyogenesis: Same signals, different cellular feedbacks.
Related Articles The secretome from embryonic stem cell cardiomyogenesis: Same signals, different cellular feedbacks. J Cell Physiol. 2020 Jun 27;: Authors: Robert AW, Stimamiglio MA Abstract Ischemic heart diseases are a global health problem that requires the search for alternative therapies to the current treatments. Thus, an understanding of how cardiomyogenic signals can affect cellular behavior would allow us to create strategies to improve...
Sun Jun 28, 2020 15:34
Related Articles Cx31.1 expression is modulated in HaCaT cells exposed to UV-induced damage and scrape-wounding. J Cell Physiol. 2020 Jun 27;: Authors: Nugent L, Ofori-Frimpong B, Martin PE, Green CR, Wright CS Abstract Connexin31.1 (Cx31.1) is a gap junction protein associated with apoptosis. In the skin, apoptosis is modulated by diabetes. A HaCaT skin model investigated whether normal (NGI) and high glucose and insulin (HGI; diabetic) conditions...
Sun Jun 28, 2020 15:34
Related Articles Involvement of mechanosensitive ion channels in the effects of mechanical stretch induces osteogenic differentiation in mouse bone marrow mesenchymal stem cells. J Cell Physiol. 2020 Jun 27;: Authors: Wu T, Yin F, Wang N, Ma X, Jiang C, Zhou L, Zong Y, Shan H, Xia W, Lin Y, Zhou Z, Yu X Abstract Bone marrow mesenchymal stem cells (BMSCs) can be induced to process osteogenic differentiation with appropriate mechanical and/or...
Sun Jun 28, 2020 15:34
Related Articles Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+ release in endothelial colony-forming cells. J Cell Physiol. 2020 Jun 24;: Authors: Moccia F, Zuccolo E, Di Nezza F, Pellavio G, Faris PS, Negri S, De Luca A, Laforenza U, Ambrosone L, Rosti V, Guerra G Abstract Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently discovered Ca2+ -releasing messenger...
Fri Jun 26, 2020 14:51
Related Articles Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor. J Cell Physiol. 2020 Jun 24;: Authors: Bergamin LS, Penolazzi L, Lambertini E, Falzoni S, Sarti AC, Molle CM, Gendron FP, De Bonis P, Di Virgilio F, Piva R Abstract Bone mineralization is an orchestrated process by which mineral crystals are deposited by osteoblasts; however, the detailed mechanisms remain to be elucidated....
Fri Jun 26, 2020 14:51
Related Articles Restoration of miR-330 expression suppresses lung cancer cell viability, proliferation, and migration. J Cell Physiol. 2020 Jun 24;: Authors: Mohammadi A, Mansoori B, Duijf PHG, Safarzadeh E, Tebbi L, Najafi S, Shokouhi B, Sorensen GL, Holmskov U, Baradaran B Abstract Lung cancer is one of the most common cancers and its incidence is rising around the world. Various studies suggest that miR-330 acts as a tumor-suppressor microRNA...
Fri Jun 26, 2020 14:51
Related Articles Effects of photobiomodulation combined with MSCs transplantation on the repair of spinal cord injury in rat. J Cell Physiol. 2020 Jun 24;: Authors: Chen H, Wang Y, Tu W, Wang H, Yin H, Sha H, Li Y Abstract Stem cell transplantation has shown promising regenerative effects against neural injury, and photobiomodulation (PBM) can aid tissue recovery. This study aims to evaluate the therapeutic effect of human umbilical cord mesenchymal...
Fri Jun 26, 2020 14:51
Related Articles Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis. J Cell Physiol. 2020 Jun 24;: Authors: Zhu H, Zhao M, Chen Y, Li D Abstract Bcl-2 associated athanogene 5 (Bag5) is a novel endoplasmic reticulum (ER) regulator. However, its role in catecholamine-induced endothelial cells damage has not been fully understood. In our study, catecholamine was used to mimic hypertension-related...
Fri Jun 26, 2020 14:51
Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury.
Related Articles Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury. J Cell Physiol. 2020 Jun 24;: Authors: Zhang J, Bi J, Ren Y, Du Z, Li T, Wang T, Zhang L, Wang M, Wei S, Lv Y, Wu R Abstract Ischemia reperfusion (I/R)-induced acute kidney injury (AKI) is a common and serious condition. Irisin, an exercise-induced hormone, improves mitochondrial function and reduces reactive oxygen species (ROS)...
Fri Jun 26, 2020 14:51
Related Articles LINC01426 contributes to clear cell renal cell carcinoma progression by modulating CTBP1/miR-423-5p/FOXM1 axis via interacting with IGF2BP1. J Cell Physiol. 2020 Jun 24;: Authors: Jiang Y, Zhang H, Li W, Yan Y, Yao X, Gu W Abstract Increasing evidence suggests that long noncoding RNAs (lncRNAs) are pivotal regulators in oncogenesis. However, the role of numerous lncRNAs has never been unmasked in clear cell renal cell carcinoma...
Fri Jun 26, 2020 14:51
Related Articles Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy. J Cell Physiol. 2020 Jun 24;: Authors: Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y Abstract Lipid deposition caused by the disorder of renal lipid metabolism is involved in diabetic nephropathy (DN). Carbohydrate response element-binding protein (ChREBP) is a key transcription factor in high glucose-induced...
Fri Jun 26, 2020 14:51
Related Articles Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus. J Cell Physiol. 2020 Jun 24;: Authors: Guo C, Zhao L, Li Y, Deng X, Yuan G Abstract Sedentary and high-calorie diets are associated with increased risk of obesity and type 2 diabetes mellitus, while exercise and diet control are also important nondrug treatments for diabetes. Fibroblast growth factor 21 (FGF21) is an important cytokine, which...
Fri Jun 26, 2020 14:51
Related Articles A Combined Nutrition and Exercise Intervention Influences Serum Vitamin B-12 and 25-Hydroxyvitamin D and Bone Turnover of Healthy Chinese Middle-Aged and Older Adults. J Nutr. 2020 Jun 26;: Authors: Groenendijk I, Chan R, Woo J, Ong S, Parikh P, Bragt MC, de Groot LC Abstract BACKGROUND: Hong Kong faces several public health problems including malnutrition and osteoporosis. Considering the typical Chinese diet and overall low...
Sat Jun 27, 2020 14:39
Related Articles Serum Phospholipid Fatty Acids and Mammographic Density in Premenopausal Women. J Nutr. 2020 Jun 25;: Authors: Lope V, Del Pozo MDP, Criado-Navarro I, Pérez-Gómez B, Pastor-Barriuso R, Ruiz E, Castelló A, Lucas P, Sierra Á, Salas-Trejo D, Llobet R, Martínez I, Romieu I, Chajès V, Priego-Capote F, Pollán M Abstract BACKGROUND: The role of fatty acids (FAs) on mammographic density (MD) is unclear, and available studies are based...
Fri Jun 26, 2020 14:50
Related Articles Food System Workers are the Unexpected but Under Protected COVID Heroes. J Nutr. 2020 Jun 25;: Authors: Parks CA, Nugent NB, Fleischhacker SE, Yaroch AL Abstract Coronavirus disease 2019 (COVID-19) poses an occupational health risk to food system workers including farmers/producers, grocery store workers, emergency food system staff and volunteers (e.g., food pantry workers), and others. These food system workers have been pushed...
Fri Jun 26, 2020 14:50
Related Articles Vagus Nerve Recordings: New Opportunities to Investigate Autonomic Function in Humans. J Physiol. 2020 Jun 27;: Authors: Park J PMID: 32592419 [PubMed - as supplied by publisher]
Sun Jun 28, 2020 15:30
Related Articles Cardiovascular and cerebrovascular responses to cardio-respiratory events in preterm infants during the transitional period. J Physiol. 2020 Jun 27;: Authors: Martini S, Frabboni G, Rucci P, Czosnyka M, Smielewski P, Galletti S, Cimatti AG, Faldella G, Corvaglia L, Austin T Abstract KEY POINTS: Non-invasive simultaneous multiparametric monitoring allows the in vivo evaluation of cerebral and cardiovascular haemodynamic responses...
Sun Jun 28, 2020 15:30
Related Articles AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 Jun 27;: Authors: Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG Abstract KEY POINTS: Pregnancy at high altitude is associated with a greater incidence of fetal growth restriction due, in part, to lesser uterine artery blood flow. AMP-activated...
Sun Jun 28, 2020 15:30
Related Articles Pitfalls and potential for the use of computational modeling to guide the treatment of atrial fibrillation. J Physiol. 2020 Jun 26;: Authors: Van Wagoner DR PMID: 32589261 [PubMed - as supplied by publisher]
Sat Jun 27, 2020 15:23
Related Articles Stretching-based vascular rehabilitation? it's not a stretch. J Physiol. 2020 Jun 26;: Authors: Gifford JR PMID: 32589259 [PubMed - as supplied by publisher]
Sat Jun 27, 2020 15:23
Related Articles Skeletal muscle AMPK is not activated during 2 hours of moderate intensity exercise at ∼65% VO2 peak in endurance trained men. J Physiol. 2020 Jun 26;: Authors: McConell GK, Wadley GD, Le Plastrier K, Linden KC Abstract KEY POINTS: AMP-activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. However, we previously showed that although AMPK activity increases 8-10 fold during...
Sat Jun 27, 2020 15:23
Related Articles Measuring nucleus mechanics within a living multicellular organism: Physical decoupling and attenuated recovery rate are physiological protective mechanisms of the cell nucleus under high mechanical load. Mol Biol Cell. 2020 Jun 25;:mbcE20010085 Authors: Zuela-Sopilniak N, Bar-Sela D, Charar C, Wintner O, Gruenbaum Y, Buxboim A Abstract Nuclei within cells are constantly subjected to compressive, tensile and shear forces, which...
Fri Jun 26, 2020 14:59
Related Articles Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking. Mol Biol Cell. 2020 Jun 25;:mbcE20010063 Authors: Ireland SC, Huang H, Zhang J, Li J, Wang Y Abstract Reactive oxygen species (ROS)-induced oxidative stress has been associated with diseases such as amyotrophic lateral sclerosis (ALS), stroke and cancer. While the effect of ROS on mitochondria and endoplasmic reticulum (ER) has been well documented,...
Fri Jun 26, 2020 14:59
Related Articles Roles for a lipid phosphatase in the activation of its opposing lipid kinase. Mol Biol Cell. 2020 Jun 25;:mbcE18090556 Authors: Strunk BS, Steinfeld N, Lee S, Jin N, Muñoz-Rivera C, Meeks G, Thomas A, Akemann C, Mapp AK, MacGurn JA, Weisman LS Abstract Fig4 is a phosphoinositide phosphatase that converts PI3,5P2 to PI3P. Paradoxically, mutation of Fig4 results in lower PI3,5P2, indicating that Fig4 is also required for PI3,5P2...
Fri Jun 26, 2020 14:59
Related Articles Geometry of the nuclear envelope determines its flexural stiffness. Mol Biol Cell. 2020 Jun 25;:mbcE20020163 Authors: Agrawal A, Lele TP Abstract During closed mitosis in fission yeast, growing microtubules push onto the nuclear envelope to deform it which results in fission into two daughter nuclei. The resistance of the envelope to bending, quantified by the flexural stiffness, helps determine the microtubule-dependent nuclear...
Fri Jun 26, 2020 14:59
Related Articles SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis. Mol Biol Cell. 2020 Jun 25;:mbcE20020100 Authors: Amano G, Matsuzaki S, Mori Y, Miyoshi K, Han S, Shikada S, Takamura H, Yoshimura T, Katayama T Abstract Arginine methylation is a common post-translational modification that modulates protein function. SCY1 like pseudokinase 1 (SCYL1) is crucial for neuronal functions and interacts...
Fri Jun 26, 2020 14:59
Related Articles Phosphatidylinositol 4-kinase III beta regulates cell shape, migration and Focal Adhesion number. Mol Biol Cell. 2020 Jun 25;:mbcE19110600 Authors: Bilodeau P, Jacobsen D, Law-Vinh D, Lee JM Abstract Cell shape is regulated by cell adhesion and cytoskeletal and membrane dynamics. Cell shape, adhesion and motility have a complex relationship and understanding them is important in understanding developmental patterning and embryogenesis....
Fri Jun 26, 2020 14:59
Related Articles Nonmuscle Myosin 2 Regulates Cortical Stability during Sprouting Angiogenesis. Mol Biol Cell. 2020 Jun 25;:mbcE20030175 Authors: Ma X, Uchida Y, Wei T, Liu C, Adams RH, Kubota Y, Gutkind JS, Mukouyama YS, Adelstein RS Abstract Among the three nonmuscle myosin 2 (NM2) paralogs, NM 2A and 2B, but not 2C, are detected in endothelial cells. To study the role of NM2 in vascular formation we ablate NM2 in endothelial cells in mice....
Fri Jun 26, 2020 14:59
Related Articles Rapidly dynamic host cell heterogeneity in bacterial adhesion governs susceptibility to infection by Listeria monocytogenes. Mol Biol Cell. 2020 Jun 25;:mbcE19080454 Authors: Rengarajan M, Theriot JA Abstract Interactions between host cells and individual pathogenic bacteria determine the clinical severity of disease during systemic infection in humans. Vascular endothelial cells, which line the lumen of blood vessels, represent...
Fri Jun 26, 2020 14:59
Related Articles Centrosomes are Required for Proper β-catenin Processing and Wnt Response. Mol Biol Cell. 2020 Jun 25;:mbcE20020139 Authors: Vora SM, Fassler JS, Phillips BT Abstract The Wnt/β-catenin signaling pathway is central to metazoan development and routinely dysregulated in cancer. Wnt/β-catenin signaling initiates transcriptional reprogramming upon stabilization of the transcription factor β-catenin, which is otherwise post-translationally...
Fri Jun 26, 2020 14:59
Related Articles Dynamic actin crosslinking governs the cytoplasm's transition to fluid-like behavior. Mol Biol Cell. 2020 Jun 24;:mbcE19090504 Authors: Chaubet L, Chaudhary AR, Heris HK, Ehrlicher AJ, Hendricks AG Abstract Cells precisely control their mechanical properties to organize and differentiate into tissues. The architecture and connectivity of cytoskeletal filaments changes in response to mechanical and biochemical cues, allowing...
Thu Jun 25, 2020 15:26
Related Articles Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells. Mol Biol Cell. 2020 Jun 24;:mbcE19120707 Authors: Balabiyev A, Podolnikova NP, Mursalimov A, Lowry D, Newbern JM, Roberson RW, Ugarova TP Abstract Macrophage fusion resulting in the formation of multinucleated giant cells (MGCs) is a multistage process that requires many adhesion-dependent steps and involves the rearrangement...
Thu Jun 25, 2020 15:26
Related Articles Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin. Mol Biol Cell. 2020 Jun 24;:mbcE20040270 Authors: Cheng KW, Mullins RD Abstract The shape of many eukaryotic cells depends on the actin cytoskeleton, and changes in actin assembly dynamics underlie many changes in cell shape. Ena/VASP-family actin polymerases, for example, modulate cell shape by locally accelerating actin filament assembly...
Thu Jun 25, 2020 15:26
Related Articles A septin-Hof1 scaffold at the yeast bud neck binds and organizes actin cables. Mol Biol Cell. 2020 Jun 24;:mbcE19120693 Authors: Garabedian MV, Wirshing A, Vakhrusheva A, Turegun B, Sokolova OS, Goode BL Abstract Cellular actin arrays are often highly organized, with characteristic patterns critical to their in vivo functions, yet the mechanisms for establishing these higher order geometries remain poorly understood. In Saccharomyces...
Thu Jun 25, 2020 15:26
Related Articles Touch-induced Mechanical Strain in Somatosensory Neurons is Independent of Extracellular Matrix Mutations in C. elegans. Mol Biol Cell. 2020 Jun 24;:mbcE20010049 Authors: Nekimken AL, Pruitt BL, Goodman MB Abstract Cutaneous mechanosensory neurons are activated by mechanical loads applied to the skin, and these stimuli are proposed to generate mechanical strain within sensory neurons. Using a microfluidic device to deliver controlled...
Thu Jun 25, 2020 15:26
Related Articles Early and non-redundant functions of dynamin isoforms in clathrin-mediated endocytosis. Mol Biol Cell. 2020 Jun 24;:mbcE20060363 Authors: Bhave M, Mettlen M, Wang X, Schmid SL Abstract Dynamin GTPases (Dyn1 and Dyn2) are indispensable proteins of the core clathrin-mediated endocytosis (CME) machinery. Best known for their role in fission at the late stages of CME, many studies have suggested that dynamin also plays a regulatory...
Thu Jun 25, 2020 15:26
Related Articles Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020 Jun 24;:mbcE19100589 Authors: Zhang H, Zhao R, Tones J, Liu M, Dilley R, Chenoweth DM, Greenberg RA, Lampson MA Abstract Telomerase-free cancer cells employ a recombination-based alternative lengthening of telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia (PML) nuclear bodies (APBs), whose function is...
Thu Jun 25, 2020 15:26
Related Articles The interplay between chromophore and protein determines the extended excited state dynamics in a single-domain phytochrome. Proc Natl Acad Sci U S A. 2020 Jun 26;: Authors: Slavov C, Fischer T, Barnoy A, Shin H, Rao AG, Wiebeler C, Zeng X, Sun Y, Xu Q, Gutt A, Zhao KH, Gärtner W, Yang X, Schapiro I, Wachtveitl J Abstract Phytochromes are a diverse family of bilin-binding photoreceptors that regulate a wide range of physiological...
Sun Jun 28, 2020 14:22
Related Articles Functional analysis of the OsNPF4.5 nitrate transporter reveals a conserved mycorrhizal pathway of nitrogen acquisition in plants. Proc Natl Acad Sci U S A. 2020 Jun 25;: Authors: Wang S, Chen A, Xie K, Yang X, Luo Z, Chen J, Zeng D, Ren Y, Yang C, Wang L, Feng H, López-Arredondo DL, Herrera-Estrella LR, Xu G Abstract Low availability of nitrogen (N) is often a major limiting factor to crop yield in most nutrient-poor soils....
Sat Jun 27, 2020 13:59
Related Articles Convergent evolution of conserved mitochondrial pathways underlies repeated adaptation to extreme environments. Proc Natl Acad Sci U S A. 2020 Jun 25;: Authors: Greenway R, Barts N, Henpita C, Brown AP, Arias Rodriguez L, Rodríguez Peña CM, Arndt S, Lau GY, Murphy MP, Wu L, Lin D, Tobler M, Kelley JL, Shaw JH Abstract Extreme environments test the limits of life; yet, some organisms thrive in harsh conditions. Extremophile lineages...
Sat Jun 27, 2020 13:59
Related Articles Multiorbital charge-density wave excitations and concomitant phonon anomalies in Bi2Sr2LaCuO6+δ. Proc Natl Acad Sci U S A. 2020 Jun 25;: Authors: Li J, Nag A, Pelliciari J, Robarts H, Walters A, Garcia-Fernandez M, Eisaki H, Song D, Ding H, Johnston S, Comin R, Zhou KJ Abstract Charge-density waves (CDWs) are ubiquitous in underdoped cuprate superconductors. As a modulation of the valence electron density, CDWs in hole-doped...
Sat Jun 27, 2020 13:59
Related Articles Dynamic human MutSα-MutLα complexes compact mismatched DNA. Proc Natl Acad Sci U S A. 2020 Jun 25;: Authors: Bradford KC, Wilkins H, Hao P, Li ZM, Wang B, Burke D, Wu D, Smith AE, Spaller L, Du C, Gauer JW, Chan E, Hsieh P, Weninger KR, Erie DA Abstract DNA mismatch repair (MMR) corrects errors that occur during DNA replication. In humans, mutations in the proteins MutSα and MutLα that initiate MMR cause Lynch syndrome, the...
Sat Jun 27, 2020 13:59
Related Articles Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Sharma M, Rajendrarao S, Shahani N, Ramírez-Jarquín UN, Subramaniam S Abstract Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain's striatum, thereby...
Fri Jun 26, 2020 13:38
Related Articles PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Tam VC, Suen R, Treuting PM, Armando A, Lucarelli R, Gorrochotegui-Escalante N, Diercks AH, Quehenberger O, Dennis EA, Aderem A, Gold ES Abstract Patients infected with influenza are at high risk of secondary bacterial infection, which is a major proximate cause of morbidity...
Fri Jun 26, 2020 13:38
Related Articles Stable readout of observed actions from format-dependent activity of monkey's anterior intraparietal neurons. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Lanzilotto M, Maranesi M, Livi A, Ferroni CG, Orban GA, Bonini L Abstract Humans accurately identify observed actions despite large dynamic changes in their retinal images and a variety of visual presentation formats. A large network of brain regions in primates participates...
Fri Jun 26, 2020 13:38
Related Articles A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR,...
Fri Jun 26, 2020 13:38
Related Articles Opinion: What models can and cannot tell us about COVID-19. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Siegenfeld AF, Taleb NN, Bar-Yam Y PMID: 32581126 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 13:38
Related Articles Core Concept: How synaptic pruning shapes neural wiring during development and, possibly, in disease. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Sakai J PMID: 32581125 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 13:38
Related Articles Enantioselective terpolymerization of racemic and meso-epoxides with anhydrides for preparation of chiral polyesters. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Li J, Liu Y, Ren WM, Lu XB Abstract The preparation of stereochemistry- and sequence-defined polymers, in which different monomer units are arranged in an ordered fashion just like biopolymers, is of great interest and has been a long-standing goal for chemists...
Fri Jun 26, 2020 13:38
Related Articles The transition to family caregiving and its effect on biomarkers of inflammation. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Roth DL, Haley WE, Sheehan OC, Huang J, Rhodes JD, Durda P, Howard VJ, Walston JD, Cushman M Abstract Chronic stress has been widely proposed to increase systemic inflammation, a pathway that may link stress with a heightened risk for many diseases. The chronic stress-inflammation relationship has...
Fri Jun 26, 2020 13:38
Related Articles Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Papuchova H, Kshirsagar S, Xu L, Bougleux Gomes HA, Li Q, Iyer V, Norwitz ER, Strominger JL, Tilburgs T Abstract During pregnancy, invading HLA-G+ extravillous trophoblasts (EVT) play a key role in placental development, uterine spiral artery remodeling, and prevention of detrimental...
Fri Jun 26, 2020 13:38
Related Articles Toward a science of delivering aid with dignity: Experimental evidence and local forecasts from Kenya. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Thomas CC, Otis NG, Abraham JR, Markus HR, Walton GM Abstract How can governments and nonprofits design aid programs that afford dignity and facilitate beneficial outcomes for recipients? We conceptualize dignity as a state that manifests when the stigma associated with receiving...
Fri Jun 26, 2020 13:38
Related Articles Science and equality of opportunity. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: McNutt M PMID: 32581120 [PubMed - as supplied by publisher]
Fri Jun 26, 2020 13:38
Related Articles Mass measurements during lymphocytic leukemia cell polyploidization decouple cell cycle- and cell size-dependent growth. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Mu L, Kang JH, Olcum S, Payer KR, Calistri NL, Kimmerling RJ, Manalis SR, Miettinen TP Abstract Cell size is believed to influence cell growth and metabolism. Consistently, several studies have revealed that large cells have lower mass accumulation rates per...
Fri Jun 26, 2020 13:38
Correcting misperceptions of exponential coronavirus growth increases support for social distancing.
Related Articles Correcting misperceptions of exponential coronavirus growth increases support for social distancing. Proc Natl Acad Sci U S A. 2020 Jun 24;: Authors: Lammers J, Crusius J, Gast A Abstract The most effective way to stem the spread of a pandemic such as coronavirus disease 2019 (COVID-19) is social distancing, but the introduction of such measures is hampered by the fact that a sizeable part of the population fails to see their...
Fri Jun 26, 2020 13:38
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/06/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Jun 25, 2020 17:20
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/06/25PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Jun 25, 2020 13:16
Ανησυχητικά είναι τα ευρήματα μελέτης του Ερευνητικού Πανεπιστημιακού Ινστιτούτου Ψυχικής Υγείας, Νευροεπιστημών και Ιατρικής Ακρίβειας «Κώστας Στεφανής» (ΕΠΙΨΥ) για τη χρήση εξαρτησιογόνων ουσιών από τους εφήβους στην Ελλάδα. Η έρευνα δίδεται στη δημοσιότητα με αφορμή τη σημερινή Παγκόσμια Ημέρα κατά των Ναρκωτικών και αφορά σε επιδημιολογικά δεδομένα του 2019 για τη χρήση παράνομων ουσιών στους έφηβους-μαθητές ηλικίας 16 ετών στη χώρα μας. Η έρευνα διενεργήθηκε την άνοιξη του 2019 σε πανελλήνιο...
Fri Jun 26, 2020 13:13
Έρευνα Βιολόγων από το Πανεπιστήμιο του Manchester εξηγεί για πρώτη φορά γιατί ο καλός ύπνος βοηθά να αντεπεξέλθουμε στις αντιξοότητες της καθημερινότητας και να διατηρήσουμε το σφρίγος μας. Η μελέτη που δημοσιεύτηκε στο Nature Cell Biology, εξέτασε σε ποντίκια τον τρόπο που οι μηχανισμοί του βιολογικού μας ρολογιού βοηθούν το σώμα να διατηρείται σε φόρμα όταν είμαστε δραστήριοι. Σύμφωνα με τον Καθηγητή Karl Kadler, επικεφαλής της έρευνας, τα ευρήματα σχετικά με αυτή τη λειτουργία του βιολογικού...
Fri Jun 26, 2020 12:46
Η γλώσσα μας «μιλά» και λέει πολλά για την υγεία μας που δεν ακούμε μα βλέπουμε. Αυτό ισχυρίζεται νέα έρευνα που παρουσιάστηκε στην επιστημονική πλατφόρμα HFA Discoveries της Ευρωπαϊκής Καρδιολογικής Εταιρείας. Συγκεκριμένα, το χρώμα της γλώσσας μας μπορεί να υποδείξει την ύπαρξη χρόνιας καρδιακή ανεπάρκειας, σύμφωνα με την επικεφαλής της μελέτης Δρ. Tianhui Yuan από το Νοσοκομείο του Πανεπιστημίου Κινεζικής Ιατρικής της Guangzhou. «Οι γλώσσες των υγιών ανθρώπων είναι ανοιχτόχρωμες με μια λευκή...
Fri Jun 26, 2020 12:20
Μια ερευνητική ομάδα από το Ινστιτούτο Ανοσολογίας MedUni Vienna, σε συνεργασία με επιστήμονες από το Πανεπιστήμιο Johns Hopkins, ανακάλυψε τον τρόπο με τον οποίο τα ακάρεα της οικιακής σκόνης ενεργοποιούν ένα γνωστό φλεγμονώδη παράγοντα – το αμυλοειδές Α (SAA), μια πρωτεΐνη οξείας φάσης – ωθώντας τον πνευμονικό ιστό σε αλλεργική αντίδραση», όπως αναφέρουν οι επιστήμονες στη σχετική δημοσίευση στο Nature Immunology. Οι ειδικοί, υπό την επίβλεψη των Ursula Smole και Winfried F. Pickl, ανακάλυψαν...
Fri Jun 26, 2020 10:20
Μια ομάδα ερευνητών από ένα δίκτυο συνεργαζόμενων ιδρυμάτων στην Κίνα διαπίστωσε ότι η επαναλαμβανόμενη έκθεση ποντικών σε μπλε φως κατά τη διάρκεια της νύχτας μπορεί να προκαλέσει την εμφάνιση καταθλιπτικών συμπτωμάτων. Τα ευρήματα θα μπορούσαν να βρουν εφαρμογή και στους ανθρώπους, ισχυρίζονται οι επιστήμονες. Η έρευνα δημοσιεύτηκε στο Nature Neuroscience. Παλαιότερη έρευνα είχε δείξει ότι οι άνθρωποι που εργάζονται νυχτερινές βάρδιες έχουν περισσότερες πιθανότητες να εμφανίσουν κατάθλιψη σε σχέση...
Fri Jun 26, 2020 09:01
Ένα σημαντικό εύρημα για τη συμβολή των στατινών στον περιορισμό της θνησιμότητας εξαιτίας του καρκίνου των ωοθηκών γεννά ελπίδα στις γυναίκες που υποφέρουν από τη νόσο. Η νέα μελέτη για την αντικαρκινική δράση των φαρμάκων που χορηγούνται για τη ρύθμιση της χοληστερόλης, κοινοποιήθηκε σε διαδικτυακό συνέδριο της Αμερικανικής Ένωσης για την Έρευνα του Καρκίνου. Όπως σημείωσε η Δρ. Kala Visvanathan, Καθηγήτρια Επιδημιολογίας και Ογκολογίας στη Σχολή Δημόσιας Υγείας Johns Hopkins Bloomberg στη Βαλτιμόρη,...
Fri Jun 26, 2020 08:52
Για να κατανοήσουμε καλύτερα τη συμπεριφορά που ακολουθούμε όταν καθόμαστε, χρειάζεται να ερευνήσουμε λεπτομερώς τα κίνητρα που μας κάνουν είτε να κάτσουμε κάπου είτε να σταθούμε όρθιοι. Για παράδειγμα, καθόμαστε περισσότερο όταν είμαστε κουρασμένοι (λόγω μιας πνευματικά απαιτητικής εργασίας) ή μήπως βιαζόμαστε να σηκωθούμε; Και ποια στιγμή της ημέρας θέλουμε να αλλάξουμε πιο γρήγορα στάση; Μία δημοσίευση ερευνητών από το Πανεπιστήμιο Radboud στο PNAS κάνει το πρώτο βήμα διερεύνησης της ψυχολογίας...
Fri Jun 26, 2020 08:35
Οι επιστήμονες ολοκλήρωσαν εκτενείς ελέγχους πάνω σε ένα νέο τεστ ούρων πέντε λεπτών που μετρά το κατά πόσο είναι υγιεινή η διατροφή που ακολουθεί ένας άνθρωπος και παράγει το μοναδικό ατομικό «αποτύπωμα» ούρων του. Οι επιστήμονες από το Κολέγιο Imperial του Λονδίνου και τα Πανεπιστήμια Northwestern, Illinois και Murdoch ανέλυσαν τα επίπεδα 46 μεταβολιτών στα ούρα 1.848 ανθρώπων στις ΗΠΑ. Όπως αναφέρεται στη σχετική δημοσίευση στο Nature Food, οι μεταβολίτες θεωρούνται ένας αντικειμενικός δείκτης...
Fri Jun 26, 2020 08:15
Η λήψη στατινών, δηλαδή φαρμάκων που μειώνουν τη χοληστερόλη, σχετίζεται με χαμηλότερα ποσοστά θανάτου και λιγότερα περιστατικά μηχανικής αναπνευστικής υποστήριξης ασθενών που νοσηλεύονται με τη νόσο COVID-19, υποστηρίζουν οι επιστήμονες σε μια νέα έρευνα που δημοσιεύθηκε στο Cell Metabolism. Η μεγάλης κλίμακας αναδρομική μελέτη έδειξε, επίσης, ότι ο κίνδυνος θανάτου και άλλων αρνητικών αποτελεσμάτων δεν αυξήθηκε από τον συνδυασμό θεραπείας με στατίνες, αναστολείς μετατρεπτικού ενζύμου της αγγειοτενσίνης...
Fri Jun 26, 2020 07:53
Ενδιαφέροντα ευρήματα κομίζει πρόσφατη μελέτη από τους επιστήμονες Υγείας του Πανεπιστημίου της Γιούτα αναφορικά με το προσδόκιμο ζωής αλλά και τη γονιμότητα. Συγκεκριμένα, τα ευρήματα που βρίσκονται δημοσιευμένα στο Scientific Reports, έδειξαν πως το σύνολο των γενετικών μεταλλάξεων που συμβαίνουν στο DNA μας μπορούν να προβλέψουν τα χρόνια ζωής που υπολείπονται και στα δύο φύλα, καθώς και την διάρκεια της γυναικείας γονιμότητας . Σύμφωνα με την έρευνα, την πρώτη στο είδος της κατά την εκτίμηση...
Thu Jun 25, 2020 14:10
Άλλο ένα σημαντικό όφελος της άσκησης ανέδειξε πρόσφατη έρευνα, η συμβολή της οποίας στην εύρυθμη λειτουργία και καλή υγεία του οργανισμού έχει επανειλημμένα αποδειχθεί. Αυτή τη φορά, τα νέα επιστημονικά δεδομένα συσχετίζουν τη σωματική άσκηση με τον μειωμένο κίνδυνο υπνικής άπνοιας, μιας πάθησης που σχετίζεται με το αναπνευστικό και ταλαιπωρεί εκατομμύρια ανθρώπους. Εάν παραμείνει χωρίς θεραπεία πολλαπλασιάζει τις πιθανότητες καρδιοπαθειών, εγκεφαλικού επεισοδίου, υπέρτασης και άλλων δυνητικά σοβαρών...
Thu Jun 25, 2020 12:15
Πολλές περισσότερες -περίπου διπλάσιες- γυναίκες νοσούν από Αλτσχάιμερ σε σχέση με τους άνδρες και οι επιστήμονες αναζητούν την αιτία γι’ αυτό. Μία νέα αμερικανική επιστημονική μελέτη το αποδίδει κυρίως στις ορμονικές αλλαγές των γυναικών κατά τη διάρκεια και μετά την εμμηνόπαυση. Οι ερευνητές, με επικεφαλής τη δρα Λάιζα Μοσκόνι του Ιατρικού Κέντρου Weill Cornell του Πανεπιστημίου Κορνέλ της Νέας Υόρκης, που έκαναν τη σχετική δημοσίευση στο Neurology της Αμερικανικής Ακαδημίας Νευρολογίας, ανέλυσαν...
Thu Jun 25, 2020 09:37
Για τους καπνιστές που είναι καλοί στα μαθηματικά, η απόφαση να σταματήσουν το τσιγάρο είναι πολύ πιο πιθανό να γίνει πραγματικότητα, σύμφωνα με μία νέα έρευνα που δημοσιεύθηκε στο Health Psychology. Συγκεκριμένα, οι ερευνητές βρήκαν ότι οι καπνιστές που είχαν υψηλότερη βαθμολογία σε ένα τεστ μαθηματικών ικανοτήτων ήταν πιο πιθανό από άλλους να πουν ότι σκοπεύουν να σταματήσουν το κάπνισμα. Ο λόγος; Θυμούνταν καλύτερα αριθμούς που σχετίζονταν με τους κινδύνους του καπνίσματος, πράγμα το οποίο τους...
Thu Jun 25, 2020 08:19
Η πολύ ενδιαφέρουσα μελέτη, που δημοσιεύθηκε στο περιοδικό της Αμερικανικής Εταιρείας Γηριατρικής (American Geriatrics Society), εξέτασε πέντε χαρακτηριστικά της προσωπικότητας και το αν και πώς αυτά συνδέονται με δύο πρόδρομες καταστάσεις άνοιας, το Σύνδρομο Κινητικού-Γνωστικού Κινδύνου (MCR) και τηνΉπια Γνωστική Διαταραχή (MCI). Τα χαρακτηριστικά αυτά ήταν ο νευρωτισμός, η εξωστρέφεια, η ευσυνειδησία, η διαλλαγή (συμβιβασμός, δεκτικότητα) και η ανοιχτοσύνη (ειλικρίνεια). Μεταξύ, λοιπόν, 524 ενηλίκων...
Thu Jun 25, 2020 07:54
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